Aliases for ACOT4 Gene
External Ids for ACOT4 Gene
Previous GeneCards Identifiers for ACOT4 Gene
GeneCards Summary for ACOT4 Gene
ACOT4 (Acyl-CoA Thioesterase 4) is a Protein Coding gene. Diseases associated with ACOT4 include Septooptic Dysplasia. Among its related pathways are palmitate biosynthesis and Ovarian steroidogenesis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT1.
UniProtKB/Swiss-Prot Summary for ACOT4 Gene
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). ACOT4 is a peroxisomal succinyl-coenzyme A thioesterase can also hydrolyze glutaryl-CoA and long chain saturated acyl-CoAs (PubMed:16940157).