Aliases for ACSL6 Gene
External Ids for ACSL6 Gene
Previous HGNC Symbols for ACSL6 Gene
Previous GeneCards Identifiers for ACSL6 Gene
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
GeneCards Summary for ACSL6 Gene
ACSL6 (Acyl-CoA Synthetase Long Chain Family Member 6) is a Protein Coding gene. Diseases associated with ACSL6 include Myelodysplastic Syndrome and Chronic Intestinal Vascular Insufficiency. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Mitochondrial LC-Fatty Acid Beta-Oxidation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ENSG00000281938.
UniProtKB/Swiss-Prot Summary for ACSL6 Gene
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490, PubMed:24269233). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.