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This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is loc... See more...
Aliases for ACP3 Gene
Aliases for ACP3 Gene
External Ids for ACP3 Gene
- HGNC: 125
- Entrez Gene: 55
- Ensembl: ENSG00000014257
- OMIM: 171790
- UniProtKB: P15309
Previous HGNC Symbols for ACP3 Gene
- ACPP
Summaries for ACP3 Gene
-
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
GeneCards Summary for ACP3 Gene
ACP3 (Acid Phosphatase 3) is a Protein Coding gene. Diseases associated with ACP3 include Prostatitis and Prostatic Hyperplasia, Benign. Among its related pathways are ATP/ITP metabolism and Innate Immune System. An important paralog of this gene is ACP2.
UniProtKB/Swiss-Prot Summary for ACP3 Gene
-
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
-
[Isoform 2]: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
Additional gene information for ACP3 Gene
- HGNC(125)
- Entrez Gene(55)
- Ensembl(ENSG00000014257)
- OMIM(171790)
- UniProtKB(P15309)
- Open Targets Platform(ENSG00000014257)
- Search for ACP3 at DataMed
- Search for ACP3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACP3 Gene
Genomics for ACP3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ACP3 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03J132316 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.4 | 408 | 2.8 | PRDM10 ZHX2 FOXA1 PRDM1 ZNF341 ATF7 ZBTB20 TCF7L2 RFX1 ZXDB | ACP3 ENSG00000261167 CPNE4 HSALNG0029010 DNAJC13 | |
| GH03J132289 | Enhancer | 0.7 | Ensembl ENCODE | 16.3 | -25.8 | -25812 | 5.3 | CREB1 ATF7 CEBPB ATF2 ZFHX2 SPI1 POLR2A JUND MYC MAX | ACP3 CPNE4 piR-56133-149 | |
| GH03J132282 | Promoter/Enhancer | 1 | Ensembl ENCODE | 4.5 | -32.6 | -32636 | 3.5 | CTCF PRDM1 ZNF740 SP1 CEBPB USF1 GTF2A2 EP300 STAT1 SPI1 | CPNE4 ACP3 RPL7P16 SNODB764 MRPL3 | |
| GH03J132324 | Enhancer | 0.3 | Ensembl | 14.7 | +8.4 | 8432 | 2 | HLF | ACP3 CPNE4 HSALNG0029010 DNAJC13 | |
| GH03J132346 | Enhancer | 0.7 | Ensembl ENCODE | 4.7 | +29.6 | 29632 | 1.6 | SOX13 RFX1 CTBP1 FOXA2 FOXP1 DPF2 SPI1 FOXA1 ZBTB40 SOX5 | ACP3 HSALNG0029010 DNAJC13 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ACP3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACP3
Genomic Locations for ACP3 Gene
Genomic Locations for ACP3 Gene
- chr3:132,317,369-132,368,765
- (GRCh38/hg38)
- Size:
- 51,397 bases
- Orientation:
- Plus strand
- chr3:132,036,211-132,087,146
- (GRCh37/hg19)
- Size:
- 50,936 bases
- Orientation:
- Plus strand
Genomic View for ACP3 Gene
Genes around ACP3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q22.1 by HGNC
- 3q22.1 by Entrez Gene
- 3q22.1 by Ensembl
ACP3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACP3 Gene
Proteins for ACP3 Gene
-
Protein details for ACP3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15309-PPAP_HUMAN
- Recommended name:
- Prostatic acid phosphatase
- Protein Accession:
- P15309
- D3DNC6
- Q5FBY0
- Q96KY0
- Q96QK9
- Q96QM0
Protein attributes for ACP3 Gene
- Size:
- 386 amino acids
- Molecular mass:
- 44566 Da
- Quaternary structure:
-
- Homodimer; dimer formation is required for phosphatase activity.
- Miscellaneous:
-
- Used as a diagnostic tool for staging metastatic prostatic cancer.
Three dimensional structures from OCA and Proteopedia for ACP3 Gene
Selected DME Specific Peptides for ACP3 Gene
- P15309:
-
- WPQGFGQLT
- DRTLMSA
- DTTVSGLQMAL
- WQPIPVHT
- RLQGGVL
Post-translational modifications for ACP3 Gene
- N-glycosylated. High mannose content, partially sialylated and fucosylated biantennary complex. Also fucosylated with partially sialylated triantennary complex oligosaccharides.
- Proteolytically cleaved in seminal fluid to produce several peptides. Peptide PAPf39, the most prominent, forms amyloid beta-sheet fibrils, SEVI (semen-derived enhancer of viral infection) which entrap HIV virions, attach them to target cells and enhance infection. SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea. Target cell attachment and enhancement of HIV infection is inhibited by surfen. Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection.
-
Glycosylation at Asn94, Asn220, and Asn333
- NX_P15309 (NX_P15309-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- PPAP_HUMAN (2001)
Other Protein References for ACP3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PSAP (1H2) monoclonal antibody and Immunotag™ ACPP Antibody
- RayBiotech Mouse anti-Human ACPP (3G9-F8-F9-E8)
- NSJ Bioreagents ACPP Antibody / PAP / Prostatic acid phosphatase
- Novus Biologicals Antibodies for ACP3
-
Abcam antibodies for ACP3
- Invitrogen Antibodies for ACP3 (AFLGC-ACP3)
- antibodies-online: Show 71 available ACPP Antibodies ranked by validation data
- Compare Top ACPP Antibodies
-
Recommended
- 113 WB Antibodies (anti-human)
- 51 IHC (p) Antibodies (anti-human)
- 19 IHC (fro) Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IRMA Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- Sino Biological Antibodies for ACP3
Protein Products
- G Biosciences Human Prostatic Acid Phosphatase/ACPP, Liquid
- RayBiotech Recombinant Human Prostatic Acid Phosphatase
-
OriGene Purified Proteins for ACP3
- Search Origene for MassSpec and Protein Over-expression Lysates for ACP3
- Origene Custom Protein Services for ACP3
- Sino Biological Cell Lysates for ACP3
- Sino Biological Recombinant Proteins for ACP3
- ProSpec Recombinant Proteins for ACP3
-
ProSci Proteins for ACP3
-
Abcam proteins for ACP3
Assay Products
- G Biosciences Immunotag™ Prostatic acid phosphatase ELISA Kit
- RayBiotech Custom Human ACPP ELISA
- Novus Biologicals ELISA Kits for ACP3
- antibodies-online: Show 65 available ACPP Elisa Kits ranked by validation data
- Compare Top ACPP Elisa Kits
-
Quality Products:
- ABIN1116723
- ABIN414438
- ABIN5519695
- ABIN414946
- ABIN1568126
- ABIN5519697
- ABIN5519696
- ABIN5591525
- ABIN512819
- ABIN996895
- ABIN1116721
- ABIN5519698
- ABIN627472
- ABIN367837
- ABIN6201097
- ABIN6201098
- ABIN6730056
- ABIN2538285
- ABIN456270
- ABIN1116722
- ABIN5519700
- ABIN5519701
- ABIN5591526
- ABIN626641
- ABIN6201099
- ABIN2950749
- ABIN368098
- ABIN956313
- ABIN5071502
- ABIN5519699
- ABIN774100
- ABIN1565900
- ABIN6227614
- ABIN368559
-
Signalway ELISA kits for ACP3
- Sino Biological Assays for ACP3
Domains & Families for ACP3 Gene
Gene Families for ACP3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Enzymes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ACP3 Gene
- InterPro:
- Blocks:
-
- Histidine acid phosphatase
- ProtoNet:
Suggested Antigen Peptide Sequences for ACP3 Gene
- GenScript: Design optimal peptide antigens:
-
- ACPP protein (A0PJ86_HUMAN)
- Thiamine monophosphatase (PPAP_HUMAN)
- cDNA FLJ54158, highly similar to Prostatic acid phosphatase (EC 3.1.3.2) (Q5FBY0_HUMAN)
- Prostatic acid phosphotase (Q6LBH1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15309- Family:
-
- Belongs to the histidine acid phosphatase family.
Function for ACP3 Gene
Molecular function for ACP3 Gene
- UniProtKB/Swiss-Prot Function:
- A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
- UniProtKB/Swiss-Prot Function:
- [Isoform 2]: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a phosphate monoester + H2O = an alcohol + phosphate; Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.2; Evidence={ECO:0000269|PubMed:15280042};.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate; Xref=Rhea:RHEA:12484, ChEBI:CHEBI:15377, ChEBI:CHEBI:18254, ChEBI:CHEBI:43474, ChEBI:CHEBI:58043; EC=3.1.3.5; Evidence={ECO:0000269|PubMed:15280042};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Phosphatase activity inhibited by L(+)-tartrate, and by its derivative, alpha-benzylaminobenzylphosphonic acid.
Enzyme Numbers (IUBMB) for ACP3 Gene
Phenotypes From GWAS Catalog for ACP3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003993 | acid phosphatase activity | IMP | 8132635 |
| GO:0005515 | protein binding | IPI | 9705354 |
| GO:0008253 | 5'-nucleotidase activity | IEA,IDA | 18940592 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016791 | phosphatase activity | IMP | 18940592 |
Phenotypes for ACP3 Gene
- MGI mutant phenotypes for ACP3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ACP3:
-
- no effect
- Decreased viability
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 25%
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability with paclitaxel
- Increased cell death in DLD-1 cells
- Increased viability after TNF/CHX stimulation
- Decreased caspase 3/7 activity
Animal Models for ACP3 Gene
- MGI Knock Outs for ACP3:
-
- Acpp Acpp<tm1Pivi>
Animal Model Products
-
Taconic Biosciences Mouse Models for ACP3
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ACP3 - Select products 50% OFF >
- * ACP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ACP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACP3
miRNA for ACP3 Gene
- miRTarBase miRNAs that target ACP3
-
- hsa-let-7b-5p (MIRT032233)
- hsa-miR-539-5p (MIRT441291)
- hsa-miR-6803-5p (MIRT443462)
- hsa-miR-6751-5p (MIRT443463)
- hsa-miR-548s (MIRT443464)
- hsa-miR-6881-5p (MIRT443465)
- hsa-miR-7110-5p (MIRT443466)
- hsa-miR-6752-5p (MIRT443467)
- hsa-miR-6842-5p (MIRT443468)
- hsa-miR-6835-5p (MIRT443469)
- hsa-miR-4731-5p (MIRT443470)
- hsa-miR-3926 (MIRT443471)
- hsa-miR-637 (MIRT443472)
- hsa-miR-3973 (MIRT443473)
- hsa-miR-5197-5p (MIRT443474)
- hsa-miR-320e (MIRT443475)
- hsa-miR-548l (MIRT443476)
- hsa-miR-4429 (MIRT443477)
- hsa-miR-320d (MIRT443478)
- hsa-miR-320c (MIRT443479)
- hsa-miR-320b (MIRT443480)
- hsa-miR-320a (MIRT443481)
- mmu-miR-3062-5p (MIRT604416)
- hsa-miR-3672 (MIRT785110)
- hsa-miR-4461 (MIRT785938)
- hsa-miR-4524a-3p (MIRT786098)
- hsa-miR-4524b-3p (MIRT786146)
- hsa-miR-6864-3p (MIRT789115)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACP3
- Browse OriGene Inhibitory RNA Products For ACP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP3
Clone Products
- Applied Biological Materials (abm): Clones for ACP3 - Select products 50% OFF >
- * ACP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227596
- MG227627
- MR227596
- MR227596L3
- MR227596L4
- MR227627
- MR227627L3
- MR227627L4
- RC205079
- RC205079L1
- RC205079L2
- RC205079L3
- RC205079L4
- RC225669
- RC225669L3
- RC225669L4
- RC237669
- RG205079
- RG225669
- RR200348
- RR200348L3
- RR200348L4
- RR200349
- RR200349L3
- RR200349L4
- MR227596L3V
- MR227596L4V
- MR227627L3V
- MR227627L4V
- RC205079L1V
- RC205079L2V
- RC205079L3V
- RC205079L4V
- RC225669L3V
- RC225669L4V
- RR200348L3V
- RR200348L4V
- RR200349L3V
- RR200349L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ACP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACP3
Cell Line Products
-
Horizon Cell Lines for ACP3
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACP3 Gene
Localization for ACP3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACP3 Gene
- [Isoform 1]: Secreted.
- [Isoform 2]: Cell membrane. Single-pass type I membrane protein. Lysosome membrane. Single-pass type I membrane protein. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). {ECO:0000269 PubMed:17638863, ECO:0000269 PubMed:17897319}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| nucleus | 4 |
| lysosome | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IMP | 22389722 |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | IEA,HDA | 17897319 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACP3 Gene
Pathways & Interactions for ACP3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | ATP/ITP metabolism |
ATP/ITP metabolism
-
|
|
Pathways by source for ACP3 Gene
3 Reactome pathways for ACP3 Gene
1 GeneGo (Thomson Reuters) pathway for ACP3 Gene
- ATP/ITP metabolism
Interacting Proteins for ACP3 Gene
Selected Interacting proteins:
P15309-PPAP_HUMAN
ENSP00000323036
for ACP3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for ACP3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006144 | purine nucleobase metabolic process | IEA | -- |
| GO:0006772 | thiamine metabolic process | IEA,ISS | -- |
| GO:0009117 | nucleotide metabolic process | IEA | -- |
| GO:0016311 | dephosphorylation | IMP | 8132635 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for ACP3 Gene
Drugs & Compounds for ACP3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sipuleucel-T | Approved, Investigational | Pharma | Target, other | 0 | ||
| Flavin Mononucleotide | Approved, Investigational | Pharma | 12 | |||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Water | Approved | Pharma | 0 | |||
| Riboflavin | Approved, Investigational, Vet_approved | Nutra | 231 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
Drug Products
- G Biosciences Human Prostatic Acid Phosphatase/ACPP, Liquid
- RayBiotech Recombinant Human Prostatic Acid Phosphatase
Transcripts for ACP3 Gene
mRNA/cDNA for ACP3 Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000336375 3174 nts (view in UCSC)
- ENST00000495911 584 nts (view in UCSC)
- ENST00000475741 1242 nts (view in UCSC)
- ENST00000351273 1783 nts (view in UCSC)
- ENST00000493235 555 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ACP3 - Select products 50% OFF >
- * ACP3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ACP3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACP3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACP3
- Browse OriGene Inhibitory RNA Products For ACP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP3
Clone Products
- Applied Biological Materials (abm): Clones for ACP3 - Select products 50% OFF >
- * ACP3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227596
- MG227627
- MR227596
- MR227596L3
- MR227596L4
- MR227627
- MR227627L3
- MR227627L4
- RC205079
- RC205079L1
- RC205079L2
- RC205079L3
- RC205079L4
- RC225669
- RC225669L3
- RC225669L4
- RC237669
- RG205079
- RG225669
- RR200348
- RR200348L3
- RR200348L4
- RR200349
- RR200349L3
- RR200349L4
- MR227596L3V
- MR227596L4V
- MR227627L3V
- MR227627L4V
- RC205079L1V
- RC205079L2V
- RC205079L3V
- RC205079L4V
- RC225669L3V
- RC225669L4V
- RR200348L3V
- RR200348L4V
- RR200349L3V
- RR200349L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ACP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACP3
Relevant External Links for ACP3 Gene
- GeneLoc Exon Structure for
- ACP3
Expression for ACP3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Podocytes Podocyte Layer
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Kidney (Urinary System)
- Podocytes Podocyte Layer
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACP3
SOURCE GeneReport for Unigene cluster for ACP3 Gene:
Hs.433060mRNA Expression by UniProt/SwissProt for ACP3 Gene:
P15309-PPAP_HUMAN
Tissue specificity:
Highly expressed in the prostate, restricted to glandular and ductal epithelial cells. Also expressed in bladder, kidney, pancreas, lung, cervix, testis and ovary. Weak expression in a subset of pancreatic islet cells, squamous epithelia, the pilosebaceous unit, colonic neuroendocrine cells and skin adnexal structures. Isoform 2 also expressed in the sarcolemma of skeletal muscle. Levels of this cellular isoform decreased in prostate cancer.
Evidence on tissue expression from TISSUES for ACP3 Gene
- Kidney(2.7)
- Skin(2.6)
- Blood(2.4)
- Nervous system(2.3)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for ACP3
-
OriGene qPCR primer pairs and template standards for ACP3
No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACP3 Gene
Orthologs for ACP3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ACPP 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ACPP 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | ACPP 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Acpp 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Acpp 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ACPP 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ACPP 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | ACPP 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | ACPP 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | acpp 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Acph-1 31 |
|
ManyToMany | |
| CG9449 31 |
|
ManyToMany | |||
| CG9451 31 |
|
ManyToMany | |||
| CG9452 31 |
|
ManyToMany | |||
| CG6656 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | pho-6 30 |
|
||
| pho-14 31 |
|
ManyToMany | |||
| pho-5 31 |
|
ManyToMany | |||
| pho-12 31 |
|
ManyToMany | |||
| pho-10 31 |
|
ManyToMany | |||
| pho-1 31 |
|
ManyToMany | |||
| F26C11.1 31 |
|
ManyToMany | |||
| C27A2.12 31 |
|
ManyToMany | |||
| pho-11 31 |
|
ManyToMany | |||
| pho-13 31 |
|
ManyToMany | |||
| pho-4 31 |
|
ManyToMany | |||
| acp-1 31 |
|
ManyToMany | |||
| acp-5 31 |
|
ManyToMany | |||
| acp-3 31 |
|
ManyToMany | |||
| acp-2 31 |
|
ManyToMany | |||
| acp-4 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11668 30 |
|
- Species where no ortholog for ACP3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for ACP3 Gene
- ENSEMBL:
- Gene Tree for ACP3 (if available)
- TreeFam:
- Gene Tree for ACP3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ACP3: view image
Paralogs for ACP3 Gene
Variants for ACP3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACP3 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 714205 | Benign: not provided | 132,352,758(+) | T/G | MISSENSE_VARIANT | |
| 714983 | Benign: not provided | 132,332,272(+) | T/C | SYNONYMOUS_VARIANT | |
| 729506 | Likely Benign: not provided | 132,337,518(+) | A/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 740129 | Likely Benign: not provided | 132,328,263(+) | T/C | INTRON_VARIANT | |
| rs864309497 | Uncertain Significance: Acute megakaryoblastic leukemia; Mediastinal germ cell tumor | 132,349,985(+) | CTCA/C | INFRAME_DELETION |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2762346 | CNV | loss | 21179565 |
| esv3597825 | CNV | loss | 21293372 |
| nsv478509 | CNV | novel sequence insertion | 20440878 |
| nsv508245 | CNV | deletion | 20534489 |
| nsv829728 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
21.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.68;
32.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ACP3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ACP3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACP3 Gene
Disorders for ACP3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostatitis |
|
|
| prostatic hyperplasia, benign |
|
|
| atypical choroid plexus papilloma |
|
|
| phosphatase, acid, of tissues |
|
|
| clear cell adenocarcinoma |
|
Search ACP3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for ACP3
No data available for UniProtKB/Swiss-Prot and Genatlas for ACP3 Gene
Publications for ACP3 Gene
- Prostatic acid phosphatase degrades lysophosphatidic acid in seminal plasma. (PMID: 15280042) Tanaka M … Arai H (FEBS letters 2004) 3 4 23
- Structural origins of L(+)-tartrate inhibition of human prostatic acid phosphatase. (PMID: 9804805) LaCount MW … Lebioda L (The Journal of biological chemistry 1998) 3 4 23
- Structure of human prostatic acid phosphatase gene. (PMID: 1375464) Sharief FS … Li SS (Biochemical and biophysical research communications 1992) 2 3 4
- Molecular cloning and sequence analysis of cDNA encoding human prostatic acid phosphatase. (PMID: 2842184) Vihko P … Huhtala ML (FEBS letters 1988) 2 3 4
- Prostatic acid phosphatase expression in human tissues. (PMID: 21487525) Graddis TJ … Trager JB (International journal of clinical and experimental pathology 2011) 3 4
ExternalLinks
Products for ACP3 Gene
- View all 5 R&D Systems ACP3 (Prostatic Acid Phosphatase/ACPP) Products
- View all R&D Systems ACP3 (Prostatic Acid Phosphatase/ACPP) Proteins and Enzymes
- View all 3 R&D Systems ACP3 (Prostatic Acid Phosphatase/ACPP) Primary Antibodies
- View all R&D Systems ACP3 (Prostatic Acid Phosphatase/ACPP) ELISAs
- Learn more about R&D Systems custom ACP3 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for ACP3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ACP3
- Search Origene for MassSpec and Protein Over-expression Lysates for ACP3
- Origene Custom Protein Services for ACP3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACP3
- Browse OriGene Inhibitory RNA Products For ACP3
- OriGene qPCR primer pairs for ACP3
- OriGene qPCR primer pairs and template standards for ACP3
- OriGene CRISPR knockouts for ACP3
- MG227596
- MG227627
- MR227596
- MR227596L3
- MR227596L4
- MR227627
- MR227627L3
- MR227627L4
- RC205079
- RC205079L1
- RC205079L2
- RC205079L3
- RC205079L4
- RC225669
- RC225669L3
- RC225669L4
- RC237669
- RG205079
- RG225669
- RR200348
- RR200348L3
- RR200348L4
- RR200349
- RR200349L3
- RR200349L4
- MR227596L3V
- MR227596L4V
- MR227627L3V
- MR227627L4V
- RC205079L1V
- RC205079L2V
- RC205079L3V
- RC205079L4V
- RC225669L3V
- RC225669L4V
- RR200348L3V
- RR200348L4V
- RR200349L3V
- RR200349L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ACP3
- Sino Biological Human cDNA Clone for ACP3
- Sino Biological Cell Lysates for ACP3
- Sino Biological Recombinant Proteins for ACP3
- Sino Biological Antibodies for ACP3
- Sino Biological Assays for ACP3
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ACP3
- Novus Biologicals proteins and lysates for ACP3
- Novus Biologicals ELISA Kits for ACP3
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ACP3
- Abcam proteins for ACP3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for ACP3
- Taconic Biosciences Mouse Models for ACP3
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for ACP3 (AFLGC-ACP3)
- VectorBuilder Custom and pre-made DNA vectors for ACP3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ACP3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ACP3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ACP3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ACP3
- antibodies-online: Show 71 available ACPP Antibodies ranked by validation data
- Compare Top ACPP Antibodies
- Recommended
- 113 WB Antibodies (anti-human)
- 51 IHC (p) Antibodies (anti-human)
- 19 IHC (fro) Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 5 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IRMA Antibody (anti-human)
- 31 WB Antibodies (anti-mouse)
- 5 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 19 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 65 available ACPP Elisa Kits ranked by validation data
- Compare Top ACPP Elisa Kits
- Quality Products:
- ABIN1116723
- ABIN414438
- ABIN5519695
- ABIN414946
- ABIN1568126
- ABIN5519697
- ABIN5519696
- ABIN5591525
- ABIN512819
- ABIN996895
- ABIN1116721
- ABIN5519698
- ABIN627472
- ABIN367837
- ABIN6201097
- ABIN6201098
- ABIN6730056
- ABIN2538285
- ABIN456270
- ABIN1116722
- ABIN5519700
- ABIN5519701
- ABIN5591526
- ABIN626641
- ABIN6201099
- ABIN2950749
- ABIN368098
- ABIN956313
- ABIN5071502
- ABIN5519699
- ABIN774100
- ABIN1565900
- ABIN6227614
- ABIN368559
- antibodies-online: Show 26 available ACPP Proteins ranked by validation data
- Compare Top ACPP Proteins
- Search for ACP3 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for ACP3
- Horizon Cell Lines for ACP3
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACP3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACP3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ACP3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP3
Sources for ACP3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB