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Aliases for ADAD2 Gene

Aliases for ADAD2 Gene

  • Adenosine Deaminase Domain Containing 2 2 3 5
  • TENRL 3 4
  • Adenosine Deaminase Domain-Containing Protein 2 3
  • Testis Nuclear RNA-Binding Protein-Like 4

External Ids for ADAD2 Gene

Previous GeneCards Identifiers for ADAD2 Gene

  • GC16P082783
  • GC16P069978

Summaries for ADAD2 Gene

GeneCards Summary for ADAD2 Gene

ADAD2 (Adenosine Deaminase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding and adenosine deaminase activity. An important paralog of this gene is ADAD1.

Additional gene information for ADAD2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAD2 Gene

Genomics for ADAD2 Gene

GeneHancer (GH) Regulatory Elements for ADAD2 Gene

Promoters and enhancers for ADAD2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I084191 Promoter 0.9 EPDnew 550.8 +0.1 70 0.1 PKNOX1 L3MBTL2 NFYC ASH1L GABPA SP1 NFYB GABPB1 PBX2 ZBTB33 ADAD2 LOC654780
GH16I084190 Enhancer 0.7 ENCODE 550.8 -0.1 -67 0.1 PKNOX1 L3MBTL2 NFYC ASH1L GABPA MBD2 SP1 ZFHX2 EGR1 PBX2 ADAD2 TAF1C
GH16I084281 Enhancer 0.9 FANTOM5 ENCODE 43.5 +90.1 90144 0.2 PKNOX1 NFYA DDX20 CEBPB NFYC SP2 ASH1L ZNF76 SP1 MBD2 ADAD2 DNAAF1 ENSG00000260300 KLHL36 LOC105376777 GC16M084262 RNA5SP433
GH16I084183 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.2 -5.5 -5476 4.1 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 POLR2B ZNF766 TAF1C LOC654780 ENSG00000260300 ADAD2 KLHL36 HSDL1 PIR55963
GH16I083993 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.3 -196.7 -196697 1.3 ELF3 ARID4B DNMT3B ZNF48 ETS1 HSF1 RCOR1 FOS ATF7 THAP11 NECAB2 SLC38A8 RNA5SP432 OSGIN1 MLYCD TAF1C ADAD2 DNAAF1 HSDL1 PIR54401
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAD2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAD2 gene promoter:

Genomic Locations for ADAD2 Gene

Genomic Locations for ADAD2 Gene
chr16:84,191,117-84,197,168
(GRCh38/hg38)
Size:
6,052 bases
Orientation:
Plus strand
chr16:84,224,723-84,230,774
(GRCh37/hg19)

Genomic View for ADAD2 Gene

Genes around ADAD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAD2 Gene

Proteins for ADAD2 Gene

  • Protein details for ADAD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCV1-ADAD2_HUMAN
    Recommended name:
    Adenosine deaminase domain-containing protein 2
    Protein Accession:
    Q8NCV1
    Secondary Accessions:
    • B2RCL6
    • Q8NA94

    Protein attributes for ADAD2 Gene

    Size:
    583 amino acids
    Molecular mass:
    61755 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAD2 Gene

Post-translational modifications for ADAD2 Gene

No Post-translational modifications

Other Protein References for ADAD2 Gene

No data available for DME Specific Peptides for ADAD2 Gene

Domains & Families for ADAD2 Gene

Gene Families for ADAD2 Gene

Protein Domains for ADAD2 Gene

Suggested Antigen Peptide Sequences for ADAD2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NCV1

UniProtKB/Swiss-Prot:

ADAD2_HUMAN :
  • Belongs to the ADAD family.
Family:
  • Belongs to the ADAD family.
genes like me logo Genes that share domains with ADAD2: view

Function for ADAD2 Gene

Phenotypes From GWAS Catalog for ADAD2 Gene

Gene Ontology (GO) - Molecular Function for ADAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004000 adenosine deaminase activity IEA --
genes like me logo Genes that share ontologies with ADAD2: view
genes like me logo Genes that share phenotypes with ADAD2: view

Animal Model Products

CRISPR Products

miRNA for ADAD2 Gene

miRTarBase miRNAs that target ADAD2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAD2 Gene

Localization for ADAD2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAD2 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ADAD2 Gene

Pathways & Interactions for ADAD2 Gene

SuperPathways for ADAD2 Gene

No Data Available

Interacting Proteins for ADAD2 Gene

Gene Ontology (GO) - Biological Process for ADAD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with ADAD2: view

No data available for Pathways by source and SIGNOR curated interactions for ADAD2 Gene

Drugs & Compounds for ADAD2 Gene

No Compound Related Data Available

Transcripts for ADAD2 Gene

Unigene Clusters for ADAD2 Gene

Adenosine deaminase domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAD2 Gene

No ASD Table

Relevant External Links for ADAD2 Gene

GeneLoc Exon Structure for
ADAD2
ECgene alternative splicing isoforms for
ADAD2

Expression for ADAD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAD2 Gene

mRNA differential expression in normal tissues according to GTEx for ADAD2 Gene

This gene is overexpressed in Testis (x34.6).

Protein differential expression in normal tissues from HIPED for ADAD2 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAD2 Gene



Protein tissue co-expression partners for ADAD2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAD2 Gene:

ADAD2

SOURCE GeneReport for Unigene cluster for ADAD2 Gene:

Hs.8977

Evidence on tissue expression from TISSUES for ADAD2 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ADAD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAD2 Gene

Orthologs for ADAD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAD2 33 34
  • 98.68 (n)
dog
(Canis familiaris)
Mammalia ADAD2 34 33
  • 81.08 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADAD2 33 34
  • 80.3 (n)
mouse
(Mus musculus)
Mammalia Adad2 16 34 33
  • 75.82 (n)
rat
(Rattus norvegicus)
Mammalia Adad2 33
  • 75.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADAD2 34
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADAD2 34
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAD2 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adad2 33
  • 44.56 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC558824 33
  • 51.87 (n)
ADAD2 34
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea D2005.1 34
  • 23 (a)
ManyToMany
adr-1 34
  • 11 (a)
ManyToMany
Species where no ortholog for ADAD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAD2 Gene

ENSEMBL:
Gene Tree for ADAD2 (if available)
TreeFam:
Gene Tree for ADAD2 (if available)

Paralogs for ADAD2 Gene

Paralogs for ADAD2 Gene

(2) SIMAP similar genes for ADAD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADAD2: view

Variants for ADAD2 Gene

Sequence variations from dbSNP and Humsavar for ADAD2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000083586 -- 84,195,526(+) C/T intron_variant
rs1000288950 -- 84,191,961(+) A/G/T intron_variant
rs1000536905 -- 84,195,228(+) G/T intron_variant
rs1000635755 -- 84,191,394(+) A/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant, upstream_transcript_variant
rs1000659075 -- 84,192,094(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAD2 Gene

Variant ID Type Subtype PubMed ID
nsv833309 CNV loss 17160897
nsv573424 CNV loss 21841781
nsv523437 CNV loss 19592680
nsv518342 CNV loss 19592680
nsv483044 CNV gain 15286789
nsv457597 CNV loss 19166990
nsv1065790 CNV loss 25217958
nsv1059227 CNV loss 25217958
esv3639414 CNV loss 21293372
esv3639413 CNV loss 21293372
esv3639412 CNV loss 21293372
esv2761930 CNV gain 21179565

Variation tolerance for ADAD2 Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.87; 91.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAD2 Gene

Disorders for ADAD2 Gene

Additional Disease Information for ADAD2

No disorders were found for ADAD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAD2 Gene

Publications for ADAD2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for ADAD2 Gene

Sources for ADAD2 Gene

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