Aliases for ACOT1 Gene

Aliases for ACOT1 Gene

  • Acyl-CoA Thioesterase 1 2 3 4 5
  • Inducible Cytosolic Acyl-Coenzyme A Thioester Hydrolase 3 4
  • Long Chain Acyl-CoA Thioester Hydrolase 3 4
  • Palmitoyl-Coenzyme A Thioesterase 3 4
  • Acyl-Coenzyme A Thioesterase 1 3 4
  • Long Chain Acyl-CoA Hydrolase 3 4
  • EC 3.1.2.2 4 52
  • CTE-Ib 3 4
  • CTE-I 3 4
  • EC 3.1.2.- 4
  • CTE-1 3
  • LACH2 3
  • ACH2 3
  • CTE1 4

External Ids for ACOT1 Gene

Previous GeneCards Identifiers for ACOT1 Gene

  • GC14U900538
  • GC14P073074
  • GC14P074003
  • GC14P054170
  • GC14P073537

Summaries for ACOT1 Gene

GeneCards Summary for ACOT1 Gene

ACOT1 (Acyl-CoA Thioesterase 1) is a Protein Coding gene. Diseases associated with ACOT1 include Aztreonam Allergy and Cefuroxime Allergy. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and palmitoyl-CoA hydrolase activity. An important paralog of this gene is ACOT2.

UniProtKB/Swiss-Prot Summary for ACOT1 Gene

  • Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).

Additional gene information for ACOT1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACOT1 Gene

Genomics for ACOT1 Gene

GeneHancer (GH) Regulatory Elements for ACOT1 Gene

Promoters and enhancers for ACOT1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACOT1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACOT1

Top Transcription factor binding sites by QIAGEN in the ACOT1 gene promoter:
  • AREB6
  • Arnt
  • HNF-4alpha1
  • HNF-4alpha2
  • PPAR-alpha
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ACOT1 Gene

Genomic Locations for ACOT1 Gene
chr14:73,493,234-73,543,799
(GRCh38/hg38)
Size:
50,566 bases
Orientation:
Plus strand
chr14:74,003,818-74,010,498
(GRCh37/hg19)
Size:
6,681 bases
Orientation:
Plus strand

Genomic View for ACOT1 Gene

Genes around ACOT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOT1 Gene

Proteins for ACOT1 Gene

  • Protein details for ACOT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TX2-ACOT1_HUMAN
    Recommended name:
    Acyl-coenzyme A thioesterase 1
    Protein Accession:
    Q86TX2
    Secondary Accessions:
    • A1L173
    • Q3I5F9

    Protein attributes for ACOT1 Gene

    Size:
    421 amino acids
    Molecular mass:
    46277 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for ACOT1 Gene

Selected DME Specific Peptides for ACOT1 Gene

Q86TX2:
  • WKSEFYA
  • VELEVLDGH
  • GLLEYRASLLAGKGFAVMALAY
  • MASFLKGITA
  • IEPPYFP
  • PEQPVTLR
  • GLLGISKG
  • PALGGSF
  • AHARYRAD
  • DDHNWKS

Post-translational modifications for ACOT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOT1 Gene

Antibody Products

  • Abcam antibodies for ACOT1
  • Boster Bio Antibodies for ACOT1

Domains & Families for ACOT1 Gene

Gene Families for ACOT1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ACOT1 Gene

Blocks:
  • Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACOT1 Gene

GenScript: Design optimal peptide antigens:
  • Acyl-CoA thioesterase 1 (A1L172_HUMAN)
  • Long chain acyl-CoA thioester hydrolase (ACOT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86TX2

UniProtKB/Swiss-Prot:

ACOT1_HUMAN :
  • Belongs to the C/M/P thioester hydrolase family.
Family:
  • Belongs to the C/M/P thioester hydrolase family.
genes like me logo Genes that share domains with ACOT1: view

Function for ACOT1 Gene

Molecular function for ACOT1 Gene

UniProtKB/Swiss-Prot Function:
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+); Xref=Rhea:RHEA:40147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32360, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40148; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+); Xref=Rhea:RHEA:40131, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40132; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9E)-octadecenoyl-CoA + H2O = (9E)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40723, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30825, ChEBI:CHEBI:57287, ChEBI:CHEBI:77537; Evidence=. ; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40724; Evidence=. ;.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=35.8 uM for C10-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C12-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.8 uM for C14-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=3.6 uM for C16-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C18-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2 uM for C20-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.4 uM for C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=4.1 uM for C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; KM=2.1 uM for C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=224 nmol/min/mg enzyme toward C10-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=700 nmol/min/mg enzyme toward C12-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=912 nmol/min/mg enzyme toward C14-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=691 nmol/min/mg enzyme toward C16-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=597 nmol/min/mg enzyme toward C18-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=520 nmol/min/mg enzyme toward C20-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=577 nmol/min/mg enzyme toward C16:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=258 nmol/min/mg enzyme toward C18:1-acyl-CoA {ECO:0000269 PubMed:16940157}; Vmax=309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA {ECO:0000269 PubMed:16940157};

Enzyme Numbers (IUBMB) for ACOT1 Gene

Phenotypes From GWAS Catalog for ACOT1 Gene

Gene Ontology (GO) - Molecular Function for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016290 palmitoyl-CoA hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0016790 thiolester hydrolase activity IEA --
GO:0047617 acyl-CoA hydrolase activity IDA 16940157
GO:0052689 carboxylic ester hydrolase activity IEA --
genes like me logo Genes that share ontologies with ACOT1: view

Phenotypes for ACOT1 Gene

genes like me logo Genes that share phenotypes with ACOT1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOT1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACOT1 Gene

Localization for ACOT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOT1 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOT1 gene
Compartment Confidence
cytosol 5
peroxisome 3
nucleus 3
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with ACOT1: view

Pathways & Interactions for ACOT1 Gene

genes like me logo Genes that share pathways with ACOT1: view

UniProtKB/Swiss-Prot Q86TX2-ACOT1_HUMAN

  • Pathway: Lipid metabolism; fatty acid metabolism.

Gene Ontology (GO) - Biological Process for ACOT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000038 very long-chain fatty acid metabolic process IDA 16940157
GO:0001676 long-chain fatty acid metabolic process IDA 16940157
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IBA 21873635
GO:0006637 acyl-CoA metabolic process TAS,IEA --
genes like me logo Genes that share ontologies with ACOT1: view

No data available for SIGNOR curated interactions for ACOT1 Gene

Drugs & Compounds for ACOT1 Gene

(14) Drugs for ACOT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docosahexaenoic acid Approved, Investigational Pharma Full agonist, Agonist 0
Gamolenic acid Approved, Investigational Pharma 0
linoleic acid Approved, Experimental Pharma Full agonist, Agonist, Pore Blocker, Channel blocker 0
oleic acid Approved, Investigational, Vet_approved Pharma Full agonist, Agonist, Activation, Activator 0
Palmitic Acid Approved Pharma Full agonist, Agonist 25

(40) Additional Compounds for ACOT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (e)-S-2-Decenoate
  • (e)-S-2-Decenoate CoA
  • (e)-S-2-Decenoate coenzyme A
  • (e)-S-2-Decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (e)-C16:1 N-14-CoA
  • (e)-Hexadec-2-enoyl-CoA tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A tetraanion
  • (e)-Hexadec-2-enoyl-coenzyme A(4-)
  • trans-2-Hexadecenoyl-CoA(4-)
4460-95-1
(2E)-Octenoyl-CoA
  • (e)-S-2-Octenoate
  • (e)-S-2-Octenoate CoA
  • (e)-S-2-Octenoate coenzyme A
  • (e)-S-2-Octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-CoA
  • trans-Tetra-dec-2-enoyl-coa.
  • trans-Tetra-dec-2-enoyl-coenzyme A
  • trans-Tetra-dec-2-enoyl-coenzyme A.
38795-33-4
genes like me logo Genes that share compounds with ACOT1: view

Transcripts for ACOT1 Gene

mRNA/cDNA for ACOT1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOT1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACOT1 Gene

No ASD Table

Relevant External Links for ACOT1 Gene

GeneLoc Exon Structure for
ACOT1

Expression for ACOT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ACOT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ACOT1 Gene

This gene is overexpressed in Nasopharynx (14.1) and Skin (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACOT1 Gene



Protein tissue co-expression partners for ACOT1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACOT1

SOURCE GeneReport for Unigene cluster for ACOT1 Gene:

Hs.568046

Evidence on tissue expression from TISSUES for ACOT1 Gene

  • Heart(2.3)
  • Liver(2.3)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with ACOT1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOT1 Gene

Orthologs for ACOT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ACOT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACOT2 31
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Acot3 30
  • 83.37 (n)
mouse
(Mus musculus)
Mammalia Acot3 17 31 30
  • 82.5 (n)
Acot1 31
  • 77 (a)
ManyToMany
Acot5 31
  • 74 (a)
ManyToMany
Acot2 31
  • 71 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ACOT2 31
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 64 (a)
ManyToMany
-- 31
  • 59 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 43 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-288i20.1 31 30
  • 53.83 (n)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K05B2.4 31
  • 28 (a)
ManyToMany
W03D8.8 31
  • 27 (a)
ManyToMany
C31H5.6 31
  • 25 (a)
ManyToMany
T05E7.1 31
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
Species where no ortholog for ACOT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACOT1 Gene

ENSEMBL:
Gene Tree for ACOT1 (if available)
TreeFam:
Gene Tree for ACOT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACOT1: view image

Paralogs for ACOT1 Gene

Paralogs for ACOT1 Gene

(4) SIMAP similar genes for ACOT1 Gene using alignment to 3 proteins:

  • ACOT1_HUMAN
  • A1L172_HUMAN
  • G3V4F2_HUMAN

Pseudogenes.org Pseudogenes for ACOT1 Gene

genes like me logo Genes that share paralogs with ACOT1: view

Variants for ACOT1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACOT1 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
725891 Benign: not provided 73,537,571(+) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT
726254 Likely Benign: not provided 73,541,639(+) AC/A FRAMESHIFT_VARIANT,INTRON_VARIANT
726638 Benign: not provided 73,543,213(+) T/C MISSENSE_VARIANT,INTRON_VARIANT
726639 Benign: not provided 73,543,216(+) G/C MISSENSE_VARIANT,INTRON_VARIANT
769865 Likely Benign: not provided 73,543,627(+) A/G MISSENSE_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ACOT1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACOT1 Gene

Variant ID Type Subtype PubMed ID
dgv1102n106 CNV deletion 24896259
dgv1935n100 CNV gain 25217958
dgv21n47 CNV loss 21111241
dgv375n67 CNV loss 20364138
dgv3761n54 CNV gain 21841781
dgv3763n54 CNV loss 21841781
dgv3764n54 CNV gain 21841781
dgv3765n54 CNV gain 21841781
dgv3766n54 CNV gain 21841781
dgv3767n54 CNV loss 21841781
dgv3768n54 CNV loss 21841781
dgv3769n54 CNV loss 21841781
dgv3770n54 CNV loss 21841781
dgv3771n54 CNV loss 21841781
dgv3772n54 CNV loss 21841781
dgv3773n54 CNV gain 21841781
dgv401e199 CNV deletion 23128226
dgv653e212 CNV gain 25503493
dgv654e212 CNV loss 25503493
dgv655e212 CNV gain 25503493
dgv656e212 CNV gain 25503493
dgv657e212 CNV gain 25503493
dgv658e212 CNV gain 25503493
dgv659e212 CNV gain 25503493
dgv660e212 CNV loss 25503493
dgv661e212 CNV loss 25503493
esv1006342 CNV deletion 20482838
esv2421969 OTHER complex 20811451
esv2518446 CNV loss 19546169
esv2672436 CNV deletion 23128226
esv2748867 CNV deletion 23290073
esv2759996 CNV gain 17122850
esv2760335 CNV gain+loss 21179565
esv2761566 CNV gain+loss 21179565
esv2904901 CNV deletion 24192839
esv29080 CNV gain+loss 19812545
esv29945 CNV loss 18421352
esv33155 CNV gain+loss 17666407
esv3423432 CNV duplication 20981092
esv3581298 CNV loss 25503493
esv3581301 CNV loss 25503493
esv3584669 CNV loss 24956385
esv3634909 CNV loss 21293372
esv3892561 CNV gain 25118596
esv990289 CNV loss 20482838
nsv1035460 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv1350 CNV deletion 18451855
nsv428295 CNV gain 18775914
nsv436178 CNV deletion 17901297
nsv442687 CNV loss 18776908
nsv482172 CNV gain 20164927
nsv510643 CNV deletion 20534489
nsv514748 CNV gain 21397061
nsv514749 CNV gain+loss 21397061
nsv565110 CNV loss 21841781
nsv565111 CNV loss 21841781
nsv565124 CNV gain+loss 21841781
nsv565125 CNV gain 21841781
nsv565153 CNV loss 21841781
nsv819138 CNV loss 19587683
nsv821106 CNV deletion 20802225
nsv826976 CNV loss 20364138
nsv826978 CNV loss 20364138
nsv826979 CNV loss 20364138
nsv832828 CNV gain+loss 17160897
nsv9153 CNV gain+loss 18304495
nsv952866 CNV deletion 24416366

Variation tolerance for ACOT1 Gene

Gene Damage Index Score: 4.61; 65.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOT1 Gene

Human Gene Mutation Database (HGMD)
ACOT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOT1 Gene

Disorders for ACOT1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ACOT1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aztreonam allergy
  • azactam allergy
cefuroxime allergy
  • cephuroxime allergy
ceftriaxone allergy
  • rocephin allergy
cefaclor allergy
  • ceclor allergy
anorectal stricture
  • stenosis of rectum and anus
- elite association - COSMIC cancer census association via MalaCards
Search ACOT1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ACOT1

genes like me logo Genes that share disorders with ACOT1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOT1 Gene

Publications for ACOT1 Gene

  1. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. (PMID: 16940157) Hunt MC … Alexson SE (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006) 2 3 4 54
  2. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. (PMID: 16103133) Hunt MC … Alexson SE (Journal of lipid research 2005) 2 3 54
  3. Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing. (PMID: 30890647) Viita T … Vartiainen MK (Journal of cell science 2019) 3 54
  4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  5. ACOT1 expression is associated with poor prognosis in gastric adenocarcinoma. (PMID: 29555575) Wang F … Mao Y (Human pathology 2018) 3 54

Products for ACOT1 Gene

Sources for ACOT1 Gene