Aliases for ACOD1 Gene

Aliases for ACOD1 Gene

  • Aconitate Decarboxylase 1 2 3 4 5
  • CAD 2 3 4
  • Cis-Aconitic Acid Decarboxylase 3 4
  • Cis-Aconitate Decarboxylase 3 4
  • IRG1 3 4
  • Immune-Responsive Gene 1 Protein Homolog 3
  • Immunoresponsive 1 Homolog (Mouse) 2
  • Immune-Responsive Gene 1 Protein 4
  • Immunoresponsive 1 Homolog 3
  • Aconitate Decarboxylase 4
  • EC 4.1.1.6 4
  • ACOD1 5

External Ids for ACOD1 Gene

Previous HGNC Symbols for ACOD1 Gene

  • IRG1

Summaries for ACOD1 Gene

GeneCards Summary for ACOD1 Gene

ACOD1 (Aconitate Decarboxylase 1) is a Protein Coding gene. Diseases associated with ACOD1 include Zika Virus Congenital Syndrome. Among its related pathways are Metabolism and Glucose / Energy Metabolism.

UniProtKB/Swiss-Prot Summary for ACOD1 Gene

  • Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

Additional gene information for ACOD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACOD1 Gene

Genomics for ACOD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ACOD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J076944 Enhancer 1 FANTOM5 Ensembl ENCODE 600.7 -1.4 -1410 7.4 CEBPB FOXA2 JUN FOS JUND EP300 CEBPG STAT3 TCF7L2 GATA2 ACOD1 KCTD12 piR-37663-020 LOC105370269 lnc-ACOD1-2
GH13J076917 Enhancer 1 Ensembl ENCODE 11.2 -30.7 -30664 1.5 RFX1 LEF1 IKZF1 BACH1 MTA2 ZIC2 ZNF24 MTA1 REST IKZF2 piR-53029-034 ACOD1 CLN5 lnc-ACOD1-2 KCTD12
GH13J076976 Enhancer 0.9 Ensembl ENCODE 10.6 +28.1 28090 2 ATF7 PRDM10 ZNF629 ZNF692 SCRT2 ZNF639 TCF7L2 ZNF10 ZXDB TSHZ1 HSALNG0098012 LOC105370269 ACOD1 CLN5 piR-36588-128 MYCBP2-AS1
GH13J076903 Enhancer 0.8 Ensembl ENCODE 10.1 -44.3 -44310 2 CTCF ZNF629 FOXA1 ZNF143 REST RAD21 TRIM22 SCRT2 BCLAF1 ZNF592 ACOD1 lnc-ACOD1-2 piR-53029-034 KCTD12
GH13J076981 Enhancer 0.6 Ensembl 10.1 +34.4 34389 2.2 RXRB IKZF2 GABPA CEBPA FOXA2 CREB1 ZBTB17 FOXP1 SAP130 SMAD4 DHX9P1 RPL7P44 lnc-FBXL3-2 FBXL3 ACOD1 CLN5 MYCBP2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACOD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACOD1

Genomic Locations for ACOD1 Gene

Genomic Locations for ACOD1 Gene
chr13:76,948,511-76,958,638
(GRCh38/hg38)
Size:
10,128 bases
Orientation:
Plus strand
chr13:77,511,985-77,532,794
(GRCh37/hg19)
Size:
20,810 bases
Orientation:
Plus strand

Genomic View for ACOD1 Gene

Genes around ACOD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACOD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACOD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACOD1 Gene

Proteins for ACOD1 Gene

  • Protein details for ACOD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK06-IRG1_HUMAN
    Recommended name:
    Cis-aconitate decarboxylase
    Protein Accession:
    A6NK06

    Protein attributes for ACOD1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52628 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ACOD1 Gene

neXtProt entry for ACOD1 Gene

Post-translational modifications for ACOD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACOD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ACOD1 Gene

Domains & Families for ACOD1 Gene

Gene Families for ACOD1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ACOD1 Gene

Suggested Antigen Peptide Sequences for ACOD1 Gene

GenScript: Design optimal peptide antigens:
  • Immune-responsive gene 1 protein homolog (IRG1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NK06

UniProtKB/Swiss-Prot:

IRG1_HUMAN :
  • Belongs to the PrpD family.
Family:
  • Belongs to the PrpD family.
genes like me logo Genes that share domains with ACOD1: view

Function for ACOD1 Gene

Molecular function for ACOD1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=cis-aconitate + H(+) = CO2 + itaconate; Xref=Rhea:RHEA:15253, ChEBI:CHEBI:15378, ChEBI:CHEBI:16383, ChEBI:CHEBI:16526, ChEBI:CHEBI:17240; EC=4.1.1.6; Evidence={ECO:0000269|PubMed:23610393};.
UniProtKB/Swiss-Prot Induction:
Up-regulated after lipopolysaccharide (LPS) stimulation. Up-regulated in LPS-tolerized macrophage by LPS. Up-regulated in peripheral blood mononuclear cells (PBMC) of patient after acute sepsis.

Enzyme Numbers (IUBMB) for ACOD1 Gene

Phenotypes From GWAS Catalog for ACOD1 Gene

Gene Ontology (GO) - Molecular Function for ACOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016829 lyase activity IEA --
GO:0047613 aconitate decarboxylase activity IBA,IDA 23610393
genes like me logo Genes that share ontologies with ACOD1: view
genes like me logo Genes that share phenotypes with ACOD1: view

Animal Models for ACOD1 Gene

MGI Knock Outs for ACOD1:
  • Acod1 Acod1<tm1a(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for ACOD1

CRISPR Products

miRNA for ACOD1 Gene

miRTarBase miRNAs that target ACOD1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOD1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ACOD1 Gene

Localization for ACOD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACOD1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACOD1 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 3
extracellular 2
peroxisome 2
lysosome 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for ACOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA,ISS --
genes like me logo Genes that share ontologies with ACOD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ACOD1 Gene

Pathways & Interactions for ACOD1 Gene

PathCards logo

SuperPathways for ACOD1 Gene

genes like me logo Genes that share pathways with ACOD1: view

Pathways by source for ACOD1 Gene

1 KEGG pathway for ACOD1 Gene
1 Cell Signaling Technology pathway for ACOD1 Gene

Gene Ontology (GO) - Biological Process for ACOD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002760 positive regulation of antimicrobial humoral response IDA 23610393
GO:0006952 defense response IBA,IDA 23610393
GO:0006954 inflammatory response IEA --
GO:0007566 embryo implantation ISS --
genes like me logo Genes that share ontologies with ACOD1: view

No data available for SIGNOR curated interactions for ACOD1 Gene

Drugs & Compounds for ACOD1 Gene

No Compound Related Data Available

Transcripts for ACOD1 Gene

mRNA/cDNA for ACOD1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACOD1

Alternative Splicing Database (ASD) splice patterns (SP) for ACOD1 Gene

No ASD Table

Relevant External Links for ACOD1 Gene

GeneLoc Exon Structure for
ACOD1

Expression for ACOD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACOD1

mRNA Expression by UniProt/SwissProt for ACOD1 Gene:

A6NK06-IRG1_HUMAN
Tissue specificity: Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells.

Evidence on tissue expression from TISSUES for ACOD1 Gene

  • Spleen(2.5)
  • Lymph node(2.3)
  • Skin(2.2)
  • Bone marrow(2.1)
  • Intestine(2.1)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACOD1 Gene

Orthologs for ACOD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACOD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IRG1 30 31
  • 98.8 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC504806 30
  • 85.25 (n)
IRG1 31
  • 82 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia IRG1 30 31
  • 84.37 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Irg1 30
  • 83.87 (n)
Mouse
(Mus musculus)
Mammalia Irg1 30 31
  • 83.23 (n)
OneToOne
Acod1 17
Oppossum
(Monodelphis domestica)
Mammalia IRG1 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IRG1 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IRG1 30 31
  • 66.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IRG1 31
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia irg1 30
  • 65.09 (n)
Zebrafish
(Danio rerio)
Actinopterygii irg1 30 31
  • 59.29 (n)
OneToOne
Species where no ortholog for ACOD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ACOD1 Gene

ENSEMBL:
Gene Tree for ACOD1 (if available)
TreeFam:
Gene Tree for ACOD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACOD1: view image

Paralogs for ACOD1 Gene

No data available for Paralogs for ACOD1 Gene

Variants for ACOD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACOD1 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
776800 Benign: not provided 76,953,656(+) G/T SYNONYMOUS_VARIANT
776801 Benign: not provided 76,955,509(+) A/G MISSENSE_VARIANT
784272 Benign: not provided 76,957,357(+) G/A MISSENSE_VARIANT
787412 Benign: not provided 76,955,316(+) C/T INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for ACOD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ACOD1 Gene

Variant ID Type Subtype PubMed ID
nsv832651 CNV gain 17160897
nsv832652 CNV gain 17160897
nsv832653 CNV loss 17160897

Variation tolerance for ACOD1 Gene

Gene Damage Index Score: 2.34; 41.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACOD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACOD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACOD1 Gene

Disorders for ACOD1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ACOD1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
zika virus congenital syndrome
  • zikv congenital infection
- elite association - COSMIC cancer census association via MalaCards
Search ACOD1 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with ACOD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ACOD1 Gene

Publications for ACOD1 Gene

  1. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. (PMID: 23610393) Michelucci A … Hiller K (Proceedings of the National Academy of Sciences of the United States of America 2013) 2 3 4
  2. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. (PMID: 23609450) Li Y … Cao X (The Journal of biological chemistry 2013) 3 4
  3. Progesterone regulation of the mammalian ortholog of methylcitrate dehydratase (immune response gene 1) in the uterine epithelium during implantation through the protein kinase C pathway. (PMID: 12893884) Chen B … Pollard JW (Molecular endocrinology (Baltimore, Md.) 2003) 2 3
  4. Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. (PMID: 31548418) Chen F … Pessler F (Proceedings of the National Academy of Sciences of the United States of America 2019) 3
  5. IRG1 increases MHC class I level in macrophages through STAT-TAP1 axis depending on NADPH oxidase mediated reactive oxygen species. (PMID: 28477473) Liu X … Liu Y (International immunopharmacology 2017) 3

Products for ACOD1 Gene

Sources for ACOD1 Gene