The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme... See more...

Aliases for ACSL5 Gene

Aliases for ACSL5 Gene

  • Acyl-CoA Synthetase Long Chain Family Member 5 2 3 5
  • Long-Chain Acyl-CoA Synthetase 5 2 3 4
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 5 2 3
  • Long-Chain Fatty Acid Coenzyme A Ligase 5 2 3
  • FACL5 For Fatty Acid Coenzyme A Ligase 5 2 3
  • Long-Chain-Fatty-Acid--CoA Ligase 5 3 4
  • Arachidonate--CoA Ligase 3 4
  • EC 6.2.1.3 4 52
  • LACS 5 3 4
  • FACL5 3 4
  • ACS5 3 4
  • Fatty Acid Coenzyme A Ligase 5 3
  • EC 6.2.1.15 4
  • EC 6.2.1 52
  • ACS2 3

External Ids for ACSL5 Gene

Previous HGNC Symbols for ACSL5 Gene

  • FACL5

Previous GeneCards Identifiers for ACSL5 Gene

  • GC10P113800
  • GC10P114123
  • GC10P107761

Summaries for ACSL5 Gene

Entrez Gene Summary for ACSL5 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACSL5 Gene

ACSL5 (Acyl-CoA Synthetase Long Chain Family Member 5) is a Protein Coding gene. Diseases associated with ACSL5 include Glioma and Her2-Receptor Negative Breast Cancer. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Mitochondrial LC-Fatty Acid Beta-Oxidation. Gene Ontology (GO) annotations related to this gene include long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL6.

UniProtKB/Swiss-Prot Summary for ACSL5 Gene

  • Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.

Gene Wiki entry for ACSL5 Gene

Additional gene information for ACSL5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACSL5 Gene

Genomics for ACSL5 Gene

GeneHancer (GH) Regulatory Elements for ACSL5 Gene

Promoters and enhancers for ACSL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J112372 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.3 +2.9 2908 9.3 FOXK2 SIN3A POLR2G SP1 NCOR1 KDM6A POLR2A TCF7 TGIF2 EP300 ACSL5 VTI1A ZDHHC6 ENSG00000232934
GH10J112381 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 65.1 +15.1 15114 14.7 FOXK2 POLR2G NCOR1 FOS REST KDM6A TCF7 FOXA1 MYC TGIF2 ACSL5 ENSG00000232934 ZDHHC6 VTI1A
GH10J112445 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 19.4 +73.3 73283 3.4 FOXK2 ZBTB40 ZNF217 EP300 CTCF TCF12 SIN3A NRF1 POLR2G NCOR1 ZDHHC6 HSALNG0080689 VTI1A ACSL5
GH10J112402 Enhancer 0.8 Ensembl ENCODE dbSUPER 37.4 +30.9 30887 4.7 ATF2 POLR2A JUND ZBTB33 ATF7 MNT ACSL5 ZDHHC6 ENSG00000232934
GH10J112330 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 23 -40.2 -40238 7.2 TCF7 RBM25 CREB1 CEBPG SAP130 CEBPB SPI1 NFE2 NR3C1 JUND ACSL5 TECTB ZDHHC6 piR-37131 GUCY2GP MIR6715B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACSL5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACSL5

Top Transcription factor binding sites by QIAGEN in the ACSL5 gene promoter:
  • p300
  • Pax-4a
  • Sox5
  • STAT5A

Genomic Locations for ACSL5 Gene

Genomic Locations for ACSL5 Gene
chr10:112,374,018-112,428,380
(GRCh38/hg38)
Size:
54,363 bases
Orientation:
Plus strand
chr10:114,133,776-114,188,138
(GRCh37/hg19)
Size:
54,363 bases
Orientation:
Plus strand

Genomic View for ACSL5 Gene

Genes around ACSL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACSL5 Gene

Proteins for ACSL5 Gene

  • Protein details for ACSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULC5-ACSL5_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 5
    Protein Accession:
    Q9ULC5
    Secondary Accessions:
    • A6GV77
    • D3DRB3
    • Q6UX44
    • Q9UIU4

    Protein attributes for ACSL5 Gene

    Size:
    683 amino acids
    Molecular mass:
    75991 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • [Isoform 1]: Localize in mitochondrion and endoplasmic reticulum.
    • [Isoform 3]: Localize in mitochondrion and endoplasmic reticulum.
    SequenceCaution:
    • Sequence=BAA85979.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA86054.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ACSL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACSL5 Gene

Selected DME Specific Peptides for ACSL5 Gene

Q9ULC5:
  • RKPNQPY
  • VPLYDTLG
  • GFFQGDIRLL
  • FAQNRPEW
  • PGDWTSGHVG
  • NVFKGYLKD
  • DGWLHTGD
  • NGLLTPTLKAKR
  • LKIIDRKK
  • LPLAHMFE
  • YGQTECT

Post-translational modifications for ACSL5 Gene

  • Ubiquitination at Lys404
  • Modification sites at PhosphoSitePlus

Other Protein References for ACSL5 Gene

Domains & Families for ACSL5 Gene

Gene Families for ACSL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for ACSL5 Gene

Blocks:
  • AMP-binding signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACSL5 Gene

GenScript: Design optimal peptide antigens:
  • Fatty acid coenzyme A ligase 5 (A6GV77_HUMAN)
  • Long-chain acyl-CoA synthetase 5 (ACSL5_HUMAN)
  • cDNA FLJ52792, highly similar to Long-chain-fatty-acid--CoA ligase 5 (EC 6.2.1.3) (B4DX30_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULC5

UniProtKB/Swiss-Prot:

ACSL5_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSL5: view

Function for ACSL5 Gene

Molecular function for ACSL5 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence={ECO:0000269 PubMed:17681178, ECO:0000269 PubMed:22633490, ECO:0000269 PubMed:24269233}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19714; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA; Xref=Rhea:RHEA:30751, ChEBI:CHEBI:7896, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30752; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36140; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52116, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:78832, ChEBI:CHEBI:136409, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52117; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52112, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:90718, ChEBI:CHEBI:136408, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52113; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52108, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65341, ChEBI:CHEBI:136407, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52109; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52016, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:84024, ChEBI:CHEBI:136117, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52017; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52012, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:76625, ChEBI:CHEBI:136115, ChEBI:CHEBI:456215; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:52013; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Absorption: 1; 1; pH dependence: Optimum pH is 9.5. {ECO:0000269 PubMed:17681178};
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Absorption: 1; 1; pH dependence: Optimum pH is 7.5-8.5. {ECO:0000269 PubMed:17681178};

Enzyme Numbers (IUBMB) for ACSL5 Gene

Phenotypes From GWAS Catalog for ACSL5 Gene

Gene Ontology (GO) - Molecular Function for ACSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0003996 acyl-CoA ligase activity IEA --
GO:0004467 long-chain fatty acid-CoA ligase activity IMP 22633490
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with ACSL5: view
genes like me logo Genes that share phenotypes with ACSL5: view

Animal Models for ACSL5 Gene

MGI Knock Outs for ACSL5:
  • Acsl5 Acsl5<tm1.1(KOMP)Vlcg>
  • Acsl5 Acsl5<tm1Lex>

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACSL5 Gene

Localization for ACSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL5 Gene

Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACSL5 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
peroxisome 4
extracellular 2
cytosol 2
cytoskeleton 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA,IEA --
GO:0005741 mitochondrial outer membrane IEA --
genes like me logo Genes that share ontologies with ACSL5: view

Pathways & Interactions for ACSL5 Gene

genes like me logo Genes that share pathways with ACSL5: view

Gene Ontology (GO) - Biological Process for ACSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IMP 22633490
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with ACSL5: view

No data available for SIGNOR curated interactions for ACSL5 Gene

Drugs & Compounds for ACSL5 Gene

(9) Drugs for ACSL5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Palmitic Acid Approved Pharma Full agonist, Agonist 25
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
Hexanoyl-CoA Experimental Pharma 0

(36) Additional Compounds for ACSL5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with ACSL5: view

Transcripts for ACSL5 Gene

mRNA/cDNA for ACSL5 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL5 Gene

No ASD Table

Relevant External Links for ACSL5 Gene

GeneLoc Exon Structure for
ACSL5

Expression for ACSL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACSL5 Gene

mRNA differential expression in normal tissues according to GTEx for ACSL5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x7.7), Colon - Transverse (x6.3), and Liver (x5.2).

Protein differential expression in normal tissues from HIPED for ACSL5 Gene

This gene is overexpressed in Breast (32.3), Nasal epithelium (8.9), and Gallbladder (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACSL5 Gene



Protein tissue co-expression partners for ACSL5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACSL5

SOURCE GeneReport for Unigene cluster for ACSL5 Gene:

Hs.11638

Evidence on tissue expression from TISSUES for ACSL5 Gene

  • Intestine(4.8)
  • Liver(4.6)
  • Heart(2.4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ACSL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACSL5 Gene

Orthologs for ACSL5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACSL5 31 30
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ACSL5 31 30
  • 86.58 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACSL5 31 30
  • 85.8 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Acsl5 17 31 30
  • 83.21 (n)
rat
(Rattus norvegicus)
Mammalia Acsl5 30
  • 82.33 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACSL5 31
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACSL5 31
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACSL5 31 30
  • 70.38 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACSL5 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acsl5 30
  • 65.98 (n)
Str.11946 30
zebrafish
(Danio rerio)
Actinopterygii acsl5 31 30
  • 63.58 (n)
OneToOne
wufa04h02 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4500 30
fruit fly
(Drosophila melanogaster)
Insecta CG3961 31 30
  • 54.73 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011603 30
  • 53.72 (n)
worm
(Caenorhabditis elegans)
Secernentea acs-13 31 30
  • 54.39 (n)
ManyToMany
acs-5 31
  • 42 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAA2 31
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LACS6 30
  • 50.68 (n)
rice
(Oryza sativa)
Liliopsida Os11g0147000 30
  • 51.29 (n)
corn
(Zea mays)
Liliopsida Zm.3042 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 50 (a)
ManyToMany
CSA.10659 31
  • 49 (a)
ManyToMany
Species where no ortholog for ACSL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACSL5 Gene

ENSEMBL:
Gene Tree for ACSL5 (if available)
TreeFam:
Gene Tree for ACSL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACSL5: view image

Paralogs for ACSL5 Gene

(6) SIMAP similar genes for ACSL5 Gene using alignment to 2 proteins:

  • ACSL5_HUMAN
  • B4DX30_HUMAN
genes like me logo Genes that share paralogs with ACSL5: view

Variants for ACSL5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACSL5 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
VAR_036377 A colorectal cancer sample p.Lys388Arg
VAR_036378 A colorectal cancer sample p.Gly466Asp
rs12254915 - p.Thr486Ala
rs3736946 - p.Met182Val

Additional dbSNP identifiers (rs#s) for ACSL5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACSL5 Gene

Variant ID Type Subtype PubMed ID
dgv517n106 CNV deletion 24896259
esv1472658 CNV deletion 17803354
esv2190783 CNV deletion 18987734
esv2546876 CNV deletion 19546169
esv2740984 CNV deletion 23290073
esv2740995 CNV deletion 23290073
esv2741006 CNV deletion 23290073
esv2741017 CNV deletion 23290073
esv3546861 CNV deletion 23714750
esv3624583 CNV loss 21293372
esv4752 CNV loss 18987735
esv7592 CNV loss 19470904
nsv1070890 CNV deletion 25765185
nsv1147511 CNV deletion 26484159
nsv473980 CNV novel sequence insertion 20440878
nsv508609 CNV deletion 20534489
nsv512186 CNV loss 21212237
nsv7211 OTHER inversion 18451855
nsv7552 CNV deletion 18451855
nsv831990 CNV loss 17160897
nsv831991 CNV loss 17160897
nsv958250 CNV deletion 24416366

Variation tolerance for ACSL5 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACSL5 Gene

Human Gene Mutation Database (HGMD)
ACSL5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACSL5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL5 Gene

Disorders for ACSL5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ACSL5 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ACSL5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ACSL5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ACSL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACSL5 Gene

Publications for ACSL5 Gene

  1. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. (PMID: 11127823) Yamashita Y … Yamamoto TT (Oncogene 2000) 2 3 23 54
  2. Identification of acyl-CoA synthetases involved in the mammalian sphingosine 1-phosphate metabolic pathway. (PMID: 24269233) Ohkuni A … Kihara A (Biochemical and biophysical research communications 2013) 3 4 54
  3. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. (PMID: 22633490) Nakahara K … Kihara A (Molecular cell 2012) 3 4 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54

Products for ACSL5 Gene

Sources for ACSL5 Gene