Aliases for ACP3 Gene
External Ids for ACP3 Gene
Previous HGNC Symbols for ACP3 Gene
This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
GeneCards Summary for ACP3 Gene
ACP3 (Acid Phosphatase 3) is a Protein Coding gene. Diseases associated with ACP3 include Prostatitis and Prostatic Hyperplasia, Benign. Among its related pathways are ATP/ITP metabolism and Innate Immune System. An important paralog of this gene is ACP2.
UniProtKB/Swiss-Prot Summary for ACP3 Gene
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.
[Isoform 2]: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.