ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] See more...

Aliases for ACVR1C Gene

Aliases for ACVR1C Gene

  • Activin A Receptor Type 1C 2 3 5
  • ALK7 2 3 4
  • Activin Receptor-Like Kinase 7 3 4
  • Activin A Receptor, Type IC 2 3
  • Activin Receptor Type-1C 3 4
  • Activin Receptor Type IC 3 4
  • EC 2.7.11.30 4 51
  • ACVRLK7 2 3
  • ACTR-IC 3 4
  • ALK-7 3 4
  • EC 2.7.11 51
  • ACVR1C 5

External Ids for ACVR1C Gene

Previous GeneCards Identifiers for ACVR1C Gene

  • GC02M158352
  • GC02M158592
  • GC02M158593
  • GC02M158214
  • GC02M158097
  • GC02M150268

Summaries for ACVR1C Gene

Entrez Gene Summary for ACVR1C Gene

  • ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ACVR1C Gene

ACVR1C (Activin A Receptor Type 1C) is a Protein Coding gene. Among its related pathways are Signaling by NODAL and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TGFBR1.

UniProtKB/Swiss-Prot Summary for ACVR1C Gene

  • Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.

Tocris Summary for ACVR1C Gene

  • Activin receptors transduce signals carried by the TGF-beta family of ligands. Such ligands include activin and bone morphogenetic proteins (BMPs). Members of this family are involved in a range of processes, including embryogenesis and tissue homeostasis.

Gene Wiki entry for ACVR1C Gene

Additional gene information for ACVR1C Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACVR1C Gene

Genomics for ACVR1C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ACVR1C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J157627 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.1 135 2 HNRNPL CTCF PRDM10 REST TFE3 IKZF1 ZIC2 ZSCAN4 RBFOX2 POLR2A ACVR1C FAM133DP lnc-GALNT5-2 CYTIP
GH02J157929 Enhancer 1.2 Ensembl ENCODE 5.4 -301.4 -301388 1.7 HNRNPL LEF1 IKZF1 JUND DDX20 MTA2 PHF21A PKNOX1 ZNF24 MTA1 ERMN ACVR1C ENSG00000271320 lnc-ACVR1-2 UPP2 CCDC148
GH02J157466 Enhancer 1 FANTOM5 ENCODE dbSUPER 3.2 +161.9 161883 0.2 RELA IKZF2 EED RELB RUNX3 BCL11A IKZF1 JUNB BATF EBF1 CYTIP ACVR1C LOC105373712 lnc-CYTIP-1 lnc-ERMN-5 ERMN
GH02J157306 Enhancer 0.6 Ensembl dbSUPER 4.7 +322.1 322063 1.6 CTCF RUNX3 MTA2 ACVR1C lnc-UPP2-7 ERMN GALNT5
GH02J157924 Enhancer 0.5 Ensembl 5.4 -295.8 -295837 1.4 FOSL1 ARNT TAL1 EGR2 CBFA2T3 ARID1B ACVR1C ENSG00000271320 lnc-ACVR1-2 UPP2 CCDC148
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACVR1C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACVR1C

Top Transcription factor binding sites by QIAGEN in the ACVR1C gene promoter:
  • AREB6
  • Bach2
  • Cdc5
  • Pbx1a
  • POU2F1
  • POU2F1a
  • S8
  • USF-1
  • USF1
  • XBP-1

Genomic Locations for ACVR1C Gene

Genomic Locations for ACVR1C Gene
chr2:157,526,767-157,628,864
(GRCh38/hg38)
Size:
102,098 bases
Orientation:
Minus strand
chr2:158,383,279-158,485,517
(GRCh37/hg19)
Size:
102,239 bases
Orientation:
Minus strand

Genomic View for ACVR1C Gene

Genes around ACVR1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACVR1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACVR1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACVR1C Gene

Proteins for ACVR1C Gene

  • Protein details for ACVR1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NER5-ACV1C_HUMAN
    Recommended name:
    Activin receptor type-1C
    Protein Accession:
    Q8NER5
    Secondary Accessions:
    • Q4ZFZ8
    • Q86UL1
    • Q86UL2
    • Q8TBG2

    Protein attributes for ACVR1C Gene

    Size:
    493 amino acids
    Molecular mass:
    54871 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Binds the type 2 receptor protein ACVR2A.

    Alternative splice isoforms for ACVR1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACVR1C Gene

Selected DME Specific Peptides for ACVR1C Gene

Q8NER5:
  • GMIKLALS
  • RHENILGFIAAD
  • KPAIAHRD
  • IADLGLA
  • FESFKRADIY
  • ARTIVLQE
  • VAVKIFSSR
  • PLLVQRTIA
  • HRDIKSKN
  • SGSGSGLP
  • ASGLAHLH
  • TLKDLIYD

Post-translational modifications for ACVR1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACVR1C Gene

Domains & Families for ACVR1C Gene

Gene Families for ACVR1C Gene

Protein Domains for ACVR1C Gene

InterPro:
Blocks:
  • Domain in TGF-beta receptor/activin receptor, type I/II
ProtoNet:

Suggested Antigen Peptide Sequences for ACVR1C Gene

GenScript: Design optimal peptide antigens:
  • Activin receptor-like kinase 7 (ACV1C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NER5

UniProtKB/Swiss-Prot:

ACV1C_HUMAN :
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
genes like me logo Genes that share domains with ACVR1C: view

Function for ACVR1C Gene

Molecular function for ACVR1C Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.30;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.30;.

Enzyme Numbers (IUBMB) for ACVR1C Gene

Phenotypes From GWAS Catalog for ACVR1C Gene

Gene Ontology (GO) - Molecular Function for ACVR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004675 transmembrane receptor protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACVR1C: view
genes like me logo Genes that share phenotypes with ACVR1C: view

Animal Models for ACVR1C Gene

MGI Knock Outs for ACVR1C:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACVR1C

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACVR1C

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACVR1C Gene

Localization for ACVR1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACVR1C Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACVR1C gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytoskeleton 3
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 0

Gene Ontology (GO) - Cellular Components for ACVR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IBA 21873635
GO:0048179 activin receptor complex IDA 15531507
genes like me logo Genes that share ontologies with ACVR1C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACVR1C Gene

Pathways & Interactions for ACVR1C Gene

genes like me logo Genes that share pathways with ACVR1C: view

Pathways by source for ACVR1C Gene

1 Qiagen pathway for ACVR1C Gene
  • Human Embryonic Stem Cell Pluripotency

SIGNOR curated interactions for ACVR1C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ACVR1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001834 trophectodermal cell proliferation IDA 15150278
GO:0002021 response to dietary excess IEA --
GO:0006468 protein phosphorylation IC 12063393
GO:0006915 apoptotic process IEA --
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA --
genes like me logo Genes that share ontologies with ACVR1C: view

Drugs & Compounds for ACVR1C Gene

(10) Drugs for ACVR1C Gene - From: ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 56
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0
SB505124 Pharma ALK4/ALK5/ALK7 inhibitor, Selective inhibitor of TGF-betaRI, ALK4 and ALK7 0
SB-505124 hydrochloride Pharma ALK5/ALK4/ALK7 inhibitor in TGF-β/activin signalling,selective 0

(3) Additional Compounds for ACVR1C Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
Alantolactone
  • (+)-Alantolactone
  • Alant camphor
  • Alantic anhydride
  • Elecampane camphor
  • Eupatal
546-43-0
DMH2
1206711-14-9

(5) Tocris Compounds for ACVR1C Gene

Compound Action Cas Number
Alantolactone Antiproliferative; induces activin/Smad3 signaling 546-43-0
DMH-1 Selective ALK2 inhibitor 1206711-16-1
DMH2 Type I BMP receptor inhibitor 1206711-14-9
K 02288 Type 1 BMP receptor inhibitor 1431985-92-0
ML 347 Potent and selective ALK1 and ALK2 inhibitor 1062368-49-3

(2) ApexBio Compounds for ACVR1C Gene

Compound Action Cas Number
SB505124 ALK4/ALK5/ALK7 inhibitor 694433-59-5
SB-505124 hydrochloride ALK5/ALK4/ALK7 inhibitor in TGF-β/activin signalling,selective 356559-13-2
genes like me logo Genes that share compounds with ACVR1C: view

Drug Products

Transcripts for ACVR1C Gene

mRNA/cDNA for ACVR1C Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACVR1C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACVR1C Gene

No ASD Table

Relevant External Links for ACVR1C Gene

GeneLoc Exon Structure for
ACVR1C

Expression for ACVR1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACVR1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACVR1C Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x15.3), Adipose - Subcutaneous (x10.2), and Breast - Mammary Tissue (x5.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACVR1C

SOURCE GeneReport for Unigene cluster for ACVR1C Gene:

Hs.562901

mRNA Expression by UniProt/SwissProt for ACVR1C Gene:

Q8NER5-ACV1C_HUMAN
Tissue specificity: Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.

Evidence on tissue expression from TISSUES for ACVR1C Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with ACVR1C: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACVR1C Gene

Orthologs for ACVR1C Gene

This gene was present in the common ancestor of animals.

Orthologs for ACVR1C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ACVR1C 30 31
  • 99.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ACVR1C 30 31
  • 93.93 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ACVR1C 31
  • 89 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia ACVR1C 30 31
  • 87.93 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ACVR1C 31
  • 87 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Acvr1c 30
  • 86.84 (n)
Mouse
(Mus musculus)
Mammalia Acvr1c 30 17 31
  • 86.55 (n)
OneToOne
Chicken
(Gallus gallus)
Aves ACVR1C 30 31
  • 73.93 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ACVR1C 31
  • 89 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia acvr1c 30
  • 74.07 (n)
Zebrafish
(Danio rerio)
Actinopterygii CABZ01079442.1 31
  • 67 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta babo 31
  • 42 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
OneToMany
Species where no ortholog for ACVR1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ACVR1C Gene

ENSEMBL:
Gene Tree for ACVR1C (if available)
TreeFam:
Gene Tree for ACVR1C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACVR1C: view image

Paralogs for ACVR1C Gene

(9) SIMAP similar genes for ACVR1C Gene using alignment to 2 proteins:

  • ACV1C_HUMAN
  • Q53SF5_HUMAN
genes like me logo Genes that share paralogs with ACVR1C: view

Variants for ACVR1C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACVR1C Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
713452 Likely Benign: not provided 157,538,579(-) A/G SYNONYMOUS_VARIANT
736643 Benign: not provided 157,544,545(-) A/G SYNONYMOUS_VARIANT
769232 Benign: not provided 157,587,377(-) G/. NO_SEQUENCE_ALTERATION,FIVE_PRIME_UTR_VARIANT
775762 Benign: not provided 157,550,337(-) T/G SYNONYMOUS_VARIANT,INTRON_VARIANT
780099 Benign: not provided 157,556,189(-) T/G MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ACVR1C Gene

Structural Variations from Database of Genomic Variants (DGV) for ACVR1C Gene

Variant ID Type Subtype PubMed ID
dgv2072n106 CNV deletion 24896259
esv1723038 CNV deletion 17803354
esv2329918 CNV deletion 18987734
esv2477101 CNV deletion 19546169
esv2643096 CNV deletion 19546169
esv2721013 CNV deletion 23290073
esv2721014 CNV deletion 23290073
esv2841457 CNV deletion 24192839
esv3303213 CNV mobile element insertion 20981092
esv3338137 CNV insertion 20981092
esv3381776 CNV insertion 20981092
esv3560409 CNV deletion 23714750
esv4635 CNV loss 18987735
nsv1006061 CNV gain 25217958
nsv1007037 CNV gain 25217958
nsv1011505 CNV gain 25217958
nsv1072038 CNV deletion 25765185
nsv956643 CNV deletion 24416366

Variation tolerance for ACVR1C Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.37; 81.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACVR1C Gene

Human Gene Mutation Database (HGMD)
ACVR1C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACVR1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACVR1C Gene

Disorders for ACVR1C Gene

Additional Disease Information for ACVR1C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ACVR1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACVR1C Gene

Publications for ACVR1C Gene

  1. cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C). (PMID: 12063393) Bondestam J … Ritvos O (Cytogenetics and cell genetics 2001) 2 3 4 23
  2. Nodal induces apoptosis and inhibits proliferation in human epithelial ovarian cancer cells via activin receptor-like kinase 7. (PMID: 15531507) Xu G … Peng C (The Journal of clinical endocrinology and metabolism 2004) 3 4 23
  3. Identification of novel isoforms of activin receptor-like kinase 7 (ALK7) generated by alternative splicing and expression of ALK7 and its ligand, Nodal, in human placenta. (PMID: 12606401) Roberts HJ … Peng C (Biology of reproduction 2003) 3 4 23
  4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41
  5. ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease. (PMID: 19275893) Carlsson LM … Sjöholm K (Biochemical and biophysical research communications 2009) 3 23

Products for ACVR1C Gene

  • Signalway Proteins for ACVR1C

Sources for ACVR1C Gene