Aliases for ACP1 Gene
External Ids for ACP1 Gene
Previous GeneCards Identifiers for ACP1 Gene
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]
GeneCards Summary for ACP1 Gene
ACP1 (Acid Phosphatase 1) is a Protein Coding gene. Diseases associated with ACP1 include Pharyngeal-Cervical-Brachial Variant Of Guillain-Barre Syndrome and Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency. Among its related pathways are Adherens junction and EPHA2 forward signaling. Gene Ontology (GO) annotations related to this gene include phosphatase activity and acid phosphatase activity. An important paralog of this gene is PTRHD1.
UniProtKB/Swiss-Prot Summary for ACP1 Gene
Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.