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Aliases for ADAD1 Gene

Aliases for ADAD1 Gene

  • Adenosine Deaminase Domain Containing 1 2 3 5
  • Adenosine Deaminase Domain Containing 1 (Testis-Specific) 2 3
  • Testis Nuclear RNA-Binding Protein 3 4
  • Tenr 3 4
  • Adenosine Deaminase Domain-Containing Protein 1 3
  • Testis Tissue Sperm-Binding Protein Li 92mP 3

External Ids for ADAD1 Gene

Previous GeneCards Identifiers for ADAD1 Gene

  • GC04P123519
  • GC04P123300
  • GC04P119026

Summaries for ADAD1 Gene

GeneCards Summary for ADAD1 Gene

ADAD1 (Adenosine Deaminase Domain Containing 1) is a Protein Coding gene. Diseases associated with ADAD1 include Celiac Disease 1. Gene Ontology (GO) annotations related to this gene include RNA binding and adenosine deaminase activity. An important paralog of this gene is ADAD2.

UniProtKB/Swiss-Prot for ADAD1 Gene

  • Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).

Additional gene information for ADAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAD1 Gene

Genomics for ADAD1 Gene

GeneHancer (GH) Regulatory Elements for ADAD1 Gene

Promoters and enhancers for ADAD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I122379 Promoter 0.6 EPDnew 550.8 +0.6 614 0.1 ZBTB33 ADAD1 IL2
GH04I122378 Promoter 0.5 EPDnew 550.8 +0.0 43 0.1 ADAD1 IL2
GH04I122456 Promoter 0.5 EPDnew 0.2 +77.5 77546 0.1 IL2 ADAD1
GH04I122341 Enhancer 0.3 ENCODE 0.3 -36.8 -36825 1.1 FOS GC04P122311 ADAD1 KIAA1109
GH04I122330 Enhancer 0.2 ENCODE 0.2 -48.4 -48363 1.1 GC04P122311 ADAD1 KIAA1109
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADAD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ADAD1 gene promoter:

Genomic Locations for ADAD1 Gene

Genomic Locations for ADAD1 Gene
chr4:122,378,966-122,429,815
(GRCh38/hg38)
Size:
50,850 bases
Orientation:
Plus strand
chr4:123,300,121-123,350,957
(GRCh37/hg19)

Genomic View for ADAD1 Gene

Genes around ADAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAD1 Gene

Proteins for ADAD1 Gene

  • Protein details for ADAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M93-ADAD1_HUMAN
    Recommended name:
    Adenosine deaminase domain-containing protein 1
    Protein Accession:
    Q96M93
    Secondary Accessions:
    • A6NKN4
    • B7WPB0
    • D3DNX2
    • Q8IWG6
    • Q8NA06

    Protein attributes for ADAD1 Gene

    Size:
    576 amino acids
    Molecular mass:
    64411 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAD1 Gene

Post-translational modifications for ADAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADAD1 Gene

Domains & Families for ADAD1 Gene

Gene Families for ADAD1 Gene

Protein Domains for ADAD1 Gene

Suggested Antigen Peptide Sequences for ADAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96M93

UniProtKB/Swiss-Prot:

ADAD1_HUMAN :
  • Belongs to the ADAD family.
Family:
  • Belongs to the ADAD family.
genes like me logo Genes that share domains with ADAD1: view

Function for ADAD1 Gene

Molecular function for ADAD1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity).

Phenotypes From GWAS Catalog for ADAD1 Gene

Gene Ontology (GO) - Molecular Function for ADAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004000 adenosine deaminase activity IEA --
genes like me logo Genes that share ontologies with ADAD1: view
genes like me logo Genes that share phenotypes with ADAD1: view

Animal Models for ADAD1 Gene

MGI Knock Outs for ADAD1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADAD1 Gene

Localization for ADAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAD1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ADAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ADAD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADAD1 Gene

Pathways & Interactions for ADAD1 Gene

SuperPathways for ADAD1 Gene

No Data Available

Interacting Proteins for ADAD1 Gene

Gene Ontology (GO) - Biological Process for ADAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007286 spermatid development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with ADAD1: view

No data available for Pathways by source and SIGNOR curated interactions for ADAD1 Gene

Drugs & Compounds for ADAD1 Gene

(1) Drugs for ADAD1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ADAD1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAD1: view

Transcripts for ADAD1 Gene

Unigene Clusters for ADAD1 Gene

Adenosine deaminase domain containing 1 (testis-specific):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAD1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP3: -
SP4:
SP5: - - -

Relevant External Links for ADAD1 Gene

GeneLoc Exon Structure for
ADAD1
ECgene alternative splicing isoforms for
ADAD1

Expression for ADAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAD1 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for ADAD1 Gene

This gene is overexpressed in Testis (44.6) and Bone marrow mesenchymal stem cell (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAD1 Gene



Protein tissue co-expression partners for ADAD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADAD1 Gene:

ADAD1

SOURCE GeneReport for Unigene cluster for ADAD1 Gene:

Hs.518957

Evidence on tissue expression from TISSUES for ADAD1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ADAD1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAD1 Gene

Orthologs for ADAD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAD1 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADAD1 34 33
  • 91.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ADAD1 33 34
  • 91.84 (n)
mouse
(Mus musculus)
Mammalia Adad1 34 16 33
  • 87.94 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adad1 33
  • 87.71 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAD1 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAD1 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAD1 34 33
  • 67.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAD1 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adad1 33
  • 67.13 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18640 33
zebrafish
(Danio rerio)
Actinopterygii adad1 33
  • 58.3 (n)
ADAD1 34
  • 47 (a)
OneToOne
wufi42e08 33
worm
(Caenorhabditis elegans)
Secernentea D2005.1 34
  • 24 (a)
ManyToMany
adr-1 34
  • 12 (a)
ManyToMany
Species where no ortholog for ADAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAD1 Gene

ENSEMBL:
Gene Tree for ADAD1 (if available)
TreeFam:
Gene Tree for ADAD1 (if available)

Paralogs for ADAD1 Gene

Paralogs for ADAD1 Gene

Pseudogenes.org Pseudogenes for ADAD1 Gene

genes like me logo Genes that share paralogs with ADAD1: view

Variants for ADAD1 Gene

Sequence variations from dbSNP and Humsavar for ADAD1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000235563 -- 122,406,031(+) A/C intron_variant
rs1000346001 -- 122,413,304(+) G/A intron_variant
rs1000385824 -- 122,426,273(+) A/C intron_variant
rs1000475149 -- 122,406,985(+) A/T intron_variant
rs1000541238 -- 122,388,217(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADAD1 Gene

Variant ID Type Subtype PubMed ID
esv2673537 CNV deletion 23128226
esv3569686 CNV loss 25503493
esv3602024 CNV loss 21293372
esv3894021 CNV loss 25118596

Variation tolerance for ADAD1 Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAD1 Gene

Disorders for ADAD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
celiac disease 1
  • celiac disease, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards
Search ADAD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ADAD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ADAD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAD1 Gene

Publications for ADAD1 Gene

  1. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson CA … Rioux JD (Nature genetics 2011) 3 44 58
  2. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PMID: 21829393) Plagnol V … Todd JA (PLoS genetics 2011) 3 44 58
  3. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 44 58
  4. Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance. (PMID: 20553587) Hollis-Moffatt JE … Merriman TR (Arthritis research & therapy 2010) 3 44 58
  5. Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study. (PMID: 19302705) Teixeira VH … European Consortium on Rheumatoid Arthritis Families (Arthritis research & therapy 2009) 3 44 58

Products for ADAD1 Gene

Sources for ADAD1 Gene

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