Aliases for ACTR10 Gene

Aliases for ACTR10 Gene

  • Actin Related Protein 10 2 3 5
  • Actin Related Protein 10 Homolog 2 3
  • Actin-Related Protein 10 3 4
  • Actin-Related Protein 11 3 4
  • HARP11 3 4
  • ACTR11 3 4
  • Actin-Related Protein 10 Homolog (S. Cerevisiae) 2
  • Arp10 3
  • Arp11 3
  • ARP11 4

External Ids for ACTR10 Gene

Previous GeneCards Identifiers for ACTR10 Gene

  • GC14P052462
  • GC14P056656
  • GC14P057736
  • GC14P058666
  • GC14P038835

Summaries for ACTR10 Gene

GeneCards Summary for ACTR10 Gene

ACTR10 (Actin Related Protein 10) is a Protein Coding gene. Among its related pathways are Innate Immune System and Cell cycle_Spindle assembly and chromosome separation. An important paralog of this gene is ACTG1.

Additional gene information for ACTR10 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTR10 Gene

Genomics for ACTR10 Gene

GeneHancer (GH) Regulatory Elements for ACTR10 Gene

Promoters and enhancers for ACTR10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J058199 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.4 421 3 ZNF24 SP1 POLR2A HCFC1 MAX DACH1 MNT NKRF ZFX ZNF687 ACTR10 ENSG00000258682 PSMA3-AS1 ARMH4 piR-32214-190
GH14J058201 Enhancer 0.3 Ensembl 750.6 -1.6 -1579 0.2 ZBTB48 ACTR10 lnc-ACTR10-2 ENSG00000258519 ARMH4 PSMA3-AS1
GH14J058198 Enhancer 0.3 ENCODE 750.6 -1.8 -1802 0.2 ZBTB48 ACTR10 lnc-ACTR10-2 ENSG00000258519 ARMH4 PSMA3-AS1
GH14J058200 Enhancer 0.2 Ensembl 750.6 -2.0 -1979 0.2 ACTR10 lnc-ACTR10-2 ENSG00000258519 PSMA3-AS1 ARMH4
GH14J058280 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +82.3 82320 4.8 SMARCE1 ELF1 HLF TEAD4 ZNF148 ELF3 SP1 CBFA2T2 CEBPG MLLT1 ACTR10 PSMA3-AS1 TOMM20L ENSG00000258682 ARID4A HMGB1P14 lnc-ARID4A-2 ARMH4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTR10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACTR10 gene promoter:
  • COMP1
  • E2F
  • E2F-1
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HNF-4alpha2
  • RORalpha1
  • RORalpha2
  • RSRFC4

Genomic Locations for ACTR10 Gene

Genomic Locations for ACTR10 Gene
35,557 bases
Plus strand
35,557 bases
Plus strand

Genomic View for ACTR10 Gene

Genes around ACTR10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTR10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTR10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTR10 Gene

Proteins for ACTR10 Gene

  • Protein details for ACTR10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-related protein 10
    Protein Accession:
    Secondary Accessions:
    • Q9H9Y5
    • Q9NWY2

    Protein attributes for ACTR10 Gene

    417 amino acids
    Molecular mass:
    46307 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTR10 Gene

Post-translational modifications for ACTR10 Gene

  • Ubiquitination at Lys26, Lys44, and Lys375
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACTR10 Gene

Domains & Families for ACTR10 Gene

Gene Families for ACTR10 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACTR10 Gene


Suggested Antigen Peptide Sequences for ACTR10 Gene

GenScript: Design optimal peptide antigens:
  • Actin-related protein 11 (ARP10_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTR10: view

Function for ACTR10 Gene

Phenotypes From GWAS Catalog for ACTR10 Gene

Gene Ontology (GO) - Molecular Function for ACTR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ACTR10: view
genes like me logo Genes that share phenotypes with ACTR10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTR10 Gene

Localization for ACTR10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTR10 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTR10 gene
Compartment Confidence
extracellular 4
cytoskeleton 4
cytosol 4
lysosome 4
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACTR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005869 dynactin complex IBA,IEA 21873635
genes like me logo Genes that share ontologies with ACTR10: view

Pathways & Interactions for ACTR10 Gene

genes like me logo Genes that share pathways with ACTR10: view

Pathways by source for ACTR10 Gene

Gene Ontology (GO) - Biological Process for ACTR10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007018 microtubule-based movement IBA,IEA 21873635
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0043312 neutrophil degranulation TAS --
GO:0098958 retrograde axonal transport of mitochondrion IBA 21873635
genes like me logo Genes that share ontologies with ACTR10: view

No data available for SIGNOR curated interactions for ACTR10 Gene

Drugs & Compounds for ACTR10 Gene

No Compound Related Data Available

Transcripts for ACTR10 Gene

mRNA/cDNA for ACTR10 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTR10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTR10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP3: - -

Relevant External Links for ACTR10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACTR10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTR10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACTR10 Gene

This gene is overexpressed in Lavage (16.0) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACTR10 Gene

Protein tissue co-expression partners for ACTR10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTR10 Gene:


SOURCE GeneReport for Unigene cluster for ACTR10 Gene:


Evidence on tissue expression from TISSUES for ACTR10 Gene

  • Nervous system(4.9)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with ACTR10: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTR10 Gene

Orthologs for ACTR10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACTR10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTR10 33 32
  • 99.85 (n)
(Bos Taurus)
Mammalia ACTR10 33 32
  • 92.57 (n)
(Canis familiaris)
Mammalia ACTR10 33 32
  • 92.01 (n)
(Mus musculus)
Mammalia Actr10 17 33 32
  • 90.65 (n)
(Rattus norvegicus)
Mammalia Actr10 32
  • 89.85 (n)
(Ornithorhynchus anatinus)
Mammalia ACTR10 33
  • 89 (a)
(Monodelphis domestica)
Mammalia ACTR10 33
  • 82 (a)
(Gallus gallus)
Aves -- 33
  • 85 (a)
ACTR10 33 32
  • 79.3 (n)
(Anolis carolinensis)
Reptilia ACTR10 33
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia actr10 32
  • 76.58 (n)
Str.5840 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.22802 32
(Danio rerio)
Actinopterygii actr10 33 32
  • 67.47 (n)
zgc55635 32
fruit fly
(Drosophila melanogaster)
Insecta Arp10 32
  • 49.68 (n)
Arp11 33
  • 40 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012077 32
  • 48.77 (n)
(Caenorhabditis elegans)
Secernentea arp-11 33
  • 23 (a)
Species where no ortholog for ACTR10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACTR10 Gene

Gene Tree for ACTR10 (if available)
Gene Tree for ACTR10 (if available)
Evolutionary constrained regions (ECRs) for ACTR10: view image

Paralogs for ACTR10 Gene

(31) SIMAP similar genes for ACTR10 Gene using alignment to 10 proteins:

  • F6S9Y6_HUMAN
  • G3V2Q5_HUMAN
  • G3V4K6_HUMAN
  • G3V524_HUMAN
  • G3V5Y4_HUMAN
  • Q05DQ7_HUMAN
genes like me logo Genes that share paralogs with ACTR10: view

Variants for ACTR10 Gene

Sequence variations from dbSNP and Humsavar for ACTR10 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000369679 -- 58,229,505(+) C/G intron_variant
rs1000390299 -- 58,209,081(+) A/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000420654 -- 58,229,393(+) T/C intron_variant
rs1000485635 -- 58,216,153(+) C/A intron_variant
rs1000487983 -- 58,202,380(+) G/T intron_variant

Variation tolerance for ACTR10 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTR10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ACTR10 Gene

Disorders for ACTR10 Gene

Additional Disease Information for ACTR10

No disorders were found for ACTR10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTR10 Gene

Publications for ACTR10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. (PMID: 12857853) Eckley DM … Schroer TA (Molecular biology of the cell 2003) 2 3 56
  4. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3 56
  5. Insights into the ubiquitin-proteasome system of human embryonic stem cells. (PMID: 29511261) Saez I … Vilchez D (Scientific reports 2018) 3 56

Products for ACTR10 Gene

Sources for ACTR10 Gene