This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nu... See more...

Aliases for ACTR1B Gene

Aliases for ACTR1B Gene

  • Actin Related Protein 1B 2 3 5
  • ARP1 Actin-Related Protein 1 Homolog B, Centractin Beta 2 3
  • ARP1 Actin Related Protein 1 Homolog B 2 3
  • Beta-Centractin 3 4
  • Centractin Beta 2 3
  • CTRN2 3 4
  • ARP1B 3 4
  • ARP1 (Actin-Related Protein 1, Yeast) Homolog B (Centractin Beta) 2
  • Actin-Related Protein 1B 4
  • PC3 3

External Ids for ACTR1B Gene

Previous HGNC Symbols for ACTR1B Gene

  • CTRN2

Previous GeneCards Identifiers for ACTR1B Gene

  • GC02M096154
  • GC02M096724
  • GC02M097877
  • GC02M097893
  • GC02M097730
  • GC02M098272
  • GC02M092038

Summaries for ACTR1B Gene

Entrez Gene Summary for ACTR1B Gene

  • This gene encodes a 42.3 kD subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex. [provided by RefSeq, Aug 2008]

GeneCards Summary for ACTR1B Gene

ACTR1B (Actin Related Protein 1B) is a Protein Coding gene. Among its related pathways are Innate Immune System and Cell cycle_Spindle assembly and chromosome separation. An important paralog of this gene is ACTR1A.

UniProtKB/Swiss-Prot Summary for ACTR1B Gene

  • Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Gene Wiki entry for ACTR1B Gene

Additional gene information for ACTR1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTR1B Gene

Genomics for ACTR1B Gene

GeneHancer (GH) Regulatory Elements for ACTR1B Gene

Promoters and enhancers for ACTR1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTR1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACTR1B gene promoter:
  • AhR
  • C/EBPalpha
  • Egr-1
  • GATA-3
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • YY1

Genomic Locations for ACTR1B Gene

Genomic Locations for ACTR1B Gene
chr2:97,655,939-97,664,107
(GRCh38/hg38)
Size:
8,169 bases
Orientation:
Minus strand
chr2:98,272,402-98,280,570
(GRCh37/hg19)
Size:
8,169 bases
Orientation:
Minus strand

Genomic View for ACTR1B Gene

Genes around ACTR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR1B Gene

Proteins for ACTR1B Gene

  • Protein details for ACTR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42025-ACTY_HUMAN
    Recommended name:
    Beta-centractin
    Protein Accession:
    P42025
    Secondary Accessions:
    • D3DVH2
    • Q53SK5
    • Q9BRB7

    Protein attributes for ACTR1B Gene

    Size:
    376 amino acids
    Molecular mass:
    42293 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTR1B Gene

Post-translational modifications for ACTR1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR1B Gene

Domains & Families for ACTR1B Gene

Gene Families for ACTR1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ACTR1B Gene

Suggested Antigen Peptide Sequences for ACTR1B Gene

GenScript: Design optimal peptide antigens:
  • Actin-related protein 1B (ACTY_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42025

UniProtKB/Swiss-Prot:

ACTY_HUMAN :
  • Belongs to the actin family. ARP1 subfamily.
Family:
  • Belongs to the actin family. ARP1 subfamily.
genes like me logo Genes that share domains with ACTR1B: view

Function for ACTR1B Gene

Molecular function for ACTR1B Gene

UniProtKB/Swiss-Prot Function:
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
GENATLAS Biochemistry:
centractin beta,an actin-related protein 1 yeast homolog,localized to microtubule-associated structures,widely expressed,component of the dynactin complex,a regulator of cytoplasmic dynein-mediated functions

Phenotypes From GWAS Catalog for ACTR1B Gene

Gene Ontology (GO) - Molecular Function for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 12857853
GO:0005524 ATP binding IEA --
GO:0106006 contributes_to microtubule cortical anchor activity IBA 21873635
genes like me logo Genes that share ontologies with ACTR1B: view
genes like me logo Genes that share phenotypes with ACTR1B: view

Animal Model Products

CRISPR Products

miRNA for ACTR1B Gene

miRTarBase miRNAs that target ACTR1B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR1B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR1B Gene

Localization for ACTR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR1B Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR1B gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 4
nucleus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IBA,IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACTR1B: view

Pathways & Interactions for ACTR1B Gene

genes like me logo Genes that share pathways with ACTR1B: view

Gene Ontology (GO) - Biological Process for ACTR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IBA 21873635
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0030473 nuclear migration along microtubule IBA 21873635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with ACTR1B: view

No data available for SIGNOR curated interactions for ACTR1B Gene

Drugs & Compounds for ACTR1B Gene

No Compound Related Data Available

Transcripts for ACTR1B Gene

mRNA/cDNA for ACTR1B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(324) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR1B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - -
SP4:
SP5:

Relevant External Links for ACTR1B Gene

GeneLoc Exon Structure for
ACTR1B
ECgene alternative splicing isoforms for
ACTR1B

Expression for ACTR1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR1B Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACTR1B Gene



Protein tissue co-expression partners for ACTR1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTR1B Gene:

ACTR1B

SOURCE GeneReport for Unigene cluster for ACTR1B Gene:

Hs.98791

Evidence on tissue expression from TISSUES for ACTR1B Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with ACTR1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR1B Gene

Orthologs for ACTR1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTR1B 33 32
  • 99.2 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACTR1B 33
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR1B 33 32
  • 91.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR1B 33 32
  • 90.96 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr1b 32
  • 90.43 (n)
mouse
(Mus musculus)
Mammalia Actr1b 17 33 32
  • 89.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR1B 33
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR1B 33
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii actr1 33 32
  • 79.7 (n)
OneToOne
Dr.5468 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8351 32
fruit fly
(Drosophila melanogaster)
Insecta Arp87C 33 34
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arp-1 33
  • 67 (a)
OneToMany
Y53F4B.22 34
  • 67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR051W 32
  • 63.09 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP1 35 32
  • 55.31 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22925g 32
  • 55.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9685 33
  • 68 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04247 32
  • 64.45 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes arp1 32
  • 54.22 (n)
Species where no ortholog for ACTR1B was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACTR1B Gene

ENSEMBL:
Gene Tree for ACTR1B (if available)
TreeFam:
Gene Tree for ACTR1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACTR1B: view image

Paralogs for ACTR1B Gene

(29) SIMAP similar genes for ACTR1B Gene using alignment to 1 proteins:

  • ACTY_HUMAN
genes like me logo Genes that share paralogs with ACTR1B: view

Variants for ACTR1B Gene

Sequence variations from dbSNP and Humsavar for ACTR1B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000420174 -- 97,656,499(-) C/G 3_prime_UTR_variant
rs1000524736 -- 97,656,005(-) TTTTTTT/TTTT 3_prime_UTR_variant
rs1000797664 -- 97,661,564(-) C/T intron_variant
rs1000849924 -- 97,661,282(-) T/C intron_variant
rs1001400126 -- 97,660,905(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTR1B Gene

Variant ID Type Subtype PubMed ID
dgv4025n100 CNV gain 25217958
dgv4026n100 CNV gain 25217958
esv2759077 CNV gain+loss 17122850
esv2763630 CNV gain+loss 21179565
esv3575281 CNV gain 25503493
esv3575285 CNV gain 25503493
esv3591717 CNV gain 21293372
nsv582512 CNV loss 21841781

Variation tolerance for ACTR1B Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.35; 81.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTR1B Gene

Disorders for ACTR1B Gene

Additional Disease Information for ACTR1B

No disorders were found for ACTR1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR1B Gene

Publications for ACTR1B Gene

  1. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PMID: 7696711) Clark SW … Meyer DI (Molecular biology of the cell 1994) 2 3 4 23 56
  2. Assignment of beta-centractin (CTRN2) to human chromosome 2 bands q11.1-->q11.2 with somatic cell hybrids and in situ hybridization. (PMID: 10343100) Elsea SH … Patel PI (Cytogenetics and cell genetics 1999) 2 3 23 56
  3. Down-regulation of beta-centractin might be involved in dendritic cells dysfunction and subsequent hepatocellular carcinoma immune escape: a proteomic study. (PMID: 17619203) Weng YQ … Tang ZY (Journal of cancer research and clinical oncology 2008) 3 23 56
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for ACTR1B Gene

Sources for ACTR1B Gene