Aliases for ACE2 Gene
External Ids for ACE2 Gene
Previous GeneCards Identifiers for ACE2 Gene
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]
GeneCards Summary for ACE2 Gene
ACE2 (Angiotensin I Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ACE2 include Severe Acute Respiratory Syndrome and Neurogenic Hypertension. Among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Peptide hormone metabolism. Gene Ontology (GO) annotations related to this gene include metallopeptidase activity and peptide binding. An important paralog of this gene is ACE.
UniProtKB/Swiss-Prot for ACE2 Gene
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function.
(Microbial infection) Acts as a receptor for SARS coronavirus/SARS-CoV.
(Microbial infection) Acts as a receptor for Human coronavirus NL63/HCoV-NL63.
Angiotensin-converting enzyme (ACE, aka peptidyl dipeptidase A, carboxycathepsin) cleaves a C-terminal dipeptide from angiotensin I to create the vasoconstrictor peptide, angiotensin II. ACE can also inactivate the vasodilator, proinflammatory peptide, bradykinin.