ADAL Gene (Protein Coding)

Adenosine Deaminase Like

GC15P043330
GIFtS:
34
See more...

Aliases for ADAL Gene

Aliases for ADAL Gene

  • Adenosine Deaminase Like 2 3 5
  • Adenosine Deaminase-Like Protein 3 4
  • N6-Methyl-AMP Aminohydrolase 3 4
  • N6-MAMP Deaminase 3 4
  • HsMAPDA 3 4
  • Adenosine Deaminase-Like Protein Isoform 1 4
  • EC 3.5.4.- 4
  • EC 3.5.4 51
  • ADAL1 4
  • ADAL 5

External Ids for ADAL Gene

Previous GeneCards Identifiers for ADAL Gene

  • GC15P041416
  • GC15P043622
  • GC15P020471

Summaries for ADAL Gene

GeneCards Summary for ADAL Gene

ADAL (Adenosine Deaminase Like) is a Protein Coding gene. Diseases associated with ADAL include Hypertropia and Spastic Hemiplegia. Among its related pathways are Metabolism of nucleotides and Abacavir transport and metabolism. Gene Ontology (GO) annotations related to this gene include adenosine deaminase activity and deaminase activity. An important paralog of this gene is ADA.

UniProtKB/Swiss-Prot Summary for ADAL Gene

  • Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941).

Additional gene information for ADAL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ADAL Gene

Genomics for ADAL Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ADAL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ADAL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ADAL

Top Transcription factor binding sites by QIAGEN in the ADAL gene promoter:
  • CHOP-10
  • Evi-1
  • HTF
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • POU3F2
  • TBP

Genomic Locations for ADAL Gene

Genomic Locations for ADAL Gene
chr15:43,330,341-43,354,569
(GRCh38/hg38)
Size:
24,229 bases
Orientation:
Plus strand
chr15:43,622,872-43,646,096
(GRCh37/hg19)
Size:
23,225 bases
Orientation:
Plus strand

Genomic View for ADAL Gene

Genes around ADAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAL Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADAL Gene

Proteins for ADAL Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6DHV7-ADAL_HUMAN
    Recommended name:
    Adenosine deaminase-like protein
    Protein Accession:
    Q6DHV7
    Secondary Accessions:
    • A6NHZ3
    • B4DQM8

    Protein attributes for ADAL Gene

    Size:
    355 amino acids
    Molecular mass:
    40264 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for ADAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAL Gene

Protein Expression for ADAL Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ADAL Gene

Q6DHV7:
  • PDRIGHGTFL
  • PKVELHAHL
  • VTKDVIKEFA
  • DGVKYLELRSTPR
  • HHFGFWY

Post-translational modifications for ADAL Gene

No Post-translational modifications

Other Protein References for ADAL Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ADAL Gene

Gene Families for ADAL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ADAL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADAL Gene

GenScript: Design optimal peptide antigens:
  • Adenosine deaminase-like protein (ADAL_HUMAN)
  • cDNA FLJ60799 (B4DQM8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6DHV7

UniProtKB/Swiss-Prot:

ADAL_HUMAN :
  • Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
Family:
  • Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
genes like me logo Genes that share domains with ADAL: view

Function for ADAL Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for ADAL Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H(+) + H2O + N(6)-methyl-AMP = IMP + methylamine; Xref=Rhea:RHEA:16001, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58053, ChEBI:CHEBI:59338, ChEBI:CHEBI:144842; Evidence={ECO:0000269|PubMed:21755941, ECO:0000269|PubMed:29884623};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=12.5 uM for N(6)-methyl-AMP {ECO:0000269|PubMed:21755941};

Enzyme Numbers (IUBMB) for ADAL Gene

Phenotypes From GWAS Catalog for ADAL Gene

Gene Ontology (GO) - Molecular Function for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004000 adenosine deaminase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0019239 deaminase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAL: view
genes like me logo Genes that share phenotypes with ADAL: view

Animal Models for ADAL Gene

MGI Knock Outs for ADAL:
  • Adal Adal<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAL

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAL

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADAL Gene

Localization for ADAL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAL gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ADAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAL Gene

Pathways & Interactions for ADAL Gene

genes like me logo Genes that share pathways with ADAL: view

Pathways by source for ADAL Gene

Gene Ontology (GO) - Biological Process for ADAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006154 adenosine catabolic process IBA 21873635
GO:0009117 nucleotide metabolic process IEA --
GO:0017144 drug metabolic process TAS --
GO:0043101 purine-containing compound salvage TAS --
GO:0046103 inosine biosynthetic process IBA 21873635
genes like me logo Genes that share ontologies with ADAL: view

No data available for SIGNOR curated interactions for ADAL Gene

Drugs & Compounds for ADAL Gene

Products:

  1. Drug

(3) Drugs for ADAL Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adalimumab Approved Pharma 602
Anti-Inflammatory Agents Pharma 12267
Antirheumatic Agents Pharma 12236
genes like me logo Genes that share compounds with ADAL: view

Transcripts for ADAL Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ADAL Gene

7 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ADAL

Alternative Splicing Database (ASD) splice patterns (SP) for ADAL Gene

No ASD Table

Relevant External Links for ADAL Gene

GeneLoc Exon Structure for
ADAL

Expression for ADAL Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADAL Gene

mRNA expression in normal human tissues for ADAL Gene
mRNA expression by GTEx for ADAL GenemRNA expression by BioGPS for ADAL Gene

Protein differential expression in normal tissues from HIPED for ADAL Gene

This gene is overexpressed in Gallbladder (19.9), Heart (13.6), Tlymphocyte (11.7), and Retina (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAL Gene



Protein tissue co-expression partners for ADAL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ADAL

SOURCE GeneReport for Unigene cluster for ADAL Gene:

Hs.533913

Evidence on tissue expression from TISSUES for ADAL Gene

  • Nervous system(4.7)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with ADAL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAL Gene

Orthologs for ADAL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ADAL 30 31
  • 99.7 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ADAL 30 31
  • 92.58 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ADAL 30 31
  • 89.13 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Adal 30 17 31
  • 84.36 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia ADAL 31
  • 73 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ADAL 31
  • 63 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ADAL 30 31
  • 74.39 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ADAL 31
  • 59 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia adal 30
  • 68.72 (n)
Str.12484 30
Zebrafish
(Danio rerio)
 Actinopterygii adal 30 31
  • 62.94 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP005158 30
  • 50.28 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta Ada 30 31
  • 47.4 (n)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea C44B7.12 30 31
  • 46.49 (n)
 OneToOne
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT4G04880 30
  • 50.33 (n)
Rice
(Oryza sativa)
 Liliopsida Os07g0661000 30
  • 51.54 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 35 (a)
 OneToOne
Species where no ortholog for ADAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ADAL Gene

ENSEMBL:
Gene Tree for ADAL (if available)
TreeFam:
Gene Tree for ADAL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ADAL: view image

Paralogs for ADAL Gene

Paralogs for ADAL Gene

Pseudogenes.org Pseudogenes for ADAL Gene

genes like me logo Genes that share paralogs with ADAL: view

Variants for ADAL Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ADAL Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
778490 Benign: not provided 43,348,987(+) C/T SYNONYMOUS_VARIANT
780160 Benign: not provided 43,343,049(+) A/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ADAL Gene

Structural Variations from Database of Genomic Variants (DGV) for ADAL Gene

Variant ID Type Subtype PubMed ID
nsv1512 CNV deletion 18451855

Variation tolerance for ADAL Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.53; 44.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAL Gene

Disorders for ADAL Gene

MalaCards: The human disease database

(4) MalaCards diseases for ADAL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypertropia
spastic hemiplegia
  • congenital hemiplegia
lymphocytic choriomeningitis
  • lcm
strabismus
  • strabismus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search ADAL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADAL

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ADAL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAL Gene

Publications for ADAL Gene

  1. Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219. (PMID: 23645737) Frey CR … Cihlar T (Anticancer research 2013) 2 3
  2. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. (PMID: 21755941) Murakami E … Furman PA (Journal of medicinal chemistry 2011) 3 4
  3. Phylogenetic analysis reveals a novel protein family closely related to adenosine deaminase. (PMID: 16245011) Maier SA … McDermid HE (Journal of molecular evolution 2005) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. m6A RNA Degradation Products Are Catabolized by an Evolutionarily Conserved N6-Methyl-AMP Deaminase in Plant and Mammalian Cells. (PMID: 29884623) Chen M … Witte CP (The Plant cell 2018) 4

ExternalLinks

View latest publications for ADAL gene in Mastermind

Products for ADAL Gene

  • Signalway ELISA kits for ADAL
  • Signalway Proteins for ADAL

Sources for ADAL Gene