Aliases for ACOT2 Gene
External Ids for ACOT2 Gene
Previous GeneCards Identifiers for ACOT2 Gene
This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
GeneCards Summary for ACOT2 Gene
ACOT2 (Acyl-CoA Thioesterase 2) is a Protein Coding gene. Among its related pathways are alpha-linolenic acid (ALA) metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT1.
UniProtKB/Swiss-Prot Summary for ACOT2 Gene
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:16940157, PubMed:10944470). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).