Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008] See more...

Aliases for ACP7 Gene

Aliases for ACP7 Gene

  • Acid Phosphatase 7, Tartrate Resistant (Putative) 2 3 5
  • PAPL1 2 3 4
  • PAPL 2 3 4
  • Purple Acid Phosphatase Long Form 1 2 3
  • Acid Phosphatase Type 7 3 4
  • Iron/Zinc Purple Acid Phosphatase-Like Protein 3
  • Purple Acid Phosphatase Long Form 4
  • EC 3.1.3.2 4
  • FLJ16165 2
  • ACP7 5

External Ids for ACP7 Gene

Previous GeneCards Identifiers for ACP7 Gene

  • GC19P039084

Summaries for ACP7 Gene

Entrez Gene Summary for ACP7 Gene

  • Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ACP7 Gene

ACP7 (Acid Phosphatase 7, Tartrate Resistant (Putative)) is a Protein Coding gene. Diseases associated with ACP7 include Spindle Cell Hemangioma.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACP7 Gene

Genomics for ACP7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ACP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J039083 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 613.4 +1.1 1089 2.2 RNF2 TEAD4 PRDM10 IKZF1 EZH2 ZNF341 ZNF148 ZBTB10 ZBTB17 ZFHX2 ACP7 lnc-FBXO27-3 FBXO27 PAK4 IFNL1 lnc-ACP7-1
GH19J039073 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -9.1 -9111 2.6 HNRNPL CREB1 ATF7 PRDM10 ZNF629 TFE3 ZNF512 ZNF692 ZNF174 ZNF300 lnc-ACP7-2 ZNF780B HNRNPL SUPT5H EID2B PAF1 PAK4 ZNF546 FBL MED29
GH19J039077 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.6 -4.1 -4110 2.2 REST ZNF747 CEBPB SP1 JUND ATF3 ESRRA FOS KDM1A SIX5 ACP7 FBXO27 PAK4 PSMC4 lnc-ACP7-1 lnc-ACP7-2 lnc-FBXO27-3
GH19J038810 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 5.3 -266.9 -266856 11.1 HNRNPL CREB1 GATAD2A LEF1 IKZF1 JUND PRDM1 PHF21A ZSCAN4 RBFOX2 LGALS4 ZNF573 HNRNPL ENSG00000269688 LGALS7 SUPT5H RN7SL566P ENSG00000225868 RINL PLEKHG2
GH19J039080 Enhancer 0.6 Ensembl dbSUPER 14.3 -2.7 -2710 0.2 ZNF10 ZNF660 KLF10 ZSCAN21 ZNF121 lnc-ACP7-1 ACP7 FBXO27 PAK4 lnc-FBXO27-3 lnc-ACP7-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACP7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACP7

Genomic Locations for ACP7 Gene

Genomic Locations for ACP7 Gene
chr19:39,083,011-39,112,074
(GRCh38/hg38)
Size:
29,064 bases
Orientation:
Plus strand
chr19:39,574,553-39,602,133
(GRCh37/hg19)
Size:
27,581 bases
Orientation:
Plus strand

Genomic View for ACP7 Gene

Genes around ACP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACP7 Gene

Proteins for ACP7 Gene

  • Protein details for ACP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNF0-ACP7_HUMAN
    Recommended name:
    Acid phosphatase type 7
    Protein Accession:
    Q6ZNF0
    Secondary Accessions:
    • B2RN68

    Protein attributes for ACP7 Gene

    Size:
    438 amino acids
    Molecular mass:
    50480 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ACP7 Gene

Post-translational modifications for ACP7 Gene

  • Glycosylation at Asn211, Asn350, and Asn404
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACP7 Gene

Domains & Families for ACP7 Gene

Gene Families for ACP7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for ACP7 Gene

GenScript: Design optimal peptide antigens:
  • Iron/zinc purple acid phosphatase-like protein (PAPL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZNF0

UniProtKB/Swiss-Prot:

ACP7_HUMAN :
  • Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
Family:
  • Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.
genes like me logo Genes that share domains with ACP7: view

Function for ACP7 Gene

Molecular function for ACP7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2;.

Enzyme Numbers (IUBMB) for ACP7 Gene

Phenotypes From GWAS Catalog for ACP7 Gene

Gene Ontology (GO) - Molecular Function for ACP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ACP7: view
genes like me logo Genes that share phenotypes with ACP7: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP7

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACP7 Gene

Localization for ACP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACP7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACP7 gene
Compartment Confidence
extracellular 4
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for ACP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ACP7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACP7 Gene

Pathways & Interactions for ACP7 Gene

PathCards logo

SuperPathways for ACP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ACP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with ACP7: view

No data available for Pathways by source and SIGNOR curated interactions for ACP7 Gene

Drugs & Compounds for ACP7 Gene

(2) Drugs for ACP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with ACP7: view

Transcripts for ACP7 Gene

mRNA/cDNA for ACP7 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP7

Alternative Splicing Database (ASD) splice patterns (SP) for ACP7 Gene

No ASD Table

Relevant External Links for ACP7 Gene

GeneLoc Exon Structure for
ACP7

Expression for ACP7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACP7

Evidence on tissue expression from TISSUES for ACP7 Gene

  • Nervous system(4.4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACP7 Gene

Orthologs for ACP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACP7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToOne
LOC456018 30
  • 99.49 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 91 (a)
OneToOne
PAPL 30
  • 87.58 (n)
Cow
(Bos Taurus)
Mammalia -- 31
  • 88 (a)
OneToOne
PAPL 30
  • 87.32 (n)
Rat
(Rattus norvegicus)
Mammalia Papl 30
  • 84.44 (n)
Mouse
(Mus musculus)
Mammalia Papl 30 31
  • 82.23 (n)
OneToOne
Acp7 17
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 73 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 66 (a)
OneToMany
-- 31
  • 61 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia papl 30
  • 63.05 (n)
Zebrafish
(Danio rerio)
Actinopterygii papl 30 31
  • 61.28 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10941 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG1637 30 31
  • 57.71 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002016 30
  • 56.98 (n)
Worm
(Caenorhabditis elegans)
Secernentea F21A3.11 30 31
  • 52.74 (n)
OneToMany
C08B6.14 31
  • 38 (a)
OneToMany
H25K10.1 31
  • 36 (a)
OneToMany
Y105C5B.15 31
  • 35 (a)
OneToMany
F18E2.1 31
  • 34 (a)
OneToMany
Y105C5B.3 31
  • 34 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PAP18 30
  • 43.08 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0568900 30
  • 42.73 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU08643 30
  • 46.53 (n)
Species where no ortholog for ACP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ACP7 Gene

ENSEMBL:
Gene Tree for ACP7 (if available)
TreeFam:
Gene Tree for ACP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACP7: view image

Paralogs for ACP7 Gene

No data available for Paralogs for ACP7 Gene

Variants for ACP7 Gene

Additional dbSNP identifiers (rs#s) for ACP7 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACP7 Gene

Variant ID Type Subtype PubMed ID
dgv3528n100 CNV gain 25217958
esv2718546 CNV deletion 23290073
nsv1114007 CNV deletion 24896259
nsv458571 CNV gain 19166990
nsv579508 CNV gain 21841781
nsv833829 CNV loss 17160897

Variation tolerance for ACP7 Gene

Residual Variation Intolerance Score: 81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.40; 42.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACP7 Gene

Disorders for ACP7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACP7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spindle cell hemangioma
  • sch
- elite association - COSMIC cancer census association via MalaCards
Search ACP7 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ACP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACP7 Gene

Publications for ACP7 Gene

  1. Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase. (PMID: 16793224) Flanagan JU … Hume DA (Gene 2006) 2 3 4
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3
  4. Role of IFN-ks, IFN-ks related genes and the DEPDC5 gene in Hepatitis B virus-related liver disease. (PMID: 25032264) Ma N … Liu D (Journal of viral hepatitis 2014) 3
  5. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3

Products for ACP7 Gene

Sources for ACP7 Gene