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Aliases for ACOT11 Gene

Aliases for ACOT11 Gene

  • Acyl-CoA Thioesterase 11 2 3 4 5
  • StAR-Related Lipid Transfer (START) Domain Containing 14 2 3
  • Brown Fat-Inducible Thioesterase 3 4
  • Thioesterase, Adipose Associated 2 3
  • Acyl-CoA Thioester Hydrolase 11 3 4
  • Adipose-Associated Thioesterase 3 4
  • THEA 3 4
  • BFIT 3 4
  • Thioesterase Superfamily Member 1 3
  • Acyl-Coenzyme A Thioesterase 11 3
  • START Domain Containing 14 3
  • EC 3.1.2.- 4
  • KIAA0707 4
  • STARD14 3
  • THEM1 3

External Ids for ACOT11 Gene

Previous HGNC Symbols for ACOT11 Gene

  • THEA

Previous GeneCards Identifiers for ACOT11 Gene

  • GC01P054720
  • GC01P054786
  • GC01P055007
  • GC01P053127

Summaries for ACOT11 Gene

Entrez Gene Summary for ACOT11 Gene

  • This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for ACOT11 Gene

ACOT11 (Acyl-CoA Thioesterase 11) is a Protein Coding gene. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. Gene Ontology (GO) annotations related to this gene include lipid binding and acyl-CoA hydrolase activity. An important paralog of this gene is ACOT12.

UniProtKB/Swiss-Prot for ACOT11 Gene

  • Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.

Gene Wiki entry for ACOT11 Gene

Additional gene information for ACOT11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACOT11 Gene

Genomics for ACOT11 Gene

GeneHancer (GH) Regulatory Elements for ACOT11 Gene

Promoters and enhancers for ACOT11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J054541 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.1 1075 3.6 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 KLF7 KLF13 SP3 SP5 ACOT11 HNRNPA3P12 FAM151A
GH01J054545 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 656.1 +5.8 5790 4.1 CTCF TFAP4 USF1 ZNF792 NFIB MAX ZMYM3 ZIC2 ZNF48 RAD21 ACOT11 LOC105378734 MROH7 FAM151A
GH01J054571 Enhancer 1 Ensembl ENCODE dbSUPER 14.9 +29.6 29631 1.4 SCRT1 RFX1 MAX ZNF384 ELF1 BMI1 ZIC2 RFX3 GLIS1 SCRT2 ACOT11 MROH7 FAM151A
GH01J054579 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 +40.1 40149 6.7 SIN3A BMI1 RAD21 YY1 SCRT2 EGR2 RXRA SP5 REST NR2F2 MROH7 ACOT11 FAM151A
GH01J054569 Enhancer 0.7 Ensembl dbSUPER 14.5 +27.2 27244 0.6 JUND KLF17 MNT FEZF1 ZIC2 ACOT11 TALDO1P1 TTC4 ENSG00000237453 TTC22 FAM151A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ACOT11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACOT11 gene promoter:
  • En-1
  • C/EBPbeta
  • POU2F1c
  • POU2F1b
  • POU2F1a
  • POU2F1
  • Nkx2-5
  • E47
  • USF-1
  • USF1

Genomic Locations for ACOT11 Gene

Genomic Locations for ACOT11 Gene
96,936 bases
Plus strand
96,936 bases
Plus strand

Genomic View for ACOT11 Gene

Genes around ACOT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT11 Gene

Proteins for ACOT11 Gene

  • Protein details for ACOT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acyl-coenzyme A thioesterase 11
    Protein Accession:
    Secondary Accessions:
    • B1AQ22
    • D3DQ50
    • O75187
    • Q52LP1
    • Q53ER9
    • Q96DI1
    • Q9H883

    Protein attributes for ACOT11 Gene

    607 amino acids
    Molecular mass:
    68492 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31682.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACOT11 Gene

    Alternative splice isoforms for ACOT11 Gene


neXtProt entry for ACOT11 Gene

Post-translational modifications for ACOT11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACOT11 Gene

Domains & Families for ACOT11 Gene

Gene Families for ACOT11 Gene

Protein Domains for ACOT11 Gene

Suggested Antigen Peptide Sequences for ACOT11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ACOT11: view

No data available for UniProtKB/Swiss-Prot for ACOT11 Gene

Function for ACOT11 Gene

Molecular function for ACOT11 Gene

UniProtKB/Swiss-Prot Function:
Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.
UniProtKB/Swiss-Prot Induction:
By cold exposure and repressed by heat exposure.

Enzyme Numbers (IUBMB) for ACOT11 Gene

Phenotypes From GWAS Catalog for ACOT11 Gene

Gene Ontology (GO) - Molecular Function for ACOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity TAS 11696000
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT11: view
genes like me logo Genes that share phenotypes with ACOT11: view

Animal Models for ACOT11 Gene

MGI Knock Outs for ACOT11:

Animal Model Products

miRNA for ACOT11 Gene

miRTarBase miRNAs that target ACOT11

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACOT11 Gene

Localization for ACOT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT11 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT11 gene
Compartment Confidence
extracellular 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS,IBA --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with ACOT11: view

Pathways & Interactions for ACOT11 Gene

genes like me logo Genes that share pathways with ACOT11: view

Interacting Proteins for ACOT11 Gene

Gene Ontology (GO) - Biological Process for ACOT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process NAS,IBA 11696000
GO:0006637 acyl-CoA metabolic process IBA,TAS --
GO:0009266 response to temperature stimulus ISS --
GO:0009409 response to cold ISS 11696000
GO:0035556 intracellular signal transduction NAS 11696000
genes like me logo Genes that share ontologies with ACOT11: view

No data available for SIGNOR curated interactions for ACOT11 Gene

Drugs & Compounds for ACOT11 Gene

(2) Drugs for ACOT11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexanoyl-CoA Experimental Pharma 0
Propanoyl-CoA Experimental Pharma 0

(30) Additional Compounds for ACOT11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
genes like me logo Genes that share compounds with ACOT11: view

Transcripts for ACOT11 Gene

mRNA/cDNA for ACOT11 Gene

Unigene Clusters for ACOT11 Gene

Acyl-CoA thioesterase 11:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT11 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - -
SP9: -
SP10: - - -
SP12: - - - - - - -

ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25
SP1: -

Relevant External Links for ACOT11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ACOT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACOT11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACOT11 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7).

Protein differential expression in normal tissues from HIPED for ACOT11 Gene

This gene is overexpressed in Stomach (12.9) and Rectum (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACOT11 Gene

NURSA nuclear receptor signaling pathways regulating expression of ACOT11 Gene:


SOURCE GeneReport for Unigene cluster for ACOT11 Gene:


mRNA Expression by UniProt/SwissProt for ACOT11 Gene:

Tissue specificity: Isoform 1 is predominantly expressed in skeletal muscle, liver, testis, stomach, spleen, lung and brain. Isoform 2 is predominantly expressed in kidney, uterus, hibernoma and white adipose tissue.

Evidence on tissue expression from TISSUES for ACOT11 Gene

  • Heart(4.4)
  • Nervous system(4.4)
  • Skin(4.1)
  • Thyroid gland(4.1)
genes like me logo Genes that share expression patterns with ACOT11: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOT11 Gene

Orthologs for ACOT11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACOT11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ACOT11 34 33
  • 99.38 (n)
(Canis familiaris)
Mammalia ACOT11 34 33
  • 90.4 (n)
(Mus musculus)
Mammalia Acot11 16 34 33
  • 86.32 (n)
(Rattus norvegicus)
Mammalia Acot11 33
  • 85.53 (n)
(Bos Taurus)
Mammalia ACOT11 34
  • 83 (a)
(Monodelphis domestica)
Mammalia ACOT11 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia ACOT11 34
  • 59 (a)
(Gallus gallus)
Aves ACOT11 34 33
  • 77.21 (n)
(Anolis carolinensis)
Reptilia ACOT11 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia acot11 33
  • 67.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8808 33
(Danio rerio)
Actinopterygii acot11a 34 33
  • 66.61 (n)
acot11b 34
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
Species where no ortholog for ACOT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ACOT11 Gene

Gene Tree for ACOT11 (if available)
Gene Tree for ACOT11 (if available)
Evolutionary constrained regions (ECRs) for ACOT11: view image

Paralogs for ACOT11 Gene

Paralogs for ACOT11 Gene

(1) SIMAP similar genes for ACOT11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ACOT11: view

Variants for ACOT11 Gene

Sequence variations from dbSNP and Humsavar for ACOT11 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000003461 -- 54,560,783(+) G/A intron_variant
rs1000015136 -- 54,602,073(+) G/T intron_variant
rs1000067788 -- 54,602,270(+) A/G intron_variant
rs1000094973 -- 54,554,448(+) C/T intron_variant
rs1000138150 -- 54,623,836(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACOT11 Gene

Variant ID Type Subtype PubMed ID
nsv950750 CNV deletion 24416366
nsv910 CNV deletion 18451855
nsv829904 CNV loss 17160897
nsv822720 CNV loss 20364138
nsv822709 CNV gain 20364138
nsv822698 CNV gain+loss 20364138
nsv822642 CNV gain 20364138
nsv821518 CNV deletion 20802225
nsv820219 CNV gain 19587683
nsv817614 CNV gain 22305530
nsv546298 CNV loss 21841781
nsv546297 CNV gain 21841781
nsv546270 CNV loss 21841781
nsv546269 CNV gain 21841781
nsv546268 CNV gain 21841781
nsv546267 CNV gain 21841781
nsv546266 CNV gain 21841781
nsv516654 CNV loss 19592680
nsv461594 CNV gain 19166990
nsv461583 CNV gain 19166990
nsv461572 CNV gain 19166990
nsv461561 CNV gain 19166990
nsv1144376 CNV deletion 24896259
nsv1076457 CNV deletion 25765185
nsv1000673 CNV gain 25217958
esv3586099 CNV loss 21293372
esv3586098 CNV loss 21293372
esv3586097 CNV loss 21293372
esv3586096 CNV gain 21293372
esv3586095 CNV loss 21293372
esv3586093 CNV loss 21293372
esv3586091 CNV loss 21293372
esv3577865 CNV loss 25503493
esv3562137 CNV deletion 23714750
esv33550 CNV gain+loss 17666407
esv2748341 CNV deletion 23290073
esv2748330 CNV deletion 23290073
esv2673445 CNV deletion 23128226
esv2662697 CNV deletion 23128226
esv2651907 CNV deletion 19546169
esv2628077 CNV loss 19546169
esv24082 CNV gain+loss 19812545
esv2181722 CNV deletion 18987734
esv1004742 CNV gain 20482838
esv1002091 CNV gain 20482838
dgv39n67 CNV gain 20364138
dgv38n67 CNV loss 20364138
dgv38e212 CNV gain 25503493
dgv37e212 CNV loss 25503493
dgv36e212 CNV loss 25503493
dgv282n54 CNV loss 21841781
dgv281n54 CNV loss 21841781
dgv280n54 CNV loss 21841781
dgv279n54 CNV loss 21841781
dgv278n54 CNV loss 21841781
dgv20e214 CNV gain 21293372

Variation tolerance for ACOT11 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.57; 93.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT11 Gene

Disorders for ACOT11 Gene

Additional Disease Information for ACOT11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ACOT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACOT11 Gene

Publications for ACOT11 Gene

  1. BFIT, a unique acyl-CoA thioesterase induced in thermogenic brown adipose tissue: cloning, organization of the human gene and assessment of a potential link to obesity. (PMID: 11696000) Adams SH … Lewin DA (The Biochemical journal 2001) 2 3 4 22 58
  2. Comparative structural analysis of lipid binding START domains. (PMID: 21738568) Thorsell AG … Lehtiö L (PloS one 2011) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt MC … Alexson SE (Journal of lipid research 2005) 2 3 58

Products for ACOT11 Gene

Sources for ACOT11 Gene

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