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ADAL (Adenosine Deaminase Like) is a Protein Coding gene. Diseases associated with ADAL include Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include adenosine deaminase activity and deaminase activity. An important paralog of this gene is ADA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004000 | adenosine deaminase activity | IBA | 21873635 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0019239 | deaminase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of nucleotides |
.01
|
|
2 | Abacavir transport and metabolism | ||
3 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006154 | adenosine catabolic process | IBA | 21873635 |
GO:0009117 | nucleotide metabolic process | IEA | -- |
GO:0017144 | drug metabolic process | TAS | -- |
GO:0043101 | purine-containing compound salvage | TAS | -- |
GO:0046103 | inosine biosynthetic process | IBA | 21873635 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ADAL 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | ADAL 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | ADAL 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Adal 17 33 32 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | ADAL 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | ADAL 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | ADAL 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | ADAL 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | adal 32 |
|
||
Str.12484 32 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | adal 33 32 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005158 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Ada 33 32 |
|
OneToOne | |
worm (Caenorhabditis elegans) |
Secernentea | C44B7.12 33 32 |
|
OneToOne | |
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT4G04880 32 |
|
||
rice (Oryza sativa) |
Liliopsida | Os07g0661000 32 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne |
SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000074569 | -- | 43,341,615(+) | G/T | intron_variant | |
rs1000136086 | -- | 43,341,024(+) | CTCTCT/CTCT | intron_variant | |
rs1000151571 | -- | 43,341,780(+) | A/G | intron_variant | |
rs1000218851 | -- | 43,352,299(+) | G/A | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant | |
rs1000277097 | -- | 43,348,714(+) | A/T | intron_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal dominant non-syndromic intellectual disability |
|
|