ACOT13 Gene (Protein Coding)

Acyl-CoA Thioesterase 13

GC06P024667
GIFtS:
37
This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different ... See more...

Aliases for ACOT13 Gene

Aliases for ACOT13 Gene

  • Acyl-CoA Thioesterase 13 2 3 4 5
  • Thioesterase Superfamily Member 2 2 3 4
  • Acyl-Coenzyme A Thioesterase 13 3 4
  • HT012 2 3
  • THEM2 3 4
  • Hypothalamus Protein HT012 3
  • EC 3.1.2.- 4
  • PNAS-27 3
  • ACOT13 5

External Ids for ACOT13 Gene

Previous HGNC Symbols for ACOT13 Gene

  • THEM2

Previous GeneCards Identifiers for ACOT13 Gene

  • GC06P024776

Summaries for ACOT13 Gene

Entrez Gene Summary for ACOT13 Gene

  • This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]

GeneCards Summary for ACOT13 Gene

ACOT13 (Acyl-CoA Thioesterase 13) is a Protein Coding gene. Diseases associated with ACOT13 include Larynx Verrucous Carcinoma and Aortic Valve Prolapse. Among its related pathways are Glucose / Energy Metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include acyl-CoA hydrolase activity.

UniProtKB/Swiss-Prot Summary for ACOT13 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).

Additional gene information for ACOT13 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACOT13 Gene

Genomics for ACOT13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ACOT13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACOT13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACOT13

Top Transcription factor binding sites by QIAGEN in the ACOT13 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXL1
  • HNF-4alpha1
  • POU2F1
  • POU2F1a
  • STAT5B

Genomic Locations for ACOT13 Gene

Genomic Locations for ACOT13 Gene
chr6:24,667,035-24,705,069
(GRCh38/hg38)
Size:
38,035 bases
Orientation:
Plus strand
chr6:24,667,263-24,705,297
(GRCh37/hg19)
Size:
38,035 bases
Orientation:
Plus strand

Genomic View for ACOT13 Gene

Genes around ACOT13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT13 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ACOT13 Gene

Proteins for ACOT13 Gene

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  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ACOT13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPJ3-ACO13_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 13
    Protein Accession:
    Q9NPJ3
    Secondary Accessions:
    • F5H2L4
    • O95549

    Protein attributes for ACOT13 Gene

    Size:
    140 amino acids
    Molecular mass:
    14960 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for ACOT13 Gene

    Alternative splice isoforms for ACOT13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACOT13 Gene

Protein Expression for ACOT13 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ACOT13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ACOT13 Gene

Domains & Families for ACOT13 Gene

Gene Families for ACOT13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ACOT13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACOT13 Gene

GenScript: Design optimal peptide antigens:
  • Thioesterase superfamily member 2 (ACO13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPJ3

UniProtKB/Swiss-Prot:

ACO13_HUMAN :
  • Belongs to the thioesterase PaaI family.
Family:
  • Belongs to the thioesterase PaaI family.
genes like me logo Genes that share domains with ACOT13: view

Function for ACOT13 Gene

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Molecular function for ACOT13 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.9 uM for n-decanoyl-CoA {ECO:0000269|PubMed:19170545}; KM=26 uM for n-octanoyl-CoA {ECO:0000269|PubMed:19170545}; KM=5 uM for myristoyl-CoA {ECO:0000269|PubMed:19170545}; KM=9 uM for palmitoyl-CoA {ECO:0000269|PubMed:19170545}; KM=9 uM for oleoyl-CoA {ECO:0000269|PubMed:19170545}; KM=10 uM for 3,4-dihydroxyphenylacetyl-CoA {ECO:0000269|PubMed:19170545}; KM=40 uM for 3-hydroxyphenylacetyl-CoA {ECO:0000269|PubMed:19170545};

Enzyme Numbers (IUBMB) for ACOT13 Gene

Phenotypes From GWAS Catalog for ACOT13 Gene

Gene Ontology (GO) - Molecular Function for ACOT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity IDA 16934754
genes like me logo Genes that share ontologies with ACOT13: view
genes like me logo Genes that share phenotypes with ACOT13: view

Animal Models for ACOT13 Gene

MGI Knock Outs for ACOT13:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOT13

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACOT13 Gene

Localization for ACOT13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT13 Gene

Cytoplasm, cytosol. Mitochondrion. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin. {ECO:0000250 UniProtKB:Q9CQR4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT13 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 4
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACOT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,HDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ACOT13: view

Pathways & Interactions for ACOT13 Gene

genes like me logo Genes that share pathways with ACOT13: view

Pathways by source for ACOT13 Gene

1 Cell Signaling Technology pathway for ACOT13 Gene

Gene Ontology (GO) - Biological Process for ACOT13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process TAS --
GO:0051289 protein homotetramerization IPI 16934754
GO:0120163 negative regulation of cold-induced thermogenesis ISS 24072708
genes like me logo Genes that share ontologies with ACOT13: view

No data available for SIGNOR curated interactions for ACOT13 Gene

Drugs & Compounds for ACOT13 Gene

Products:

  1. Drug

(1) Drugs for ACOT13 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-Undecanone Experimental Pharma Target 0
genes like me logo Genes that share compounds with ACOT13: view

Transcripts for ACOT13 Gene

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mRNA/cDNA for ACOT13 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOT13

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3: -

Relevant External Links for ACOT13 Gene

GeneLoc Exon Structure for
ACOT13

Expression for ACOT13 Gene

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  1. Primer
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACOT13 Gene

mRNA expression in normal human tissues for ACOT13 Gene
mRNA expression by GTEx for ACOT13 GenemRNA expression by BioGPS for ACOT13 Gene

Protein differential expression in normal tissues from HIPED for ACOT13 Gene

This gene is overexpressed in Liver, secretome (16.9), Liver (7.9), and Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACOT13 Gene



Protein tissue co-expression partners for ACOT13 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACOT13

SOURCE GeneReport for Unigene cluster for ACOT13 Gene:

Hs.731605

Evidence on tissue expression from TISSUES for ACOT13 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Adrenal gland(4.3)
  • Lung(4.3)
  • Skin(3.7)
  • Intestine(3.7)
  • Pancreas(3.3)
  • Blood(3.2)
  • Heart(3)
  • Muscle(2.9)
  • Kidney(2.8)
  • Eye(2.6)
  • Bone(2.2)
genes like me logo Genes that share expression patterns with ACOT13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOT13 Gene

Orthologs for ACOT13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACOT13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ACOT13 30 31
  • 99.76 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ACOT13 30 31
  • 84.29 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Acot13 30 17 31
  • 83.1 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Acot13 30
  • 81.67 (n)
Cow
(Bos Taurus)
 Mammalia ACOT13 30
  • 80 (n)
THEM2 31
  • 63 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia ACOT13 31
  • 71 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ACOT13 31
  • 61 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 70 (a)
 OneToMany
-- 31
  • 68 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia acot13 30
  • 69.05 (n)
Str.9973 30
Zebrafish
(Danio rerio)
 Actinopterygii acot13 30 31
  • 67.62 (n)
 OneToOne
Dr.13640 30
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP007238 30
  • 47.87 (n)
Fruit Fly
(Drosophila melanogaster)
 Insecta CG16986 30 31
  • 46.25 (n)
 OneToMany
CG16985 31
  • 34 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea F42H10.6 30 31
  • 51.2 (n)
 OneToMany
C25H3.3 31
  • 40 (a)
 OneToMany
C25H3.14 31
  • 39 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT1G04290 30
  • 46.06 (n)
Rice
(Oryza sativa)
 Liliopsida Os04g0436100 30
  • 48.87 (n)
Species where no ortholog for ACOT13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ACOT13 Gene

ENSEMBL:
Gene Tree for ACOT13 (if available)
TreeFam:
Gene Tree for ACOT13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACOT13: view image

Paralogs for ACOT13 Gene

Pseudogenes.org Pseudogenes for ACOT13 Gene

genes like me logo Genes that share paralogs with ACOT13: view

No data available for Paralogs for ACOT13 Gene

Variants for ACOT13 Gene

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Additional dbSNP identifiers (rs#s) for ACOT13 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACOT13 Gene

Variant ID Type Subtype PubMed ID
esv2590495 CNV insertion 19546169
esv3608369 CNV loss 21293372
nsv512870 CNV insertion 21212237

Variation tolerance for ACOT13 Gene

Residual Variation Intolerance Score: 70.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOT13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOT13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACOT13 Gene

Disorders for ACOT13 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ACOT13 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
larynx verrucous carcinoma
  • verrucous carcinoma of the larynx
aortic valve prolapse
vulvar dystrophy
  • dystrophy of vulva
dyslexia
spindle cell thymoma
  • medullary thymoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ACOT13

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ACOT13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT13 Gene

Publications for ACOT13 Gene

  1. The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. (PMID: 19170545) Cao J … Dunaway-Mariano D (Biochemistry 2009) 3 4 23
  2. Crystal structure of human thioesterase superfamily member 2. (PMID: 16934754) Cheng Z … Gong W (Biochemical and biophysical research communications 2006) 2 3 4
  3. Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs. (PMID: 19405909) Wei J … Cohen DE (The Biochemical journal 2009) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

ExternalLinks

View latest publications for ACOT13 gene in Mastermind

Products for ACOT13 Gene

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