Aliases for ACOX2 Gene
- Acyl-CoA Oxidase 2 2 3 5
- 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA 24-Hydroxylase 2 3 4
- Trihydroxycoprostanoyl-CoA Oxidase 2 3 4
- 3-Alpha,7-Alpha,12-Alpha-Trihydroxy-5-Beta-Cholestanoyl-CoA Oxidase 3 4
- Acyl-Coenzyme A Oxidase 2, Branched Chain 2 3
- Peroxisomal Acyl-Coenzyme A Oxidase 2 3 4
- Acyl-CoA Oxidase 2, Branched Chain 2 3
- Branched Chain Acyl-CoA Oxidase 2 3
External Ids for ACOX2 Gene
Previous GeneCards Identifiers for ACOX2 Gene
The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009]
GeneCards Summary for ACOX2 Gene
ACOX2 (Acyl-CoA Oxidase 2) is a Protein Coding gene. Diseases associated with ACOX2 include Bile Acid Synthesis Defect, Congenital, 6 and Congenital Bile Acid Synthesis Defect. Among its related pathways are Synthesis of bile acids and bile salts and Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and oxidoreductase activity, acting on the CH-CH group of donors. An important paralog of this gene is ACOX1.
UniProtKB/Swiss-Prot Summary for ACOX2 Gene
Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids (PubMed:27884763). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity).