Aliases for ACOT7 Gene
External Ids for ACOT7 Gene
Previous GeneCards Identifiers for ACOT7 Gene
This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACOT7 Gene
ACOT7 (Acyl-CoA Thioesterase 7) is a Protein Coding gene. Diseases associated with ACOT7 include Temporal Lobe Epilepsy and Hyperinsulinemic Hypoglycemia, Familial, 7. Among its related pathways are alpha-linolenic (omega3) and linoleic (omega6) acid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and fatty-acyl-CoA binding. An important paralog of this gene is ACOT12.
UniProtKB/Swiss-Prot Summary for ACOT7 Gene
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:10578051). Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (PubMed:10578051). May play an important physiological function in brain (PubMed:10578051).