Aliases for ADAL Gene
External Ids for ADAL Gene
Previous GeneCards Identifiers for ADAL Gene
GeneCards Summary for ADAL Gene
ADAL (Adenosine Deaminase Like) is a Protein Coding gene. Diseases associated with ADAL include Hypertropia and Spastic Hemiplegia. Among its related pathways are Metabolism of nucleotides and Abacavir transport and metabolism. Gene Ontology (GO) annotations related to this gene include adenosine deaminase activity and deaminase activity. An important paralog of this gene is ADA.
UniProtKB/Swiss-Prot Summary for ADAL Gene
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941).