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Aliases for ACTR8 Gene

Aliases for ACTR8 Gene

  • ARP8 Actin Related Protein 8 Homolog 2 3 5
  • INO80 Complex Subunit N 2 3 4
  • INO80N 3 4
  • HArp8 3 4
  • ARP8 3 4
  • ARP8 (Actin-Related Protein 8, Yeast) Homolog 2
  • Actin-Related Protein 8 3

External Ids for ACTR8 Gene

Previous GeneCards Identifiers for ACTR8 Gene

  • GC03U990227
  • GC03M053152
  • GC03M053755
  • GC03M053858
  • GC03M053877
  • GC03M053901

Summaries for ACTR8 Gene

GeneCards Summary for ACTR8 Gene

ACTR8 (ARP8 Actin Related Protein 8 Homolog) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6.

UniProtKB/Swiss-Prot for ACTR8 Gene

  • Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.

Additional gene information for ACTR8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR8 Gene

Genomics for ACTR8 Gene

GeneHancer (GH) Regulatory Elements for ACTR8 Gene

Promoters and enhancers for ACTR8 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I053880 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 587.7 +0.6 627 2.5 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 ZNF143 ACTR8 ENSG00000271976
GH03I053890 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 37.2 -9.6 -9618 2.8 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B SELENOK ACTR8 ENSG00000271976
GH03I053345 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.4 +534.9 534877 2.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 DCP1A NISCH PBRM1 ENSG00000271976 RFT1 PHF7 ENSG00000212608 PRKCD NEK4 ACTR8
GH03I053140 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +741.1 741101 1.4 HDGF ZSCAN26 ZSCAN4 ZNF133 MAX PAX8 SALL2 EBF1 ZFHX2 FOXK2 GLT8D1 RFT1 NISCH PRKCD ACTR8 NEK4 STIMATE ITIH4 DCP1A ITIH3
GH03I053492 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 5.1 +388.3 388340 2.3 CTCF MXI1 SIN3A ZIC2 ZEB1 CTBP1 POLR2A PATZ1 EZH2 MAZ CACNA1D ACTR8 DCP1A TKT RFT1 RPS25P4 GC03P053524
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACTR8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACTR8 gene promoter:

Genomic Locations for ACTR8 Gene

Genomic Locations for ACTR8 Gene
chr3:53,864,931-53,882,202
(GRCh38/hg38)
Size:
17,272 bases
Orientation:
Minus strand
chr3:53,901,093-53,916,229
(GRCh37/hg19)

Genomic View for ACTR8 Gene

Genes around ACTR8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR8 Gene

Proteins for ACTR8 Gene

  • Protein details for ACTR8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H981-ARP8_HUMAN
    Recommended name:
    Actin-related protein 8
    Protein Accession:
    Q9H981
    Secondary Accessions:
    • B3KSW7
    • Q8N566
    • Q9H663

    Protein attributes for ACTR8 Gene

    Size:
    624 amino acids
    Molecular mass:
    70484 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Interacts with ACTR5; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
    SequenceCaution:
    • Sequence=BAB15402.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACTR8 Gene

    Alternative splice isoforms for ACTR8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR8 Gene

Post-translational modifications for ACTR8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR8 Gene

No data available for DME Specific Peptides for ACTR8 Gene

Domains & Families for ACTR8 Gene

Gene Families for ACTR8 Gene

Protein Domains for ACTR8 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H981

UniProtKB/Swiss-Prot:

ARP8_HUMAN :
  • Belongs to the actin family. ARP8 subfamily.
Family:
  • Belongs to the actin family. ARP8 subfamily.
genes like me logo Genes that share domains with ACTR8: view

Function for ACTR8 Gene

Molecular function for ACTR8 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.

Phenotypes From GWAS Catalog for ACTR8 Gene

Gene Ontology (GO) - Molecular Function for ACTR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16230350
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR8: view
genes like me logo Genes that share phenotypes with ACTR8: view

Animal Models for ACTR8 Gene

MGI Knock Outs for ACTR8:

Animal Model Products

CRISPR Products

miRNA for ACTR8 Gene

miRTarBase miRNAs that target ACTR8

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACTR8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACTR8 Gene

Localization for ACTR8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR8 Gene

Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR8 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Centrosome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACTR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18026119
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005813 centrosome IDA --
GO:0031011 Ino80 complex IEA,IDA 18026119
genes like me logo Genes that share ontologies with ACTR8: view

Pathways & Interactions for ACTR8 Gene

genes like me logo Genes that share pathways with ACTR8: view

Gene Ontology (GO) - Biological Process for ACTR8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0006338 chromatin remodeling IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ACTR8: view

No data available for SIGNOR curated interactions for ACTR8 Gene

Drugs & Compounds for ACTR8 Gene

No Compound Related Data Available

Transcripts for ACTR8 Gene

Unigene Clusters for ACTR8 Gene

ARP8 actin-related protein 8 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ACTR8

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR8 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2: - -
SP3: -
SP4: - - -
SP5:

Relevant External Links for ACTR8 Gene

GeneLoc Exon Structure for
ACTR8
ECgene alternative splicing isoforms for
ACTR8

Expression for ACTR8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR8 Gene

Protein differential expression in normal tissues from HIPED for ACTR8 Gene

This gene is overexpressed in Platelet (25.2), Placenta (12.9), Peripheral blood mononuclear cells (8.3), and Blymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR8 Gene



Protein tissue co-expression partners for ACTR8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTR8 Gene:

ACTR8

SOURCE GeneReport for Unigene cluster for ACTR8 Gene:

Hs.412186

Evidence on tissue expression from TISSUES for ACTR8 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ACTR8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR8 Gene

Orthologs for ACTR8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR8 33 34
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia ACTR8 33 34
  • 93.32 (n)
dog
(Canis familiaris)
Mammalia ACTR8 33 34
  • 92.79 (n)
oppossum
(Monodelphis domestica)
Mammalia ACTR8 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Actr8 16 34 33
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Actr8 33
  • 88.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR8 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACTR8 33 34
  • 79.05 (n)
lizard
(Anolis carolinensis)
Reptilia ACTR8 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr8 33
  • 73.58 (n)
Str.3965 33
African clawed frog
(Xenopus laevis)
Amphibia actr8-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii actr8 33 34
  • 69.61 (n)
Dr.7670 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10425 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010671 33
  • 49.85 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arp8 33 34
  • 46 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP8 33 34 36
  • 46.09 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR135W 33
  • 45.44 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E03213g 33
  • 44.99 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP9 33
  • 46.04 (n)
rice
(Oryza sativa)
Liliopsida Os04g0177600 33
  • 47.8 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06238 33
  • 46.73 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp8 33
  • 43.35 (n)
Species where no ortholog for ACTR8 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTR8 Gene

ENSEMBL:
Gene Tree for ACTR8 (if available)
TreeFam:
Gene Tree for ACTR8 (if available)

Paralogs for ACTR8 Gene

No data available for Paralogs for ACTR8 Gene

Variants for ACTR8 Gene

Sequence variations from dbSNP and Humsavar for ACTR8 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000007560 -- 53,866,229(-) AAAAAA/AAAAAAA genic_downstream_transcript_variant, intron_variant
rs1000200108 -- 53,880,201(-) C/T intron_variant
rs1000438448 -- 53,868,766(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000532778 -- 53,878,554(-) G/A intron_variant
rs1000782666 -- 53,862,706(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR8 Gene

Variant ID Type Subtype PubMed ID
dgv1376e212 CNV loss 25503493
dgv4747n100 CNV gain 25217958
esv3575570 CNV gain 25503493
nsv1003621 CNV loss 25217958
nsv1006990 CNV gain 25217958
nsv1013783 CNV gain 25217958
nsv1014752 CNV loss 25217958

Variation tolerance for ACTR8 Gene

Residual Variation Intolerance Score: 15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.42; 77.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR8

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR8 Gene

Disorders for ACTR8 Gene

Additional Disease Information for ACTR8

No disorders were found for ACTR8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR8 Gene

Publications for ACTR8 Gene

  1. The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. (PMID: 18163988) Aoyama N … Harata M (Experimental cell research 2008) 2 3 4 58
  2. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4 58
  3. Structure of Actin-related protein 8 and its contribution to nucleosome binding. (PMID: 22977180) Gerhold CB … Hopfner KP (Nucleic acids research 2012) 3 4 58
  4. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4 58
  5. Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. (PMID: 18922472) Yao T … Conaway JW (Molecular cell 2008) 3 4 58

Products for ACTR8 Gene

  • Addgene plasmids for ACTR8

Sources for ACTR8 Gene

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