Aliases for ACOXL Gene

Aliases for ACOXL Gene

  • Acyl-CoA Oxidase Like 2 3 5
  • Acyl-Coenzyme A Oxidase-Like Protein 3 4
  • Acyl-CoA Oxidase-Like Protein 3 4
  • Acyl-Coenzyme A Oxidase-Like 2
  • EC 1.3.3.- 4

External Ids for ACOXL Gene

Previous GeneCards Identifiers for ACOXL Gene

  • GC02P111586
  • GC02P111206
  • GC02P104369
  • GC02P111587
  • GC02P111729
  • GC02P112074
  • GC02P112268
  • GC02P112536

Summaries for ACOXL Gene

GeneCards Summary for ACOXL Gene

ACOXL (Acyl-CoA Oxidase Like) is a Protein Coding gene. Among its related pathways are Peroxisomal lipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include flavin adenine dinucleotide binding and acyl-CoA dehydrogenase activity. An important paralog of this gene is ACOX3.

Additional gene information for ACOXL Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACOXL Gene

Genomics for ACOXL Gene

GeneHancer (GH) Regulatory Elements for ACOXL Gene

Promoters and enhancers for ACOXL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J110732 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 750.6 +0.8 773 2.6 PRDM1 KLF14 IKZF1 GLIS2 RNF2 ZBTB8A PRDM10 CTBP1 LARP7 PATZ1 ACOXL lnc-BUB1-4 MTLN ENSG00000184115 ENSG00000186148 piR-48010
GH02J110673 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -55.5 -55547 6.5 ZBTB40 SP1 RBPJ SMARCE1 POLR2A HDAC2 FOS HCFC1 ZNF362 MYC BUB1 AB372698 LOC105373554 lnc-ACOXL-3 piR-39765 piR-40555 piR-43941 piR-44027 piR-58918 piR-56423
GH02J110768 Enhancer 0.8 Ensembl 11.6 +36.2 36162 1 MLX NR2F1 ATF1 NR2F6 CREB1 MIXL1 RERE ELF3 TFE3 SP5 ACOXL ENSG00000184115 piR-48010
GH02J110687 Enhancer 0.8 FANTOM5 ENCODE 11.6 -44.2 -44247 2.6 POU5F1 SP1 IKZF1 ZIC2 SOX6 ETS1 SIN3A BACH1 NANOG RF02002-024 piR-38969 piR-39056 piR-31137 piR-39359 piR-42795 piR-36747 piR-33447 piR-33802 piR-37858
GH02J110706 Enhancer 0.6 Ensembl 12.7 -23.8 -23838 4.2 ZNF121 RNF2 ZNF512 FOXK2 TRIM24 CREB1 BCOR CEBPG CEBPB ATF2 ACOXL MTLN ENSG00000184115 piR-38284 piR-41531 ENSG00000235881
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACOXL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACOXL gene promoter:
  • E2F
  • E2F-1
  • FOXD3
  • FOXO3
  • FOXO3a
  • FOXO3b
  • Pax-5

Genomic Locations for ACOXL Gene

Genomic Locations for ACOXL Gene
388,072 bases
Plus strand
385,650 bases
Plus strand

Genomic View for ACOXL Gene

Genes around ACOXL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOXL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOXL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOXL Gene

Proteins for ACOXL Gene

  • Protein details for ACOXL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A oxidase-like protein
    Protein Accession:
    Secondary Accessions:
    • A2RRB7
    • B7WPB3
    • B7WPP7
    • E9PB20
    • Q53R27
    • Q53R31
    • Q53SC6
    • Q8TCE7

    Protein attributes for ACOXL Gene

    547 amino acids
    Molecular mass:
    61795 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    • Sequence=AAH22268.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAA91970.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ACOXL Gene


neXtProt entry for ACOXL Gene

Post-translational modifications for ACOXL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACOXL Gene

Domains & Families for ACOXL Gene

Gene Families for ACOXL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACOXL Gene

GenScript: Design optimal peptide antigens:
  • Acyl-coenzyme A oxidase-like protein (ACOXL_HUMAN)
  • Acyl-coenzyme A oxidase (E9PB20_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the acyl-CoA oxidase family.
  • Belongs to the acyl-CoA oxidase family.
genes like me logo Genes that share domains with ACOXL: view

Function for ACOXL Gene

Enzyme Numbers (IUBMB) for ACOXL Gene

Phenotypes From GWAS Catalog for ACOXL Gene

Gene Ontology (GO) - Molecular Function for ACOXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003997 acyl-CoA oxidase activity IBA,IEA 21873635
GO:0005504 fatty acid binding IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
genes like me logo Genes that share ontologies with ACOXL: view
genes like me logo Genes that share phenotypes with ACOXL: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACOXL Gene

Localization for ACOXL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOXL gene
Compartment Confidence
peroxisome 5
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACOXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005777 peroxisome IBA,IEA 21873635
GO:0005782 peroxisomal matrix TAS --
genes like me logo Genes that share ontologies with ACOXL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ACOXL Gene

Pathways & Interactions for ACOXL Gene

genes like me logo Genes that share pathways with ACOXL: view

Pathways by source for ACOXL Gene

Interacting Proteins for ACOXL Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000407761 Q9NUZ1-ACOXL_HUMAN for ACOXL Gene via STRING IID

Gene Ontology (GO) - Biological Process for ACOXL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IEA --
GO:0006635 fatty acid beta-oxidation IEA --
GO:0008150 biological_process ND --
GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase TAS,IBA --
GO:0055088 lipid homeostasis IBA 21873635
genes like me logo Genes that share ontologies with ACOXL: view

No data available for SIGNOR curated interactions for ACOXL Gene

Drugs & Compounds for ACOXL Gene

(3) Drugs for ACOXL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(30) Additional Compounds for ACOXL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
genes like me logo Genes that share compounds with ACOXL: view

Transcripts for ACOXL Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOXL Gene

No ASD Table

Relevant External Links for ACOXL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOXL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACOXL Gene

mRNA differential expression in normal tissues according to GTEx for ACOXL Gene

This gene is overexpressed in Lung (x10.2), Bladder (x9.8), Testis (x5.9), and Prostate (x4.4).

Protein differential expression in normal tissues from HIPED for ACOXL Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACOXL Gene

Protein tissue co-expression partners for ACOXL Gene

NURSA nuclear receptor signaling pathways regulating expression of ACOXL Gene:


SOURCE GeneReport for Unigene cluster for ACOXL Gene:

genes like me logo Genes that share expression patterns with ACOXL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOXL Gene

Orthologs for ACOXL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOXL Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ACOXL 33 32
  • 89.71 (n)
(Bos Taurus)
Mammalia ACOXL 33 32
  • 86.15 (n)
(Mus musculus)
Mammalia Acoxl 17 33 32
  • 80.72 (n)
(Rattus norvegicus)
Mammalia Acoxl 32
  • 80.37 (n)
(Monodelphis domestica)
Mammalia ACOXL 33
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ACOXL 33
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acoxl 32
  • 70.97 (n)
(Danio rerio)
Actinopterygii acoxl 33 32
  • 64.82 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POX1 33
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ACX2 32
  • 46.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6640 33
  • 27 (a)
-- 33
  • 18 (a)
-- 33
  • 9 (a)
Species where no ortholog for ACOXL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOXL Gene

Gene Tree for ACOXL (if available)
Gene Tree for ACOXL (if available)
Evolutionary constrained regions (ECRs) for ACOXL: view image

Paralogs for ACOXL Gene

(2) SIMAP similar genes for ACOXL Gene using alignment to 5 proteins:

  • H7C0A6_HUMAN
  • H7C2M3_HUMAN
  • H7C345_HUMAN
genes like me logo Genes that share paralogs with ACOXL: view

Variants for ACOXL Gene

Sequence variations from dbSNP and Humsavar for ACOXL Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000011218 -- 111,019,897(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000011771 -- 111,100,043(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000013537 -- 111,036,268(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000017590 -- 111,099,129(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000017799 -- 110,876,546(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACOXL Gene

Variant ID Type Subtype PubMed ID
dgv1994n106 CNV deletion 24896259
dgv4047n100 CNV loss 25217958
dgv4048n100 CNV loss 25217958
dgv730e214 CNV gain 21293372
esv2658917 CNV deletion 23128226
esv2666908 CNV deletion 23128226
esv2720513 CNV deletion 23290073
esv2720514 CNV deletion 23290073
esv2720515 CNV deletion 23290073
esv2762272 CNV loss 21179565
esv3303240 CNV mobile element insertion 20981092
esv3309159 CNV mobile element insertion 20981092
esv3428994 CNV insertion 20981092
esv3559939 CNV deletion 23714750
esv3584011 CNV loss 25503493
esv3591965 CNV gain 21293372
esv3591969 CNV insertion 21293372
esv3591970 CNV loss 21293372
esv3591972 CNV loss 21293372
esv3591974 CNV loss 21293372
esv3591977 CNV loss 21293372
esv7277 CNV loss 19470904
nsv1148884 CNV deletion 26484159
nsv1149522 OTHER inversion 26484159
nsv521956 CNV loss 19592680
nsv582699 CNV loss 21841781
nsv819214 CNV loss 19587683
nsv819716 CNV gain 19587683
nsv829618 CNV gain 20364138
nsv834330 CNV gain 17160897
nsv834331 CNV loss 17160897
nsv955063 CNV deletion 24416366
nsv963699 CNV duplication 23825009

Variation tolerance for ACOXL Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.27; 92.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOXL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOXL Gene

Disorders for ACOXL Gene

Additional Disease Information for ACOXL

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ACOXL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOXL Gene

Publications for ACOXL Gene

  1. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 43 56
  2. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PMID: 21738478) Okada Y … Kamatani N (PLoS genetics 2011) 3 43 56
  3. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PMID: 22197929) Yu XQ … Liu JJ (Nature genetics 2011) 3 43 56
  4. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong. (PMID: 20731705) Lan Q … Rothman N (European journal of haematology 2010) 3 43 56
  5. Genetic susceptibility variants for chronic lymphocytic leukemia. (PMID: 20332261) Slager SL … Cerhan JR (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 43 56

Products for ACOXL Gene

Sources for ACOXL Gene