Aliases for ACP2 Gene
Aliases for ACP2 Gene
External Ids for ACP2 Gene
- HGNC: 123
- Entrez Gene: 53
- Ensembl: ENSG00000134575
- OMIM: 171650
- UniProtKB: P11117
Previous GeneCards Identifiers for ACP2 Gene
- GC11M049200
- GC11M048138
- GC11M047292
- GC11M047225
- GC11M047218
- GC11M046959
- GC11M047260
- GC11M047358
- GC11M047942
- GC11M050794
- GC11M051589
- GC11M052251
- GC11M052911
- GC11M053579
- GC11M054245
Summaries for ACP2 Gene
-
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
GeneCards Summary for ACP2 Gene
ACP2 (Acid Phosphatase 2, Lysosomal) is a Protein Coding gene. Diseases associated with ACP2 include Acid Phosphatase Deficiency and Phosphatase, Acid, Of Tissues. Among its related pathways are Metabolism and Riboflavin metabolism. Gene Ontology (GO) annotations related to this gene include acid phosphatase activity. An important paralog of this gene is ACPP.
Additional gene information for ACP2 Gene
- Monarch Initiative
- Search for ACP2 at DataMed
- Search for ACP2 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACP2 Gene
Genomics for ACP2 Gene
GeneHancer (GH) Regulatory Elements for ACP2 Gene
Promoters and enhancers for ACP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ACP2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ACP2 gene promoter:
-
- HNF-4alpha2
- HNF-4alpha1
- COUP-TF1
- COUP-TF
- COUP
- GATA-2
- Nkx2-5
- MAZR
- NF-1
- NF-1/L
Regulatory Element Products
Genomic Locations for ACP2 Gene
Genomic Locations for ACP2 Gene
- chr11:47,239,302-47,248,906
- (GRCh38/hg38)
- Size:
- 9,605 bases
- Orientation:
- Minus strand
- chr11:47,260,853-47,270,457
- (GRCh37/hg19)
- Size:
- 9,605 bases
- Orientation:
- Minus strand
Genomic View for ACP2 Gene
Genes around ACP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2|11p12-p11 by Entrez Gene
- 11p11.2 by HGNC
- 11p11.2 by Ensembl
ACP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACP2 Gene
Proteins for ACP2 Gene
-
Protein details for ACP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P11117-PPAL_HUMAN
- Recommended name:
- Lysosomal acid phosphatase
- Protein Accession:
- P11117
- E9PCI1
- Q561W5
- Q9BTU7
Protein attributes for ACP2 Gene
- Size:
- 423 amino acids
- Molecular mass:
- 48344 Da
- Quaternary structure:
- No Data Available
Protein Expression for ACP2 Gene
Post-translational modifications for ACP2 Gene
- The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen.
- N-glycosylated. The intermediates formed during enzymatic deglycosylation suggest that all eight predicted N-glycosylation sites are used.
- Glycosylation at posLast=331331, Asn322, posLast=267267, Asn191, Asn177, Asn167, posLast=133133, and posLast=9292
- Modification sites at PhosphoSitePlus
Other Protein References for ACP2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACP2
- Novus Biologicals Antibodies for ACP2
- Invitrogen Antibodies for ACP2 (AFLGC-ACP2)
- GeneTex ACP2 Antibody for ACP2
-
Biorbyt antibodies for ACP2
-
Boster Bio Antibodies for ACP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ACP2
Protein Products
-
OriGene Purified Proteins for ACP2
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- antibodies-online: Search results for 8 available ACP2 Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for ACP2
Assay Products
- antibodies-online: Search results for 14 available ACP2 Elisa Kits ranked by validation data
- Compare Top ACP2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ACP2 Gene
Domains & Families for ACP2 Gene
Gene Families for ACP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for ACP2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACP2 Gene
Graphical View of Domain Structure for InterPro Entry
P11117- Family:
-
- Belongs to the histidine acid phosphatase family.
Function for ACP2 Gene
Molecular function for ACP2 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- A phosphate monoester + H(2)O = an alcohol + phosphate.
- GENATLAS Biochemistry:
- phosphatase acid,lysosomal
Enzyme Numbers (IUBMB) for ACP2 Gene
Phenotypes From GWAS Catalog for ACP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003993 | acid phosphatase activity | TAS,IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for ACP2 Gene
- MGI mutant phenotypes for ACP2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for ACP2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACP2
-
CRISPR Products
-
OriGene CRISPR knockouts for ACP2
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- Overview of 108 available ACP2 gene related products
- Applied Biological Materials CRISPR for ACP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACP2
- GenScript: Design CRISPR guide RNA sequences for ACP2
miRNA for ACP2 Gene
- miRTarBase miRNAs that target ACP2
miRNA Products
Inhibitory RNA Products
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- Overview of 108 available ACP2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ACP2
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- Applied Biological Materials Clones for ACP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ACP2
No data available for Transcription Factor Targets and HOMER Transcription for ACP2 Gene
Localization for ACP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ACP2 Gene
- Lysosome membrane; Single-pass membrane protein; Lumenal side. Lysosome lumen. Note=The soluble form arises by proteolytic processing of the membrane-bound form. {ECO:0000269 PubMed:2684640, ECO:0000269 PubMed:3056714}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 5 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| golgi apparatus | 2 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005764 | lysosome | IDA | 3160696 |
| GO:0005765 | lysosomal membrane | IEA | -- |
| GO:0016020 | membrane | HDA,IEA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0043202 | lysosomal lumen | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACP2 Gene
Pathways & Interactions for ACP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Lysosome |
-
|
|
| 2 | Metabolism | ||
| 3 | Riboflavin metabolism | ||
| 4 | Pyrimidine metabolism (KEGG) | ||
Pathways by source for ACP2 Gene
3 KEGG pathways for ACP2 Gene
1 GeneGo (Thomson Reuters) pathway for ACP2 Gene
Interacting Proteins for ACP2 Gene
GPS-Prot Interaction Network for ACP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0007040 | lysosome organization | IEA | -- |
| GO:0016311 | dephosphorylation | IEA | -- |
No data available for SIGNOR curated interactions for ACP2 Gene
Drugs & Compounds for ACP2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-Hexanol |
|
111-27-3 |
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| Isobutanol |
|
78-83-1 |
|
|||
| Phosphate |
|
14265-44-2 |
|
Drug Products
Transcripts for ACP2 Gene
mRNA/cDNA for ACP2 Gene
- (7) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (293) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000529788 570 bps (uc058bcf.1)
- ENST00000444355 640 bps (uc010rhj.3)
- ENST00000530453 826 bps (uc058bce.1)
- ENST00000524769 727 bps (uc058bcd.1)
- ENST00000529663 967 bps (uc058bcc.1)
Unigene Clusters for ACP2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ACP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACP2
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- Overview of 108 available ACP2 gene related products
- Applied Biological Materials CRISPR for ACP2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACP2
- GenScript: Design CRISPR guide RNA sequences for ACP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACP2
- Browse OriGene Inhibitory RNA Products For ACP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP2
- genomics-online: shRNA clones - Search results for 108 available ACP2 gene related products
- Overview of 108 available ACP2 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ACP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACP2
- Applied Biological Materials Clones for ACP2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for ACP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
This gene is overexpressed in Urine (23.7) and Nasal epithelium (13.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACP2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ACP2 Gene:
ACP2SOURCE GeneReport for Unigene cluster for ACP2 Gene:
Hs.532492Evidence on tissue expression from TISSUES for ACP2 Gene
- Nervous system(5)
- Kidney(4.8)
- Liver(4.7)
- Blood(4.6)
- Lung(2.9)
- Intestine(2.6)
- Spleen(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ACP2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- nervous
- skeletal muscle
Regions:
Head and neck:
- brain
- head
Thorax:
- esophagus
Abdomen:
- stomach
General:
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
Primer Products
-
OriGene qPCR primer pairs for ACP2
-
OriGene qPCR primer pairs and template standards for ACP2
- genomics-online: primer clones - Search results for 108 available ACP2 gene related products
- Overview of 108 available ACP2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ACP2 Gene
Orthologs for ACP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACP2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ACP2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ACP2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Acp2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Acp2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ACP2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACP2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ACP2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ACP2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | acp2 33 |
|
||
| Str.3282 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | acp2 33 |
|
||
| ACP2 34 |
|
OneToOne | |||
| Dr.25243 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Acph-1 34 35 33 |
|
ManyToMany | |
| CG9449 34 35 |
|
ManyToMany | |||
| CG9451 34 35 |
|
ManyToMany | |||
| CG6656 34 35 |
|
ManyToMany | |||
| CG9452 34 35 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002387 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pho-5 34 33 |
|
ManyToMany | |
| T13B5.3 35 |
|
|
|||
| R13H4.3 35 |
|
|
|||
| T21B6.2 35 |
|
|
|||
| F52E1.8 35 |
|
|
|||
| B0361.7 35 |
|
|
|||
| pho-14 34 |
|
ManyToMany | |||
| pho-12 34 |
|
ManyToMany | |||
| pho-10 34 |
|
ManyToMany | |||
| acp-5 34 |
|
ManyToMany | |||
| pho-4 34 |
|
ManyToMany | |||
| pho-1 34 |
|
ManyToMany | |||
| pho-13 34 |
|
ManyToMany | |||
| F26C11.1 34 |
|
ManyToMany | |||
| pho-11 34 |
|
ManyToMany | |||
| C27A2.12 34 |
|
ManyToMany | |||
| acp-1 34 |
|
ManyToMany | |||
| acp-3 34 |
|
ManyToMany | |||
| acp-4 34 |
|
ManyToMany | |||
| acp-2 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ACP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ACP2 Gene
- ENSEMBL:
- Gene Tree for ACP2 (if available)
- TreeFam:
- Gene Tree for ACP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ACP2: view image
Paralogs for ACP2 Gene
Variants for ACP2 Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1050244 | likely-benign, Xeroderma pigmentosum | 47,238,926(-) | C/T | downstream_transcript_variant | |
| rs4647760 | uncertain-significance, Xeroderma pigmentosum | 47,239,000(-) | C/A | downstream_transcript_variant | |
| rs4647761 | uncertain-significance, Xeroderma pigmentosum | 47,239,182(-) | CAC/C | downstream_transcript_variant | |
| rs554676341 | uncertain-significance, Xeroderma pigmentosum | 47,238,975(-) | T/C | downstream_transcript_variant | |
| rs1000214685 | -- | 47,250,638(-) | A/C | upstream_transcript_variant |
Residual Variation Intolerance Score:
34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.87;
34.98% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ACP2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ACP2 Gene
Disorders for ACP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acid phosphatase deficiency |
|
|
| phosphatase, acid, of tissues |
|
|
| atrichia with papular lesions |
|
|
| keratoconus |
|
Search ACP2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PPAL_HUMAN- Note=Lysosomal acid phosphatase has been shown to be deficient in cultured fibroblasts from patients manifesting intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding and death in early infancy. {ECO:0000269 PubMed:5410815}.
Genatlas disease for ACP2 Gene
phosphatase acid,deficiency
Additional Disease Information for ACP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for ACP2 Gene
- Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 44 58
- Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms. (PMID: 17357082) Melquist S … Stephan DA (American journal of human genetics 2007) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomes. (PMID: 11801736) Obermüller S … Höning S (Journal of cell science 2002) 3 22 58
- Sequential processing of lysosomal acid phosphatase by a cytoplasmic thiol proteinase and a lysosomal aspartyl proteinase. (PMID: 2684640) Gottschalk S … von Figura K (The EMBO journal 1989) 3 4 58
Products for ACP2 Gene
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- genomics-online: primer clones - Search results for 108 available ACP2 gene related products
- Overview of 108 available ACP2 gene related products
- genomics-online: shRNA clones - Search results for 108 available ACP2 gene related products
- Overview of 108 available ACP2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACP2
- GeneCopoeia miRNA 3'UTR Target clone products for ACP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACP2
- Boster Bio Antibodies for ACP2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for ACP2
Sources for ACP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt