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Aliases for ACP7 Gene

Aliases for ACP7 Gene

  • Acid Phosphatase 7, Tartrate Resistant (Putative) 2 3 5
  • Purple Acid Phosphatase Long Form 1 2 3
  • PAPL1 3 4
  • PAPL 3 4
  • Iron/Zinc Purple Acid Phosphatase-Like Protein 3
  • Purple Acid Phosphatase Long Form 4
  • Acid Phosphatase Type 7 3
  • EC 4

External Ids for ACP7 Gene

Summaries for ACP7 Gene

Entrez Gene Summary for ACP7 Gene

  • Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ACP7 Gene

ACP7 (Acid Phosphatase 7, Tartrate Resistant (Putative)) is a Protein Coding gene.

Additional gene information for ACP7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACP7 Gene

Genomics for ACP7 Gene

GeneHancer (GH) Regulatory Elements for ACP7 Gene

Promoters and enhancers for ACP7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039083 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 663.5 0.0 -12 1.8 ZBTB10 ZBTB6 RNF2 YY2 SUZ12 REST ZNF148 ZFHX2 SMARCA4 IKZF1 ACP7 GC19P039085 FBXO27 PAK4 IFNL1
GH19J039073 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -10.0 -9970 1.8 ZNF493 SIN3A ZNF2 ZNF121 GLIS2 ATF7 FOS KLF13 SP3 YY2 ZNF780B HNRNPL SUPT5H EID2B PAF1 ZNF546 ENSG00000266963 PAK4 FBL MED29
GH19J039078 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.7 -4.9 -4900 1.8 BCOR ZNF146 ESRRA JUN ZMYM3 SIN3A POLR2A ADNP FOSL2 FOS ACP7 FBXO27 PAK4 PSMC4 GC19P039085 GC19M039038
GH19J038810 Promoter/Enhancer 1.7 EPDnew ENCODE dbSUPER 5.3 -267.8 -267758 11.1 FOXA2 PKNOX1 ATF1 ARNT YY1 TCF12 ZNF121 ZNF766 ZNF416 KLF7 LGALS4 ZNF573 HNRNPL ENSG00000269688 LGALS7 SUPT5H RN7SL566P LOC100631378 RINL PLEKHG2
GH19J039064 Enhancer 0.6 dbSUPER 12.5 -19.2 -19218 0.8 ZBTB6 KLF17 ZIC2 ZSCAN21 ZNF366 PATZ1 GLIS1 SP7 ACP7 FBXO27 PAK4 FBXO17 IFNL1 SARS2 GC19P039085 GC19M039038
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACP7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ACP7 Gene

Genomic Locations for ACP7 Gene
27,581 bases
Plus strand
27,581 bases
Plus strand

Genomic View for ACP7 Gene

Genes around ACP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACP7 Gene

Proteins for ACP7 Gene

  • Protein details for ACP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acid phosphatase type 7
    Protein Accession:
    Secondary Accessions:
    • B2RN68

    Protein attributes for ACP7 Gene

    438 amino acids
    Molecular mass:
    50480 Da
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ACP7 Gene

Post-translational modifications for ACP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACP7 Gene

Domains & Families for ACP7 Gene

Gene Families for ACP7 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ACP7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
  • Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
genes like me logo Genes that share domains with ACP7: view

Function for ACP7 Gene

Molecular function for ACP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.

Enzyme Numbers (IUBMB) for ACP7 Gene

Phenotypes From GWAS Catalog for ACP7 Gene

Gene Ontology (GO) - Molecular Function for ACP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ACP7: view
genes like me logo Genes that share phenotypes with ACP7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP7

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACP7 Gene

Localization for ACP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACP7 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACP7 gene
Compartment Confidence
extracellular 4
cytosol 2
golgi apparatus 2
peroxisome 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ACP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ACP7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACP7 Gene

Pathways & Interactions for ACP7 Gene

No Data Available

Interacting Proteins for ACP7 Gene

Gene Ontology (GO) - Biological Process for ACP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with ACP7: view

No data available for Pathways by source and SIGNOR curated interactions for ACP7 Gene

Drugs & Compounds for ACP7 Gene

(2) Drugs for ACP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with ACP7: view

Transcripts for ACP7 Gene

mRNA/cDNA for ACP7 Gene

(7) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP7

Alternative Splicing Database (ASD) splice patterns (SP) for ACP7 Gene

No ASD Table

Relevant External Links for ACP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACP7 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACP7 Gene:


Evidence on tissue expression from TISSUES for ACP7 Gene

  • Nervous system(4.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACP7 Gene

Orthologs for ACP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
LOC456018 33
  • 99.49 (n)
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
  • 87.58 (n)
(Bos Taurus)
Mammalia -- 34
  • 88 (a)
  • 87.32 (n)
(Rattus norvegicus)
Mammalia Papl 33
  • 84.44 (n)
(Mus musculus)
Mammalia Papl 34 33
  • 82.23 (n)
Acp7 16
(Monodelphis domestica)
Mammalia -- 34
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 66 (a)
-- 34
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia papl 33
  • 63.05 (n)
(Danio rerio)
Actinopterygii papl 34 33
  • 61.28 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10941 33
fruit fly
(Drosophila melanogaster)
Insecta CG1637 34 33
  • 57.71 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002016 33
  • 56.98 (n)
(Caenorhabditis elegans)
Secernentea F21A3.11 34 33
  • 52.74 (n)
C08B6.14 34
  • 38 (a)
H25K10.1 34
  • 36 (a)
Y105C5B.15 34
  • 35 (a)
F18E2.1 34
  • 34 (a)
Y105C5B.3 34
  • 34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PAP18 33
  • 43.08 (n)
(Oryza sativa)
Liliopsida Os03g0568900 33
  • 42.73 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU08643 33
  • 46.53 (n)
Species where no ortholog for ACP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACP7 Gene

Gene Tree for ACP7 (if available)
Gene Tree for ACP7 (if available)
Evolutionary constrained regions (ECRs) for ACP7: view image

Paralogs for ACP7 Gene

No data available for Paralogs for ACP7 Gene

Variants for ACP7 Gene

Sequence variations from dbSNP and Humsavar for ACP7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000072158 -- 39,096,121(+) C/G intron_variant
rs1000310302 -- 39,084,598(+) C/A intron_variant
rs1000332593 -- 39,090,868(+) A/G intron_variant
rs1000385173 -- 39,090,507(+) G/C intron_variant
rs1000392240 -- 39,096,659(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACP7 Gene

Variant ID Type Subtype PubMed ID
dgv3528n100 CNV gain 25217958
esv2718546 CNV deletion 23290073
nsv1114007 CNV deletion 24896259
nsv458571 CNV gain 19166990
nsv579508 CNV gain 21841781
nsv833829 CNV loss 17160897

Variation tolerance for ACP7 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACP7 Gene

Disorders for ACP7 Gene

No disorders were found for ACP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACP7 Gene

Publications for ACP7 Gene

  1. Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. (PMID: 16793224) Flanagan JU … Hume DA (Gene 2006) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Role of IFN-ks, IFN-ks related genes and the DEPDC5 gene in Hepatitis B virus-related liver disease. (PMID: 25032264) Ma N … Liu D (Journal of viral hepatitis 2014) 3 58
  4. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for ACP7 Gene

Sources for ACP7 Gene

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