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Aliases for ACTR5 Gene

Aliases for ACTR5 Gene

  • ARP5 Actin Related Protein 5 Homolog 2 3 5
  • Sarcoma Antigen NY-SAR-16 3 4
  • INO80 Complex Subunit M 2 3
  • HARP5 3 4
  • Arp5 3 4
  • ARP5 (Actin-Related Protein 5, Yeast) Homolog 2
  • ARP5 Actin-Related Protein 5 Homolog (Yeast) 2
  • Actin-Related Protein 5 3
  • INO80M 3

External Ids for ACTR5 Gene

Previous GeneCards Identifiers for ACTR5 Gene

  • GC00U991039
  • GC20P038063
  • GC20P036810
  • GC20P037377
  • GC20P034114

Summaries for ACTR5 Gene

GeneCards Summary for ACTR5 Gene

ACTR5 (ARP5 Actin Related Protein 5 Homolog) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6.

UniProtKB/Swiss-Prot for ACTR5 Gene

  • Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.

Additional gene information for ACTR5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR5 Gene

Genomics for ACTR5 Gene

GeneHancer (GH) Regulatory Elements for ACTR5 Gene

Promoters and enhancers for ACTR5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I038747 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 584.1 +0.2 226 2 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 KLF13 SP3 ACTR5 GC20P038762
GH20I038139 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 45.2 -592.3 -592268 33.6 MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 MCM3 SP3 NFYC TGM2 SNHG17 RALGAPB ACTR5 RN7SKP173 SNORA71A TTI1 SNORA71C RPN2 DHX35
GH20I038433 Promoter/Enhancer 1.6 Ensembl ENCODE 73.9 -313.4 -313440 2.9 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SNHG17 GC20M038434 GC20M038437 SNORA71D ACTR5 RALGAPB ENSG00000224635 TTI1 SNORA71A SNORA71C
GH20I038031 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 31.8 -714.6 -714576 3.5 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TTI1 RPRD1B SNHG17 SNORA71A ACTR5 RALGAPB SNORA71C RN7SKP173 RPN2 RPS3P2
GH20I038803 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.7 +58.3 58336 6.3 HDGF PKNOX1 ATF1 FEZF1 IRF4 TCF12 POLR2B GLIS2 ZNF207 ZNF143 PPP1R16B ACTR5 ARHGAP40 RALGAPB DHX35 RN7SL116P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACTR5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACTR5 gene promoter:

Genomic Locations for ACTR5 Gene

Genomic Locations for ACTR5 Gene
24,263 bases
Plus strand

Genomic View for ACTR5 Gene

Genes around ACTR5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR5 Gene

Proteins for ACTR5 Gene

  • Protein details for ACTR5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein 5
    Protein Accession:
    Secondary Accessions:
    • Q86WF7
    • Q8IUY5
    • Q8N724
    • Q9BRN0
    • Q9BVB7

    Protein attributes for ACTR5 Gene

    607 amino acids
    Molecular mass:
    68297 Da
    Quaternary structure:
    • Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the helicase ATP-binding and the helicase C-terminal domain of INO80. Interacts with DDB1. Interacts with ACTR8; the interaction is observed in asynchronous (interphase) cells but not in metaphase-arrested cells indicative for a possible dissociation of the INO80 complex in mitotic cells.
    • Sequence=AAO65164.1; Type=Frameshift; Positions=319, 343, 347; Evidence={ECO:0000305};

neXtProt entry for ACTR5 Gene

Post-translational modifications for ACTR5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR5 Gene

Domains & Families for ACTR5 Gene

Gene Families for ACTR5 Gene

Protein Domains for ACTR5 Gene


Suggested Antigen Peptide Sequences for ACTR5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family. ARP5 subfamily.
  • Belongs to the actin family. ARP5 subfamily.
genes like me logo Genes that share domains with ACTR5: view

Function for ACTR5 Gene

Molecular function for ACTR5 Gene

UniProtKB/Swiss-Prot Function:
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.

Phenotypes From GWAS Catalog for ACTR5 Gene

Gene Ontology (GO) - Molecular Function for ACTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16230350
genes like me logo Genes that share ontologies with ACTR5: view
genes like me logo Genes that share phenotypes with ACTR5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR5 Gene

Localization for ACTR5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR5 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR5 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ACTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18026119
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IEA 19014934
GO:0031011 Ino80 complex IDA 18026119
genes like me logo Genes that share ontologies with ACTR5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACTR5 Gene

Pathways & Interactions for ACTR5 Gene

genes like me logo Genes that share pathways with ACTR5: view

Gene Ontology (GO) - Biological Process for ACTR5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair IMP 19014934
GO:0006310 DNA recombination IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ACTR5: view

No data available for SIGNOR curated interactions for ACTR5 Gene

Drugs & Compounds for ACTR5 Gene

No Compound Related Data Available

Transcripts for ACTR5 Gene

mRNA/cDNA for ACTR5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTR5 Gene

ARP5 actin-related protein 5 homolog (yeast):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9

Relevant External Links for ACTR5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTR5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR5 Gene

Protein differential expression in normal tissues from HIPED for ACTR5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.5), Breast (12.8), Bone marrow mesenchymal stem cell (7.4), and Blymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ACTR5 Gene

Protein tissue co-expression partners for ACTR5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTR5 Gene:


SOURCE GeneReport for Unigene cluster for ACTR5 Gene:


Evidence on tissue expression from TISSUES for ACTR5 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ACTR5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR5 Gene

Orthologs for ACTR5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTR5 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia ACTR5 33 34
  • 90.34 (n)
(Bos Taurus)
Mammalia ACTR5 33 34
  • 87.97 (n)
(Mus musculus)
Mammalia Actr5 16 34 33
  • 85.14 (n)
(Rattus norvegicus)
Mammalia Actr5 33
  • 84.25 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
-- 34
  • 72 (a)
(Monodelphis domestica)
Mammalia ACTR5 34
  • 78 (a)
(Gallus gallus)
Aves ACTR5 33 34
  • 75.85 (n)
(Anolis carolinensis)
Reptilia ACTR5 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia actr5 33
  • 67.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16529 33
(Danio rerio)
Actinopterygii actr5 33 34
  • 62.53 (n)
Dr.26688 33
fruit fly
(Drosophila melanogaster)
Insecta Arp5 33 34
  • 51.69 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004488 33
  • 50.45 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL253C 33
  • 47.9 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP5 33 34 36
  • 44.51 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03421g 33
  • 44.4 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARP5 33
  • 49.21 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU06394 33
  • 46.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp5 33
  • 46.14 (n)
Species where no ortholog for ACTR5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACTR5 Gene

Gene Tree for ACTR5 (if available)
Gene Tree for ACTR5 (if available)

Paralogs for ACTR5 Gene

No data available for Paralogs for ACTR5 Gene

Variants for ACTR5 Gene

Sequence variations from dbSNP and Humsavar for ACTR5 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000023887 -- 38,747,277(+) A/T upstream_transcript_variant
rs1000084184 -- 38,748,095(+) C/G upstream_transcript_variant
rs1000089273 -- 38,753,347(+) C/T intron_variant
rs1000176750 -- 38,747,929(+) T/C upstream_transcript_variant
rs1000383968 -- 38,754,266(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR5 Gene

Variant ID Type Subtype PubMed ID
dgv1242e212 CNV loss 25503493
esv3567959 CNV loss 25503493
nsv1058457 CNV loss 25217958

Variation tolerance for ACTR5 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.64; 56.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR5 Gene

Disorders for ACTR5 Gene

Additional Disease Information for ACTR5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ACTR5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR5 Gene

Publications for ACTR5 Gene

  1. A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. (PMID: 16230350) Jin J … Conaway JW (The Journal of biological chemistry 2005) 2 3 4 58
  2. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. (PMID: 21303910) Chen L … Conaway RC (The Journal of biological chemistry 2011) 3 4 58
  3. INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. (PMID: 20855601) Jiang Y … Li L (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58
  4. The human actin-related protein hArp5: nucleo-cytoplasmic shuttling and involvement in DNA repair. (PMID: 19014934) Kitayama K … Harata M (Experimental cell research 2009) 3 4 58
  5. The actin-related protein hArp8 accumulates on the mitotic chromosomes and functions in chromosome alignment. (PMID: 18163988) Aoyama N … Harata M (Experimental cell research 2008) 3 4 58

Products for ACTR5 Gene

Sources for ACTR5 Gene

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