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Aliases for ACP6 Gene

Aliases for ACP6 Gene

  • Acid Phosphatase 6, Lysophosphatidic 2 3 4 5
  • Acid Phosphatase-Like Protein 1 3 4
  • PACPL1 3 4
  • ACPL1 3 4
  • LPAP 3 4
  • Lysophosphatidic Acid Phosphatase Type 6 3
  • Lysophosphatidic Acid Phosphatase 2
  • EC 3.1.3.2 4

External Ids for ACP6 Gene

Previous GeneCards Identifiers for ACP6 Gene

  • GC01M145333
  • GC01M143844
  • GC01M144463
  • GC01M144626
  • GC01M144343
  • GC01M145585
  • GC01M147119
  • GC01M120532

Summaries for ACP6 Gene

Entrez Gene Summary for ACP6 Gene

  • This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]

GeneCards Summary for ACP6 Gene

ACP6 (Acid Phosphatase 6, Lysophosphatidic) is a Protein Coding gene. Among its related pathways are Acyl chain remodelling of PE and Metabolism. Gene Ontology (GO) annotations related to this gene include acid phosphatase activity and lysophosphatidic acid phosphatase activity. An important paralog of this gene is ACP4.

UniProtKB/Swiss-Prot for ACP6 Gene

  • Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.

Gene Wiki entry for ACP6 Gene

Additional gene information for ACP6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACP6 Gene

Genomics for ACP6 Gene

GeneHancer (GH) Regulatory Elements for ACP6 Gene

Promoters and enhancers for ACP6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J147668 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 655 +0.5 461 2.3 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF143 SP3 REST SMARCB1 KAT8 ACP6 GPR89B LOC647481 GC01P147574
GH01J147773 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 655.3 -103.0 -102989 0.6 ZFHX2 EGR1 SCRT2 ZNF207 ZNF398 EGR2 ACP6 ENSG00000234190 GJA5 ENSG00000274415 LOC102723321
GH01J147538 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.4 +129.5 129502 5.8 PKNOX1 FOXA2 ARNT NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF416 BCL9 LOC647481 GPR89B LOC101927468 ACP6 OR13Z3P OR13Z2P OR13Z1P LOC100130018 ENSG00000235988
GH01J147640 Enhancer 0.9 Ensembl ENCODE 47.7 +29.3 29312 0.8 SIX4 CTCF KLF1 SIN3A ZMYM3 EBF1 KLF14 ZNF2 ZNF48 RAD21 ACP6 BCL9 GC01P147574
GH01J147611 Enhancer 0.9 ENCODE 41.4 +58.3 58273 2 PKNOX1 CLOCK FOXA2 ARID4B NEUROD1 SIN3A ZBTB7B ETS1 SLC30A9 ELK1 ACP6 BCL9 GC01P147574
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACP6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACP6 gene promoter:
  • c-Myb
  • AREB6
  • AP-2rep
  • ATF6
  • Pax-5
  • FOXO4
  • FOXI1
  • HFH-3
  • AP-4
  • RORalpha1

Genomic Locations for ACP6 Gene

Genomic Locations for ACP6 Gene
chr1:147,629,286-147,670,512
(GRCh38/hg38)
Size:
41,227 bases
Orientation:
Minus strand
chr1:147,101,453-147,142,634
(GRCh37/hg19)
Size:
41,182 bases
Orientation:
Minus strand

Genomic View for ACP6 Gene

Genes around ACP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACP6 Gene

Proteins for ACP6 Gene

  • Protein details for ACP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH0-PPA6_HUMAN
    Recommended name:
    Lysophosphatidic acid phosphatase type 6
    Protein Accession:
    Q9NPH0
    Secondary Accessions:
    • Q59G61
    • Q5T490
    • Q6IAQ3
    • Q7LG81
    • Q9UIG6
    • X5D289

    Protein attributes for ACP6 Gene

    Size:
    428 amino acids
    Molecular mass:
    48886 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=BAA89311.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92485.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACP6 Gene

    Alternative splice isoforms for ACP6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACP6 Gene

Post-translational modifications for ACP6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACP6 Gene

Domains & Families for ACP6 Gene

Gene Families for ACP6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for ACP6 Gene

Suggested Antigen Peptide Sequences for ACP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPH0

UniProtKB/Swiss-Prot:

PPA6_HUMAN :
  • Belongs to the histidine acid phosphatase family.
Family:
  • Belongs to the histidine acid phosphatase family.
genes like me logo Genes that share domains with ACP6: view

Function for ACP6 Gene

Molecular function for ACP6 Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.
UniProtKB/Swiss-Prot CatalyticActivity:
A phosphate monoester + H(2)O = an alcohol + phosphate.
UniProtKB/Swiss-Prot Induction:
Induced with the differentiation from myoblast to myotube.

Enzyme Numbers (IUBMB) for ACP6 Gene

Phenotypes From GWAS Catalog for ACP6 Gene

Gene Ontology (GO) - Molecular Function for ACP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003993 acid phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0052642 lysophosphatidic acid phosphatase activity TAS --
genes like me logo Genes that share ontologies with ACP6: view
genes like me logo Genes that share phenotypes with ACP6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ACP6

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACP6 Gene

Localization for ACP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACP6 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACP6 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
golgi apparatus 2
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ACP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12010880
GO:0005739 mitochondrion IDA,IEA 10506173
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ACP6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACP6 Gene

Pathways & Interactions for ACP6 Gene

genes like me logo Genes that share pathways with ACP6: view

Interacting Proteins for ACP6 Gene

Gene Ontology (GO) - Biological Process for ACP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006644 phospholipid metabolic process IMP 10506173
GO:0006654 phosphatidic acid biosynthetic process TAS --
GO:0016311 dephosphorylation IEA --
GO:2001311 lysobisphosphatidic acid metabolic process IDA 23807634
genes like me logo Genes that share ontologies with ACP6: view

No data available for SIGNOR curated interactions for ACP6 Gene

Drugs & Compounds for ACP6 Gene

(5) Drugs for ACP6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Flavin Mononucleotide Approved, Investigational Pharma 8
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Riboflavin Approved, Investigational, Vet_approved Nutra 188
4-Nitrophenol Experimental Pharma 0

(75) Additional Compounds for ACP6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Arachidonylglycerol
  • 2-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-glycerol
  • 2-AG
  • 2-Ara-GL
  • 2-Arachidonoyl-glycerol
  • 2-Arachidonyl-glycerol
53847-30-6
LysoPA(0:0/16:0)
  • 2-palmitoyl-glycero-3-phosphate
  • LPA(0:0/16:0)
  • Lysophosphatidic Acid(0:0/16:0)
  • LPA(16:0)
  • 2-hexadecanoyl-phosphatidic acid
LysoPA(0:0/18:0)
  • LPA(0:0/18:0)
  • LPA(18:0)
  • Lysophosphatidic Acid(0:0/18:0)
  • Lysophosphatidic Acid(18:0)
  • 2-stearoyl-glycero-3-phosphate
LysoPA(0:0/18:1(9Z))
  • Lysophosphatidic Acid(18:1)
  • LPA(0:0/18:1(9Z))
  • LPA(0:0/18:1)
  • Lysophosphatidic Acid(0:0/18:1)
  • 2-oleoyl-glycero-3-phosphate
LysoPA(0:0/18:2(9Z,12Z))
  • {3-hydroxy-2-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propoxy}phosphonate
  • LPA(18:2)
  • LPA(0:0/18:2(9Z,12Z))
  • 2-(9Z,12Z-octadecadienoyl)-phosphatidic acid
  • Lysophosphatidic Acid(18:2)
genes like me logo Genes that share compounds with ACP6: view

Transcripts for ACP6 Gene

Unigene Clusters for ACP6 Gene

Acid phosphatase 6, lysophosphatidic:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACP6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: -
SP3:
SP4: - - - - - -
SP5:
SP6: - - - -
SP7: - - -
SP8:

Relevant External Links for ACP6 Gene

GeneLoc Exon Structure for
ACP6
ECgene alternative splicing isoforms for
ACP6

Expression for ACP6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACP6 Gene

Protein differential expression in normal tissues from HIPED for ACP6 Gene

This gene is overexpressed in Salivary gland (25.5), Oral epithelium (11.8), and Gallbladder (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACP6 Gene



NURSA nuclear receptor signaling pathways regulating expression of ACP6 Gene:

ACP6

SOURCE GeneReport for Unigene cluster for ACP6 Gene:

Hs.562154

mRNA Expression by UniProt/SwissProt for ACP6 Gene:

Q9NPH0-PPA6_HUMAN
Tissue specificity: Highly expressed in kidney, heart, small intestine, muscle, liver, prostate, testis, ovary and weakly expressed in thymus and colon.

Evidence on tissue expression from TISSUES for ACP6 Gene

  • Nervous system(4.6)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ACP6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACP6 Gene

Orthologs for ACP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACP6 34 33
  • 99.69 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACP6 34 33
  • 87.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ACP6 34 33
  • 85.71 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Acp6 16 34 33
  • 81.69 (n)
rat
(Rattus norvegicus)
Mammalia Acp6 33
  • 81.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACP6 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACP6 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACP6 34 33
  • 64.2 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACP6 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acp6 33
  • 61.61 (n)
zebrafish
(Danio rerio)
Actinopterygii acp6 34 33
  • 55.68 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pho-6 34
  • 21 (a)
OneToMany
pho-7 34
  • 20 (a)
OneToMany
pho-9 34
  • 20 (a)
OneToMany
pho-8 34
  • 19 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU06460 33
  • 45.36 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC4.06 33
  • 41.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for ACP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACP6 Gene

ENSEMBL:
Gene Tree for ACP6 (if available)
TreeFam:
Gene Tree for ACP6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACP6: view image

Paralogs for ACP6 Gene

Paralogs for ACP6 Gene

genes like me logo Genes that share paralogs with ACP6: view

Variants for ACP6 Gene

Sequence variations from dbSNP and Humsavar for ACP6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs144959805 likely-pathogenic, Cerebral visual impairment and intellectual disability 147,659,496(-) C/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs140566115 benign, not specified 147,654,322(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000033626 -- 147,632,273(-) A/C genic_downstream_transcript_variant, intron_variant
rs1000467002 -- 147,659,298(-) C/T intron_variant
rs1000612063 -- 147,639,086(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACP6 Gene

Variant ID Type Subtype PubMed ID
nsv831426 CNV loss 17160897
nsv510962 OTHER complex 20534489
nsv509457 CNV insertion 20534489
nsv1144402 CNV deletion 24896259
nsv1132304 CNV duplication 24896259
nsv1005055 CNV loss 25217958
nsv1003688 CNV gain 25217958
esv2761299 CNV gain+loss 21179565
dgv66e199 CNV deletion 23128226
dgv327n100 CNV gain 25217958

Variation tolerance for ACP6 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACP6 Gene

Human Gene Mutation Database (HGMD)
ACP6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACP6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACP6 Gene

Disorders for ACP6 Gene

Additional Disease Information for ACP6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ACP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACP6 Gene

Publications for ACP6 Gene

  1. Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum. (PMID: 12010880) Takayama I … Fujino MA (Gut 2002) 2 3 4 22 58
  2. Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis. (PMID: 10506173) Hiroyama M … Takenawa T (The Journal of biological chemistry 1999) 2 3 4 22 58
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 4 58
  4. Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6. (PMID: 23807634) Li J … Rao Z (Protein & cell 2013) 3 4 58
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58

Products for ACP6 Gene

Sources for ACP6 Gene

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