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Aliases for ACTL9 Gene

Aliases for ACTL9 Gene

  • Actin Like 9 2 3 5
  • Actin-Like Protein 9 3 4
  • Testicular Tissue Protein Li 15 3
  • Testicular Tissue Protein Li 9 3
  • ACTL7C 4
  • HSD21 3

External Ids for ACTL9 Gene

Previous GeneCards Identifiers for ACTL9 Gene

  • GC19M008807
  • GC19M008423

Summaries for ACTL9 Gene

GeneCards Summary for ACTL9 Gene

ACTL9 (Actin Like 9) is a Protein Coding gene. An important paralog of this gene is ACTL7A.

Additional gene information for ACTL9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTL9 Gene

Genomics for ACTL9 Gene

GeneHancer (GH) Regulatory Elements for ACTL9 Gene

Promoters and enhancers for ACTL9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008698 Enhancer 0.6 ENCODE 600.7 +0.5 524 0.2 EGR1 GMEB1 REST CTCF NRF1 ZNF143 RAD21 MYC L3MBTL2 ACTL9 ENSG00000279426 GC19P008695
GH19J008639 Enhancer 1.2 FANTOM5 ENCODE 11.7 +58.4 58430 1.7 ELF3 ZNF121 CEBPG SP1 HNF1A ZNF384 ZNF644 KAT8 RXRA CEBPA MYO1F ADAMTS10 ACTL9 PRAM1 ENSG00000270614 LINC01862 ENSG00000261866 GC19P008677
GH19J008878 Enhancer 0.6 FANTOM5 14.9 -179.6 -179644 0.2 SIX5 ZNF512 GABPA SOX6 NFYB ZBTB17 MBD2 HCFC1 ELF1 ZNF366 PIR31458 ACTL9 MUC16 ZNF177 OR7G1 GC19P008942
GH19J008637 Enhancer 0.8 ENCODE 11.6 +60.3 60333 1.1 ELF3 CEBPG ZNF24 SP1 ZNF644 KAT8 CEBPA GATAD2A RXRB REST ADAMTS10 ACTL9 MYO1F LINC01862 ENSG00000261866 GC19P008677
GH19J008663 Enhancer 0.6 ENCODE 12.9 +34.4 34420 1.2 ATF1 ZSCAN4 ZNF580 CREB1 BCOR CREM VEZF1 ZMYM3 KDM1A ACTL9 ADAMTS10 ZNF559 ENSG00000261866 GC19P008677 LINC01862
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTL9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ACTL9 Gene

Genomic Locations for ACTL9 Gene
chr19:8,697,397-8,698,830
(GRCh38/hg38)
Size:
1,434 bases
Orientation:
Minus strand
chr19:8,807,751-8,809,172
(GRCh37/hg19)
Size:
1,422 bases
Orientation:
Minus strand

Genomic View for ACTL9 Gene

Genes around ACTL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTL9 Gene

Proteins for ACTL9 Gene

  • Protein details for ACTL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TC94-ACTL9_HUMAN
    Recommended name:
    Actin-like protein 9
    Protein Accession:
    Q8TC94
    Secondary Accessions:
    • A8K893
    • Q6X960

    Protein attributes for ACTL9 Gene

    Size:
    416 amino acids
    Molecular mass:
    45627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTL9 Gene

Post-translational modifications for ACTL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTL9 Gene

Domains & Families for ACTL9 Gene

Gene Families for ACTL9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACTL9 Gene

Suggested Antigen Peptide Sequences for ACTL9 Gene

GenScript: Design optimal peptide antigens:
  • Actin-like protein 9 (ACTL9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TC94

UniProtKB/Swiss-Prot:

ACTL9_HUMAN :
  • Belongs to the actin family.
Family:
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTL9: view

Function for ACTL9 Gene

Phenotypes From GWAS Catalog for ACTL9 Gene

genes like me logo Genes that share phenotypes with ACTL9: view

Animal Model Products

CRISPR Products

miRNA for ACTL9 Gene

miRTarBase miRNAs that target ACTL9

Clone Products

  • Applied Biological Materials (abm): Clones for ACTL9 - Now 50% OFF >
  • * ACTL9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ACTL9 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTL9 Gene

Localization for ACTL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTL9 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTL9 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
peroxisome 0

Gene Ontology (GO) - Cellular Components for ACTL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ACTL9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACTL9 Gene

Pathways & Interactions for ACTL9 Gene

PathCards logo

SuperPathways for ACTL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTL9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ACTL9 Gene

Drugs & Compounds for ACTL9 Gene

No Compound Related Data Available

Transcripts for ACTL9 Gene

mRNA/cDNA for ACTL9 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for ACTL9 Gene

Actin-like 9:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ACTL9 - Now 50% OFF >
  • * ACTL9 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ACTL9 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ACTL9 Gene

No ASD Table

Relevant External Links for ACTL9 Gene

GeneLoc Exon Structure for
ACTL9
ECgene alternative splicing isoforms for
ACTL9

Expression for ACTL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTL9 Gene

mRNA differential expression in normal tissues according to GTEx for ACTL9 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for ACTL9 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACTL9 Gene



Protein tissue co-expression partners for ACTL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACTL9 Gene:

ACTL9

SOURCE GeneReport for Unigene cluster for ACTL9 Gene:

Hs.209206
genes like me logo Genes that share expression patterns with ACTL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTL9 Gene

Orthologs for ACTL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTL9 35 34
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ACTL9 35 34
  • 83.81 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACTL9 35 34
  • 83.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Actl9 17 35 34
  • 76.09 (n)
rat
(Rattus norvegicus)
Mammalia Actl9 34
  • 75.9 (n)
oppossum
(Monodelphis domestica)
Mammalia ACTL9 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACTL9 35 34
  • 56.59 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACTL9 35
  • 54 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 35
  • 31 (a)
OneToMany
Species where no ortholog for ACTL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTL9 Gene

ENSEMBL:
Gene Tree for ACTL9 (if available)
TreeFam:
Gene Tree for ACTL9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACTL9: view image

Paralogs for ACTL9 Gene

(21) SIMAP similar genes for ACTL9 Gene using alignment to 1 proteins:

  • ACTL9_HUMAN
genes like me logo Genes that share paralogs with ACTL9: view

Variants for ACTL9 Gene

Sequence variations from dbSNP and Humsavar for ACTL9 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_043001 A colorectal cancer sample p.Ala42Asp
VAR_043004 A colorectal cancer sample p.Ala332Thr
rs1000979064 -- 8,699,063(-) C/G/T upstream_transcript_variant
rs1000983990 -- 8,699,430(-) A/G upstream_transcript_variant
rs1003583455 -- 8,697,887(-) G/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTL9 Gene

Variant ID Type Subtype PubMed ID
dgv3425n100 CNV gain 25217958
dgv3426n100 CNV gain 25217958
esv2762024 CNV gain 21179565
nsv1057425 CNV gain 25217958
nsv1060576 CNV loss 25217958
nsv469648 CNV gain+loss 16826518
nsv469747 CNV gain+loss 16826518
nsv471705 CNV gain+loss 15918152
nsv833735 CNV gain+loss 17160897

Variation tolerance for ACTL9 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTL9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTL9 Gene

Disorders for ACTL9 Gene

Additional Disease Information for ACTL9

No disorders were found for ACTL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTL9 Gene

Publications for ACTL9 Gene

  1. Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients. (PMID: 26127003) Kang Z … Xu F (Gene 2015) 3 58
  2. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients. (PMID: 23278845) Lepre T … Giardina E (The British journal of dermatology 2013) 3 58
  3. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58
  4. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (PMID: 22197932) Paternoster L … EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (Nature genetics 2011) 3 58
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 58

Products for ACTL9 Gene

Sources for ACTL9 Gene

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