The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitiv... See more...

Aliases for ACOX2 Gene

Aliases for ACOX2 Gene

  • Acyl-CoA Oxidase 2 2 3 5
  • 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA 24-Hydroxylase 2 3 4
  • Trihydroxycoprostanoyl-CoA Oxidase 2 3 4
  • THCCox 2 3 4
  • 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA Oxidase 3 4
  • Acyl-Coenzyme A Oxidase 2, Branched Chain 2 3
  • Peroxisomal Acyl-Coenzyme A Oxidase 2 3 4
  • Acyl-CoA Oxidase 2, Branched Chain 2 3
  • Branched Chain Acyl-CoA Oxidase 2 3
  • THCA-CoA Oxidase 3 4
  • BRCACOX 2 3
  • BRCOX 2 3
  • Peroxisomal Branched Chain Acyl-CoA Oxidase 3
  • EC 1.17.99.3 4
  • CBAS6 3
  • ACOX2 5
  • BCOX 3

External Ids for ACOX2 Gene

Previous GeneCards Identifiers for ACOX2 Gene

  • GC03M057354
  • GC03M057859
  • GC03M058345
  • GC03M058448
  • GC03M058465

Summaries for ACOX2 Gene

Entrez Gene Summary for ACOX2 Gene

  • The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009]

GeneCards Summary for ACOX2 Gene

ACOX2 (Acyl-CoA Oxidase 2) is a Protein Coding gene. Diseases associated with ACOX2 include Bile Acid Synthesis Defect, Congenital, 6 and Congenital Bile Acid Synthesis Defect. Among its related pathways are Synthesis of bile acids and bile salts and Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is ACOX1.

UniProtKB/Swiss-Prot Summary for ACOX2 Gene

  • Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (PubMed:27884763). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity).

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACOX2 Gene

Genomics for ACOX2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ACOX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACOX2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACOX2

Top Transcription factor binding sites by QIAGEN in the ACOX2 gene promoter:
  • c-Ets-1
  • C/EBPalpha
  • Olf-1
  • Pax-2
  • Pax-2a
  • Pax-2b
  • RFX1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for ACOX2 Gene

Genomic Locations for ACOX2 Gene
chr3:58,505,136-58,537,283
(GRCh38/hg38)
Size:
32,148 bases
Orientation:
Minus strand
chr3:58,490,863-58,523,046
(GRCh37/hg19)
Size:
32,184 bases
Orientation:
Minus strand

Genomic View for ACOX2 Gene

Genes around ACOX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOX2 Gene

Proteins for ACOX2 Gene

  • Protein details for ACOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99424-ACOX2_HUMAN
    Recommended name:
    Peroxisomal acyl-coenzyme A oxidase 2
    Protein Accession:
    Q99424
    Secondary Accessions:
    • A6NF16
    • B2R8U5

    Protein attributes for ACOX2 Gene

    Size:
    681 amino acids
    Molecular mass:
    76827 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.

neXtProt entry for ACOX2 Gene

Post-translational modifications for ACOX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ACOX2 Gene

Domains & Families for ACOX2 Gene

Gene Families for ACOX2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACOX2 Gene

GenScript: Design optimal peptide antigens:
  • Trihydroxycoprostanoyl-CoA oxidase (ACOX2_HUMAN)
  • cDNA FLJ58373, highly similar to Acyl-coenzyme A oxidase 2, peroxisomal (EC 1.17.99.3) (B4DPM1_HUMAN)
  • Acyl-coenzyme A oxidase (C9J0G0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99424

UniProtKB/Swiss-Prot:

ACOX2_HUMAN :
  • Belongs to the acyl-CoA oxidase family.
Family:
  • Belongs to the acyl-CoA oxidase family.
genes like me logo Genes that share domains with ACOX2: view

Function for ACOX2 Gene

Molecular function for ACOX2 Gene

UniProtKB/Swiss-Prot Function:
Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (PubMed:27884763). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2; Xref=Rhea:RHEA:15733, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377, ChEBI:CHEBI:17499, ChEBI:CHEBI:58677, ChEBI:CHEBI:59807; EC=1.17.99.3; Evidence={ECO:0000269|PubMed:27884763};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + O2 = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O2; Xref=Rhea:RHEA:46728, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240, ChEBI:CHEBI:59879, ChEBI:CHEBI:77251; Evidence={ECO:0000250|UniProtKB:O02767};.
GENATLAS Biochemistry:
peroxisomal acyl-CoA oxidase,acting on the CoA-esters of bile acid intermediates and pristanic acid ,expressed in liver and extrahepatic tissues,about null activity in the Zellweger cerebrohepatorenal syndrome

Enzyme Numbers (IUBMB) for ACOX2 Gene

Phenotypes From GWAS Catalog for ACOX2 Gene

Gene Ontology (GO) - Molecular Function for ACOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003997 acyl-CoA oxidase activity IEA,IBA 21873635
GO:0005504 fatty acid binding IBA 21873635
GO:0016401 palmitoyl-CoA oxidase activity IBA 21873635
GO:0016491 oxidoreductase activity IEA --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
genes like me logo Genes that share ontologies with ACOX2: view
genes like me logo Genes that share phenotypes with ACOX2: view

Human Phenotype Ontology for ACOX2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for ACOX2

CRISPR Products

miRNA for ACOX2 Gene

miRTarBase miRNAs that target ACOX2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOX2

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ACOX2 Gene

Localization for ACOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOX2 Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOX2 gene
Compartment Confidence
peroxisome 5
cytosol 5
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome IEA,ISS --
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with ACOX2: view

Pathways & Interactions for ACOX2 Gene

genes like me logo Genes that share pathways with ACOX2: view

Gene Ontology (GO) - Biological Process for ACOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IBA 21873635
GO:0006625 protein targeting to peroxisome TAS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006635 fatty acid beta-oxidation IEA --
genes like me logo Genes that share ontologies with ACOX2: view

No data available for SIGNOR curated interactions for ACOX2 Gene

Drugs & Compounds for ACOX2 Gene

(5) Drugs for ACOX2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Water Approved Pharma 0
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(38) Additional Compounds for ACOX2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(25S)-3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-oyl-CoA
  • (25S)-3,7,12-Trihydroxycoprostanoyl-CoA
  • (25S)-THCA-CoA
  • (25S)-3a,7a,12a-Trihydroxy-5b-cholestanoyl-CoA
  • (25S)-3α,7α,12α-trihydroxy-5β-cholestanoyl-CoA
(25S)-3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
genes like me logo Genes that share compounds with ACOX2: view

Transcripts for ACOX2 Gene

mRNA/cDNA for ACOX2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOX2

Alternative Splicing Database (ASD) splice patterns (SP) for ACOX2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a ·
SP1: - - - - - - -
SP2: - - - -
SP3:
SP4:
SP5: - - -
SP6: -
SP7: - -
SP8: - -
SP9: -
SP10: -
SP11: -

ExUns: 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for ACOX2 Gene

GeneLoc Exon Structure for
ACOX2

Expression for ACOX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOX2 Gene

This gene is overexpressed in Liver (x12.1).

Protein differential expression in normal tissues from HIPED for ACOX2 Gene

This gene is overexpressed in Liver (50.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACOX2 Gene



Protein tissue co-expression partners for ACOX2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACOX2

SOURCE GeneReport for Unigene cluster for ACOX2 Gene:

Hs.444959

mRNA Expression by UniProt/SwissProt for ACOX2 Gene:

Q99424-ACOX2_HUMAN
Tissue specificity: Present in all tissues tested: heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Most abundant in heart, liver and kidney.

Evidence on tissue expression from TISSUES for ACOX2 Gene

  • Liver(4.7)
  • Kidney(4.5)
  • Intestine(4.4)
  • Muscle(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with ACOX2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOX2 Gene

Orthologs for ACOX2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ACOX2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ACOX2 30 31
  • 99.46 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ACOX2 30 31
  • 84.39 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ACOX2 30 31
  • 83.14 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Acox2 30 17 31
  • 79.83 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Acox2 30
  • 79.1 (n)
Oppossum
(Monodelphis domestica)
Mammalia ACOX2 31
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 62 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ACOX2 30 31
  • 63.17 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ACOX2 31
  • 54 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia acox2 30
  • 60.18 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16340 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG5009 31
  • 36 (a)
ManyToMany
CG4586 31 32
  • 34 (a)
ManyToMany
Acox57D-d 31 32
  • 34 (a)
ManyToMany
Acox57D-p 31 32
  • 34 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea F08A8.4 31 32
  • 37 (a)
ManyToMany
acox-1 31
  • 37 (a)
ManyToMany
F08A8.1 32
  • 37 (a)
F08A8.2 31 32
  • 36 (a)
ManyToMany
F59F4.1 31
  • 36 (a)
ManyToMany
F08A8.3 31 32
  • 35 (a)
ManyToMany
C48B4.1 31 32
  • 33 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes POX1 31
  • 23 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 45 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
Species where no ortholog for ACOX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Zebrafish (Danio rerio)

Evolution for ACOX2 Gene

ENSEMBL:
Gene Tree for ACOX2 (if available)
TreeFam:
Gene Tree for ACOX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACOX2: view image

Paralogs for ACOX2 Gene

(2) SIMAP similar genes for ACOX2 Gene using alignment to 6 proteins:

  • ACOX2_HUMAN
  • C9J0G0_HUMAN
  • C9JY29_HUMAN
  • H7C4Q2_HUMAN
  • H7C4Y2_HUMAN
  • H7C573_HUMAN
genes like me logo Genes that share paralogs with ACOX2: view

Variants for ACOX2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACOX2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
710623 Benign: not provided 58,534,004(-) CTCTG/C FRAMESHIFT_VARIANT
718938 Benign: not provided 58,535,079(-) A/G SYNONYMOUS_VARIANT
721583 Likely Benign: not provided 58,508,886(-) C/G INTRON_VARIANT
722318 Benign: not provided 58,530,591(-) G/A SYNONYMOUS_VARIANT
729128 Likely Benign: not provided 58,530,608(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ACOX2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACOX2 Gene

Variant ID Type Subtype PubMed ID
dgv4749n100 CNV gain 25217958
nsv1136727 CNV deletion 24896259
nsv3839 CNV deletion 18451855
nsv520486 CNV gain 19592680
nsv590370 CNV loss 21841781

Variation tolerance for ACOX2 Gene

Residual Variation Intolerance Score: 41.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOX2 Gene

Human Gene Mutation Database (HGMD)
ACOX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOX2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOX2 Gene

Disorders for ACOX2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for ACOX2 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ACOX2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ACOX2_HUMAN
  • Congenital bile acid synthesis defect 6 (CBAS6) [MIM:617308]: An inborn error of bile acid synthesis characterized by abnormally increased liver enzymes, hypolipidemia and low cholesterol, vitamin D deficiency, elevated plasma and urinary levels of C27 intermediate bile acids 3alpha,7alpha-dihydroxy-5beta-cholestanoic acid (DHCA) and 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid (THCA). Serum levels of phytanic and pristanic acids are normal. Clinical features include liver fibrosis, mild ataxia, delayed development, and cognitive impairment. Liver histology shows many thin fibrous septa, swollen hepatocytes, glycogenated nuclei, and focal acinar transformation, consistent with hepatocellular injury and regeneration, without signs of obvious cholestasis, cholate stasis, or steatosis. CBAS6 transmission pattern is consistent with autosomal recessive inheritance. {ECO:0000269 PubMed:27647924, ECO:0000269 PubMed:27884763}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ACOX2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ACOX2: view

No data available for Genatlas for ACOX2 Gene

Publications for ACOX2 Gene

  1. Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome. (PMID: 8943006) Baumgart E … van Veldhoven PP (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 23
  2. ACOX2 deficiency: An inborn error of bile acid synthesis identified in an adolescent with persistent hypertransaminasemia. (PMID: 27884763) Monte MJ … Marin JJG (Journal of hepatology 2017) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Assignment of the human peroxisomal branched-chain acyl-CoA oxidase gene to chromosome 3p21.1-p14.2 by rodent/human somatic cell hybridization. (PMID: 9070889) Moghrabi NN … Bennett MJ (Biochemical and biophysical research communications 1997) 2 3

Products for ACOX2 Gene

  • Signalway Proteins for ACOX2

Sources for ACOX2 Gene