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Aliases for ACOT6 Gene

Aliases for ACOT6 Gene

  • Acyl-CoA Thioesterase 6 2 3 5
  • Putative Acyl-CoA Thioesterase 6 3 4
  • C14orf42 3 4
  • Putative Acyl-Coenzyme A Thioesterase 6 3
  • Chromosome 14 Open Reading Frame 42 2
  • EC 3.1.2.- 4
  • C14_5530 3

External Ids for ACOT6 Gene

Previous HGNC Symbols for ACOT6 Gene

  • C14orf42

Previous GeneCards Identifiers for ACOT6 Gene

  • GC14U900539
  • GC14P073153
  • GC14P074083
  • GC14P054251

Summaries for ACOT6 Gene

GeneCards Summary for ACOT6 Gene

ACOT6 (Acyl-CoA Thioesterase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include carboxylic ester hydrolase activity. An important paralog of this gene is ACOT1.

Additional gene information for ACOT6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT6 Gene

Genomics for ACOT6 Gene

GeneHancer (GH) Regulatory Elements for ACOT6 Gene

Promoters and enhancers for ACOT6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J073611 Enhancer 1.1 Ensembl ENCODE 650.7 +1.8 1807 1.7 ARID4B SIN3A ZNF48 YY1 GTF3C2 GLIS2 ZNF207 RXRA SP5 NFYC ACOT6 LOC100420966 ELMSAN1 ZNF410 RBM25 DCAF4 ACOT4 LOC100506476 GC14P073623
GH14J073591 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 0.4 -18.9 -18921 1.2 RB1 SIN3A RAD21 RFX5 YY1 ELK1 ZNF207 ZNF143 HCFC1 ELF1 ACOT4 PIR31448 DCAF4 NUMB LOC100506476 ACOT1 DNAL1 ACOT6
GH14J073613 Enhancer 0.5 ENCODE 0.7 +2.8 2815 0.1 SOX5 SOX13 FOXA2 FOXA3 ETV4 ZKSCAN8 FOXA1 ACOT6 GC14P073623
GH14J073602 Enhancer 0.6 ENCODE 0.4 -8.6 -8613 0.2 NCOA3 ESRRA DPF2 ELF1 ZNF217 CTBP1 GATA3 JUND RCOR1 ACOT6 ACOT4
GH14J073599 Enhancer 0.3 ENCODE 0.4 -11.2 -11213 1.1 ATF4 RNU6-240P ENSG00000223300 PTGR2 LOC100506476 ACOT2 ACOT4 ACOT6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACOT6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACOT6 gene promoter:
  • Pax-2a
  • Pax-2
  • FOXF2
  • CUTL1
  • ZID
  • RFX1
  • PPAR-alpha

Genomic Locations for ACOT6 Gene

Genomic Locations for ACOT6 Gene
8,964 bases
Plus strand
8,944 bases
Plus strand

Genomic View for ACOT6 Gene

Genes around ACOT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT6 Gene

Proteins for ACOT6 Gene

  • Protein details for ACOT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative acyl-coenzyme A thioesterase 6
    Protein Accession:

    Protein attributes for ACOT6 Gene

    207 amino acids
    Molecular mass:
    22991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACOT6 Gene

Post-translational modifications for ACOT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT6 Gene

No data available for DME Specific Peptides for ACOT6 Gene

Domains & Families for ACOT6 Gene

Gene Families for ACOT6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACOT6 Gene


Suggested Antigen Peptide Sequences for ACOT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the C/M/P thioester hydrolase family.
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT6: view

Function for ACOT6 Gene

Enzyme Numbers (IUBMB) for ACOT6 Gene

Phenotypes From GWAS Catalog for ACOT6 Gene

Gene Ontology (GO) - Molecular Function for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS,IBA --
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT6: view
genes like me logo Genes that share phenotypes with ACOT6: view

Animal Model Products

miRNA for ACOT6 Gene

miRTarBase miRNAs that target ACOT6

Clone Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOT6 Gene

Localization for ACOT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT6 gene
Compartment Confidence
peroxisome 5
cytosol 5
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol IDA 16940157
genes like me logo Genes that share ontologies with ACOT6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACOT6 Gene

Pathways & Interactions for ACOT6 Gene

genes like me logo Genes that share pathways with ACOT6: view

Interacting Proteins for ACOT6 Gene

Gene Ontology (GO) - Biological Process for ACOT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process IBA --
GO:0006637 acyl-CoA metabolic process TAS,IBA --
genes like me logo Genes that share ontologies with ACOT6: view

No data available for SIGNOR curated interactions for ACOT6 Gene

Drugs & Compounds for ACOT6 Gene

(1) Additional Compounds for ACOT6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Behenoyl-CoA
  • Behenoyl-coenzyme A
genes like me logo Genes that share compounds with ACOT6: view

Transcripts for ACOT6 Gene

mRNA/cDNA for ACOT6 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACOT6 Gene

Acyl-CoA thioesterase 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT6 Gene

No ASD Table

Relevant External Links for ACOT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACOT6 Gene

mRNA differential expression in normal tissues according to GTEx for ACOT6 Gene

This gene is overexpressed in Liver (x8.3).

NURSA nuclear receptor signaling pathways regulating expression of ACOT6 Gene:


SOURCE GeneReport for Unigene cluster for ACOT6 Gene:

genes like me logo Genes that share expression patterns with ACOT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOT6 Gene

Orthologs for ACOT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACOT6 34
  • 97 (a)
(Bos Taurus)
Mammalia ACOT6 34
  • 38 (a)
(Canis familiaris)
Mammalia ACOT6 34
  • 36 (a)
(Mus musculus)
Mammalia Acot6 34
  • 34 (a)
(Monodelphis domestica)
Mammalia ACOT6 34
  • 33 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 29 (a)
-- 34
  • 27 (a)
(Gallus gallus)
Aves -- 34
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 28 (a)
(Danio rerio)
Actinopterygii si:dkey-11e23.3 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea K05B2.4 34
  • 11 (a)
W03D8.8 34
  • 11 (a)
C31H5.6 34
  • 10 (a)
T05E7.1 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 15 (a)
-- 34
  • 14 (a)
-- 34
  • 13 (a)
-- 34
  • 13 (a)
-- 34
  • 13 (a)
-- 34
  • 12 (a)
-- 34
  • 10 (a)
-- 34
-- 34
-- 34
Species where no ortholog for ACOT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT6 Gene

Gene Tree for ACOT6 (if available)
Gene Tree for ACOT6 (if available)
Evolutionary constrained regions (ECRs) for ACOT6: view image

Paralogs for ACOT6 Gene

Paralogs for ACOT6 Gene

(3) SIMAP similar genes for ACOT6 Gene using alignment to 2 proteins:

  • G3V3W6_HUMAN
genes like me logo Genes that share paralogs with ACOT6: view

Variants for ACOT6 Gene

Sequence variations from dbSNP and Humsavar for ACOT6 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001054758 -- 73,615,505(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001151014 -- 73,615,421(+) AAAC/ genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001156058 -- 73,614,427(+) A/T genic_upstream_transcript_variant, intron_variant
rs1001163912 -- 73,616,179(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001435701 -- 73,616,701(+) T/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT6 Gene

Variant ID Type Subtype PubMed ID
esv2677257 CNV deletion 23128226
esv2759996 CNV gain 17122850
esv3892561 CNV gain 25118596
nsv1035460 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv428295 CNV gain 18775914
nsv832828 CNV gain+loss 17160897

Variation tolerance for ACOT6 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT6 Gene

Disorders for ACOT6 Gene

Additional Disease Information for ACOT6

No disorders were found for ACOT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOT6 Gene

Publications for ACOT6 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt MC … Alexson SE (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Exome sequencing supports a de novo mutational paradigm for schizophrenia. (PMID: 21822266) Xu B … Karayiorgou M (Nature genetics 2011) 3 58
  4. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt MC … Alexson SE (Journal of lipid research 2005) 3 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for ACOT6 Gene

Sources for ACOT6 Gene

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