The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this ge... See more...

Aliases for ACTR3 Gene

Aliases for ACTR3 Gene

  • Actin Related Protein 3 2 3 5
  • ARP3 Actin Related Protein 3 Homolog 2 3
  • Actin-Related Protein 3 3 4
  • Actin-Like Protein 3 3 4
  • ARP3 3 4
  • ARP3 (Actin-Related Protein 3, Yeast) Homolog 2
  • ARP3 Actin-Related Protein 3 Homolog (Yeast) 2

External Ids for ACTR3 Gene

Previous GeneCards Identifiers for ACTR3 Gene

  • GC02P111853
  • GC02P112568
  • GC02P114554
  • GC02P114742
  • GC02P114363
  • GC02P114647
  • GC02P106964

Summaries for ACTR3 Gene

Entrez Gene Summary for ACTR3 Gene

  • The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for ACTR3 Gene

ACTR3 (Actin Related Protein 3) is a Protein Coding gene. Diseases associated with ACTR3 include Wiskott-Aldrich Syndrome and Retinitis Pigmentosa 20. Among its related pathways are Signaling by Slit and Immune response Role of DAP12 receptors in NK cells. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ACTR3B.

UniProtKB/Swiss-Prot Summary for ACTR3 Gene

  • ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563).

Gene Wiki entry for ACTR3 Gene

Additional gene information for ACTR3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTR3 Gene

Genomics for ACTR3 Gene

GeneHancer (GH) Regulatory Elements for ACTR3 Gene


GeneHancers around ACTR3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACTR3

Top Transcription factor binding sites by QIAGEN in the ACTR3 gene promoter:
  • AML1a
  • AREB6
  • c-Ets-1
  • Max
  • POU3F1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RSRFC4

Genomic Locations for ACTR3 Gene

Genomic Locations for ACTR3 Gene
chr2:113,889,934-113,962,596
(GRCh38/hg38)
Size:
72,663 bases
Orientation:
Plus strand
chr2:114,647,537-114,720,173
(GRCh37/hg19)
Size:
72,637 bases
Orientation:
Plus strand

Genomic View for ACTR3 Gene

Genes around ACTR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR3 Gene

Proteins for ACTR3 Gene

  • Protein details for ACTR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61158-ARP3_HUMAN
    Recommended name:
    Actin-related protein 3
    Protein Accession:
    P61158
    Secondary Accessions:
    • P32391
    • Q53QM2

    Protein attributes for ACTR3 Gene

    Size:
    418 amino acids
    Molecular mass:
    47371 Da
    Quaternary structure:
    • Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:9000076, PubMed:9230079, PubMed:11741539). Interacts with WHDC1 (PubMed:18614018). Interacts weakly with MEFV (PubMed:19109554).

neXtProt entry for ACTR3 Gene

Post-translational modifications for ACTR3 Gene

  • Ubiquitination at Lys38, Lys53, Lys69, Lys75, Lys99, Lys191, Lys240, Lys251, Lys254, Lys265, Lys317, Lys348, Lys359, and Lys361
  • Modification sites at PhosphoSitePlus

Other Protein References for ACTR3 Gene

No data available for DME Specific Peptides for ACTR3 Gene

Domains & Families for ACTR3 Gene

Gene Families for ACTR3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ACTR3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTR3 Gene

GenScript: Design optimal peptide antigens:
  • Actin-like protein 3 (ARP3_HUMAN)
  • cDNA FLJ52521, highly similar to Actin-like protein 3 (B4DTI0_HUMAN)
  • cDNA, FLJ79295, highly similar to Actin-like protein 3 (B4DXW1_HUMAN)
  • cDNA, FLJ93049, Homo sapiens ARP3 actin-related protein 3 homolog (yeast) (ACTR3), mRNA (Q53QM2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61158

UniProtKB/Swiss-Prot:

ARP3_HUMAN :
  • Belongs to the actin family. ARP3 subfamily.
Family:
  • Belongs to the actin family. ARP3 subfamily.
genes like me logo Genes that share domains with ACTR3: view

Function for ACTR3 Gene

Molecular function for ACTR3 Gene

UniProtKB/Swiss-Prot Function:
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563).

Phenotypes From GWAS Catalog for ACTR3 Gene

Gene Ontology (GO) - Molecular Function for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005200 structural constituent of cytoskeleton IDA 11741539
GO:0005515 protein binding IPI 20195357
GO:0005524 ATP binding IEA --
GO:0051015 contributes_to actin filament binding IDA 11741539
genes like me logo Genes that share ontologies with ACTR3: view
genes like me logo Genes that share phenotypes with ACTR3: view

Animal Model Products

CRISPR Products

miRNA for ACTR3 Gene

miRTarBase miRNAs that target ACTR3

Clone Products

  • Addgene plasmids for ACTR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR3 Gene

Localization for ACTR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR3 Gene

Cytoplasm, cytoskeleton. Cell projection. Nucleus. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR3 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,IEA 16767080
GO:0005737 cytoplasm IDA,IEA 17220302
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACTR3 Gene

Pathways & Interactions for ACTR3 Gene

PathCards logo

SuperPathways for ACTR3 Gene

SuperPathway Contained pathways
1 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
.35
2 G-protein signaling RAC1 in cellular process
.37
.37
3 EPH-Ephrin signaling
.35
4 Regulation of actin dynamics for phagocytic cup formation
5 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
.49
.37
genes like me logo Genes that share pathways with ACTR3: view

Pathways by source for ACTR3 Gene

14 GeneGo (Thomson Reuters) pathways for ACTR3 Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cell adhesion_Cadherin-mediated cell adhesion
  • Cytoskeleton remodeling CDC42 in cellular processes
  • Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
  • Cytoskeleton remodeling Integrin outside-in signaling
20 Qiagen pathways for ACTR3 Gene
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • CD28 Signaling in T-Helper Cell
  • CDC42 Pathway
1 Cell Signaling Technology pathway for ACTR3 Gene

Gene Ontology (GO) - Biological Process for ACTR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0007163 establishment or maintenance of cell polarity IEA --
GO:0008356 asymmetric cell division IEA --
GO:0016344 meiotic chromosome movement towards spindle pole IEA --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with ACTR3: view

No data available for SIGNOR curated interactions for ACTR3 Gene

Drugs & Compounds for ACTR3 Gene

(3) Drugs for ACTR3 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one Experimental Pharma Target 0
N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide Experimental Pharma Target 0

(1) Additional Compounds for ACTR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACTR3: view

Transcripts for ACTR3 Gene

mRNA/cDNA for ACTR3 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for ACTR3

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR3 Gene

No ASD Table

Relevant External Links for ACTR3 Gene

GeneLoc Exon Structure for
ACTR3

Expression for ACTR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACTR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACTR3 Gene

This gene is overexpressed in Whole Blood (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACTR3 Gene



Protein tissue co-expression partners for ACTR3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACTR3

SOURCE GeneReport for Unigene cluster for ACTR3 Gene:

Hs.433512

Evidence on tissue expression from TISSUES for ACTR3 Gene

  • Nervous system(4.9)
  • Blood(4.8)
  • Liver(4.6)
  • Skin(3.7)
  • Kidney(3.6)
  • Lung(3.2)
  • Intestine(2.9)
  • Spleen(2.4)
  • Lymph node(2.2)
  • Bone marrow(2)
  • Heart(2)
genes like me logo Genes that share expression patterns with ACTR3: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR3 Gene

Orthologs for ACTR3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACTR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR3 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ARP3 31
  • 97 (a)
OneToOne
ACTR3B 30
  • 96.73 (n)
cow
(Bos Taurus)
Mammalia ACTR3 31 30
  • 96.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Actr3 17 31 30
  • 93.46 (n)
rat
(Rattus norvegicus)
Mammalia Actr3 30
  • 93.3 (n)
oppossum
(Monodelphis domestica)
Mammalia ACTR3 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACTR3 31 30
  • 88.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR3 31
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr3 30
  • 79.11 (n)
zebrafish
(Danio rerio)
Actinopterygii ACTR3 (2 of 2) 31
  • 97 (a)
OneToMany
ACTR3 (1 of 2) 31
  • 97 (a)
OneToMany
actr3 30
  • 75.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arp66B 31 32
  • 80 (a)
OneToMany
Arp3 30
  • 67.3 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005110 30
  • 68.9 (n)
worm
(Caenorhabditis elegans)
Secernentea arx-1 31 30
  • 67.55 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP3 31 30
  • 61.74 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13904g 30
  • 59.93 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR419C 30
  • 59.75 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.5713 30
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp3 30
  • 60.58 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01756 30
  • 57.7 (n)
Species where no ortholog for ACTR3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR3 Gene

ENSEMBL:
Gene Tree for ACTR3 (if available)
TreeFam:
Gene Tree for ACTR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACTR3: view image

Paralogs for ACTR3 Gene

(25) SIMAP similar genes for ACTR3 Gene using alignment to 6 proteins:

  • ARP3_HUMAN
  • B4DXW1_HUMAN
  • F5H3P5_HUMAN
  • F8WDR7_HUMAN
  • F8WE84_HUMAN
  • F8WEW2_HUMAN
genes like me logo Genes that share paralogs with ACTR3: view

Variants for ACTR3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACTR3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
783339 Benign: not provided 113,942,363(+) A/AT INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ACTR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACTR3 Gene

Variant ID Type Subtype PubMed ID
esv3334973 CNV insertion 20981092
esv990446 CNV insertion 20482838
nsv1127757 CNV deletion 24896259
nsv479438 CNV novel sequence insertion 20440878
nsv508860 CNV insertion 20534489

Variation tolerance for ACTR3 Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR3 Gene

Disorders for ACTR3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ACTR3 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ACTR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ACTR3

genes like me logo Genes that share disorders with ACTR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR3 Gene

Publications for ACTR3 Gene

  1. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4 54
  2. Functional genomic screen for modulators of ciliogenesis and cilium length. (PMID: 20393563) Kim J … Gleeson JG (Nature 2010) 3 4 54
  3. A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. (PMID: 17220302) Yoo Y … Guan JL (The Journal of biological chemistry 2007) 3 4 54
  4. Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. (PMID: 16767080) Wu X … Guan JL (Nature cell biology 2006) 3 4 54
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 54

Products for ACTR3 Gene

Sources for ACTR3 Gene