Aliases for ACTR3B Gene
External Ids for ACTR3B Gene
Previous GeneCards Identifiers for ACTR3B Gene
This gene encodes a member of the actin-related proteins (ARP), which form multiprotein complexes and share 35-55% amino acid identity with conventional actin. The protein encoded by this gene may have a regulatory role in the actin cytoskeleton and induce cell-shape change and motility. Pseudogenes of this gene are located on chromosomes 2, 4, 10, 16, 22 and Y. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for ACTR3B Gene
ACTR3B (ARP3 Actin Related Protein 3 Homolog B) is a Protein Coding gene. Diseases associated with ACTR3B include Lung Cancer Susceptibility 3. Among its related pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and G-protein signaling RAC1 in cellular process. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is ACTR3.
UniProtKB/Swiss-Prot for ACTR3B Gene
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.