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Aliases for ACYP1 Gene

Aliases for ACYP1 Gene

  • Acylphosphatase 1 2 3 5
  • Acylphosphatase 1, Erythrocyte (Common) Type 2 3
  • Acylphosphatase, Organ-Common Type Isozyme 3 4
  • Acylphosphatase, Erythrocyte Isozyme 3 4
  • Acylphosphate Phosphohydrolase 1 3 4
  • ACYPE 3 4
  • Acylphosphatase-1 3
  • EC 4

External Ids for ACYP1 Gene

Previous GeneCards Identifiers for ACYP1 Gene

  • GC14M073046
  • GC14M069337
  • GC14M073509
  • GC14M074589
  • GC14M075519
  • GC14M055688

Summaries for ACYP1 Gene

Entrez Gene Summary for ACYP1 Gene

  • This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue localization: erythrocyte (common) type acylphosphatase encoded by this gene, and muscle type acylphosphatase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for ACYP1 Gene

ACYP1 (Acylphosphatase 1) is a Protein Coding gene. Among its related pathways are Pyruvate metabolism and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include acylphosphatase activity. An important paralog of this gene is ACYP2.

UniProtKB/Swiss-Prot for ACYP1 Gene

  • Its physiological role is not yet clear.

Gene Wiki entry for ACYP1 Gene

Additional gene information for ACYP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACYP1 Gene

Genomics for ACYP1 Gene

GeneHancer (GH) Regulatory Elements for ACYP1 Gene

Promoters and enhancers for ACYP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J075067 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 657.4 -0.1 -140 4.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 YY1 ZC2HC1C ACYP1 GC14M075064 EIF2B2 NEK9 RNU6-689P GC14P075088
GH14J075062 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655.9 +5.6 5558 2.1 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 POLR2B GLIS2 ELK1 ZNF143 MLH3 ACYP1 ZC2HC1C EIF2B2 NEK9 FCF1 YLPM1 PGF GC14M075064
GH14J075273 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 -208.3 -208337 9.2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B FOS GC14P075279 GC14P075280 GPATCH2L ENSG00000258559 ABCD4 FCF1 NEK9 PROX2 ACYP1
GH14J074977 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +87.9 87867 8.3 FOXA2 RAD21 RFX5 RCOR1 FOS EGR2 REST NR2F2 SP1 GLIS1 EIF2B2 ACYP1 PGF MLH3 ZC2HC1C RPS6KL1 PROX2 RNU6-689P DLST GC14P074952
GH14J075041 Enhancer 1 Ensembl ENCODE 18 +27.5 27525 1.7 ELF3 FOXA2 ARID4B RAD21 RARA YY1 RCOR1 RXRA REST ELF1 ACYP1 ZC2HC1C PGF MLH3 RNU6-689P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACYP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACYP1 gene promoter:
  • Roaz
  • Pax-4a
  • Brachyury
  • STAT1
  • POU2F1a
  • POU2F1
  • IRF-1
  • STAT2
  • STAT1alpha

Genomic Locations for ACYP1 Gene

Genomic Locations for ACYP1 Gene
16,263 bases
Minus strand
16,263 bases
Minus strand

Genomic View for ACYP1 Gene

Genes around ACYP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACYP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACYP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACYP1 Gene

Proteins for ACYP1 Gene

  • Protein details for ACYP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A6NDV8
    • B2R590

    Protein attributes for ACYP1 Gene

    99 amino acids
    Molecular mass:
    11261 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACYP1 Gene

    Alternative splice isoforms for ACYP1 Gene


neXtProt entry for ACYP1 Gene

Post-translational modifications for ACYP1 Gene

  • Ubiquitination at posLast=8989, Lys58, and Lys33
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ACYP1 Gene

Domains & Families for ACYP1 Gene

Gene Families for ACYP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ACYP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the acylphosphatase family.
  • Belongs to the acylphosphatase family.
genes like me logo Genes that share domains with ACYP1: view

Function for ACYP1 Gene

Molecular function for ACYP1 Gene

UniProtKB/Swiss-Prot Function:
Its physiological role is not yet clear.
UniProtKB/Swiss-Prot CatalyticActivity:
An acylphosphate + H(2)O = a carboxylate + phosphate.
GENATLAS Biochemistry:
acylphosphatase 1erythrocyte (common) type,11kDa

Enzyme Numbers (IUBMB) for ACYP1 Gene

Phenotypes From GWAS Catalog for ACYP1 Gene

Gene Ontology (GO) - Molecular Function for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003998 acylphosphatase activity IBA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACYP1: view
genes like me logo Genes that share phenotypes with ACYP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACYP1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACYP1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACYP1 Gene

Localization for ACYP1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACYP1 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with ACYP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACYP1 Gene

Pathways & Interactions for ACYP1 Gene

genes like me logo Genes that share pathways with ACYP1: view

Pathways by source for ACYP1 Gene

1 KEGG pathway for ACYP1 Gene
2 GeneGo (Thomson Reuters) pathways for ACYP1 Gene

Gene Ontology (GO) - Biological Process for ACYP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006796 phosphate-containing compound metabolic process TAS 3026468
genes like me logo Genes that share ontologies with ACYP1: view

No data available for SIGNOR curated interactions for ACYP1 Gene

Drugs & Compounds for ACYP1 Gene

(11) Drugs for ACYP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Benzoic Acid Approved, Investigational Pharma 8
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist 23
Phosphoric acid Approved Pharma 0
Stearic acid Approved, Experimental Pharma 0
Water Approved Pharma 0

(7) Additional Compounds for ACYP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachidinic acid
  • Arachinsaeure
  • C20:0
  • CH3-[CH2]18-COOH
  • Eicosanoic acid
Benzoyl phosphate
Glyceric acid 1,3-biphosphate
  • 1,3-Biphosphoglycerate
  • 1,3-Biphosphoglyceric acid
  • 1,3-Bis-phosphoglycerate
  • 1,3-Bisphosphoglycerate
  • 1,3-Diphosphateglycerate
Heptadecanoic acid
  • 17:0
  • C17:0
  • CH3-[CH2]15-COOH
  • Heptadecoic acid
  • Heptadecylic acid
Heptadecanoyl CoA
  • Heptadecanoyl-coenzyme A
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid CoA
  • Heptadecanoyl coenzyme A
genes like me logo Genes that share compounds with ACYP1: view

Transcripts for ACYP1 Gene

mRNA/cDNA for ACYP1 Gene

Unigene Clusters for ACYP1 Gene

Acylphosphatase 1, erythrocyte (common) type:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACYP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACYP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4: - - - -

Relevant External Links for ACYP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACYP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACYP1 Gene

Protein differential expression in normal tissues from HIPED for ACYP1 Gene

This gene is overexpressed in Tlymphocyte (7.7) and Oral epithelium (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACYP1 Gene

Protein tissue co-expression partners for ACYP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACYP1 Gene:


SOURCE GeneReport for Unigene cluster for ACYP1 Gene:


mRNA Expression by UniProt/SwissProt for ACYP1 Gene:

Tissue specificity: Organ-common type isozyme is found in many different tissues.
genes like me logo Genes that share expression patterns with ACYP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACYP1 Gene

Orthologs for ACYP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACYP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACYP1 34 33
  • 100 (n)
(Canis familiaris)
Mammalia ACYP1 34 33
  • 92.59 (n)
(Bos Taurus)
Mammalia ACYP1 34 33
  • 89.56 (n)
(Mus musculus)
Mammalia Acyp1 16 34 33
  • 85.86 (n)
(Rattus norvegicus)
Mammalia Acyp1 33
  • 85.86 (n)
(Monodelphis domestica)
Mammalia ACYP1 34
  • 81 (a)
(Gallus gallus)
Aves ACYP1 34 33
  • 63.3 (n)
(Anolis carolinensis)
Reptilia ACYP1 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acyp1 33
  • 64.29 (n)
(Danio rerio)
Actinopterygii acyp1 33
  • 66.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta Acyp2 34
  • 40 (a)
CG18371 34
  • 37 (a)
CG34161 34
  • 34 (a)
Acyp 34
  • 33 (a)
CG11052 34
  • 24 (a)
Species where no ortholog for ACYP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACYP1 Gene

Gene Tree for ACYP1 (if available)
Gene Tree for ACYP1 (if available)
Evolutionary constrained regions (ECRs) for ACYP1: view image

Paralogs for ACYP1 Gene

Paralogs for ACYP1 Gene

(1) SIMAP similar genes for ACYP1 Gene using alignment to 4 proteins:

  • G3V2U7_HUMAN
  • G3V3F8_HUMAN
  • G3V597_HUMAN
genes like me logo Genes that share paralogs with ACYP1: view

Variants for ACYP1 Gene

Sequence variations from dbSNP and Humsavar for ACYP1 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000336708 -- 75,070,589(-) C/T upstream_transcript_variant
rs1000554238 -- 75,059,978(-) G/A intron_variant
rs1000750374 -- 75,062,291(-) T/G intron_variant
rs1000993243 -- 75,063,652(-) A/G intron_variant
rs1001045360 -- 75,063,836(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACYP1 Gene

Variant ID Type Subtype PubMed ID
dgv1103n106 CNV deletion 24896259
dgv3778n54 CNV loss 21841781
dgv3779n54 CNV loss 21841781
dgv3780n54 CNV loss 21841781
dgv3781n54 CNV loss 21841781
esv2677383 CNV deletion 23128226
esv29535 CNV loss 19812545
esv3551775 CNV deletion 23714750
esv3634953 CNV loss 21293372
nsv510644 CNV deletion 20534489
nsv565188 CNV loss 21841781

Variation tolerance for ACYP1 Gene

Residual Variation Intolerance Score: 44.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACYP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACYP1 Gene

Disorders for ACYP1 Gene

Additional Disease Information for ACYP1

No disorders were found for ACYP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACYP1 Gene

Publications for ACYP1 Gene

  1. Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3. (PMID: 9730610) Fiaschi T … Ramponi G (Cytogenetics and cell genetics 1998) 2 3 22 58
  2. Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase. (PMID: 7796909) Fiaschi T … Ramponi G (FEBS letters 1995) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. ACYP1 gene possesses two alternative splicing forms that induce apoptosis. (PMID: 14992377) Degl'Innocenti D … Ramponi G (IUBMB life 2004) 3 22 58
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58

Products for ACYP1 Gene

Sources for ACYP1 Gene

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