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Aliases for ACOX3 Gene

Aliases for ACOX3 Gene

  • Acyl-CoA Oxidase 3, Pristanoyl 2 3 5
  • Acyl-Coenzyme A Oxidase 3, Pristanoyl 2 3
  • Branched-Chain Acyl-CoA Oxidase 3 4
  • Pristanoyl-CoA Oxidase 3 4
  • BRCACox 3 4
  • Peroxisomal Acyl-Coenzyme A Oxidase 3 3
  • EC 1.3.3.6 4
  • BRCOX 4
  • PRCOX 4

External Ids for ACOX3 Gene

Previous GeneCards Identifiers for ACOX3 Gene

  • GC04M008343
  • GC04M008549
  • GC04M008561
  • GC04M008486
  • GC04M008368
  • GC04M008287

Summaries for ACOX3 Gene

Entrez Gene Summary for ACOX3 Gene

  • Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACOX3 Gene

ACOX3 (Acyl-CoA Oxidase 3, Pristanoyl) is a Protein Coding gene. Among its related pathways are Metabolism and Peroxisomal lipid metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is ACOX1.

UniProtKB/Swiss-Prot for ACOX3 Gene

  • Oxidizes the CoA-esters of 2-methyl-branched fatty acids.

Gene Wiki entry for ACOX3 Gene

Additional gene information for ACOX3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOX3 Gene

Genomics for ACOX3 Gene

GeneHancer (GH) Regulatory Elements for ACOX3 Gene

Promoters and enhancers for ACOX3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J008438 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.5 466 3.7 PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 TRMT44 ACOX3 ENSG00000251615 LOC105374376
GH04J008427 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.4 +12.5 12525 2.1 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 SP3 SP5 ACOX3 TRMT44 ENSG00000251186 GMPSP1 SH3TC1 ENSG00000251615 PIR46187
GH04J008410 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.4 +29.8 29794 0.9 HDGF HDAC1 PKNOX1 RAD21 ZNF335 ZNF143 ATF7 EGR2 SMARCA5 ZNF654 ACOX3 TRMT44 ENSG00000251186 SH3TC1 GMPSP1 PIR46187
GH04J008402 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.4 +37.9 37861 1.6 CTCF RB1 MAX ZNF2 RAD21 CC2D1A ZNF316 POLR2A ZNF143 SMC3 TRMT44 ENSG00000205959 HTRA3 ACOX3 GMPSP1 SH3TC1 ENSG00000251615 PIR46187 PIR54498
GH04J008408 Enhancer 0.8 ENCODE dbSUPER 11.4 +31.3 31254 1.5 KLF1 SP3 SP2 KLF14 ZIC2 ZFHX2 VEZF1 PRDM10 EGR2 TRMT44 ACOX3 ENSG00000251186 SH3TC1 GMPSP1 ENSG00000205959 PIR46187
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACOX3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACOX3 gene promoter:
  • TFIID
  • TBP
  • HNF-3beta
  • XBP-1
  • deltaCREB
  • CREB
  • COMP1
  • RFX1
  • Pax-2
  • Pax-2a

Genomic Locations for ACOX3 Gene

Genomic Locations for ACOX3 Gene
chr4:8,366,263-8,440,725
(GRCh38/hg38)
Size:
74,463 bases
Orientation:
Minus strand
chr4:8,368,009-8,442,452
(GRCh37/hg19)
Size:
74,444 bases
Orientation:
Minus strand

Genomic View for ACOX3 Gene

Genes around ACOX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOX3 Gene

Proteins for ACOX3 Gene

  • Protein details for ACOX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15254-ACOX3_HUMAN
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 3
    Protein Accession:
    O15254
    Secondary Accessions:
    • Q96AJ8

    Protein attributes for ACOX3 Gene

    Size:
    700 amino acids
    Molecular mass:
    77629 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ACOX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOX3 Gene

Post-translational modifications for ACOX3 Gene

  • Ubiquitination at posLast=291291 and posLast=265265
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACOX3 Gene

Domains & Families for ACOX3 Gene

Gene Families for ACOX3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACOX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15254

UniProtKB/Swiss-Prot:

ACOX3_HUMAN :
  • Belongs to the acyl-CoA oxidase family.
Family:
  • Belongs to the acyl-CoA oxidase family.
genes like me logo Genes that share domains with ACOX3: view

Function for ACOX3 Gene

Molecular function for ACOX3 Gene

UniProtKB/Swiss-Prot Function:
Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
GENATLAS Biochemistry:
branched-chain acyl-CoA oxidase 3,peroxisomal,acting on the CoA-esters of pristanic acid and straight chain mono-and dicarboxy fatty acids,expression below detection limit in man,extremely weakly expressed in liver,may be expressed under special conditions and tissues so far not examined

Enzyme Numbers (IUBMB) for ACOX3 Gene

Phenotypes From GWAS Catalog for ACOX3 Gene

Gene Ontology (GO) - Molecular Function for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003995 acyl-CoA dehydrogenase activity IBA --
GO:0003997 acyl-CoA oxidase activity IEA --
GO:0005102 signaling receptor binding IPI 20178365
GO:0016402 pristanoyl-CoA oxidase activity TAS --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ACOX3: view
genes like me logo Genes that share phenotypes with ACOX3: view

Animal Model Products

miRNA for ACOX3 Gene

miRTarBase miRNAs that target ACOX3

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOX3 Gene

Localization for ACOX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOX3 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOX3 gene
Compartment Confidence
peroxisome 5
mitochondrion 3
nucleus 2
cytosol 2
plasma membrane 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005777 peroxisome IDA 8993592
GO:0005782 peroxisomal matrix TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with ACOX3: view

Pathways & Interactions for ACOX3 Gene

genes like me logo Genes that share pathways with ACOX3: view

UniProtKB/Swiss-Prot O15254-ACOX3_HUMAN

  • Pathway: Lipid metabolism; peroxisomal fatty acid beta-oxidation.

Gene Ontology (GO) - Biological Process for ACOX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006635 fatty acid beta-oxidation IEA --
GO:0008152 metabolic process IEA --
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA --
genes like me logo Genes that share ontologies with ACOX3: view

No data available for SIGNOR curated interactions for ACOX3 Gene

Drugs & Compounds for ACOX3 Gene

(7) Drugs for ACOX3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Hydrogen peroxide Approved, Vet_approved Pharma 73
Oxygen Approved, Vet_approved Pharma 0
Hexanoyl-CoA Experimental Pharma 0
myristoyl-coa Experimental Pharma 0

(49) Additional Compounds for ACOX3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with ACOX3: view

Transcripts for ACOX3 Gene

Unigene Clusters for ACOX3 Gene

Acyl-CoA oxidase 3, pristanoyl:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - -
SP2: - - - - - - -
SP3:
SP4: -
SP5: - -
SP6: -
SP7:
SP8:

ExUns: 21b · 21c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ACOX3 Gene

GeneLoc Exon Structure for
ACOX3
ECgene alternative splicing isoforms for
ACOX3

Expression for ACOX3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACOX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACOX3 Gene

This gene is overexpressed in Cervix (18.9), Breast (14.2), and Bone (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACOX3 Gene



Protein tissue co-expression partners for ACOX3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACOX3 Gene:

ACOX3

SOURCE GeneReport for Unigene cluster for ACOX3 Gene:

Hs.479122

Evidence on tissue expression from TISSUES for ACOX3 Gene

  • Liver(4.5)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ACOX3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOX3 Gene

Orthologs for ACOX3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOX3 34 33
  • 99.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ACOX3 34 33
  • 79.14 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACOX3 34 33
  • 78.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Acox3 16 34 33
  • 76.19 (n)
rat
(Rattus norvegicus)
Mammalia Acox3 33
  • 76.14 (n)
oppossum
(Monodelphis domestica)
Mammalia ACOX3 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACOX3 34 33
  • 65.41 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ACOX3 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia acox3 33
  • 66.33 (n)
zebrafish
(Danio rerio)
Actinopterygii acox3 34 33
  • 65.46 (n)
OneToOne
wufj81d02 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4390 33
fruit fly
(Drosophila melanogaster)
Insecta CG9527 34 35 33
  • 52.27 (n)
OneToMany
CG17544 34 35
  • 43 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007958 33
  • 50.97 (n)
worm
(Caenorhabditis elegans)
Secernentea F58F9.7 34 35 33
  • 47.73 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POX1 34
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACX6 33
  • 46.69 (n)
rice
(Oryza sativa)
Liliopsida Os06g0354500 33
  • 46.25 (n)
Species where no ortholog for ACOX3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ACOX3 Gene

ENSEMBL:
Gene Tree for ACOX3 (if available)
TreeFam:
Gene Tree for ACOX3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACOX3: view image

Paralogs for ACOX3 Gene

Paralogs for ACOX3 Gene

(3) SIMAP similar genes for ACOX3 Gene using alignment to 2 proteins:

  • ACOX3_HUMAN
  • D6RJ89_HUMAN
genes like me logo Genes that share paralogs with ACOX3: view

Variants for ACOX3 Gene

Sequence variations from dbSNP and Humsavar for ACOX3 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000027635 -- 8,384,550(-) T/C intron_variant, non_coding_transcript_variant
rs1000049077 -- 8,377,116(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000159529 -- 8,411,868(-) C/G intron_variant
rs1000164101 -- 8,429,063(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000183891 -- 8,436,323(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ACOX3 Gene

Variant ID Type Subtype PubMed ID
nsv593637 CNV loss 21841781
nsv593638 CNV loss 21841781
nsv593639 CNV loss 21841781
nsv829854 CNV gain+loss 17160897
nsv964028 CNV duplication 23825009
nsv526508 CNV loss 19592680
nsv524994 CNV loss 19592680
nsv473112 CNV novel sequence insertion 20440878
nsv470014 CNV loss 18288195
nsv470013 CNV gain 18288195
nsv461220 CNV loss 19166990
nsv4223 CNV insertion 18451855
nsv1009011 CNV loss 25217958
nsv1005698 CNV gain 25217958
nsv1002794 CNV gain 25217958
esv3599545 CNV loss 21293372
esv3563378 CNV deletion 23714750
esv34196 OTHER inversion 12058347
esv3046818 CNV deletion 24192839
esv2727114 CNV deletion 23290073
esv2727113 CNV deletion 23290073
esv2676067 CNV deletion 23128226
esv2148081 CNV deletion 18987734
esv1516082 CNV deletion 17803354
esv1005399 CNV deletion 20482838

Variation tolerance for ACOX3 Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.75; 57.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOX3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOX3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOX3 Gene

Disorders for ACOX3 Gene

Additional Disease Information for ACOX3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ACOX3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOX3 Gene

Publications for ACOX3 Gene

  1. Evidence for the existence of a pristanoyl-CoA oxidase gene in man. (PMID: 9271077) Vanhooren JC … Van Veldhoven PP (The Biochemical journal 1997) 2 3 4 22 58
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. (PMID: 15599942) Zha S … Isaacs WB (The Prostate 2005) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ACOX3 Gene

Sources for ACOX3 Gene

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