Aliases for ACTR2 Gene
External Ids for ACTR2 Gene
Previous GeneCards Identifiers for ACTR2 Gene
The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACTR2 Gene
ACTR2 (ARP2 Actin Related Protein 2 Homolog) is a Protein Coding gene. Diseases associated with ACTR2 include Wiskott-Aldrich Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include actin filament binding and structural constituent of cytoskeleton. An important paralog of this gene is ACTL8.
UniProtKB/Swiss-Prot for ACTR2 Gene
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.