ACSL3 Gene (Protein Coding)

Acyl-CoA Synthetase Long Chain Family Member 3

GC02P222860
GIFtS:
42
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme... See more...

Aliases for ACSL3 Gene

Aliases for ACSL3 Gene

  • Acyl-CoA Synthetase Long Chain Family Member 3 2 3 5
  • ACS3 2 3 4
  • Fatty-Acid-Coenzyme A Ligase, Long-Chain 3 2 3
  • Long-Chain-Fatty-Acid--CoA Ligase 3 3 4
  • Long-Chain Acyl-CoA Synthetase 3 3 4
  • Arachidonate--CoA Ligase 3 4
  • EC 6.2.1.3 4 51
  • PRO2194 2 3
  • LACS 3 3 4
  • FACL3 3 4
  • LACS3 3 4
  • Lignoceroyl-CoA Synthase 3
  • EC 6.2.1.15 4
  • ACSL3 5

External Ids for ACSL3 Gene

Previous HGNC Symbols for ACSL3 Gene

  • FACL3

Previous GeneCards Identifiers for ACSL3 Gene

  • GC02P223968
  • GC02P223551
  • GC02P223433
  • GC02P223725
  • GC02P215580

Summaries for ACSL3 Gene

Entrez Gene Summary for ACSL3 Gene

  • The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACSL3 Gene

ACSL3 (Acyl-CoA Synthetase Long Chain Family Member 3) is a Protein Coding gene. Diseases associated with ACSL3 include Mental Retardation, Autosomal Dominant 38 and Her2-Receptor Negative Breast Cancer. Among its related pathways are Fatty Acid Biosynthesis (WikiPathways) and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include protein kinase binding and long-chain fatty acid-CoA ligase activity. An important paralog of this gene is ACSL4.

UniProtKB/Swiss-Prot Summary for ACSL3 Gene

  • Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).

Gene Wiki entry for ACSL3 Gene

Additional gene information for ACSL3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACSL3 Gene

Genomics for ACSL3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ACSL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J222859 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 259.5 +1.2 1237 5.6 ZSCAN16 CHD2 TBP SP1 MXD4 FEZF1 CEBPA MNT IKZF1 SMAD5 ACSL3 ACSL3-AS1 lnc-KCNE4-1 KCNE4
GH02J222842 Promoter/Enhancer 1.4 EPDnew ENCODE CraniofacialAtlas 250.4 -18.2 -18239 1.2 CEBPA FOXA1 HOMEZ KDM6A CEBPB FOXA2 SMAD4 SAP130 EP300 RXRA HSALNG0022551 ACSL3 ACSL3-AS1 piR-30091-104 MOGAT1
GH02J222805 Enhancer 1.1 FANTOM5 ENCODE 15.3 -54.5 -54498 2 MXD4 CEBPA ZFP64 KDM6A THAP11 ZNF395 ZNF511 SMAD4 MAFF SAP130 HSALNG0022547 ACSL3 ENSG00000203531 ACSL3-AS1 piR-52438-066 MOGAT1
GH02J223050 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10 +193.6 193560 7.6 NFATC3 TAL1 RXRA ZFP91 ZNF316 JUND PRDM10 EHMT2 ZBTB33 TCF12 HSALNG0022569 ACSL3-AS1 ACSL3 KCNE4 MRPL44 SCG2
GH02J222707 Enhancer 1.2 ENCODE CraniofacialAtlas 11.8 -152.2 -152178 3.3 MXD4 CEBPA MNT IKZF1 MBD2 CTCF BHLHE40 NONO ZIC2 HOMEZ ACSL3 MOGAT1 ACSL3-AS1 FARSB RPL31P17 lnc-MOGAT1-2 ENSG00000203531 lnc-FARSB-5 HSALNG0022539
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACSL3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACSL3

Top Transcription factor binding sites by QIAGEN in the ACSL3 gene promoter:
  • AP-4
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • HNF-4alpha1
  • NF-kappaB1
  • Pax-2a

Genomic Locations for ACSL3 Gene

Latest Assembly
chr2:222,860,942-222,944,639
(GRCh38/hg38)
Size:
83,698 bases
Orientation:
Plus strand

Previous Assembly
chr2:223,725,754-223,809,357
(GRCh37/hg19 by Entrez Gene)
Size:
83,604 bases
Orientation:
Plus strand

chr2:223,725,652-223,809,357
(GRCh37/hg19 by Ensembl)
Size:
83,706 bases
Orientation:
Plus strand

Genomic View for ACSL3 Gene

Genes around ACSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACSL3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ACSL3 Gene

Proteins for ACSL3 Gene

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  • Protein details for ACSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95573-ACSL3_HUMAN
    Recommended name:
    Long-chain-fatty-acid--CoA ligase 3
    Protein Accession:
    O95573
    Secondary Accessions:
    • Q60I92
    • Q8IUM9

    Protein attributes for ACSL3 Gene

    Size:
    720 amino acids
    Molecular mass:
    80420 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for ACSL3 Gene

Protein Expression for ACSL3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for ACSL3 Gene

O95573:
  • GCRIGYSSP
  • CGGAPLS
  • YIGYLPLAHVLEL
  • IAIFCETRAEWMIAAQ
  • LGKVEAALKN
  • TGRVGAPL
  • IIDRKKDLVKLQAGEYV
  • LKIIDRKK
  • DQSSKIKKGSKGD

Post-translational modifications for ACSL3 Gene

  • Ubiquitination at Lys679
  • Modification sites at PhosphoSitePlus

Other Protein References for ACSL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ACSL3 Gene

Gene Families for ACSL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ACSL3 Gene

InterPro:
Blocks:
  • AMP-binding signature
ProtoNet:

Suggested Antigen Peptide Sequences for ACSL3 Gene

GenScript: Design optimal peptide antigens:
  • Long-chain acyl-CoA synthetase 3 (ACSL3_HUMAN)
  • ACSL3 protein (Q6PIM8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95573

UniProtKB/Swiss-Prot:

ACSL3_HUMAN :
  • Belongs to the ATP-dependent AMP-binding enzyme family.
Family:
  • Belongs to the ATP-dependent AMP-binding enzyme family.
genes like me logo Genes that share domains with ACSL3: view

Function for ACSL3 Gene

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  6. Cell Lines for research

Molecular function for ACSL3 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560, ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3; Evidence={ECO:0000269|PubMed:22633490};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:19713, ChEBI:CHEBI:30616, ChEBI:CHEBI:32395, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368, ChEBI:CHEBI:456215; EC=6.2.1.15; Evidence={ECO:0000250|UniProtKB:Q63151};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(E)-hexadec-2-enoate + ATP + CoA = (2E)-hexadecenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:36139, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61526, ChEBI:CHEBI:72745, ChEBI:CHEBI:456215; Evidence={ECO:0000269|PubMed:22633490};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + ATP + CoA = 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52116, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:78832, ChEBI:CHEBI:136409, ChEBI:CHEBI:456215; Evidence={ECO:0000250|UniProtKB:Q63151};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + ATP + CoA = 12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52112, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:90718, ChEBI:CHEBI:136408, ChEBI:CHEBI:456215; Evidence={ECO:0000250|UniProtKB:Q63151};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = 5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52108, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:65341, ChEBI:CHEBI:136407, ChEBI:CHEBI:456215; Evidence={ECO:0000250|UniProtKB:Q63151};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52016, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:84024, ChEBI:CHEBI:136117, ChEBI:CHEBI:456215; Evidence={ECO:0000250|UniProtKB:Q63151};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:52012, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:76625, ChEBI:CHEBI:136115, ChEBI:CHEBI:456215; Evidence={ECO:0000250|UniProtKB:Q63151};.

Enzyme Numbers (IUBMB) for ACSL3 Gene

Phenotypes From GWAS Catalog for ACSL3 Gene

Gene Ontology (GO) - Molecular Function for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004467 long-chain fatty acid-CoA ligase activity IBA,ISS --
GO:0005515 protein binding IPI 29549094
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ACSL3: view
genes like me logo Genes that share phenotypes with ACSL3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACSL3

Clone products for research

  • Addgene plasmids for ACSL3

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACSL3 Gene

Localization for ACSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACSL3 Gene

Mitochondrion outer membrane. Single-pass type III membrane protein. Peroxisome membrane. Single-pass type III membrane protein. Microsome membrane. Single-pass type III membrane protein. Endoplasmic reticulum membrane. Single-pass type III membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACSL3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 4
mitochondrion 4
peroxisome 4
extracellular 2
nucleus 2
cytosol 2
cytoskeleton 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Lipid droplets (2)
  • Nucleoli (2)
  • Nucleoli rim (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0005777 peroxisome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0005783 endoplasmic reticulum IBA,IDA 14741744
genes like me logo Genes that share ontologies with ACSL3: view

Pathways & Interactions for ACSL3 Gene

genes like me logo Genes that share pathways with ACSL3: view

Gene Ontology (GO) - Biological Process for ACSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001676 long-chain fatty acid metabolic process IBA,ISS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with ACSL3: view

No data available for SIGNOR curated interactions for ACSL3 Gene

Drugs & Compounds for ACSL3 Gene

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(9) Drugs for ACSL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Palmitic Acid Approved Pharma 27
Adenosine monophosphate Approved, Investigational Nutra 0
Icosapent Approved Nutra Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation 0
Hexanoyl-CoA Experimental Pharma 0

(32) Additional Compounds for ACSL3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
 10018-95-8
(2E)-Dodecenoyl-CoA
  • Dodecenoyl-CoA
  • Dodecenoyl+2-dodecenoyl, (e)-isomer
  • Dodecenoyl-coenzyme A
  • Dodecenoyl+2-dodecenoyl
 1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
 4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
 10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
 38795-33-4
genes like me logo Genes that share compounds with ACSL3: view

Transcripts for ACSL3 Gene

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mRNA/cDNA for ACSL3 Gene

4 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
36 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACSL3

Clone products for research

  • Addgene plasmids for ACSL3

Alternative Splicing Database (ASD) splice patterns (SP) for ACSL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9 ^ 10 ^
SP1: - - - -
SP2: - - - - - -
SP3:
SP4: - - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: -
SP7:
SP8: -
SP9: -
SP10: -
SP11: - - - - - -
SP12:

ExUns: 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ACSL3 Gene

GeneLoc Exon Structure for
ACSL3

Expression for ACSL3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACSL3 Gene

mRNA expression in normal human tissues for ACSL3 Gene
mRNA expression by BioGPS for ACSL3 GenemRNA expression by GTEx for ACSL3 Gene

Protein differential expression in normal tissues from HIPED for ACSL3 Gene

This gene is overexpressed in Nasal epithelium (7.9) and Retina (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACSL3 Gene



Protein tissue co-expression partners for ACSL3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACSL3

SOURCE GeneReport for Unigene cluster for ACSL3 Gene:

Hs.655772

Evidence on tissue expression from TISSUES for ACSL3 Gene

  • Nervous system(4.7)
  • Pancreas(4.4)
  • Liver(3)
  • Intestine(2.7)
  • Lung(2.5)
  • Heart(2.5)
  • Muscle(2.3)
  • Kidney(2.3)
  • Blood(2.2)
  • Adrenal gland(2.1)
  • Stomach(2.1)
  • Thyroid gland(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with ACSL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACSL3 Gene

Orthologs for ACSL3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACSL3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ACSL3 30 31
  • 99.77 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ACSL3 30 31
  • 92.22 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ACSL3 30 31
  • 90.83 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Acsl3 30 17 31
  • 88.89 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Acsl3 30
  • 88.06 (n)
Oppossum
(Monodelphis domestica)
 Mammalia ACSL3 31
  • 88 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ACSL3 31
  • 86 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ACSL3 30 31
  • 79.02 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia ACSL3 31
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia acsl4 30
  • 68.55 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.33876 30
Zebrafish
(Danio rerio)
 Actinopterygii acsl3a 31
  • 69 (a)
 OneToMany
acsl3b 30 31
  • 66.76 (n)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta Acsl 30 31
  • 52.6 (n)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003623 30
  • 51.7 (n)
Worm
(Caenorhabditis elegans)
 Secernentea acs-17 31
  • 44 (a)
 ManyToMany
acs-4 31
  • 43 (a)
 ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FAA3 31 33
  • 30 (a)
 ManyToMany
FAA1 31
  • 30 (a)
 ManyToMany
FAA4 31
  • 30 (a)
 ManyToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons LACS8 30
  • 54.37 (n)
Rice
(Oryza sativa)
 Liliopsida Os05g0317200 30
  • 54.45 (n)
Os.7310 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.7413 30
Corn
(Zea mays)
 Liliopsida Zm.8032 30
Species where no ortholog for ACSL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ACSL3 Gene

ENSEMBL:
Gene Tree for ACSL3 (if available)
TreeFam:
Gene Tree for ACSL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACSL3: view image

Paralogs for ACSL3 Gene

Paralogs for ACSL3 Gene

(6) SIMAP similar genes for ACSL3 Gene using alignment to 7 proteins:

  • ACSL3_HUMAN
  • C9JC11_HUMAN
  • F5GWH2_HUMAN
  • F5H062_HUMAN
  • H7BYZ7_HUMAN
  • H7C260_HUMAN
  • Q6PIM8_HUMAN

Pseudogenes.org Pseudogenes for ACSL3 Gene

genes like me logo Genes that share paralogs with ACSL3: view

Variants for ACSL3 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACSL3 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs141462096 Benign: not provided 222,934,572(+) G/A
NM_004457.5(ACSL3):c.1890G>A (p.Lys630=) 		SYNONYMOUS
rs144556995 Likely Benign: not provided 222,919,191(+) A/G
NM_004457.5(ACSL3):c.794A>G (p.Lys265Arg) 		MISSENSE
rs145651020 Benign: not provided 222,916,468(+) A/G
NM_004457.5(ACSL3):c.528A>G (p.Ala176=) 		SYNONYMOUS
rs146044900 Benign: not provided 222,908,805(+) C/T
NM_004457.5(ACSL3):c.33C>T (p.Thr11=) 		SYNONYMOUS
rs1046032 - p.Phe551Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ACSL3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ACSL3 Gene

Variant ID Type Subtype PubMed ID
dgv109n73 CNV deletion 24416366
dgv2156n106 CNV deletion 24896259
esv1240242 CNV deletion 17803354
esv1617678 CNV deletion 17803354
esv2151193 CNV deletion 18987734
esv2621841 CNV deletion 19546169
esv2652841 CNV deletion 19546169
esv2721520 CNV deletion 23290073
esv2721521 CNV deletion 23290073
esv2838902 CNV deletion 24192839
esv3561055 CNV deletion 23714750
esv3561056 CNV deletion 23714750
esv3575333 CNV gain 25503493
esv3584363 CNV loss 25503493
esv3594432 CNV loss 21293372
esv3725 CNV loss 18987735
esv4072 CNV loss 18987735
esv9602 CNV loss 19470904
esv997784 CNV deletion 20482838
nsv1011830 CNV gain 25217958
nsv1072498 CNV deletion 25765185
nsv1116829 CNV deletion 24896259
nsv1151451 CNV deletion 26484159
nsv215259 CNV deletion 16902084
nsv3181 CNV deletion 18451855
nsv435722 CNV deletion 17901297
nsv436299 CNV deletion 17901297
nsv511839 CNV loss 21212237
nsv819092 CNV loss 19587683
nsv954182 CNV deletion 24416366

Variation tolerance for ACSL3 Gene

Residual Variation Intolerance Score: 40.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACSL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACSL3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACSL3 Gene

Disorders for ACSL3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ACSL3 Gene - From: COP and GCD

- elite association - COSMIC cancer census association via MalaCards
Search ACSL3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ACSL3

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ACSL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACSL3 Gene

Publications for ACSL3 Gene

  1. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. (PMID: 22633490) Nakahara K … Kihara A (Molecular cell 2012) 3 4
  2. ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells. (PMID: 21328461) Chang YS … Lai MD (Journal of cellular biochemistry 2011) 2 3
  3. Long chain acyl-CoA synthetase 3-mediated phosphatidylcholine synthesis is required for assembly of very low density lipoproteins in human hepatoma Huh7 cells. (PMID: 18003621) Yao H … Ye J (The Journal of biological chemistry 2008) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Vitamin D3 inhibits fatty acid synthase expression by stimulating the expression of long-chain fatty-acid-CoA ligase 3 in prostate cancer cells. (PMID: 15556626) Qiao S … Tuohimaa P (FEBS letters 2004) 3 23

ExternalLinks

View latest publications for ACSL3 gene in Mastermind

Products for ACSL3 Gene

  • Addgene plasmids for ACSL3

Sources for ACSL3 Gene