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This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
ACP3 (Acid Phosphatase 3) is a Protein Coding gene. Diseases associated with ACP3 include Prostatitis and Prostatic Hyperplasia, Benign. Among its related pathways are ATP/ITP metabolism and Innate Immune System. An important paralog of this gene is ACP2.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03J132316 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +0.4 | 408 | 2.8 | PRDM10 ZHX2 FOXA1 PRDM1 ZNF341 ATF7 ZBTB20 TCF7L2 RFX1 ZXDB | ACP3 ENSG00000261167 CPNE4 HSALNG0029010 DNAJC13 | |
GH03J132289 | Enhancer | 0.7 | Ensembl ENCODE | 16.3 | -25.8 | -25812 | 5.3 | CREB1 ATF7 CEBPB ATF2 ZFHX2 SPI1 POLR2A JUND MYC MAX | ACP3 CPNE4 piR-56133-149 | |
GH03J132282 | Promoter/Enhancer | 1 | Ensembl ENCODE | 4.5 | -32.6 | -32636 | 3.5 | CTCF PRDM1 ZNF740 SP1 CEBPB USF1 GTF2A2 EP300 STAT1 SPI1 | CPNE4 ACP3 RPL7P16 SNODB764 MRPL3 | |
GH03J132324 | Enhancer | 0.3 | Ensembl | 14.7 | +8.4 | 8432 | 2 | HLF | ACP3 CPNE4 HSALNG0029010 DNAJC13 | |
GH03J132346 | Enhancer | 0.7 | Ensembl ENCODE | 4.7 | +29.6 | 29632 | 1.6 | SOX13 RFX1 CTBP1 FOXA2 FOXP1 DPF2 SPI1 FOXA1 ZBTB40 SOX5 | ACP3 HSALNG0029010 DNAJC13 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003993 | acid phosphatase activity | IMP | 8132635 |
GO:0005515 | protein binding | IPI | 9705354 |
GO:0008253 | 5'-nucleotidase activity | IEA,IDA | 18940592 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016791 | phosphatase activity | IMP | 18940592 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005615 | extracellular space | IMP | 22389722 |
GO:0005634 | nucleus | HDA | 21630459 |
GO:0005764 | lysosome | IEA | -- |
GO:0005765 | lysosomal membrane | IEA,HDA | 17897319 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
|
2 | ATP/ITP metabolism |
ATP/ITP metabolism
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006144 | purine nucleobase metabolic process | IEA | -- |
GO:0006772 | thiamine metabolic process | IEA,ISS | -- |
GO:0009117 | nucleotide metabolic process | IEA | -- |
GO:0016311 | dephosphorylation | IMP | 8132635 |
GO:0043312 | neutrophil degranulation | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Sipuleucel-T | Approved, Investigational | Pharma | Target, other | 0 | ||
Flavin Mononucleotide | Approved, Investigational | Pharma | 12 | |||
Phosphoric acid | Approved | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
Riboflavin | Approved, Investigational, Vet_approved | Nutra | 231 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ACPP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | ACPP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ACPP 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Acpp 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Acpp 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | ACPP 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ACPP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ACPP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ACPP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | acpp 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Acph-1 31 |
|
ManyToMany | |
CG9449 31 |
|
ManyToMany | |||
CG9451 31 |
|
ManyToMany | |||
CG9452 31 |
|
ManyToMany | |||
CG6656 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | pho-6 30 |
|
||
pho-14 31 |
|
ManyToMany | |||
pho-5 31 |
|
ManyToMany | |||
pho-12 31 |
|
ManyToMany | |||
pho-10 31 |
|
ManyToMany | |||
pho-1 31 |
|
ManyToMany | |||
F26C11.1 31 |
|
ManyToMany | |||
C27A2.12 31 |
|
ManyToMany | |||
pho-11 31 |
|
ManyToMany | |||
pho-13 31 |
|
ManyToMany | |||
pho-4 31 |
|
ManyToMany | |||
acp-1 31 |
|
ManyToMany | |||
acp-5 31 |
|
ManyToMany | |||
acp-3 31 |
|
ManyToMany | |||
acp-2 31 |
|
ManyToMany | |||
acp-4 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.11668 30 |
|
SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
714205 | Benign: not provided | 132,352,758(+) | T/G | MISSENSE_VARIANT | |
714983 | Benign: not provided | 132,332,272(+) | T/C | SYNONYMOUS_VARIANT | |
729506 | Likely Benign: not provided | 132,337,518(+) | A/G | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
740129 | Likely Benign: not provided | 132,328,263(+) | T/C | INTRON_VARIANT | |
rs864309497 | Uncertain Significance: Acute megakaryoblastic leukemia; Mediastinal germ cell tumor | 132,349,985(+) | CTCA/C | INFRAME_DELETION |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2762346 | CNV | loss | 21179565 |
esv3597825 | CNV | loss | 21293372 |
nsv478509 | CNV | novel sequence insertion | 20440878 |
nsv508245 | CNV | deletion | 20534489 |
nsv829728 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
prostatitis |
|
|
prostatic hyperplasia, benign |
|
|
atypical choroid plexus papilloma |
|
|
phosphatase, acid, of tissues |
|
|
clear cell adenocarcinoma |
|