Aliases for ACPP Gene
External Ids for ACPP Gene
Previous GeneCards Identifiers for ACPP Gene
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
GeneCards Summary for ACPP Gene
ACPP (Acid Phosphatase, Prostate) is a Protein Coding gene. Diseases associated with ACPP include Prostate Cancer and Nephrogenic Adenoma Of The Urethra. Among its related pathways are Innate Immune System and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and phosphatase activity. An important paralog of this gene is ACP2.
UniProtKB/Swiss-Prot Summary for ACPP Gene
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.