This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement,... See more...

Aliases for ACTR1A Gene

Aliases for ACTR1A Gene

  • Actin Related Protein 1A 2 3 5
  • ARP1 Actin-Related Protein 1 Homolog A, Centractin Alpha 2 3
  • ARP1 Actin Related Protein 1 Homolog A 2 3
  • Centrosome-Associated Actin Homolog 3 4
  • Alpha-Centractin 3 4
  • Centractin 3 4
  • Actin-RPV 3 4
  • CTRN1 3 4
  • ARP1 3 4
  • ARP1 (Actin-Related Protein 1, Yeast) Homolog A (Centractin Alpha) 2
  • Epididymis Secretory Sperm Binding Protein 3
  • Centractin Alpha 2
  • Arp1A 3

External Ids for ACTR1A Gene

Previous GeneCards Identifiers for ACTR1A Gene

  • GC10M103132
  • GC10M103472
  • GC10M104370
  • GC10M103903
  • GC10M104228
  • GC10M097872

Summaries for ACTR1A Gene

Entrez Gene Summary for ACTR1A Gene

  • This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACTR1A Gene

ACTR1A (Actin Related Protein 1A) is a Protein Coding gene. Diseases associated with ACTR1A include Brachydactyly, Type A3. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is ACTR1B.

UniProtKB/Swiss-Prot Summary for ACTR1A Gene

  • Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Gene Wiki entry for ACTR1A Gene

Additional gene information for ACTR1A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTR1A Gene

Genomics for ACTR1A Gene

GeneHancer (GH) Regulatory Elements for ACTR1A Gene

Promoters and enhancers for ACTR1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTR1A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACTR1A

Top Transcription factor binding sites by QIAGEN in the ACTR1A gene promoter:
  • AhR
  • AREB6
  • Egr-2
  • FOXD1
  • LCR-F1
  • NF-1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • YY1

Genomic Locations for ACTR1A Gene

Genomic Locations for ACTR1A Gene
chr10:102,461,881-102,502,755
(GRCh38/hg38)
Size:
40,875 bases
Orientation:
Minus strand
chr10:104,238,986-104,262,512
(GRCh37/hg19)
Size:
23,527 bases
Orientation:
Minus strand

Genomic View for ACTR1A Gene

Genes around ACTR1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR1A Gene

Proteins for ACTR1A Gene

  • Protein details for ACTR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61163-ACTZ_HUMAN
    Recommended name:
    Alpha-centractin
    Protein Accession:
    P61163
    Secondary Accessions:
    • B2R6B0
    • P42024

    Protein attributes for ACTR1A Gene

    Size:
    376 amino acids
    Molecular mass:
    42614 Da
    Quaternary structure:
    • Interacts with BCCIP (isoform 2/alpha).

neXtProt entry for ACTR1A Gene

Post-translational modifications for ACTR1A Gene

  • Ubiquitination at Lys96, Lys200, and Lys308
  • Modification sites at PhosphoSitePlus

Other Protein References for ACTR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTR1A Gene

Domains & Families for ACTR1A Gene

Gene Families for ACTR1A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ACTR1A Gene

Suggested Antigen Peptide Sequences for ACTR1A Gene

GenScript: Design optimal peptide antigens:
  • Centrosome-associated actin homolog (ACTZ_HUMAN)
  • cDNA FLJ52800, highly similar to Alpha-centractin (B4DXP9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61163

UniProtKB/Swiss-Prot:

ACTZ_HUMAN :
  • Belongs to the actin family. ARP1 subfamily.
Family:
  • Belongs to the actin family. ARP1 subfamily.
genes like me logo Genes that share domains with ACTR1A: view

Function for ACTR1A Gene

Molecular function for ACTR1A Gene

UniProtKB/Swiss-Prot Function:
Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.

Phenotypes From GWAS Catalog for ACTR1A Gene

Gene Ontology (GO) - Molecular Function for ACTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 28394342
GO:0005524 ATP binding IEA --
GO:0106006 contributes_to microtubule cortical anchor activity IBA 21873635
genes like me logo Genes that share ontologies with ACTR1A: view
genes like me logo Genes that share phenotypes with ACTR1A: view

Animal Model Products

CRISPR Products

miRNA for ACTR1A Gene

miRTarBase miRNAs that target ACTR1A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR1A Gene

Localization for ACTR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR1A Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR1A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002177 manchette IEA --
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA,IBA 21399614
GO:0005814 centriole IEA --
genes like me logo Genes that share ontologies with ACTR1A: view

Pathways & Interactions for ACTR1A Gene

genes like me logo Genes that share pathways with ACTR1A: view

Pathways by source for ACTR1A Gene

2 GeneGo (Thomson Reuters) pathways for ACTR1A Gene
  • Cell cycle_Spindle assembly and chromosome separation
  • Cytoskeleton remodeling Neurofilaments

Gene Ontology (GO) - Biological Process for ACTR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000132 establishment of mitotic spindle orientation IBA 21873635
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007283 spermatogenesis IEA --
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with ACTR1A: view

No data available for SIGNOR curated interactions for ACTR1A Gene

Drugs & Compounds for ACTR1A Gene

(1) Drugs for ACTR1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ACTR1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACTR1A: view

Transcripts for ACTR1A Gene

mRNA/cDNA for ACTR1A Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR1A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:
SP7:

Relevant External Links for ACTR1A Gene

GeneLoc Exon Structure for
ACTR1A

Expression for ACTR1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACTR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACTR1A Gene

This gene is overexpressed in Fetal Brain (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACTR1A Gene



Protein tissue co-expression partners for ACTR1A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACTR1A

SOURCE GeneReport for Unigene cluster for ACTR1A Gene:

Hs.153961

Evidence on tissue expression from TISSUES for ACTR1A Gene

  • Nervous system(5)
  • Kidney(4.7)
  • Muscle(4.4)
  • Liver(4.2)
  • Lung(3.4)
  • Skin(3.4)
  • Eye(2.7)
genes like me logo Genes that share expression patterns with ACTR1A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR1A Gene

Orthologs for ACTR1A Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTR1A Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia ACTR1A 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ACTR1A 31 30
  • 99.65 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACTR1A 31
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTR1A 31 30
  • 92.82 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACTR1A 31 30
  • 91.93 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actr1a 30
  • 91.49 (n)
mouse
(Mus musculus)
Mammalia Actr1a 17 31 30
  • 91.4 (n)
chicken
(Gallus gallus)
Aves ACTR1A 31 30
  • 83.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTR1A 31
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia actr1a 30
  • 79.61 (n)
Str.11859 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.11469 30
zebrafish
(Danio rerio)
Actinopterygii si:ch211-241j12.3 31
  • 10 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Arp87C 31 32
  • 79 (a)
OneToMany
Arp1 30
  • 71.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002127 30
  • 70.57 (n)
worm
(Caenorhabditis elegans)
Secernentea Y53F4B.22 32
  • 69 (a)
arp-1 31 30
  • 62.9 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9685 31
  • 69 (a)
OneToMany
Cin.4114 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4114 30
Species where no ortholog for ACTR1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR1A Gene

ENSEMBL:
Gene Tree for ACTR1A (if available)
TreeFam:
Gene Tree for ACTR1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACTR1A: view image

Paralogs for ACTR1A Gene

(31) SIMAP similar genes for ACTR1A Gene using alignment to 4 proteins:

  • ACTZ_HUMAN
  • B4DXP9_HUMAN
  • F5H3I4_HUMAN
  • R4GMT0_HUMAN

Pseudogenes.org Pseudogenes for ACTR1A Gene

genes like me logo Genes that share paralogs with ACTR1A: view

Variants for ACTR1A Gene

Additional dbSNP identifiers (rs#s) for ACTR1A Gene

Structural Variations from Database of Genomic Variants (DGV) for ACTR1A Gene

Variant ID Type Subtype PubMed ID
nsv467445 CNV loss 19166990
nsv552059 CNV loss 21841781
nsv831968 CNV gain 17160897

Variation tolerance for ACTR1A Gene

Residual Variation Intolerance Score: 21.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACTR1A Gene

Disorders for ACTR1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACTR1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
brachydactyly, type a3
  • bda3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ACTR1A

genes like me logo Genes that share disorders with ACTR1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTR1A Gene

Publications for ACTR1A Gene

  1. A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. (PMID: 1528266) Lees-Miller JP … Schroer TA (Nature 1992) 2 3 4 23 54
  2. Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins. (PMID: 7696711) Clark SW … Meyer DI (Molecular biology of the cell 1994) 3 4 23 54
  3. Regulation of spindle integrity and mitotic fidelity by BCCIP. (PMID: 28394342) Huhn SC … Shen Z (Oncogene 2017) 3 4 54
  4. Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation. (PMID: 22327364) Kiyomitsu T … Cheeseman IM (Nature cell biology 2012) 3 4 54
  5. Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6. (PMID: 19737819) Zilberman Y … Bershadsky A (Journal of cell science 2009) 3 23 54

Products for ACTR1A Gene

Sources for ACTR1A Gene