Aliases for ACTRT3 Gene

Aliases for ACTRT3 Gene

  • Actin Related Protein T3 2 3 5
  • Actin-Related Protein M1 3 4
  • Actin-Related Protein T3 3 4
  • ARP-T3 3 4
  • ARPM1 3 4
  • Actin Related Protein M1 2

External Ids for ACTRT3 Gene

Previous GeneCards Identifiers for ACTRT3 Gene

  • GC03M169485
  • GC03M169487
  • GC03M169492
  • GC03M169497

Summaries for ACTRT3 Gene

GeneCards Summary for ACTRT3 Gene

ACTRT3 (Actin Related Protein T3) is a Protein Coding gene. An important paralog of this gene is ACTG1.

Additional gene information for ACTRT3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTRT3 Gene

Genomics for ACTRT3 Gene

GeneHancer (GH) Regulatory Elements for ACTRT3 Gene

Promoters and enhancers for ACTRT3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J169768 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.3 292 1.6 SIN3A ZBTB6 RBPJ POLR2A CC2D1A MNT ZBTB33 ELF3 SP7 ELF1 MYNN ACTRT3 ENSG00000269889 PRKCI LRRC34 AF047386 TERC
GH03J170352 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 -588.9 -588920 11.6 GTF3C2 ZNF24 SP1 ZBTB40 CTCF SREBF1 RBPJ SMARCE1 POLR2A NR2F6 SKIL lnc-SKIL-3 MYNN PHC3 SEC62-AS1 PRKCI ACTRT3 RPL22L1 ENSG00000239628 GPR160
GH03J169657 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.3 +106.5 106467 12.8 FOXK2 CTCF ZBTB6 RBPJ POLR2A CTBP1 ZNF217 ZNF362 L3MBTL2 RAD21 MECOM HSALNG0030580 HSALNG0030581 lnc-ACTRT3-5 MYNN PHC3 PRKCI ENSG00000239628 SEC62-AS1 RPL22P1
GH03J169008 Enhancer 0.9 FANTOM5 Ensembl 10.7 +761.6 761594 1.8 BCL6B ZNF473 MAFK SP7 ZSCAN21 ZNF639 ZSCAN4 NFE2L2 ZNF629 NFE2 ACTRT3 MECOM EGFEM1P LINC01997 lnc-MECOM-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTRT3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ACTRT3 Gene

Genomic Locations for ACTRT3 Gene
2,975 bases
Minus strand
2,975 bases
Minus strand

Genomic View for ACTRT3 Gene

Genes around ACTRT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTRT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTRT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTRT3 Gene

Proteins for ACTRT3 Gene

  • Protein details for ACTRT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein T3
    Protein Accession:
    Secondary Accessions:
    • Q96IS0
    • Q96NJ0

    Protein attributes for ACTRT3 Gene

    372 amino acids
    Molecular mass:
    41008 Da
    Quaternary structure:
    • Interacts with PFN3.

neXtProt entry for ACTRT3 Gene

Post-translational modifications for ACTRT3 Gene

No Post-translational modifications

Other Protein References for ACTRT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTRT3 Gene

Domains & Families for ACTRT3 Gene

Gene Families for ACTRT3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACTRT3 Gene

Suggested Antigen Peptide Sequences for ACTRT3 Gene

GenScript: Design optimal peptide antigens:
  • Actin-related protein M1 (ARPM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTRT3: view

Function for ACTRT3 Gene

Phenotypes From GWAS Catalog for ACTRT3 Gene

genes like me logo Genes that share phenotypes with ACTRT3: view

Animal Models for ACTRT3 Gene

MGI Knock Outs for ACTRT3:
  • Actrt3 Actrt3<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTRT3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACTRT3 Gene

Localization for ACTRT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTRT3 Gene

Cytoplasm, cytoskeleton. Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTRT3 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3
plasma membrane 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACTRT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton IBA 21873635
genes like me logo Genes that share ontologies with ACTRT3: view

Pathways & Interactions for ACTRT3 Gene

PathCards logo

SuperPathways for ACTRT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTRT3 Gene


No data available for Pathways by source and SIGNOR curated interactions for ACTRT3 Gene

Drugs & Compounds for ACTRT3 Gene

No Compound Related Data Available

Transcripts for ACTRT3 Gene

mRNA/cDNA for ACTRT3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTRT3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTRT3 Gene

No ASD Table

Relevant External Links for ACTRT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTRT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTRT3 Gene

mRNA differential expression in normal tissues according to GTEx for ACTRT3 Gene

This gene is overexpressed in Testis (x21.9).

Protein differential expression in normal tissues from HIPED for ACTRT3 Gene

This gene is overexpressed in Testis (50.1) and Ovary (18.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACTRT3 Gene

Protein tissue co-expression partners for ACTRT3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTRT3 Gene:


SOURCE GeneReport for Unigene cluster for ACTRT3 Gene:


mRNA Expression by UniProt/SwissProt for ACTRT3 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ACTRT3 Gene

  • Nervous system(4.1)
  • Intestine(4)
genes like me logo Genes that share expression patterns with ACTRT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTRT3 Gene

Orthologs for ACTRT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTRT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTRT3 32
  • 99.55 (n)
ARPM1 33
  • 99 (a)
(Bos Taurus)
Mammalia ARPM1 33 32
  • 87.23 (n)
(Canis familiaris)
Mammalia ACTRT3 33 32
  • 87.01 (n)
(Mus musculus)
Mammalia Actrt3 17 33 32
  • 82.02 (n)
(Rattus norvegicus)
Mammalia Actrt3 32
  • 80.86 (n)
(Monodelphis domestica)
Mammalia ACTRT3 33
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 34 (a)
(Anolis carolinensis)
Reptilia ACTRT3 33
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arp53D 33
  • 44 (a)
Species where no ortholog for ACTRT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTRT3 Gene

Gene Tree for ACTRT3 (if available)
Gene Tree for ACTRT3 (if available)
Evolutionary constrained regions (ECRs) for ACTRT3: view image

Paralogs for ACTRT3 Gene

(26) SIMAP similar genes for ACTRT3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACTRT3: view

Variants for ACTRT3 Gene

Sequence variations from dbSNP and Humsavar for ACTRT3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000090994 -- 169,769,736(-) A/C upstream_transcript_variant
rs1000369014 -- 169,770,039(-) G/A upstream_transcript_variant
rs1000800661 -- 169,770,197(-) A/G upstream_transcript_variant
rs1002635219 -- 169,767,696(-) G/T coding_sequence_variant, synonymous_variant
rs1003501596 -- 169,769,205(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTRT3 Gene

Variant ID Type Subtype PubMed ID
esv2422204 CNV deletion 17116639
esv2503104 CNV insertion 19546169
nsv7356 OTHER inversion 18451855

Variation tolerance for ACTRT3 Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.70; 66.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTRT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTRT3 Gene

Disorders for ACTRT3 Gene

Additional Disease Information for ACTRT3

No disorders were found for ACTRT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTRT3 Gene

Publications for ACTRT3 Gene

  1. Identification of two cDNAs for human actin-related proteins (Arps) that have remarkable similarity to conventional actin. (PMID: 11750065) Harata M … Hatta S (Biochimica et biophysica acta 2001) 2 3 4 56
  2. Nuclear localization of profilin III-ArpM1 complex in mouse spermiogenesis. (PMID: 18692047) Hara Y … Baba T (FEBS letters 2008) 2 3 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Identification of a melanoma susceptibility locus and somatic mutation in TET2. (PMID: 24980573) Song F … Han J (Carcinogenesis 2014) 3 56

Products for ACTRT3 Gene

Sources for ACTRT3 Gene