Aliases for ACLY Gene
External Ids for ACLY Gene
Previous GeneCards Identifiers for ACLY Gene
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for ACLY Gene
ACLY (ATP Citrate Lyase) is a Protein Coding gene. Diseases associated with ACLY include Ciliary Dyskinesia, Primary, 35 and Acrocallosal Syndrome. Among its related pathways are Innate Immune System and Fatty Acid Biosynthesis (WikiPathways). Gene Ontology (GO) annotations related to this gene include cofactor binding and ATP citrate synthase activity.
UniProtKB/Swiss-Prot Summary for ACLY Gene
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
ATP citrate lyase (ATP citrate synthase, ACLY) is a transferase that catalyzes the conversion of citrate and coenzyme A to acetyl-CoA. ACLY is the key regulator between the high rates of aerobic glycolysis and de novo lipid synthesis exhibited in many types of tumor cells.