Aliases for ACTA2-AS1 Gene

Subcategory (RNA class) for ACTA2-AS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for ACTA2-AS1 Gene

  • ACTA2 Antisense RNA 1 2 3 5
  • ACTA2-AS1 2 168
  • NONHSAG006474 92
  • HSALNG0079547 167
  • Uc001kfo.1 3
  • UC001kfo 3
  • ZXF1 3

External Ids for ACTA2-AS1 Gene

Previous GeneCards Identifiers for ACTA2-AS1 Gene

  • GC10P090693

Summaries for ACTA2-AS1 Gene

GeneCards Summary for ACTA2-AS1 Gene

ACTA2-AS1 (ACTA2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with ACTA2-AS1 include Lung Cancer Susceptibility 3 and Hepatocellular Carcinoma.

Additional gene information for ACTA2-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACTA2-AS1 Gene

Genomics for ACTA2-AS1 Gene

GeneHancer (GH) Regulatory Elements for ACTA2-AS1 Gene

Promoters and enhancers for ACTA2-AS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACTA2-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ACTA2-AS1 Gene

Genomic Locations for ACTA2-AS1 Gene
chr10:88,932,390-88,940,820
(GRCh38/hg38)
Size:
8,431 bases
Orientation:
Plus strand
chr10:90,692,400-90,700,368
(GRCh37/hg19)
Size:
7,969 bases
Orientation:
Plus strand

Genomic View for ACTA2-AS1 Gene

Genes around ACTA2-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACTA2-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACTA2-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACTA2-AS1 Gene

Proteins for ACTA2-AS1 Gene

Post-translational modifications for ACTA2-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ACTA2-AS1 Gene

Domains & Families for ACTA2-AS1 Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ACTA2-AS1 Gene

Function for ACTA2-AS1 Gene

Phenotypes From GWAS Catalog for ACTA2-AS1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACTA2-AS1 Gene

Localization for ACTA2-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACTA2-AS1 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ACTA2-AS1 Gene

Pathways & Interactions for ACTA2-AS1 Gene

PathCards logo

SuperPathways for ACTA2-AS1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for ACTA2-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for ACTA2-AS1 Gene

Drugs & Compounds for ACTA2-AS1 Gene

No Compound Related Data Available

Transcripts for ACTA2-AS1 Gene

mRNA/cDNA for ACTA2-AS1 Gene

9 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
6 NONCODE transcripts :
4 LncBook transcripts :
2 LNCipedia transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for ACTA2-AS1 Gene

No ASD Table

Relevant External Links for ACTA2-AS1 Gene

GeneLoc Exon Structure for
ACTA2-AS1

Expression for ACTA2-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACTA2-AS1 Gene

mRNA differential expression in normal tissues according to GTEx for ACTA2-AS1 Gene

This gene is overexpressed in Artery - Tibial (x7.0), Artery - Coronary (x5.6), Artery - Aorta (x5.5), and Esophagus - Gastroesophageal Junction (x4.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACTA2-AS1

SOURCE GeneReport for Unigene cluster for ACTA2-AS1 Gene:

Hs.713690
genes like me logo Genes that share expression patterns with ACTA2-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACTA2-AS1 Gene

Orthologs for ACTA2-AS1 Gene

Evolution for ACTA2-AS1 Gene

ENSEMBL:
Gene Tree for ACTA2-AS1 (if available)
TreeFam:
Gene Tree for ACTA2-AS1 (if available)

No data available for Orthologs for ACTA2-AS1 Gene

Paralogs for ACTA2-AS1 Gene

No data available for Paralogs for ACTA2-AS1 Gene

Variants for ACTA2-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACTA2-AS1 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
573994 Uncertain Significance: Aortic aneurysm, familial thoracic 6 88,938,097(+) C/G MISSENSE_VARIANT
636479 Uncertain Significance: not provided 88,935,327(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
636533 Likely Pathogenic: not provided 88,935,366(+) TC/T SPLICE_ACCEPTOR_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
649765 Uncertain Significance: Aortic aneurysm, familial thoracic 6 88,938,153(+) C/T MISSENSE_VARIANT
674576 Benign: not provided 88,935,486(+) G/A NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ACTA2-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACTA2-AS1 Gene

Variant ID Type Subtype PubMed ID
esv3624139 CNV gain 21293372
esv3624143 CNV loss 21293372
esv3624144 CNV gain 21293372
nsv831942 CNV gain 17160897
nsv831943 CNV gain 17160897
nsv948130 CNV duplication 23825009

Additional Variant Information for ACTA2-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACTA2-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ACTA2-AS1 Gene

Disorders for ACTA2-AS1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ACTA2-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ACTA2-AS1

genes like me logo Genes that share disorders with ACTA2-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACTA2-AS1 Gene

Publications for ACTA2-AS1 Gene

  1. Long non-coding RNA UC001kfo promotes hepatocellular carcinoma proliferation and metastasis by targeting α-SMA. (PMID: 28088733) Pan Y … Mu L (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 2 3 54
  2. Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma. (PMID: 24721325) Zhang L … Zhao JP (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014) 2 3 54
  3. Knockdown of ACTA2‑AS1 promotes liver cancer cell proliferation, migration and invasion. (PMID: 30664183) Zhou RJ … Lv HZ (Molecular medicine reports 2019) 3 54
  4. Differential expression of genes in HepG2 cells caused by UC001kfo RNAi as shown by RNA-seq. (PMID: 28786067) Pan YF … Qin T (Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2017) 3 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 54

Products for ACTA2-AS1 Gene

Sources for ACTA2-AS1 Gene