This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] See more...

Aliases for ACOT2 Gene

Aliases for ACOT2 Gene

  • Acyl-CoA Thioesterase 2 2 3 4 5
  • ZAP128 2 3 4
  • Acyl-Coenzyme A Thioesterase 2, Mitochondrial 3 4
  • Acyl-Coenzyme A Thioester Hydrolase 2a 3 4
  • Mitochondrial Acyl-CoA Thioesterase 1 2 3
  • Long-Chain Acyl-CoA Thioesterase 2 3 4
  • EC 3.1.2.2 4 51
  • PTE2A 3 4
  • PTE2 3 4
  • Peroxisomal Long-Chain Acyl-CoA Thioesterase 2 3
  • CTE-IA 3
  • CTE-Ia 4
  • CTE1A 3
  • ACOT2 5
  • MTE1 3
  • Mte1 2

External Ids for ACOT2 Gene

Previous GeneCards Identifiers for ACOT2 Gene

  • GC14P073106
  • GC14P074036
  • GC14P054203

Summaries for ACOT2 Gene

Entrez Gene Summary for ACOT2 Gene

  • This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

GeneCards Summary for ACOT2 Gene

ACOT2 (Acyl-CoA Thioesterase 2) is a Protein Coding gene. Among its related pathways are palmitate biosynthesis and Ovarian steroidogenesis. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT1.

UniProtKB/Swiss-Prot Summary for ACOT2 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:16940157, PubMed:10944470). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).

Gene Wiki entry for ACOT2 Gene

Additional gene information for ACOT2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACOT2 Gene

Genomics for ACOT2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ACOT2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACOT2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACOT2

Top Transcription factor binding sites by QIAGEN in the ACOT2 gene promoter:
  • AML1a
  • AREB6
  • Arnt
  • FOXD1
  • GR
  • GR-alpha
  • HFH-1
  • Pax-5
  • STAT5B

Genomic Locations for ACOT2 Gene

Genomic Locations for ACOT2 Gene
chr14:73,567,620-73,575,658
(GRCh38/hg38)
Size:
8,039 bases
Orientation:
Plus strand
chr14:74,034,324-74,042,359
(GRCh37/hg19)
Size:
8,036 bases
Orientation:
Plus strand

Genomic View for ACOT2 Gene

Genes around ACOT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT2 Gene

Proteins for ACOT2 Gene

  • Protein details for ACOT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49753-ACOT2_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 2, mitochondrial
    Protein Accession:
    P49753
    Secondary Accessions:
    • Q3I5F8
    • Q53EK4
    • Q9NUX4

    Protein attributes for ACOT2 Gene

    Size:
    483 amino acids
    Molecular mass:
    53218 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAC42007.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACOT2 Gene

    Alternative splice isoforms for ACOT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOT2 Gene

Selected DME Specific Peptides for ACOT2 Gene

P49753:
  • WKSEFYA
  • VELEVLDGH
  • GLLEYRASLLAGKGFAVMALAY
  • MASFLKGITA
  • IEPPYFP
  • PEQPVTLR
  • GLLGISKG
  • PALGGSF
  • AHARYRAD
  • DDHNWKS

Post-translational modifications for ACOT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT2 Gene

Antibody Products

Domains & Families for ACOT2 Gene

Gene Families for ACOT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for ACOT2 Gene

InterPro:
Blocks:
  • Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
ProtoNet:

Suggested Antigen Peptide Sequences for ACOT2 Gene

GenScript: Design optimal peptide antigens:
  • ZAP128 (ACOT2_HUMAN)
  • cDNA FLJ35812 fis, clone TESTI2006051, highly similar to Acyl-coenzyme A thioesterase 1 (EC 3.1.2.2) (B3KSA0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P49753

UniProtKB/Swiss-Prot:

ACOT2_HUMAN :
  • Belongs to the C/M/P thioester hydrolase family.
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT2: view

Function for ACOT2 Gene

Molecular function for ACOT2 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:16940157). Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:16940157, PubMed:10944470). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+); Xref=Rhea:RHEA:40147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32360, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence={ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence={ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+); Xref=Rhea:RHEA:40131, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540; Evidence={ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40723, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30825, ChEBI:CHEBI:57287, ChEBI:CHEBI:77537; Evidence={ECO:0000269|PubMed:16940157};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+); Xref=Rhea:RHEA:40143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence={ECO:0000250|UniProtKB:Q9QYR9};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=40.3 uM for C10-acyl-CoA {ECO:0000269|PubMed:16940157}; KM=8.9 uM for C12-acyl-CoA {ECO:0000269|PubMed:16940157}; KM=1.6 uM for C14-acyl-CoA {ECO:0000269|PubMed:16940157}; KM=2.0 uM for C16-acyl-CoA {ECO:0000269|PubMed:16940157}; KM=2.8 uM for C18-acyl-CoA {ECO:0000269|PubMed:16940157}; KM=4.8 uM for C20-acyl-CoA {ECO:0000269|PubMed:16940157}; KM=4.5 uM for C16:1-acyl-CoA {ECO:0000269|PubMed:16940157}; KM=6.1 uM for C18:1-acyl-CoA {ECO:0000269|PubMed:16940157}; KM=4.3 uM for C18:1-trans-acyl-CoA {ECO:0000269|PubMed:16940157}; Vmax=212 nmol/min/mg enzyme with C10-acyl-CoA as substrate {ECO:0000269|PubMed:16940157}; Vmax=681 nmol/min/mg enzyme with C12-acyl-CoA as substrate {ECO:0000269|PubMed:16940157}; Vmax=766 nmol/min/mg enzyme with C14-acyl-CoA as substrate {ECO:0000269|PubMed:16940157}; Vmax=656 nmol/min/mg enzyme with C16-acyl-CoA as substrate {ECO:0000269|PubMed:16940157}; Vmax=488 nmol/min/mg enzyme with C18-acyl-CoA as substrate {ECO:0000269|PubMed:16940157}; Vmax=408 nmol/min/mg enzyme with C20-acyl-CoA as substrate {ECO:0000269|PubMed:16940157}; Vmax=661 nmol/min/mg enzyme with C16:1-acyl-CoA as substrate {ECO:0000269|PubMed:16940157}; Vmax=304 nmol/min/mg enzyme with C18:1-acyl-CoA as substrate {ECO:0000269|PubMed:16940157}; Vmax=418 nmol/min/mg enzyme with C18:1-trans-acyl-CoA as substrate {ECO:0000269|PubMed:16940157};

Enzyme Numbers (IUBMB) for ACOT2 Gene

Phenotypes From GWAS Catalog for ACOT2 Gene

Gene Ontology (GO) - Molecular Function for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25464930
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity IDA 10944470
genes like me logo Genes that share ontologies with ACOT2: view
genes like me logo Genes that share phenotypes with ACOT2: view

Animal Model Products

CRISPR Products

miRNA for ACOT2 Gene

miRTarBase miRNAs that target ACOT2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOT2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ACOT2 Gene

Localization for ACOT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT2 gene
Compartment Confidence
mitochondrion 5
peroxisome 5
cytosol 4
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 16940157
GO:0005759 mitochondrial matrix TAS --
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACOT2: view

Pathways & Interactions for ACOT2 Gene

genes like me logo Genes that share pathways with ACOT2: view

UniProtKB/Swiss-Prot P49753-ACOT2_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Gene Ontology (GO) - Biological Process for ACOT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006625 protein targeting to peroxisome TAS --
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IBA 21873635
genes like me logo Genes that share ontologies with ACOT2: view

No data available for SIGNOR curated interactions for ACOT2 Gene

Drugs & Compounds for ACOT2 Gene

(14) Drugs for ACOT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docosahexaenoic acid Approved, Investigational Pharma Agonist, Full agonist 0
Gamolenic acid Approved, Investigational Pharma 0
linoleic acid Approved, Experimental Pharma Agonist, Full agonist, Activator, Pore Blocker, Channel blocker 0
oleic acid Approved, Investigational, Vet_approved Pharma Agonist, Full agonist, Activator, Activation 0
Palmitic Acid Approved Pharma Agonist, Full agonist 27

(40) Additional Compounds for ACOT2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with ACOT2: view

Transcripts for ACOT2 Gene

mRNA/cDNA for ACOT2 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOT2

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT2 Gene

No ASD Table

Relevant External Links for ACOT2 Gene

GeneLoc Exon Structure for
ACOT2

Expression for ACOT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACOT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACOT2 Gene

This gene is overexpressed in Kidney (10.8), Prostate (8.5), and Heart (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACOT2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACOT2

SOURCE GeneReport for Unigene cluster for ACOT2 Gene:

Hs.446685

mRNA Expression by UniProt/SwissProt for ACOT2 Gene:

P49753-ACOT2_HUMAN
Tissue specificity: Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas.

Evidence on tissue expression from TISSUES for ACOT2 Gene

  • Nervous system(4.7)
  • Lung(4.5)
  • Spleen(4.2)
  • Heart(3.2)
  • Liver(3)
  • Muscle(2.6)
  • Skin(2.6)
  • Kidney(2.4)
  • Intestine(2.2)
genes like me logo Genes that share expression patterns with ACOT2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOT2 Gene

Orthologs for ACOT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ACOT2 30
  • 98.62 (n)
Cow
(Bos Taurus)
Mammalia ACOT2 30 31
  • 85.67 (n)
OneToMany
Dog
(Canis familiaris)
Mammalia ACOT2 30
  • 84.76 (n)
-- 31
  • 80 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Acot2 30 17 31
  • 79.81 (n)
ManyToMany
Acot1 31
  • 77 (a)
ManyToMany
Acot3 31
  • 75 (a)
ManyToMany
Acot5 31
  • 74 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Acot2 30
  • 79.48 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
ManyToMany
-- 31
  • 60 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 60 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves LOC771753 30
  • 67.32 (n)
-- 31
  • 62 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 62 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia acot2 30
  • 60.69 (n)
Str.12247 30
Zebrafish
(Danio rerio)
Actinopterygii zgc:77651 31
  • 33 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea K05B2.4 31
  • 28 (a)
ManyToMany
W03D8.8 31
  • 27 (a)
ManyToMany
C31H5.6 31
  • 25 (a)
ManyToMany
T05E7.1 31
  • 22 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
Species where no ortholog for ACOT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ACOT2 Gene

ENSEMBL:
Gene Tree for ACOT2 (if available)
TreeFam:
Gene Tree for ACOT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACOT2: view image

Paralogs for ACOT2 Gene

Paralogs for ACOT2 Gene

(4) SIMAP similar genes for ACOT2 Gene using alignment to 2 proteins:

  • ACOT2_HUMAN
  • B3KSA0_HUMAN
genes like me logo Genes that share paralogs with ACOT2: view

Variants for ACOT2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACOT2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
684519 Benign: not provided 73,575,044(+) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs11545741 - p.Arg16Ser
rs7494 - p.His475Arg

Additional dbSNP identifiers (rs#s) for ACOT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACOT2 Gene

Variant ID Type Subtype PubMed ID
dgv1935n100 CNV gain 25217958
dgv3764n54 CNV gain 21841781
dgv3774n54 CNV loss 21841781
dgv408e214 CNV gain 21293372
dgv656e212 CNV gain 25503493
dgv662e212 CNV loss 25503493
esv1006342 CNV deletion 20482838
esv2672436 CNV deletion 23128226
esv2748867 CNV deletion 23290073
esv2759996 CNV gain 17122850
esv2760335 CNV gain+loss 21179565
esv2761566 CNV gain+loss 21179565
esv29080 CNV gain+loss 19812545
esv29945 CNV loss 18421352
esv30006 CNV gain 17803354
esv33155 CNV gain+loss 17666407
esv3634913 CNV loss 21293372
esv3892561 CNV gain 25118596
esv3892562 CNV gain 25118596
nsv1035460 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv1350 CNV deletion 18451855
nsv428295 CNV gain 18775914
nsv436178 CNV deletion 17901297
nsv442346 CNV gain+loss 18776908
nsv510643 CNV deletion 20534489
nsv514751 CNV gain 21397061
nsv565162 CNV loss 21841781
nsv565172 CNV loss 21841781
nsv819954 CNV gain 19587683
nsv821106 CNV deletion 20802225
nsv826976 CNV loss 20364138
nsv826985 CNV loss 20364138
nsv826987 CNV loss 20364138
nsv826988 CNV loss 20364138
nsv832828 CNV gain+loss 17160897
nsv9153 CNV gain+loss 18304495

Variation tolerance for ACOT2 Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.71; 57.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT2 Gene

Disorders for ACOT2 Gene

Additional Disease Information for ACOT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for ACOT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOT2 Gene

Publications for ACOT2 Gene

  1. Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2). (PMID: 19497300) Mandel CR … Tong L (Biochemical and biophysical research communications 2009) 3 4 23
  2. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt MC … Alexson SE (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 4
  3. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. (PMID: 10944470) Jones JM … Gould SJ (Biochemical and biophysical research communications 2000) 3 4 23
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41

Products for ACOT2 Gene

  • Signalway Proteins for ACOT2

Sources for ACOT2 Gene