Aliases for ACP6 Gene
External Ids for ACP6 Gene
Previous GeneCards Identifiers for ACP6 Gene
This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]
GeneCards Summary for ACP6 Gene
ACP6 (Acid Phosphatase 6, Lysophosphatidic) is a Protein Coding gene. Diseases associated with ACP6 include Cerebral Visual Impairment and Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. Gene Ontology (GO) annotations related to this gene include acid phosphatase activity and lysophosphatidic acid phosphatase activity. An important paralog of this gene is ACP2.
UniProtKB/Swiss-Prot Summary for ACP6 Gene
Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.