Aliases for ADA2 Gene
External Ids for ADA2 Gene
Previous HGNC Symbols for ADA2 Gene
This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for ADA2 Gene
ADA2 (Adenosine Deaminase 2) is a Protein Coding gene. Diseases associated with ADA2 include Sneddon Syndrome and Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome. Among its related pathways are Innate Immune System and Metabolism. An important paralog of this gene is ADAL.
UniProtKB/Swiss-Prot Summary for ADA2 Gene
Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.