Aliases for ACOT8 Gene
- Acyl-CoA Thioesterase 8 2 3 4 5
- Nef (Lentivirus Myristoylated Factor) Associated Protein 1 2 3
- Peroxisomal Acyl-Coenzyme A Thioester Hydrolase 1 3 4
- Peroxisomal Long-Chain Acyl-CoA Thioesterase 1 3 4
- Peroxisomal Acyl-CoA Thioesterase 1 2 3
- Choloyl-Coenzyme A Thioesterase 3 4
- Choloyl-CoA Hydrolase 2 3
- Thioesterase II 3 4
- HACTE-III 3 4
- PTE-1 3 4
- PTE-2 3 4
- PTE1 3 4
- PTE2 3 4
- HTE 3 4
External Ids for ACOT8 Gene
Previous HGNC Symbols for ACOT8 Gene
Previous GeneCards Identifiers for ACOT8 Gene
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]
GeneCards Summary for ACOT8 Gene
ACOT8 (Acyl-CoA Thioesterase 8) is a Protein Coding gene. Diseases associated with ACOT8 include Von Economo's Disease. Among its related pathways are Peroxisomal lipid metabolism and alpha-linolenic (omega3) and linoleic (omega6) acid metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and palmitoyl-CoA hydrolase activity.
UniProtKB/Swiss-Prot for ACOT8 Gene
Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:9299485, PubMed:9153233, PubMed:15194431). Competes with bile acid CoA:amino acid N-acyltransferase (BAAT) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (C2 to C20) (PubMed:9299485, PubMed:9153233). Inactive towards substrates with more than C20 aliphatic chains (PubMed:9153233). Involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431).
(Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233).