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The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [p... See more...
Aliases for ACTR2 Gene
Aliases for ACTR2 Gene
External Ids for ACTR2 Gene
- HGNC: 169
- Entrez Gene: 10097
- Ensembl: ENSG00000138071
- OMIM: 604221
- UniProtKB: P61160
Previous GeneCards Identifiers for ACTR2 Gene
- GC02P065588
- GC02P065412
- GC02P065429
- GC02P065366
- GC02P065308
- GC02P065454
- GC02P065189
Summaries for ACTR2 Gene
-
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACTR2 Gene
ACTR2 (Actin Related Protein 2) is a Protein Coding gene. Diseases associated with ACTR2 include Wiskott-Aldrich Syndrome and Myopathy, Centronuclear, 2. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Development Slit-Robo signaling. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ACTC1.
UniProtKB/Swiss-Prot Summary for ACTR2 Gene
-
ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Additional gene information for ACTR2 Gene
- HGNC(169)
- Entrez Gene(10097)
- Ensembl(ENSG00000138071)
- OMIM(604221)
- UniProtKB(P61160)
- Open Targets Platform(ENSG00000138071)
- Search for ACTR2 at DataMed
- Search for ACTR2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTR2 Gene
Genomics for ACTR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ACTR2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ACTR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACTR2
- Top Transcription factor binding sites by QIAGEN in the ACTR2 gene promoter:
-
- AP-1
- c-Fos
- c-Jun
- FosB
- Fra-1
- JunB
- JunD
- p53
- YY1
Genomic Locations for ACTR2 Gene
Genomic Locations for ACTR2 Gene
- chr2:65,227,695-65,271,253
- (GRCh38/hg38)
- Size:
- 43,559 bases
- Orientation:
- Plus strand
- chr2:65,454,829-65,498,387
- (GRCh37/hg19)
- Size:
- 43,559 bases
- Orientation:
- Plus strand
Genomic View for ACTR2 Gene
Genes around ACTR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p14 by HGNC
- 2p14 by Entrez Gene
- 2p14 by Ensembl
ACTR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACTR2 Gene
Proteins for ACTR2 Gene
-
Protein details for ACTR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61160-ARP2_HUMAN
- Recommended name:
- Actin-related protein 2
- Protein Accession:
- P61160
- B2RCP5
- D6W5F4
- E9PF41
- O15142
- Q96C82
Protein attributes for ACTR2 Gene
- Size:
- 394 amino acids
- Molecular mass:
- 44761 Da
- Quaternary structure:
-
- Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with AVIL (PubMed:29058690).
Protein Expression for ACTR2 Gene
Post-translational modifications for ACTR2 Gene
Other Protein References for ACTR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences ACTR2 / ARP2 Antibody
- Novus Biologicals Antibodies for ACTR2
-
Abcam antibodies for ACTR2
- Invitrogen Antibodies for ACTR2 (AFLGC-ACTR2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for ACTR2
Protein Products
-
OriGene Purified Proteins for ACTR2
- Search Origene for MassSpec and Protein Over-expression Lysates for ACTR2
- Origene Custom Protein Services for ACTR2
-
Signalway Proteins for ACTR2
-
Abcam proteins for ACTR2
No data available for DME Specific Peptides for ACTR2 Gene
Domains & Families for ACTR2 Gene
Gene Families for ACTR2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for ACTR2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACTR2 Gene
- GenScript: Design optimal peptide antigens:
-
- Actin-like protein 2 (ARP2_HUMAN)
- ACTR2 protein (Q8IY98_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P61160- Family:
-
- Belongs to the actin family. ARP2 subfamily.
Function for ACTR2 Gene
Molecular function for ACTR2 Gene
- UniProtKB/Swiss-Prot Function:
- ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Phenotypes From GWAS Catalog for ACTR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003779 | actin binding | IEA | -- |
| GO:0005200 | structural constituent of cytoskeleton | IDA | 11741539 |
| GO:0005515 | protein binding | IPI | 29058690 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for ACTR2 Gene
- MGI mutant phenotypes for ACTR2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ACTR2:
-
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with Ras
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium binding
- Decreased Salmonella enterica Typhimurium ruffling
- Increased shRNA abundance (Z-score > 2)
- Decreased viability (cell death)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ACTR2 - Select products 50% OFF >
- * ACTR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ACTR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACTR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACTR2
miRNA for ACTR2 Gene
- miRTarBase miRNAs that target ACTR2
-
- mmu-miR-340-5p (MIRT010554)
- hsa-miR-155-5p (MIRT020780)
- hsa-miR-132-3p (MIRT021852)
- hsa-miR-215-5p (MIRT024581)
- hsa-miR-192-5p (MIRT026515)
- hsa-miR-93-5p (MIRT028015)
- hsa-miR-21-5p (MIRT030897)
- hsa-miR-15a-5p (MIRT089206)
- hsa-miR-16-5p (MIRT089207)
- hsa-miR-103a-3p (MIRT089208)
- hsa-miR-107 (MIRT089209)
- hsa-miR-15b-5p (MIRT089210)
- hsa-miR-195-5p (MIRT089211)
- hsa-miR-424-5p (MIRT089212)
- hsa-miR-497-5p (MIRT089213)
- hsa-miR-545-5p (MIRT089214)
- hsa-miR-671-5p (MIRT089215)
- hsa-miR-2278 (MIRT089216)
- hsa-miR-4310 (MIRT089217)
- hsa-miR-3609 (MIRT089218)
- hsa-miR-548ah-5p (MIRT089219)
- hsa-miR-4524a-5p (MIRT089221)
- hsa-miR-4524b-5p (MIRT089223)
- hsa-miR-6838-5p (MIRT089224)
- hsa-miR-7157-5p (MIRT089225)
- hsa-miR-4799-5p (MIRT159773)
- hsa-miR-183-3p (MIRT236759)
- hsa-miR-135b-3p (MIRT236760)
- hsa-miR-6828-5p (MIRT236769)
- hsa-miR-9500 (MIRT236770)
- hsa-miR-219a-1-3p (MIRT353694)
- hsa-miR-4254 (MIRT353697)
- hsa-miR-218-5p (MIRT441277)
- hsa-miR-6759-3p (MIRT450481)
- hsa-miR-5582-3p (MIRT450482)
- hsa-miR-548f-3p (MIRT450483)
- hsa-miR-548e-3p (MIRT450484)
- hsa-miR-548az-3p (MIRT450485)
- hsa-miR-548ar-3p (MIRT450486)
- hsa-miR-548a-3p (MIRT450487)
- hsa-miR-6876-5p (MIRT512316)
- hsa-miR-4476 (MIRT512317)
- hsa-miR-4796-3p (MIRT512318)
- hsa-miR-526b-3p (MIRT512319)
- hsa-miR-519d-3p (MIRT512320)
- hsa-miR-20b-5p (MIRT512321)
- hsa-miR-20a-5p (MIRT512322)
- hsa-miR-17-5p (MIRT512323)
- hsa-miR-106b-5p (MIRT512324)
- hsa-miR-106a-5p (MIRT512325)
- hsa-miR-7977 (MIRT531998)
- hsa-miR-3162-5p (MIRT531999)
- hsa-miR-563 (MIRT532000)
- hsa-miR-380-5p (MIRT532001)
- hsa-miR-4294 (MIRT532002)
- hsa-miR-758-5p (MIRT532003)
- hsa-miR-4756-5p (MIRT532004)
- hsa-miR-4739 (MIRT532005)
- hsa-miR-1321 (MIRT532006)
- hsa-miR-6760-5p (MIRT532007)
- hsa-miR-646 (MIRT549438)
- hsa-miR-503-5p (MIRT549439)
- hsa-miR-4452 (MIRT561129)
- hsa-miR-7852-3p (MIRT561130)
- hsa-miR-3668 (MIRT561131)
- hsa-miR-6822-5p (MIRT561132)
- hsa-miR-6750-5p (MIRT561133)
- hsa-miR-5584-5p (MIRT561134)
- hsa-miR-4653-3p (MIRT574209)
- hsa-miR-3690 (MIRT574210)
- hsa-miR-6083 (MIRT641556)
- hsa-miR-5007-3p (MIRT641557)
- hsa-miR-4261 (MIRT641558)
- hsa-miR-3140-3p (MIRT641559)
- hsa-miR-4645-5p (MIRT641560)
- hsa-miR-4673 (MIRT641561)
- hsa-miR-6736-3p (MIRT641562)
- hsa-miR-3688-3p (MIRT641563)
- hsa-miR-487a-3p (MIRT641564)
- hsa-miR-8076 (MIRT641565)
- hsa-miR-154-3p (MIRT641566)
- hsa-miR-3074-3p (MIRT641567)
- hsa-miR-7152-5p (MIRT649917)
- hsa-miR-3074-5p (MIRT649918)
- hsa-miR-6834-5p (MIRT649919)
- hsa-miR-1200 (MIRT649920)
- hsa-miR-378a-5p (MIRT649921)
- hsa-miR-6133 (MIRT649922)
- hsa-miR-6130 (MIRT649923)
- hsa-miR-6129 (MIRT649924)
- hsa-miR-6127 (MIRT649925)
- hsa-miR-4510 (MIRT649926)
- hsa-miR-6875-5p (MIRT649927)
- hsa-miR-4419a (MIRT649928)
- hsa-miR-3126-5p (MIRT649929)
- hsa-miR-4324 (MIRT649930)
- hsa-miR-544b (MIRT649931)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACTR2
- Browse OriGene Inhibitory RNA Products For ACTR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR2
Clone Products
- Applied Biological Materials (abm): Clones for ACTR2 - Select products 50% OFF >
- * ACTR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206161
- MR206161
- MR206161L3
- MR206161L4
- RC203111
- RC203111L1
- RC203111L2
- RC203111L3
- RC203111L4
- RC217981
- RC217981L1
- RC217981L2
- RC217981L3
- RC217981L4
- RG203111
- RG217981
- RR207334
- RR207334L3
- RR207334L4
- MR206161L3V
- MR206161L4V
- RC203111L1V
- RC203111L2V
- RC203111L3V
- RC203111L4V
- RC217981L1V
- RC217981L2V
- RC217981L3V
- RC217981L4V
- RR207334L3V
- RR207334L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ACTR2
- Addgene plasmids for ACTR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACTR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR2 Gene
Localization for ACTR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACTR2 Gene
- Cytoplasm, cytoskeleton. Cell projection. Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| lysosome | 4 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 17220302 |
| GO:0005737 | cytoplasm | IEA,IDA | 17220302 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for ACTR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Actin Nucleation by ARP-WASP Complex |
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
|
CDC42 Pathway
.41
RhoA Pathway
.35
|
| 2 | G-protein signaling RAC1 in cellular process |
Cytoskeleton remodeling CDC42 in cellular processes
.37
G-protein signaling RAC1 in cellular process
.37
|
|
| 3 | EPH-Ephrin signaling |
Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
.35
|
|
| 4 | Regulation of actin dynamics for phagocytic cup formation | ||
| 5 | Innate Immune System |
.61
|
|
Pathways by source for ACTR2 Gene
4 BioSystems pathways for ACTR2 Gene
16 Reactome pathways for ACTR2 Gene
2 KEGG pathways for ACTR2 Gene
14 GeneGo (Thomson Reuters) pathways for ACTR2 Gene
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cell adhesion_Cadherin-mediated cell adhesion
- Cytoskeleton remodeling CDC42 in cellular processes
- Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
- Cytoskeleton remodeling Integrin outside-in signaling
20 Qiagen pathways for ACTR2 Gene
- Actin Nucleation and Branching
- Actin Nucleation by ARP-WASP Complex
- Actin-Based Motility by Rho Family GTPases
- CD28 Signaling in T-Helper Cell
- CDC42 Pathway
1 Cell Signaling Technology pathway for ACTR2 Gene
Interacting Proteins for ACTR2 Gene
GPS-Prot Interaction Network for ACTR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007015 | actin filament organization | IEA | -- |
| GO:0007163 | establishment or maintenance of cell polarity | IEA | -- |
| GO:0008306 | associative learning | IEA | -- |
| GO:0008356 | asymmetric cell division | IEA | -- |
| GO:0010592 | positive regulation of lamellipodium assembly | IDA | 29058690 |
Transcripts for ACTR2 Gene
mRNA/cDNA for ACTR2 Gene
- 2 REFSEQ mRNAs :
- 16 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000260641 3861 nts (view in UCSC)
- ENST00000476840 587 nts (view in UCSC)
- ENST00000471552 554 nts (view in UCSC)
- ENST00000377982 2685 nts (view in UCSC)
- ENST00000542850 1429 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ACTR2 - Select products 50% OFF >
- * ACTR2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ACTR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACTR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACTR2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACTR2
- Browse OriGene Inhibitory RNA Products For ACTR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR2
Clone Products
- Applied Biological Materials (abm): Clones for ACTR2 - Select products 50% OFF >
- * ACTR2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG206161
- MR206161
- MR206161L3
- MR206161L4
- RC203111
- RC203111L1
- RC203111L2
- RC203111L3
- RC203111L4
- RC217981
- RC217981L1
- RC217981L2
- RC217981L3
- RC217981L4
- RG203111
- RG217981
- RR207334
- RR207334L3
- RR207334L4
- MR206161L3V
- MR206161L4V
- RC203111L1V
- RC203111L2V
- RC203111L3V
- RC203111L4V
- RC217981L1V
- RC217981L2V
- RC217981L3V
- RC217981L4V
- RR207334L3V
- RR207334L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ACTR2
- Addgene plasmids for ACTR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACTR2
Relevant External Links for ACTR2 Gene
- GeneLoc Exon Structure for
- ACTR2
Expression for ACTR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- Hematopoietic Bone Marrow
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for ACTR2 Gene
This gene is overexpressed in Whole Blood (x4.4).
This gene is overexpressed in Spleen (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACTR2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACTR2
SOURCE GeneReport for Unigene cluster for ACTR2 Gene:
Hs.744913Evidence on tissue expression from TISSUES for ACTR2 Gene
- Nervous system(4.7)
- Muscle(4.7)
- Liver(4.5)
- Skin(3.1)
- Spleen(3.1)
- Blood(3)
- Kidney(2.9)
- Lymph node(2.9)
- Heart(2.9)
- Intestine(2.9)
- Lung(2.8)
- Eye(2.7)
- Bone(2.6)
- Stomach(2.4)
- Bone marrow(2.4)
- Adrenal gland(2.2)
- Thyroid gland(2.1)
Primer Products
-
OriGene qPCR primer pairs for ACTR2
-
OriGene qPCR primer pairs and template standards for ACTR2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR2 Gene
Orthologs for ACTR2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Oppossum (Monodelphis domestica) |
Mammalia | ACTR2 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | ACTR2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ACTR2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ACTR2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Actr2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Actr2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ACTR2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ACTR2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ACTR2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | actr2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | actr2b 31 |
|
OneToOne | |
| actr2a 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Arp14D 31 32 |
|
OneToOne | |
| Arp2 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000985 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | arx-2 30 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ARP2 30 31 33 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C03850g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR316W 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ARP2 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.11919 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.7173 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os08g0369300 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11313 31 |
|
OneToOne | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | arp2 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU07171 30 |
|
- Species where no ortholog for ACTR2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for ACTR2 Gene
- ENSEMBL:
- Gene Tree for ACTR2 (if available)
- TreeFam:
- Gene Tree for ACTR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ACTR2: view image
Paralogs for ACTR2 Gene
Paralogs for ACTR2 Gene
(30) SIMAP similar genes for ACTR2 Gene using alignment to 3 proteins:
- ARP2_HUMAN
- F5H6T1_HUMAN
- Q8IY98_HUMAN
Pseudogenes.org Pseudogenes for ACTR2 Gene
Variants for ACTR2 Gene
Residual Variation Intolerance Score:
29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.07;
1.69% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ACTR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACTR2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACTR2 Gene
Disorders for ACTR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wiskott-aldrich syndrome |
|
|
| myopathy, centronuclear, 2 |
|
|
| spinocerebellar ataxia, autosomal recessive 3 |
|
|
Search ACTR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ACTR2
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR2 Gene
Publications for ACTR2 Gene
- The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. (PMID: 9230079) Welch MD … Mitchison TJ (The Journal of cell biology 1997) 2 3 4
- Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. (PMID: 29925947) Schrank BR … Gautier J (Nature 2018) 3 4
- Advillin acts upstream of phospholipase C ϵ1 in steroid-resistant nephrotic syndrome. (PMID: 29058690) Rao J … Hildebrandt F (The Journal of clinical investigation 2017) 3 4
- A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. (PMID: 17220302) Yoo Y … Guan JL (The Journal of biological chemistry 2007) 3 4
- Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma. (PMID: 17459058) Iwaya K … Mukai K (Cancer science 2007) 3 23
ExternalLinks
Products for ACTR2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ACTR2
- Search Origene for MassSpec and Protein Over-expression Lysates for ACTR2
- Origene Custom Protein Services for ACTR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACTR2
- Browse OriGene Inhibitory RNA Products For ACTR2
- OriGene qPCR primer pairs for ACTR2
- OriGene qPCR primer pairs and template standards for ACTR2
- OriGene CRISPR knockouts for ACTR2
- MG206161
- MR206161
- MR206161L3
- MR206161L4
- RC203111
- RC203111L1
- RC203111L2
- RC203111L3
- RC203111L4
- RC217981
- RC217981L1
- RC217981L2
- RC217981L3
- RC217981L4
- RG203111
- RG217981
- RR207334
- RR207334L3
- RR207334L4
- MR206161L3V
- MR206161L4V
- RC203111L1V
- RC203111L2V
- RC203111L3V
- RC203111L4V
- RC217981L1V
- RC217981L2V
- RC217981L3V
- RC217981L4V
- RR207334L3V
- RR207334L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ACTR2
- Sino Biological Human cDNA Clone for ACTR2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ACTR2
- Novus Biologicals proteins and lysates for ACTR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ACTR2
- Abcam proteins for ACTR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for ACTR2 (AFLGC-ACTR2)
- VectorBuilder Custom and pre-made DNA vectors for ACTR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ACTR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ACTR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ACTR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ACTR2
- Addgene plasmids for ACTR2
- antibodies-online: Show 13 available ACTR2 Antibodies ranked by validation data
- Compare Top ACTR2 Antibodies
- antibodies-online: Show 12 available ACTR2 Elisa Kits ranked by validation data
- Compare Top ACTR2 Elisa Kits
- antibodies-online: Show 17 available ACTR2 Proteins ranked by validation data
- Compare Top ACTR2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for ACTR2
- Search Santa Cruz Biotechnology (SCBT) for ACTR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ACTR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACTR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACTR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ACTR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR2
- Signalway Proteins for ACTR2
Sources for ACTR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB