Aliases for ACTR3 Gene
External Ids for ACTR3 Gene
Previous GeneCards Identifiers for ACTR3 Gene
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
GeneCards Summary for ACTR3 Gene
ACTR3 (ARP3 Actin Related Protein 3 Homolog) is a Protein Coding gene. Diseases associated with ACTR3 include Wiskott-Aldrich Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ACTR3B.
UniProtKB/Swiss-Prot for ACTR3 Gene
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.