Aliases for ACTL9 Gene

Aliases for ACTL9 Gene

  • Actin Like 9 2 3 5
  • Actin-Like Protein 9 3 4
  • Testicular Tissue Protein Li 15 3
  • Testicular Tissue Protein Li 9 3
  • MGC33407 2
  • ACTL7C 4
  • HSD21 3
  • ACTL9 5

External Ids for ACTL9 Gene

Previous GeneCards Identifiers for ACTL9 Gene

  • GC19M008807
  • GC19M008423

Summaries for ACTL9 Gene

GeneCards Summary for ACTL9 Gene

ACTL9 (Actin Like 9) is a Protein Coding gene. Diseases associated with ACTL9 include Allergic Urticaria. An important paralog of this gene is ACTL7A.

Additional gene information for ACTL9 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTL9 Gene

Genomics for ACTL9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ACTL9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008698 Enhancer 0.6 ENCODE 600.7 +0.5 489 0.2 CTCF REST NRF1 EGR1 SAFB ZNF143 RAD21 MYC L3MBTL2 GMEB1 ACTL9 ENSG00000279426 NFILZ
GH19J008700 Enhancer 0.4 Ensembl 600.7 -1.3 -1306 0.2 BCOR ZMYM3 ZFP36 ACTL9 piR-48209-324 OR2Z1
GH19J008639 Enhancer 1.1 FANTOM5 ENCODE 11.7 +58.4 58395 1.7 GATAD2A REST KDM1A RXRB SP1 CEBPA SOX13 CEBPB TCF7 ZNF184 MYO1F ADAMTS10 ACTL9 PRAM1 ENSG00000270614 FJ601684-213 NFILZ LINC01862-001
GH19J008878 Enhancer 0.6 FANTOM5 14.9 -179.7 -179679 0.2 ZNF512 SIX5 GABPA SOX6 ZBTB17 HCFC1 MBD2 NFYB ELF1 ZNF366 ACTL9 MUC16 ZNF177 OR7G1 lnc-ZNF558-2 ZNF558 HSALNG0123795
GH19J008637 Enhancer 0.8 ENCODE 11.6 +60.3 60298 1.1 GATAD2A FOXA1 RXRB IRF2 REST CEBPA MNT SOX13 CEBPB SP1 ADAMTS10 ACTL9 MYO1F FJ601684-213 NFILZ LINC01862-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTL9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACTL9

Genomic Locations for ACTL9 Gene

Genomic Locations for ACTL9 Gene
1,396 bases
Minus strand
1,422 bases
Minus strand

Genomic View for ACTL9 Gene

Genes around ACTL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTL9 Gene

Proteins for ACTL9 Gene

  • Protein details for ACTL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Actin-like protein 9
    Protein Accession:
    Secondary Accessions:
    • A8K893
    • Q6X960

    Protein attributes for ACTL9 Gene

    416 amino acids
    Molecular mass:
    45627 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTL9 Gene

Post-translational modifications for ACTL9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTL9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTL9 Gene

Domains & Families for ACTL9 Gene

Gene Families for ACTL9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACTL9 Gene

  • Actin/actin-like
  • N-6 Adenine-specific DNA methylase

Suggested Antigen Peptide Sequences for ACTL9 Gene

GenScript: Design optimal peptide antigens:
  • Actin-like protein 9 (ACTL9_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the actin family.
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTL9: view

Function for ACTL9 Gene

Phenotypes From GWAS Catalog for ACTL9 Gene

genes like me logo Genes that share phenotypes with ACTL9: view

Animal Model Products

CRISPR Products

miRNA for ACTL9 Gene

miRTarBase miRNAs that target ACTL9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTL9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACTL9 Gene

Localization for ACTL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACTL9 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTL9 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
extracellular 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for ACTL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005869 dynactin complex IBA 21873635
GO:0015629 actin cytoskeleton IBA 21873635
genes like me logo Genes that share ontologies with ACTL9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACTL9 Gene

Pathways & Interactions for ACTL9 Gene

PathCards logo

SuperPathways for ACTL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for ACTL9 Gene

Drugs & Compounds for ACTL9 Gene

No Compound Related Data Available

Transcripts for ACTL9 Gene

mRNA/cDNA for ACTL9 Gene

9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACTL9

Alternative Splicing Database (ASD) splice patterns (SP) for ACTL9 Gene

No ASD Table

Relevant External Links for ACTL9 Gene

GeneLoc Exon Structure for

Expression for ACTL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACTL9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for ACTL9 Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for ACTL9 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACTL9 Gene

Protein tissue co-expression partners for ACTL9 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACTL9

SOURCE GeneReport for Unigene cluster for ACTL9 Gene:

genes like me logo Genes that share expression patterns with ACTL9: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTL9 Gene

Orthologs for ACTL9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACTL9 30 31
  • 99.52 (n)
(Canis familiaris)
Mammalia ACTL9 30 31
  • 83.81 (n)
(Bos Taurus)
Mammalia ACTL9 30 31
  • 83.41 (n)
(Mus musculus)
Mammalia Actl9 30 17 31
  • 76.09 (n)
(Rattus norvegicus)
Mammalia Actl9 30
  • 75.9 (n)
(Monodelphis domestica)
Mammalia ACTL9 31
  • 63 (a)
(Gallus gallus)
Aves ACTL9 30 31
  • 56.59 (n)
(Anolis carolinensis)
Reptilia ACTL9 31
  • 54 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 31
  • 31 (a)
Species where no ortholog for ACTL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ACTL9 Gene

Gene Tree for ACTL9 (if available)
Gene Tree for ACTL9 (if available)
Evolutionary constrained regions (ECRs) for ACTL9: view image

Paralogs for ACTL9 Gene

(21) SIMAP similar genes for ACTL9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACTL9: view

Variants for ACTL9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACTL9 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs782721280 A colorectal cancer sample p.Ala332Thr
VAR_043001 A colorectal cancer sample p.Ala42Asp
rs10410943 - p.Val51Ala
rs2340550 - p.Phe37Ser
rs4804079 - p.His227Asn

Additional dbSNP identifiers (rs#s) for ACTL9 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACTL9 Gene

Variant ID Type Subtype PubMed ID
dgv3425n100 CNV gain 25217958
dgv3426n100 CNV gain 25217958
esv2762024 CNV gain 21179565
nsv1057425 CNV gain 25217958
nsv1060576 CNV loss 25217958
nsv469648 CNV gain+loss 16826518
nsv469747 CNV gain+loss 16826518
nsv471705 CNV gain+loss 15918152
nsv833735 CNV gain+loss 17160897

Variation tolerance for ACTL9 Gene

Residual Variation Intolerance Score: 82.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTL9 Gene

Disorders for ACTL9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACTL9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
allergic urticaria
- elite association - COSMIC cancer census association via MalaCards
Search ACTL9 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ACTL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTL9 Gene

Publications for ACTL9 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients. (PMID: 26127003) Kang Z … Xu F (Gene 2015) 3
  3. Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients. (PMID: 23278845) Lepre T … Giardina E (The British journal of dermatology 2013) 3
  4. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ACTL9 Gene

Sources for ACTL9 Gene