The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens an... See more...

Aliases for ACRBP Gene

Aliases for ACRBP Gene

  • Acrosin Binding Protein 2 3 5
  • Cancer/Testis Antigen 23 2 3 4
  • Proacrosin Binding Protein Sp32 2 3
  • Cancer/Testis Antigen OY-TES-1 3 4
  • Acrosin-Binding Protein 3 4
  • CT23 3 4
  • Testicular Tissue Protein Li 10 3
  • Proacrosin-Binding Protein Sp32 4
  • OY-TES-1 3
  • SP32 3

External Ids for ACRBP Gene

Previous GeneCards Identifiers for ACRBP Gene

  • GC12M006688
  • GC12M006813
  • GC12M006626
  • GC12M006617
  • GC12M006748

Summaries for ACRBP Gene

Entrez Gene Summary for ACRBP Gene

  • The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACRBP Gene

ACRBP (Acrosin Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for ACRBP Gene

  • May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.

Additional gene information for ACRBP Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACRBP Gene

Genomics for ACRBP Gene

GeneHancer (GH) Regulatory Elements for ACRBP Gene

Promoters and enhancers for ACRBP Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACRBP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACRBP

Top Transcription factor binding sites by QIAGEN in the ACRBP gene promoter:
  • ATF
  • ATF6
  • CP2
  • FOXD3
  • IRF-1
  • MyoD
  • MZF-1
  • p53
  • Pax-4a
  • STAT5A

Genomic Locations for ACRBP Gene

Genomic Locations for ACRBP Gene
chr12:6,638,075-6,647,433
(GRCh38/hg38)
Size:
9,359 bases
Orientation:
Minus strand
chr12:6,747,241-6,756,626
(GRCh37/hg19)
Size:
9,386 bases
Orientation:
Minus strand

Genomic View for ACRBP Gene

Genes around ACRBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACRBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACRBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACRBP Gene

Proteins for ACRBP Gene

  • Protein details for ACRBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEB7-ACRBP_HUMAN
    Recommended name:
    Acrosin-binding protein
    Protein Accession:
    Q8NEB7
    Secondary Accessions:
    • Q9BY87

    Protein attributes for ACRBP Gene

    Size:
    543 amino acids
    Molecular mass:
    61359 Da
    Quaternary structure:
    • Binds proacrosin.

neXtProt entry for ACRBP Gene

Post-translational modifications for ACRBP Gene

Other Protein References for ACRBP Gene

Antibody Products

  • Abcam antibodies for ACRBP
  • Boster Bio Antibodies for ACRBP

No data available for DME Specific Peptides for ACRBP Gene

Domains & Families for ACRBP Gene

Gene Families for ACRBP Gene

Protein Domains for ACRBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACRBP Gene

GenScript: Design optimal peptide antigens:
  • Proacrosin-binding protein sp32 (ACRBP_HUMAN)
genes like me logo Genes that share domains with ACRBP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ACRBP Gene

Function for ACRBP Gene

Molecular function for ACRBP Gene

UniProtKB/Swiss-Prot Function:
May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin.

Phenotypes From GWAS Catalog for ACRBP Gene

Gene Ontology (GO) - Molecular Function for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ACRBP: view
genes like me logo Genes that share phenotypes with ACRBP: view

Animal Models for ACRBP Gene

MGI Knock Outs for ACRBP:

Animal Model Products

  • Taconic Biosciences Mouse Models for ACRBP

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACRBP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ACRBP Gene

Localization for ACRBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACRBP Gene

Secreted. Cytoplasmic vesicle, secretory vesicle, acrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACRBP gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1
cytosol 1
golgi apparatus 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0002080 acrosomal membrane ISS --
GO:0005576 extracellular region ISS --
GO:0005634 nucleus HDA 21630459
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ACRBP: view

Pathways & Interactions for ACRBP Gene

PathCards logo

SuperPathways for ACRBP Gene

No Data Available

Interacting Proteins for ACRBP Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000229243 Q8NEB7-ACRBP_HUMAN for ACRBP Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for ACRBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001675 acrosome assembly ISS --
GO:0007286 spermatid development IEA --
GO:0008150 biological_process ND --
GO:0009566 fertilization IEA --
genes like me logo Genes that share ontologies with ACRBP: view

No data available for Pathways by source and SIGNOR curated interactions for ACRBP Gene

Drugs & Compounds for ACRBP Gene

No Compound Related Data Available

Transcripts for ACRBP Gene

mRNA/cDNA for ACRBP Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACRBP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACRBP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b
SP1: - - -
SP2: -
SP3: -
SP4: - - - - - - - -
SP5: - -
SP6:
SP7:
SP8:

Relevant External Links for ACRBP Gene

GeneLoc Exon Structure for
ACRBP

Expression for ACRBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACRBP Gene

mRNA differential expression in normal tissues according to GTEx for ACRBP Gene

This gene is overexpressed in Testis (x38.4).

Protein differential expression in normal tissues from HIPED for ACRBP Gene

This gene is overexpressed in Testis (50.4) and Ovary (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACRBP Gene



Protein tissue co-expression partners for ACRBP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACRBP

SOURCE GeneReport for Unigene cluster for ACRBP Gene:

Hs.123239

mRNA Expression by UniProt/SwissProt for ACRBP Gene:

Q8NEB7-ACRBP_HUMAN
Tissue specificity: Expression restricted to testis in normal tissue. Expressed in a wide spectrum of cancers, including bladder, breast, liver, lung and colon cancers.

Evidence on tissue expression from TISSUES for ACRBP Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with ACRBP: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACRBP Gene

Orthologs for ACRBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACRBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACRBP 31 30
  • 99.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ACRBP 31 30
  • 85.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACRBP 31 30
  • 81.21 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Acrbp 17 31 30
  • 80.95 (n)
rat
(Rattus norvegicus)
Mammalia Acrbp 30
  • 78.98 (n)
oppossum
(Monodelphis domestica)
Mammalia ACRBP 31
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ACRBP 31
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACRBP 31 30
  • 56.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACRBP 31
  • 35 (a)
OneToOne
Species where no ortholog for ACRBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACRBP Gene

ENSEMBL:
Gene Tree for ACRBP (if available)
TreeFam:
Gene Tree for ACRBP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACRBP: view image

Paralogs for ACRBP Gene

No data available for Paralogs for ACRBP Gene

Variants for ACRBP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACRBP Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs3741923 - p.Thr336Ala

Additional dbSNP identifiers (rs#s) for ACRBP Gene

Structural Variations from Database of Genomic Variants (DGV) for ACRBP Gene

Variant ID Type Subtype PubMed ID
nsv509452 CNV insertion 20534489
nsv557256 CNV loss 21841781
nsv832322 CNV loss 17160897

Variation tolerance for ACRBP Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACRBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACRBP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACRBP Gene

Disorders for ACRBP Gene

Additional Disease Information for ACRBP

No disorders were found for ACRBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACRBP Gene

Publications for ACRBP Gene

  1. Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. (PMID: 11248070) Ono T … Nakayama E (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 23 54
  2. Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells. (PMID: 16301813) Okumura H … Nakayama E (Microbiology and immunology 2005) 3 23 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54
  5. Down-regulation of cancer/testis antigen OY-TES-1 attenuates malignant behaviors of hepatocellular carcinoma cells in vitro. (PMID: 26339343) Fu J … Xie XX (International journal of clinical and experimental pathology 2015) 3 54

Products for ACRBP Gene

Sources for ACRBP Gene