Aliases for ACP4 Gene
External Ids for ACP4 Gene
Previous HGNC Symbols for ACP4 Gene
Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACP4 Gene
ACP4 (Acid Phosphatase 4) is a Protein Coding gene. Diseases associated with ACP4 include Amelogenesis Imperfecta, Type Ij and Hypoplastic Amelogenesis Imperfecta. An important paralog of this gene is ACP2.
UniProtKB/Swiss-Prot Summary for ACP4 Gene
May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage (PubMed:15219672). May play a role in odontogenesis (PubMed:27843125).