Aliases for ACLY Gene
External Ids for ACLY Gene
Previous GeneCards Identifiers for ACLY Gene
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
GeneCards Summary for ACLY Gene
ACLY (ATP Citrate Lyase) is a Protein Coding gene. Diseases associated with ACLY include Trichothiodystrophy 1, Photosensitive and Trigonitis. Among its related pathways are Regulation of lipid metabolism Insulin signaling-generic cascades and Fatty Acid Biosynthesis (WikiPathways). Gene Ontology (GO) annotations related to this gene include cofactor binding and ATP citrate synthase activity.
UniProtKB/Swiss-Prot Summary for ACLY Gene
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
ATP citrate lyase (ATP citrate synthase, ACLY) is a transferase that catalyzes the conversion of citrate and coenzyme A to acetyl-CoA. ACLY is the key regulator between the high rates of aerobic glycolysis and de novo lipid synthesis exhibited in many types of tumor cells.