Aliases for ACTR1A Gene
External Ids for ACTR1A Gene
Previous GeneCards Identifiers for ACTR1A Gene
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACTR1A Gene
ACTR1A (Actin Related Protein 1A) is a Protein Coding gene. Diseases associated with ACTR1A include Brachydactyly, Type A3. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ACTR1B.
UniProtKB/Swiss-Prot Summary for ACTR1A Gene
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.