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Aliases for ACTL10 Gene

Aliases for ACTL10 Gene

  • Actin Like 10 2 3 5
  • C20orf134 3 4
  • Chromosome 20 Open Reading Frame 134 2
  • Actin-Like Protein 10 3
  • DJ63M2.2 3

External Ids for ACTL10 Gene

Previous HGNC Symbols for ACTL10 Gene

  • C20orf134

Previous GeneCards Identifiers for ACTL10 Gene

  • GC20P032255

Summaries for ACTL10 Gene

GeneCards Summary for ACTL10 Gene

ACTL10 (Actin Like 10) is a Protein Coding gene. An important paralog of this gene is ACTR2.

Additional gene information for ACTL10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACTL10 Gene

Genomics for ACTL10 Gene

GeneHancer (GH) Regulatory Elements for ACTL10 Gene

Promoters and enhancers for ACTL10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J033665 Promoter/Enhancer 1.5 Ensembl ENCODE 650.7 +0.6 632 3.1 HDGF PKNOX1 ATF1 SMAD1 SIN3A ZNF2 IRF4 ZNF48 YY1 ZNF143 ACTL10 CDK5RAP1 CBFA2T2 DNMT3B ZNF341-AS1 ENSG00000272945 E2F1 CHMP4B C20orf144 NECAB3
GH20J033664 Enhancer 0.6 ENCODE 650.7 -1.5 -1498 0.3 HMG20B SP3 ZNF189 ZNF335 ZFHX2 ZNF316 SCRT2 ZNF600 EMSY PRDM1 ACTL10 C20orf144 NECAB3
GH20J034514 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 +849.5 849547 3.1 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B DYNLRB1 MAP1LC3A NCOA6 ZNF341-AS1 PIGU TRPC4AP EIF6 TP53INP2 ACTL10 ITCH
GH20J033684 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.6 +19.4 19402 2.9 HDGF SMAD1 ARNT MLX ARID4B SIN3A DMAP1 SLC30A9 E2F8 ZNF143 E2F1 ZNF341-AS1 BAK1P1 ENSG00000229188 ENSG00000228386 BPIFB5P RPL12P3 BPIFA3 ENSG00000224876 SUN5
GH20J033561 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 11 -104.1 -104148 1.2 FOXA2 ARID4B DMAP1 ZNF2 YY1 SLC30A9 SP3 SP5 NFYC MXD4 CBFA2T2 GC20P033562 C20orf144 ACTL10 NECAB3 PXMP4 ZNF341 ENSG00000229188 GC20P033492 GC20P033491
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACTL10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ACTL10 Gene

Genomic Locations for ACTL10 Gene
chr20:33,666,498-33,668,525
(GRCh38/hg38)
Size:
2,028 bases
Orientation:
Plus strand
chr20:32,254,304-32,256,331
(GRCh37/hg19)
Size:
2,028 bases
Orientation:
Plus strand

Genomic View for ACTL10 Gene

Genes around ACTL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTL10 Gene

Proteins for ACTL10 Gene

  • Protein details for ACTL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JWF8-ACL10_HUMAN
    Recommended name:
    Actin-like protein 10
    Protein Accession:
    Q5JWF8
    Secondary Accessions:
    • B9EH76

    Protein attributes for ACTL10 Gene

    Size:
    245 amino acids
    Molecular mass:
    26751 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACTL10 Gene

Post-translational modifications for ACTL10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACTL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACTL10 Gene

Domains & Families for ACTL10 Gene

Gene Families for ACTL10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for ACTL10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACTL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JWF8

UniProtKB/Swiss-Prot:

ACL10_HUMAN :
  • Belongs to the actin family.
Family:
  • Belongs to the actin family.
genes like me logo Genes that share domains with ACTL10: view

Function for ACTL10 Gene

genes like me logo Genes that share phenotypes with ACTL10: view

Animal Models for ACTL10 Gene

MGI Knock Outs for ACTL10:
  • Actl10 Actl10<tm1a(EUCOMM)Wtsi>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ACTL10 Gene

Localization for ACTL10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTL10 gene
Compartment Confidence
extracellular 3
cytosol 2
mitochondrion 1
nucleus 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ACTL10 Gene

Pathways & Interactions for ACTL10 Gene

SuperPathways for ACTL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACTL10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ACTL10 Gene

Drugs & Compounds for ACTL10 Gene

No Compound Related Data Available

Transcripts for ACTL10 Gene

mRNA/cDNA for ACTL10 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACTL10 Gene

Actin-like 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACTL10 Gene

No ASD Table

Relevant External Links for ACTL10 Gene

GeneLoc Exon Structure for
ACTL10
ECgene alternative splicing isoforms for
ACTL10

Expression for ACTL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACTL10 Gene

Protein differential expression in normal tissues from HIPED for ACTL10 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACTL10 Gene



Protein tissue co-expression partners for ACTL10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACTL10 Gene:

ACTL10

SOURCE GeneReport for Unigene cluster for ACTL10 Gene:

Hs.592151
genes like me logo Genes that share expression patterns with ACTL10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTL10 Gene

Orthologs for ACTL10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACTL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACTL10 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ACTL10 34 33
  • 83.13 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Actl10 33
  • 81.09 (n)
mouse
(Mus musculus)
Mammalia Actl10 16 34 33
  • 80.27 (n)
oppossum
(Monodelphis domestica)
Mammalia ACTL10 34
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ACTL10 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACTL10 34
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARP2 34
  • 19 (a)
OneToMany
Species where no ortholog for ACTL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACTL10 Gene

ENSEMBL:
Gene Tree for ACTL10 (if available)
TreeFam:
Gene Tree for ACTL10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACTL10: view image

Paralogs for ACTL10 Gene

Paralogs for ACTL10 Gene

(15) SIMAP similar genes for ACTL10 Gene using alignment to 1 proteins:

  • ACL10_HUMAN
genes like me logo Genes that share paralogs with ACTL10: view

Variants for ACTL10 Gene

Sequence variations from dbSNP and Humsavar for ACTL10 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000357529 -- 33,667,458(+) G/A/T 5_prime_UTR_variant
rs1000765217 -- 33,665,958(+) C/T upstream_transcript_variant
rs1001427673 -- 33,668,303(+) T/G 3_prime_UTR_variant
rs1002024755 -- 33,667,301(+) C/T 5_prime_UTR_variant
rs1002843880 -- 33,665,891(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ACTL10 Gene

Variant ID Type Subtype PubMed ID
nsv954024 CNV deletion 24416366
nsv833961 CNV loss 17160897
nsv833960 CNV loss 17160897
nsv482067 CNV gain 20164927
nsv1065189 CNV loss 25217958
dgv7560n54 CNV loss 21841781

Variation tolerance for ACTL10 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACTL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACTL10 Gene

Disorders for ACTL10 Gene

Additional Disease Information for ACTL10

No disorders were found for ACTL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACTL10 Gene

Publications for ACTL10 Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ACTL10 Gene

Sources for ACTL10 Gene

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