Aliases for ACTR6 Gene

Aliases for ACTR6 Gene

  • Actin Related Protein 6 2 3 5
  • ARP6 Actin Related Protein 6 Homolog 2 3
  • Actin-Related Protein 6 3 4
  • HARPX 3 4
  • ARP6 Actin-Related Protein 6 Homolog (Yeast) 2
  • HSPC281 3
  • MSTP136 3
  • CDA12 3
  • HARP6 3
  • HArp6 4
  • ARP6 3

External Ids for ACTR6 Gene

Previous GeneCards Identifiers for ACTR6 Gene

  • GC12P100527
  • GC12P099097
  • GC12P099096
  • GC12P099117
  • GC12P100594
  • GC12P097655

Summaries for ACTR6 Gene

GeneCards Summary for ACTR6 Gene

ACTR6 (Actin Related Protein 6) is a Protein Coding gene. An important paralog of this gene is ACTR5.

Additional gene information for ACTR6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTR6 Gene

Genomics for ACTR6 Gene

GeneHancer (GH) Regulatory Elements for ACTR6 Gene

Promoters and enhancers for ACTR6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTR6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACTR6 gene promoter:
  • AML1a
  • c-Myb
  • GATA-1
  • HNF-1
  • HNF-1A
  • Ik-3
  • p300
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for ACTR6 Gene

Genomic Locations for ACTR6 Gene
42,744 bases
Plus strand
42,744 bases
Plus strand

Genomic View for ACTR6 Gene

Genes around ACTR6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR6 Gene

Proteins for ACTR6 Gene

  • Protein details for ACTR6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein 6
    Protein Accession:
    Secondary Accessions:
    • B3KW37
    • B4DLG9
    • Q53GH2
    • Q9BY39
    • Q9H8H6

    Protein attributes for ACTR6 Gene

    396 amino acids
    Molecular mass:
    45810 Da
    Quaternary structure:
    • Interacts with CBX1, CBX3 and CBX5.

    Alternative splice isoforms for ACTR6 Gene


neXtProt entry for ACTR6 Gene

Post-translational modifications for ACTR6 Gene

  • Ubiquitination at Lys38
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACTR6 Gene

Domains & Families for ACTR6 Gene

Gene Families for ACTR6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACTR6 Gene


Suggested Antigen Peptide Sequences for ACTR6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family. ARP6 subfamily.
  • Belongs to the actin family. ARP6 subfamily.
genes like me logo Genes that share domains with ACTR6: view

Function for ACTR6 Gene

Phenotypes From GWAS Catalog for ACTR6 Gene

Gene Ontology (GO) - Molecular Function for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15647280
GO:0031491 nucleosome binding IBA 21873635
genes like me logo Genes that share ontologies with ACTR6: view
genes like me logo Genes that share phenotypes with ACTR6: view

Animal Models for ACTR6 Gene

MGI Knock Outs for ACTR6:
  • Actr6 Actr6<tm1a(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ACTR6 Gene

miRTarBase miRNAs that target ACTR6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACTR6 Gene

Localization for ACTR6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR6 Gene

Cytoplasm, cytoskeleton. Nucleus. Note=Colocalizes with HP1 family proteins at pericentric heterochromatin.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR6 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 3
plasma membrane 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000812 Swr1 complex IBA 21873635
GO:0005634 nucleus IEA,ISS --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTR6: view

Pathways & Interactions for ACTR6 Gene

PathCards logo

SuperPathways for ACTR6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTR6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IEA --
GO:0043486 histone exchange IBA 21873635
genes like me logo Genes that share ontologies with ACTR6: view

No data available for Pathways by source and SIGNOR curated interactions for ACTR6 Gene

Drugs & Compounds for ACTR6 Gene

No Compound Related Data Available

Transcripts for ACTR6 Gene

mRNA/cDNA for ACTR6 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR6

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR6 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - -
SP8: -

Relevant External Links for ACTR6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTR6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR6 Gene

Protein differential expression in normal tissues from HIPED for ACTR6 Gene

This gene is overexpressed in Serum (53.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACTR6 Gene

Protein tissue co-expression partners for ACTR6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACTR6 Gene:


SOURCE GeneReport for Unigene cluster for ACTR6 Gene:


Evidence on tissue expression from TISSUES for ACTR6 Gene

  • Nervous system(4.7)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with ACTR6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR6 Gene

Orthologs for ACTR6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTR6 33 32
  • 99.75 (n)
(Ornithorhynchus anatinus)
Mammalia ACTR6 33
  • 97 (a)
(Bos Taurus)
Mammalia ACTR6 33 32
  • 95.54 (n)
(Canis familiaris)
Mammalia ACTR6 33 32
  • 94.95 (n)
(Monodelphis domestica)
Mammalia ACTR6 33
  • 93 (a)
(Mus musculus)
Mammalia Actr6 17 33 32
  • 89.48 (n)
(Rattus norvegicus)
Mammalia Actr6 32
  • 88.8 (n)
(Gallus gallus)
Aves ACTR6 33 32
  • 83.59 (n)
(Anolis carolinensis)
Reptilia ACTR6 33
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia actr6 32
  • 79.04 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14417 32
(Danio rerio)
Actinopterygii actr6 33 32
  • 75.08 (n)
wufc44c08 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4078 32
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005857 32
  • 54.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arp6 32
  • 53.26 (n)
Actr13E 33
  • 46 (a)
(Caenorhabditis elegans)
Secernentea arp-6 33 32
  • 51.65 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F19063g 32
  • 47.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP6 35 33 32
  • 47.53 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR091W 32
  • 44.24 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP6 32
  • 50.61 (n)
(Oryza sativa)
Liliopsida Os01g0269900 32
  • 49.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp6 32
  • 51.43 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05587 32
  • 47.61 (n)
Species where no ortholog for ACTR6 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR6 Gene

Gene Tree for ACTR6 (if available)
Gene Tree for ACTR6 (if available)
Evolutionary constrained regions (ECRs) for ACTR6: view image

Paralogs for ACTR6 Gene

(13) SIMAP similar genes for ACTR6 Gene using alignment to 8 proteins:

  • F8VP72_HUMAN
  • F8W043_HUMAN
  • F8W057_HUMAN
  • F8W0Q1_HUMAN
  • G3V1Y1_HUMAN Pseudogenes for ACTR6 Gene

genes like me logo Genes that share paralogs with ACTR6: view

Variants for ACTR6 Gene

Sequence variations from dbSNP and Humsavar for ACTR6 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000093090 -- 100,215,528(+) T/C intron_variant
rs1000113729 -- 100,200,047(+) C/T upstream_transcript_variant
rs1000148765 -- 100,213,485(+) A/G intron_variant
rs1000193578 -- 100,205,465(+) A/G intron_variant
rs1000377215 -- 100,212,689(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR6 Gene

Variant ID Type Subtype PubMed ID
esv3630550 CNV gain 21293372
esv3892256 CNV loss 25118596
nsv1048784 CNV gain 25217958
nsv559964 CNV gain 21841781

Variation tolerance for ACTR6 Gene

Residual Variation Intolerance Score: 24.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR6 Gene

Disorders for ACTR6 Gene

Additional Disease Information for ACTR6

No disorders were found for ACTR6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR6 Gene

Publications for ACTR6 Gene

  1. Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin. (PMID: 11368909) Kato M … Harata M (Gene 2001) 2 3 4 23 56
  2. Vertebrate Arp6, a novel nuclear actin-related protein, interacts with heterochromatin protein 1. (PMID: 16487625) Ohfuchi E … Harata M (European journal of cell biology 2006) 3 4 56
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for ACTR6 Gene

Sources for ACTR6 Gene