Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ACTR3C Gene

Aliases for ACTR3C Gene

  • ARP3 Actin Related Protein 3 Homolog C 2 3 5
  • Actin-Related Protein 11 3 4
  • ARP11 3 4
  • ARP3 Actin-Related Protein 3 Homolog C (Yeast) 2
  • Actin-Related Protein 3C 3
  • Actin-Related Arp11 3

External Ids for ACTR3C Gene

Previous GeneCards Identifiers for ACTR3C Gene

  • GC07M149577
  • GC07M143760
  • GC07M150243

Summaries for ACTR3C Gene

GeneCards Summary for ACTR3C Gene

ACTR3C (ARP3 Actin Related Protein 3 Homolog C) is a Protein Coding gene. Diseases associated with ACTR3C include Lung Adenoma. Among its related pathways are Tight junction. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is ACTR3B.

UniProtKB/Swiss-Prot for ACTR3C Gene

  • May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.

Additional gene information for ACTR3C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTR3C Gene

Genomics for ACTR3C Gene

GeneHancer (GH) Regulatory Elements for ACTR3C Gene

Promoters and enhancers for ACTR3C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J150319 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.7 689 6.6 MLX DMAP1 IRF4 YY1 E2F8 SP3 MEF2D GLIS1 NBN NR2C1 LRRC61 ACTR3C GC07P150324 ENSG00000244151 ZNF767P ZNF777 ZNF775 LOC105375564 ZNF862 ZNF746
GH07J150303 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 650.3 +20.6 20578 0.2 HDAC1 HDGF PKNOX1 ATF1 ARNT CHAMP1 E2F8 ZFP91 ETV6 ATF7 ACTR3C RARRES2 ZNF775 LOC105375564 GC07P150294 LRRC61
GH07J150398 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 11.3 -80.4 -80440 11.2 MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF263 SP3 ZNF610 LOC728743 ZNF767P ZNF777 ENSG00000244151 NUB1 ZNF775 LRRC61 REPIN1 LOC105375564 ZNF862
GH07J150339 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 7.9 -17.3 -17281 2.9 ELF3 PKNOX1 ARID4B SIN3A RAD21 RARA YY1 EGR1 FOS CREM ENSG00000261305 RARRES2 LRRC61 ACTR3C LOC105375560
GH07J150375 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 5 -57.3 -57343 11.7 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ENSG00000284048 ZNF775 NUB1 REPIN1 ENSG00000244151 ZNF777 ZNF767P ZNF862 ZBED6CL TMEM176A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACTR3C on UCSC Golden Path with GeneCards custom track

Genomic Locations for ACTR3C Gene

Genomic Locations for ACTR3C Gene
chr7:149,887,178-150,323,725
(GRCh38/hg38)
Size:
436,548 bases
Orientation:
Minus strand
chr7:149,941,005-150,020,814
(GRCh37/hg19)
Size:
79,810 bases
Orientation:
Minus strand

Genomic View for ACTR3C Gene

Genes around ACTR3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR3C Gene

Proteins for ACTR3C Gene

  • Protein details for ACTR3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0K3-ARP3C_HUMAN
    Recommended name:
    Actin-related protein 3C
    Protein Accession:
    Q9C0K3
    Secondary Accessions:
    • Q5CZI4

    Protein attributes for ACTR3C Gene

    Size:
    210 amino acids
    Molecular mass:
    23712 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACTR3C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACTR3C Gene

Post-translational modifications for ACTR3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACTR3C Gene

Domains & Families for ACTR3C Gene

Gene Families for ACTR3C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACTR3C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0K3

UniProtKB/Swiss-Prot:

ARP3C_HUMAN :
  • Belongs to the actin family.
Family:
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTR3C: view

Function for ACTR3C Gene

Molecular function for ACTR3C Gene

UniProtKB/Swiss-Prot Function:
May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells.

Phenotypes From GWAS Catalog for ACTR3C Gene

Gene Ontology (GO) - Molecular Function for ACTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACTR3C: view

Animal Model Products

miRNA for ACTR3C Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR3C Gene

Localization for ACTR3C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR3C gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ACTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005885 Arp2/3 protein complex IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with ACTR3C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ACTR3C Gene

Pathways & Interactions for ACTR3C Gene

SuperPathways for ACTR3C Gene

SuperPathway Contained pathways
1 Tight junction
genes like me logo Genes that share pathways with ACTR3C: view

Pathways by source for ACTR3C Gene

1 KEGG pathway for ACTR3C Gene

Gene Ontology (GO) - Biological Process for ACTR3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0008150 biological_process ND --
GO:0034314 Arp2/3 complex-mediated actin nucleation IEA --
genes like me logo Genes that share ontologies with ACTR3C: view

No data available for SIGNOR curated interactions for ACTR3C Gene

Drugs & Compounds for ACTR3C Gene

No Compound Related Data Available

Transcripts for ACTR3C Gene

mRNA/cDNA for ACTR3C Gene

(21) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTR3C Gene

ARP3 actin-related protein 3 homolog C (yeast):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR3C Gene

No ASD Table

Relevant External Links for ACTR3C Gene

GeneLoc Exon Structure for
ACTR3C
ECgene alternative splicing isoforms for
ACTR3C

Expression for ACTR3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR3C Gene

mRNA differential expression in normal tissues according to GTEx for ACTR3C Gene

This gene is overexpressed in Liver (x8.5).

Protein differential expression in normal tissues from HIPED for ACTR3C Gene

This gene is overexpressed in Skin (43.4) and Brain (25.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACTR3C Gene



Protein tissue co-expression partners for ACTR3C Gene

NURSA nuclear receptor signaling pathways regulating expression of ACTR3C Gene:

ACTR3C

SOURCE GeneReport for Unigene cluster for ACTR3C Gene:

Hs.664579

mRNA Expression by UniProt/SwissProt for ACTR3C Gene:

Q9C0K3-ARP3C_HUMAN
Tissue specificity: Expressed in kidney, stomach, spleen, bone marrow, uterus, testis, placenta, skeletal muscle, mammary gland, lung, fetal liver, and fetal kidney, but not detected in small intestine, brain, and thymus. Expressed in low-metastatic lung adenocarcinoma cells but not in high-metastatic ones.

Evidence on tissue expression from TISSUES for ACTR3C Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with ACTR3C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR3C Gene

Orthologs for ACTR3C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTR3C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 34
  • 45 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 39 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii actr3b 34
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Arp66B 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arx-1 34
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP3 34
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToMany
Species where no ortholog for ACTR3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACTR3C Gene

ENSEMBL:
Gene Tree for ACTR3C (if available)
TreeFam:
Gene Tree for ACTR3C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACTR3C: view image

Paralogs for ACTR3C Gene

Paralogs for ACTR3C Gene

(20) SIMAP similar genes for ACTR3C Gene using alignment to 4 proteins:

  • ARP3C_HUMAN
  • C9IZN3_HUMAN
  • C9J580_HUMAN
  • H7C4J1_HUMAN
genes like me logo Genes that share paralogs with ACTR3C: view

Variants for ACTR3C Gene

Sequence variations from dbSNP and Humsavar for ACTR3C Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs78661149 benign, not specified 150,286,477(-) G/A 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, stop_gained
rs1000002215 -- 150,127,353(-) C/G genic_downstream_transcript_variant, intron_variant
rs1000014160 -- 150,032,693(-) C/A genic_downstream_transcript_variant, intron_variant
rs1000027285 -- 150,278,144(-) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000028133 -- 150,230,241(-) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR3C Gene

Variant ID Type Subtype PubMed ID
nsv981608 CNV duplication 23825009
nsv970966 CNV duplication 23825009
nsv608990 CNV gain 21841781
nsv521407 CNV loss 19592680
nsv508490 CNV deletion 20534489
nsv472351 CNV novel sequence insertion 20440878
nsv1151906 OTHER inversion 26484159
nsv1119147 CNV deletion 24896259
nsv1078990 CNV insertion 25765185
nsv1074561 CNV deletion 25765185
nsv1074560 CNV deletion 25765185
nsv1067934 OTHER inversion 25765185
nsv1034409 CNV gain 25217958
nsv1015582 CNV gain 25217958
esv3615458 CNV loss 21293372
esv3615457 CNV gain 21293372
esv2759571 CNV gain 17122850
dgv6753n100 CNV loss 25217958
dgv435n21 CNV loss 19592680
dgv3695n106 OTHER inversion 24896259
dgv1336e214 CNV gain 21293372

Variation tolerance for ACTR3C Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.67; 78.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR3C Gene

Human Gene Mutation Database (HGMD)
ACTR3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3C Gene

Disorders for ACTR3C Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACTR3C Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
lung adenoma
  • adenoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ACTR3C

genes like me logo Genes that share disorders with ACTR3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR3C Gene

Publications for ACTR3C Gene

  1. Isolation of a novel actin-related gene expressed in low-metastatic PC-14 human lung adenocarcinoma. (PMID: 11162478) Shindo-Okada N … Shimizu K (Biochemical and biophysical research communications 2001) 2 3 4 58
  2. Expression of the Arp11 gene suppresses the tumorigenicity of PC-14 human lung adenocarcinoma cells. (PMID: 14651955) Shindo-Okada N … Iigo M (Biochemical and biophysical research communications 2003) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3. (PMID: 27926873) Jozwik KM … Carroll JS (Cell reports 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for ACTR3C Gene

Sources for ACTR3C Gene

Content
Loading form....