Aliases for ACSL3 Gene
Aliases for ACSL3 Gene
External Ids for ACSL3 Gene
- HGNC: 3570
- Entrez Gene: 2181
- Ensembl: ENSG00000123983
- OMIM: 602371
- UniProtKB: O95573
Previous HGNC Symbols for ACSL3 Gene
- FACL3
Previous GeneCards Identifiers for ACSL3 Gene
- GC02P223968
- GC02P223551
- GC02P223433
- GC02P223725
- GC02P215580
Summaries for ACSL3 Gene
-
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACSL3 Gene
ACSL3 (Acyl-CoA Synthetase Long Chain Family Member 3) is a Protein Coding gene. Among its related pathways are Ferroptosis and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.
UniProtKB/Swiss-Prot for ACSL3 Gene
-
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACSL3 Gene
Genomics for ACSL3 Gene
GeneHancer (GH) Regulatory Elements for ACSL3 Gene
Promoters and enhancers for ACSL3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ACSL3 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ACSL3 gene promoter:
-
- HNF-4alpha1
- AP-4
- NF-kappaB1
- CP1A
- Pax-2a
- CBF(2)
- CBF-A
- CBF-B
- CBF-C
- CP1C
Regulatory Element Products
Genomic Locations for ACSL3 Gene
Genomic Locations for ACSL3 Gene
- chr2:222,860,934-222,944,639
- (GRCh38/hg38)
- Size:
- 83,706 bases
- Orientation:
- Plus strand
- chr2:223,725,652-223,809,357
- (GRCh37/hg19)
- Size:
- 83,706 bases
- Orientation:
- Plus strand
Genomic View for ACSL3 Gene
Genes around ACSL3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.1 by Entrez Gene
- 2q36.1 by HGNC
- 2q36.1 by Ensembl
ACSL3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACSL3 Gene
Proteins for ACSL3 Gene
-
Protein details for ACSL3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O95573-ACSL3_HUMAN
- Recommended name:
- Long-chain-fatty-acid--CoA ligase 3
- Protein Accession:
- O95573
- Q60I92
- Q8IUM9
Protein attributes for ACSL3 Gene
- Size:
- 720 amino acids
- Molecular mass:
- 80420 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
- No Data Available
Protein Expression for ACSL3 Gene
Post-translational modifications for ACSL3 Gene
Other Protein References for ACSL3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACSL3
- Novus Biologicals Antibodies for ACSL3
-
Abcam antibodies for ACSL3
- Invitrogen Antibodies for ACSL3
- GeneTex ACSL3 Antibody for ACSL3
-
Santa Cruz Biotechnology (SCBT) Antibodies for ACSL3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ACSL3
- Origene Custom Protein Services for ACSL3
- antibodies-online: Search results for 8 available Acsl3 Proteins ranked by validation data
- Compare Top Acsl3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for ACSL3
Assay Products
No data available for DME Specific Peptides for ACSL3 Gene
Domains & Families for ACSL3 Gene
Gene Families for ACSL3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ACSL3 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACSL3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O95573- Family:
-
- Belongs to the ATP-dependent AMP-binding enzyme family.
Function for ACSL3 Gene
Molecular function for ACSL3 Gene
- UniProtKB/Swiss-Prot Function:
- Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Enzyme Numbers (IUBMB) for ACSL3 Gene
Phenotypes From GWAS Catalog for ACSL3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004467 | long-chain fatty acid-CoA ligase activity | TAS | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016874 | ligase activity | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 20605918 |
Phenotypes for ACSL3 Gene
- MGI mutant phenotypes for ACSL3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ACSL3:
Animal Model Products
-
Taconic Biosciences Mouse Models for ACSL3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACSL3
-
CRISPR Products
-
OriGene CRISPR knockouts for ACSL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACSL3
- genomics-online: gRNA clones - Search results for 99 available Acsl3 gene related products
- Overview of 99 available Acsl3 gene related products
- Applied Biological Materials CRISPR for ACSL3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACSL3
- GenScript: Design CRISPR guide RNA sequences for ACSL3
miRNA for ACSL3 Gene
- miRTarBase miRNAs that target ACSL3
-
- hsa-mir-335-5p (MIRT017614)
- hsa-mir-340-5p (MIRT019639)
- hsa-mir-375 (MIRT019874)
- hsa-mir-221-3p (MIRT024182)
- hsa-mir-100-5p (MIRT048455)
- hsa-mir-377-5p (MIRT441287)
- hsa-mir-6086 (MIRT446291)
- hsa-mir-655-5p (MIRT446292)
- hsa-mir-96-3p (MIRT446293)
- hsa-mir-329-5p (MIRT446294)
- hsa-mir-551b-5p (MIRT446295)
- hsa-mir-5582-3p (MIRT446296)
- hsa-mir-548x-3p (MIRT446297)
- hsa-mir-548j-3p (MIRT446298)
- hsa-mir-548aq-3p (MIRT446299)
- hsa-mir-548am-3p (MIRT446300)
- hsa-mir-548aj-3p (MIRT446301)
- hsa-mir-548ah-3p (MIRT446302)
- hsa-mir-548ae-3p (MIRT446303)
- hsa-mir-548z (MIRT446304)
- hsa-mir-548h-3p (MIRT446305)
- hsa-mir-548d-3p (MIRT446306)
- hsa-mir-548bb-3p (MIRT446307)
- hsa-mir-548ac (MIRT446308)
- hsa-mir-26b-5p (MIRT728395)
- hsa-mir-26a-5p (MIRT728396)
- hsa-mir-26a-1-3p (MIRT732422)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ACSL3
- Browse OriGene Inhibitory RNA Products For ACSL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACSL3
- genomics-online: shRNA clones - Search results for 99 available Acsl3 gene related products
- Overview of 99 available Acsl3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ACSL3
- VectorBuilder custom plasmid, inducible vectors for ACSL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ACSL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACSL3
- Applied Biological Materials Clones for ACSL3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ACSL3
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSL3 Gene
Localization for ACSL3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACSL3 Gene
- Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein.
| Compartment | Confidence |
|---|---|
| peroxisome | 5 |
| endoplasmic reticulum | 5 |
| golgi apparatus | 5 |
| mitochondrion | 4 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytosol | 1 |
| lysosome | 1 |
- Lipid droplets (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | IEA | -- |
| GO:0005777 | peroxisome | IEA | -- |
| GO:0005778 | peroxisomal membrane | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA,IDA | 14741744 |
Pathways & Interactions for ACSL3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Fatty Acyl-CoA Biosynthesis | ||
| 2 | fatty acid beta-oxidation (peroxisome) | ||
| 3 | Metabolism |
.37
|
|
| 4 | Fatty acid metabolism | ||
| 5 | Mitochondrial LC-Fatty Acid Beta-Oxidation | ||
Pathways by source for ACSL3 Gene
9 BioSystems pathways for ACSL3 Gene
9 KEGG pathways for ACSL3 Gene
Interacting Proteins for ACSL3 Gene
GPS-Prot Interaction Network for ACSL3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001676 | long-chain fatty acid metabolic process | IEA | -- |
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0006631 | fatty acid metabolic process | IEA | -- |
| GO:0006633 | fatty acid biosynthetic process | IEA | -- |
| GO:0007420 | brain development | IEA | -- |
No data available for SIGNOR curated interactions for ACSL3 Gene
Drugs & Compounds for ACSL3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Icosapent | Approved | Nutra | Target, inducer | Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation | 0 | |
| Palmitic Acid | Approved, Experimental | Pharma | Full agonist, Agonist | 23 | ||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Adenosine monophosphate | Approved, Investigational | Nutra | 0 | |||
| Magnesium | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| (2E)-Decenoyl-CoA |
|
10018-95-8 |
|
|||
| (2E)-Dodecenoyl-CoA |
|
1066-12-2 |
|
|||
| (2E)-Hexadecenoyl-CoA |
|
4460-95-1 |
|
|||
| (2E)-Octenoyl-CoA |
|
10018-94-7 |
|
|||
| (2E)-Tetradecenoyl-CoA |
|
38795-33-4 |
|
Transcripts for ACSL3 Gene
mRNA/cDNA for ACSL3 Gene
- (4) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (379) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000413316 650 bps (uc061tbn.1)
- ENST00000542810 428 bps (uc061tbo.1)
- ENST00000540115 624 bps (uc061tbp.1)
- ENST00000463813 509 bps (uc061tbr.1)
- ENST00000421680 639 bps (uc061tbs.1)
Unigene Clusters for ACSL3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ACSL3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACSL3
- genomics-online: gRNA clones - Search results for 99 available Acsl3 gene related products
- Overview of 99 available Acsl3 gene related products
- Applied Biological Materials CRISPR for ACSL3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACSL3
- GenScript: Design CRISPR guide RNA sequences for ACSL3
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ACSL3
- Browse OriGene Inhibitory RNA Products For ACSL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACSL3
- genomics-online: shRNA clones - Search results for 99 available Acsl3 gene related products
- Overview of 99 available Acsl3 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ACSL3
- VectorBuilder custom plasmid, inducible vectors for ACSL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSL3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ACSL3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACSL3
- Applied Biological Materials Clones for ACSL3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||
| SP2: | |||||||||||||
| SP3: | |||||||||||||
| SP4: | - | - | |||||||||||
| SP5: | |||||||||||||
| SP6: | |||||||||||||
| SP7: | |||||||||||||
| SP8: | |||||||||||||
| SP9: | |||||||||||||
| SP10: | |||||||||||||
| SP11: | |||||||||||||
| SP12: |
Expression for ACSL3 Gene
This gene is overexpressed in Nasal epithelium (7.9) and Retina (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACSL3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ACSL3 Gene:
ACSL3SOURCE GeneReport for Unigene cluster for ACSL3 Gene:
Hs.655772Evidence on tissue expression from TISSUES for ACSL3 Gene
- Nervous system(4.6)
- Pancreas(4.3)
- Liver(2.8)
Primer Products
-
OriGene qPCR primer pairs and template standards for ACSL3
-
OriGene qPCR primer pairs for ACSL3
- genomics-online: primer clones - Search results for 99 available Acsl3 gene related products
- Overview of 99 available Acsl3 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACSL3 Gene
Orthologs for ACSL3 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACSL3 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ACSL3 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ACSL3 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Acsl3 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Acsl3 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ACSL3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACSL3 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ACSL3 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ACSL3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | acsl4 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33876 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | acsl3a 34 |
|
OneToMany | |
| acsl3b 34 33 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Acsl 34 33 |
|
OneToMany | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003623 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | acs-17 34 |
|
ManyToMany | |
| acs-4 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FAA3 36 34 |
|
||
| FAA1 34 |
|
ManyToMany | |||
| FAA4 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | LACS8 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os05g0317200 33 |
|
||
| Os.7310 33 |
|
||||
| corn (Zea mays) |
Liliopsida | Zm.8032 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.7413 33 |
|
- Species where no ortholog for ACSL3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for ACSL3 Gene
- ENSEMBL:
- Gene Tree for ACSL3 (if available)
- TreeFam:
- Gene Tree for ACSL3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ACSL3: view image
Paralogs for ACSL3 Gene
(6) SIMAP similar genes for ACSL3 Gene using alignment to 7 proteins:
- ACSL3_HUMAN
- C9JC11_HUMAN
- F5GWH2_HUMAN
- F5H062_HUMAN
- H7BYZ7_HUMAN
- H7C260_HUMAN
- Q6PIM8_HUMAN
Pseudogenes.org Pseudogenes for ACSL3 Gene
Variants for ACSL3 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000016553 | -- | 222,898,368(+) | C/T | intron_variant | |
| rs1000024308 | -- | 222,862,087(+) | A/C | intron_variant | |
| rs1000031438 | -- | 222,889,163(+) | C/A | intron_variant | |
| rs1000071562 | -- | 222,870,660(+) | A/T | intron_variant | |
| rs1000129745 | -- | 222,928,313(+) | A/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv109n73 | CNV | deletion | 24416366 |
| dgv2156n106 | CNV | deletion | 24896259 |
| esv1240242 | CNV | deletion | 17803354 |
| esv1617678 | CNV | deletion | 17803354 |
| esv2151193 | CNV | deletion | 18987734 |
| esv2621841 | CNV | deletion | 19546169 |
| esv2652841 | CNV | deletion | 19546169 |
| esv2721520 | CNV | deletion | 23290073 |
| esv2721521 | CNV | deletion | 23290073 |
| esv2838902 | CNV | deletion | 24192839 |
| esv3561055 | CNV | deletion | 23714750 |
| esv3561056 | CNV | deletion | 23714750 |
| esv3575333 | CNV | gain | 25503493 |
| esv3584363 | CNV | loss | 25503493 |
| esv3594432 | CNV | loss | 21293372 |
| esv3725 | CNV | loss | 18987735 |
| esv4072 | CNV | loss | 18987735 |
| esv9602 | CNV | loss | 19470904 |
| esv997784 | CNV | deletion | 20482838 |
| nsv1011830 | CNV | gain | 25217958 |
| nsv1072498 | CNV | deletion | 25765185 |
| nsv1116829 | CNV | deletion | 24896259 |
| nsv1151451 | CNV | deletion | 26484159 |
| nsv215259 | CNV | deletion | 16902084 |
| nsv3181 | CNV | deletion | 18451855 |
| nsv435722 | CNV | deletion | 17901297 |
| nsv436299 | CNV | deletion | 17901297 |
| nsv511839 | CNV | loss | 21212237 |
| nsv819092 | CNV | loss | 19587683 |
| nsv954182 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.08;
38.05% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ACSL3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACSL3
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL3 Gene
Disorders for ACSL3 Gene
Additional Disease Information for ACSL3
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for ACSL3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACSL3 Gene
Publications for ACSL3 Gene
- Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PMID: 18003621) Yao H … Ye J (The Journal of biological chemistry 2008) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PMID: 15556626) Qiao S … Tuohimaa P (FEBS letters 2004) 3 22 58
- Genomic organization and transcription units of the human acyl-CoA synthetase 3 gene. (PMID: 11707336) Minekura H … Yamamoto TT (Gene 2001) 3 4 58
- Human acyl-coenzyme A synthetase 3 cDNA and localization of its gene (ACS3) to chromosome band 2q34-q35. (PMID: 9177793) Minekura H … Yamamoto TT (Genomics 1997) 3 4 58
Products for ACSL3 Gene
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- Custom Antibody ServicesOriGene Antibodies for ACSL3
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Taconic Biosciences Mouse Models for ACSL3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ACSL3
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACSL3
- VectorBuilder custom plasmid, inducible vectors for ACSL3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ACSL3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ACSL3
- antibodies-online: Search results for 67 available Acsl3 Antibodies ranked by validation data
- Compare Top Acsl3 Antibodies
- Quality Products:
- antibodies-online: Search results for available Acsl3 related products ranked by validation data
- antibodies-online: Search results for 8 available Acsl3 Proteins ranked by validation data
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- Quality Products:
- GeneTex ACSL3 Antibody for ACSL3
- Search GeneTex for Proteins for ACSL3
- Santa Cruz Biotechnology (SCBT) Antibodies for ACSL3
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- Horizon Cell Lines for ACSL3
- genomics-online: cdna clones - Search results for 99 available Acsl3 gene related products
- Overview of 99 available Acsl3 gene related products
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- Overview of 99 available Acsl3 gene related products
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- Overview of 99 available Acsl3 gene related products
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- Overview of 99 available Acsl3 gene related products
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- Overview of 99 available Acsl3 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACSL3
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- GeneCopoeia miRNA 3'UTR Target clone products for ACSL3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACSL3
Sources for ACSL3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt