This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the acces... See more...

Aliases for ACD Gene

Aliases for ACD Gene

  • ACD Shelterin Complex Subunit And Telomerase Recruitment Factor 2 3 5
  • Adrenocortical Dysplasia Protein Homolog 3 4
  • POT1 And TIN2-Interacting Protein 3 4
  • TIN2 Interacting Protein 1 2 3
  • TINT1 3 4
  • PIP1 3 4
  • PTOP 3 4
  • TPP1 3 4
  • Adrenocortical Dysplasia Homolog (Mouse) 2
  • Adrenocortical Dysplasia Homolog 3
  • POT1 And TIN2 Organizing Protein 2

External Ids for ACD Gene

Previous GeneCards Identifiers for ACD Gene

  • GC16M066249
  • GC16M067691
  • GC16M053564

Summaries for ACD Gene

Entrez Gene Summary for ACD Gene

  • This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]

GeneCards Summary for ACD Gene

ACD (ACD Shelterin Complex Subunit And Telomerase Recruitment Factor) is a Protein Coding gene. Diseases associated with ACD include Dyskeratosis Congenita, Autosomal Dominant 6 and Hoyeraal Hreidarsson Syndrome. Among its related pathways are Cellular Senescence (REACTOME) and Cell Cycle, Mitotic. Gene Ontology (GO) annotations related to this gene include DNA polymerase binding.

UniProtKB/Swiss-Prot Summary for ACD Gene

  • Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Gene Wiki entry for ACD Gene

Additional gene information for ACD Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACD Gene

Genomics for ACD Gene

GeneHancer (GH) Regulatory Elements for ACD Gene

Promoters and enhancers for ACD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067658 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 774.3 +0.3 328 3 E2F8 ZBTB40 RBPJ POLR2A CREB1 HCFC1 NFYC HLF L3MBTL2 CEBPB ACD PARD6A lnc-ENKD1-1 EDC4 CTCF CENPT NFATC3 E2F4 NAE1 ZDHHC1
GH16J067871 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 43.8 -212.5 -212495 3.8 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SIX5 ZBTB6 MLX RBPJ POLR2A EDC4 ACD E2F4 ZFP90 PRMT7 TRADD ENSG00000263276 CTCF CENPT FBXL8
GH16J068077 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 29.3 -424.9 -424866 16 SIN3A SP1 ZBTB40 SIX5 LCORL FOXA1 MLX RBPJ SMARCE1 POLR2A NFATC3 lnc-DDX28-2 EDC4 E2F4 PRMT7 ACD CENPT TRADD CTCF PSKH1
GH16J067992 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 33.3 -334.1 -334064 4.1 ZNF785 SP1 CTCF ZBTB6 RBPJ CREB1 MIXL1 RUNX1 CC2D1A NFYC DPEP2 EDC4 CENPT PRMT7 CTCF ACD ENSG00000263276 DDX28 E2F4 SLC7A6OS
GH16J067963 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 33.9 -305.8 -305841 7.1 ZNF785 SP1 ZBTB40 SREBF1 RBPJ POLR2A NR2F1 NR2F6 ATF1 NFYC SLC12A4 PRMT7 ACD KIAA0895L ZFP90 TRADD EDC4 E2F4 FBXL8 CENPT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACD gene promoter:
  • AML1a
  • AREB6
  • Nkx2-5
  • Pax-5

Genomic Locations for ACD Gene

Genomic Locations for ACD Gene
chr16:67,657,512-67,660,815
(GRCh38/hg38)
Size:
3,304 bases
Orientation:
Minus strand
chr16:67,691,415-67,694,718
(GRCh37/hg19)
Size:
3,304 bases
Orientation:
Minus strand

Genomic View for ACD Gene

Genes around ACD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACD Gene

Proteins for ACD Gene

  • Protein details for ACD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AP0-ACD_HUMAN
    Recommended name:
    Adrenocortical dysplasia protein homolog
    Protein Accession:
    Q96AP0
    Secondary Accessions:
    • Q562H5
    • Q9H8F9

    Protein attributes for ACD Gene

    Size:
    544 amino acids
    Molecular mass:
    57733 Da
    Quaternary structure:
    • Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2.
    SequenceCaution:
    • Sequence=AAX82621.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ACD Gene

    Alternative splice isoforms for ACD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ACD Gene

Post-translational modifications for ACD Gene

  • Ubiquitination at Lys492
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ACD Gene

Domains & Families for ACD Gene

Gene Families for ACD Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for ACD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ACD Gene

GenScript: Design optimal peptide antigens:
  • POT1 and TIN2-interacting protein (ACD_HUMAN)
genes like me logo Genes that share domains with ACD: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ACD Gene

Function for ACD Gene

Molecular function for ACD Gene

UniProtKB/Swiss-Prot Function:
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Phenotypes From GWAS Catalog for ACD Gene

Gene Ontology (GO) - Molecular Function for ACD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15181449
GO:0042162 telomeric DNA binding IDA 23685356
GO:0044877 protein-containing complex binding IPI 25172512
GO:0070182 DNA polymerase binding TAS 25467444
genes like me logo Genes that share ontologies with ACD: view
genes like me logo Genes that share phenotypes with ACD: view

Human Phenotype Ontology for ACD Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ACD Gene

MGI Knock Outs for ACD:
  • Acd Acd<tm1.2Cek>

Animal Model Products

CRISPR Products

miRNA for ACD Gene

miRTarBase miRNAs that target ACD

Clone Products

  • Addgene plasmids for ACD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ACD Gene

Localization for ACD Gene

Subcellular locations from UniProtKB/Swiss-Prot for ACD Gene

Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACD gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
mitochondrion 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ACD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0000783 nuclear telomere cap complex IBA,IDA 16880378
GO:0000784 nuclear chromosome, telomeric region IDA 15380063
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ACD: view

Pathways & Interactions for ACD Gene

genes like me logo Genes that share pathways with ACD: view

Pathways by source for ACD Gene

SIGNOR curated interactions for ACD Gene

Activates:

Gene Ontology (GO) - Biological Process for ACD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IDA 15181449
GO:0006886 intracellular protein transport IMP 15181449
GO:0016233 telomere capping TAS,NAS 17237768
GO:0031848 protection from non-homologous end joining at telomere ISS 18185984
GO:0032202 telomere assembly IMP 16880378
genes like me logo Genes that share ontologies with ACD: view

Drugs & Compounds for ACD Gene

(1) Additional Compounds for ACD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ACD: view

Transcripts for ACD Gene

CRISPR Products

Clone Products

  • Addgene plasmids for ACD

Alternative Splicing Database (ASD) splice patterns (SP) for ACD Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h · 1i ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - - -
SP7: - - -
SP8: - - -
SP9: - - - - -
SP10: - -
SP11: -
SP12: -
SP13:

ExUns: 10a · 10b ^ 11 ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ACD Gene

GeneLoc Exon Structure for
ACD
ECgene alternative splicing isoforms for
ACD

Expression for ACD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACD Gene

Protein differential expression in normal tissues from HIPED for ACD Gene

This gene is overexpressed in Fetal testis (21.5), Peripheral blood mononuclear cells (15.0), Blymphocyte (13.9), and CD8 Tcells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ACD Gene



Protein tissue co-expression partners for ACD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ACD Gene:

ACD

SOURCE GeneReport for Unigene cluster for ACD Gene:

Hs.78019

Evidence on tissue expression from TISSUES for ACD Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Nervous system(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ACD Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • lacrimal apparatus
  • mandible
  • maxilla
  • mouth
  • neck
  • salivary gland
  • skull
  • tooth
Thorax:
  • breast
  • chest wall
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • kidney
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • pelvis
  • penis
  • rectum
  • testicle
  • urethra
  • urinary bladder
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nervous system
  • red blood cell
  • skin
  • spinal column
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with ACD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ACD Gene

Orthologs for ACD Gene

This gene was present in the common ancestor of chordates.

Orthologs for ACD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACD 33 32
  • 98.78 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ACD 33 32
  • 82.53 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACD 33 32
  • 80.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Acd 17 33 32
  • 76 (n)
rat
(Rattus norvegicus)
Mammalia Acd 32
  • 75.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACD 33
  • 40 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACD 33
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves ACD 33
  • 21 (a)
OneToOne
Species where no ortholog for ACD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ACD Gene

ENSEMBL:
Gene Tree for ACD (if available)
TreeFam:
Gene Tree for ACD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACD: view image

Paralogs for ACD Gene

Pseudogenes.org Pseudogenes for ACD Gene

genes like me logo Genes that share paralogs with ACD: view

No data available for Paralogs for ACD Gene

Variants for ACD Gene

Sequence variations from dbSNP and Humsavar for ACD Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1017802690 likely-benign, Dyskeratosis congenita, autosomal dominant 6 67,659,530(-) C/T intron_variant
rs1035052101 uncertain-significance, Dyskeratosis congenita, autosomal dominant 6 67,658,575(-) G/A coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1377497479 likely-benign, Dyskeratosis congenita, autosomal dominant 6 67,660,257(-) G/A/C 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant, synonymous_variant
rs138527794 likely-benign, benign, not specified, Dyskeratosis congenita, autosomal dominant 6 67,660,013(-) G/A/C coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs138740815 benign, Dyskeratosis congenita, autosomal dominant 6 67,658,565(-) G/A coding_sequence_variant, intron_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ACD Gene

Variant ID Type Subtype PubMed ID
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv952046 CNV deletion 24416366

Variation tolerance for ACD Gene

Residual Variation Intolerance Score: 23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACD Gene

Human Gene Mutation Database (HGMD)
ACD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACD Gene

Disorders for ACD Gene

MalaCards: The human disease database

(11) MalaCards diseases for ACD Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
dyskeratosis congenita, autosomal dominant 6
  • dkca6
hoyeraal hreidarsson syndrome
  • cerebellar hypoplasia with pancytopenia
hereditary lymphedema i
  • nonne-milroy lymphedema
dyskeratosis congenita autosomal dominant
  • autosomal dominant dyskeratosis congenita
dyskeratosis congenita
  • zinsser-cole-engman syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ACD in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ACD_HUMAN
  • Dyskeratosis congenita, autosomal dominant, 6 (DKCA6) [MIM:616553]: A form of dyskeratosis congenita, a rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. {ECO:0000269 PubMed:25205116}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Dyskeratosis congenita, autosomal recessive, 7 (DKCB7) [MIM:616553]: A form of dyskeratosis congenita, a rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. {ECO:0000269 PubMed:25233904}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ACD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ACD: view

No data available for Genatlas for ACD Gene

Publications for ACD Gene

  1. PTOP interacts with POT1 and regulates its localization to telomeres. (PMID: 15181449) Liu D … Songyang Z (Nature cell biology 2004) 2 3 4 23 56
  2. POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. (PMID: 15231715) Ye JZ … de Lange T (Genes & development 2004) 2 3 4 23 56
  3. Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. (PMID: 15383534) Liu D … Songyang Z (The Journal of biological chemistry 2004) 3 4 23 56
  4. TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. (PMID: 15316005) Ye JZ … de Lange T (The Journal of biological chemistry 2004) 3 4 23 56
  5. Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1. (PMID: 25205116) Guo Y … Bryan TM (Blood 2014) 3 4 56

Products for ACD Gene

Sources for ACD Gene