Aliases for ACOT13 Gene
External Ids for ACOT13 Gene
Previous HGNC Symbols for ACOT13 Gene
Previous GeneCards Identifiers for ACOT13 Gene
This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
GeneCards Summary for ACOT13 Gene
ACOT13 (Acyl-CoA Thioesterase 13) is a Protein Coding gene. Diseases associated with ACOT13 include Aortic Valve Prolapse and Larynx Verrucous Carcinoma. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include acyl-CoA hydrolase activity.
UniProtKB/Swiss-Prot Summary for ACOT13 Gene
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis (By similarity).