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Aliases for ACCSL Gene
Aliases for ACCSL Gene
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like 2 3 5
- Probable Inactive 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 2 3 4
- ACC Synthase-Like Protein 2 3 4
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)-Like 2
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog(Non-Functional)-Like 3
- 1-Aminocyclopropane-1-Carboxylate Synthase (Inactive)-Like 3
- 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 2 3
- ACCSL 5
External Ids for ACCSL Gene
- HGNC: 34391
- Entrez Gene: 390110
- Ensembl: ENSG00000205126
- UniProtKB: Q4AC99
Previous GeneCards Identifiers for ACCSL Gene
- GC11P043778
- GC11P043922
Summaries for ACCSL Gene
GeneCards Summary for ACCSL Gene
ACCSL (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding. An important paralog of this gene is ACCS.
Additional gene information for ACCSL Gene
- HGNC(34391)
- Entrez Gene(390110)
- Ensembl(ENSG00000205126)
- UniProtKB(Q4AC99)
- Open Targets Platform(ENSG00000205126)
- Search for ACCSL at DataMed
- Search for ACCSL at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACCSL Gene
Genomics for ACCSL Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for ACCSL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ACCSL on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ACCSL
- Top Transcription factor binding sites by QIAGEN in the ACCSL gene promoter:
-
- HOXA5
- Ik-2
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- STAT4
- STAT5A
- STAT6
Genomic Locations for ACCSL Gene
Genomic Locations for ACCSL Gene
- chr11:44,047,981-44,059,977
- (GRCh38/hg38)
- Size:
- 11,997 bases
- Orientation:
- Plus strand
- chr11:44,069,531-44,081,527
- (GRCh37/hg19)
- Size:
- 11,997 bases
- Orientation:
- Plus strand
Genomic View for ACCSL Gene
Genes around ACCSL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
ACCSL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACCSL Gene
Proteins for ACCSL Gene
-
Protein details for ACCSL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4AC99-1A1L2_HUMAN
- Recommended name:
- Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
- Protein Accession:
- Q4AC99
Protein attributes for ACCSL Gene
- Size:
- 568 amino acids
- Molecular mass:
- 65249 Da
- Quaternary structure:
- No Data Available
Protein Expression for ACCSL Gene
Post-translational modifications for ACCSL Gene
Other Protein References for ACCSL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACCSL
- Novus Biologicals Antibodies for ACCSL
- Invitrogen Antibodies for ACCSL (AFLGC-ACCSL)
- antibodies-online: Show 23 available ACCSL Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for ACCSL
- Search Origene for MassSpec and Protein Over-expression Lysates for ACCSL
- Origene Custom Protein Services for ACCSL
- Novus Biologicals lysates for ACCSL
No data available for DME Specific Peptides for ACCSL Gene
Domains & Families for ACCSL Gene
Gene Families for ACCSL Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ACCSL Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACCSL Gene
- GenScript: Design optimal peptide antigens:
-
- 1-aminocyclopropane-1-carboxylate synthase-like protein 2 (1A1L2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q4AC99UniProtKB/Swiss-Prot:
1A1L2_HUMAN :- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
- Family:
-
- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Function for ACCSL Gene
Phenotypes From GWAS Catalog for ACCSL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0030170 | pyridoxal phosphate binding | IEA | -- |
Phenotypes for ACCSL Gene
- GenomeRNAi human phenotypes for ACCSL:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ACCSL - Select products 50% OFF >
- * ACCSL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ACCSL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACCSL
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACCSL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACCSL
Clone Products
- Applied Biological Materials (abm): Clones for ACCSL - Select products 50% OFF >
- * ACCSL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
Cell Line Products
-
Horizon Cell Lines for ACCSL
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACCSL Gene
Localization for ACCSL Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| plasma membrane | 0 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ACCSL Gene
Pathways & Interactions for ACCSL Gene
Interacting Proteins for ACCSL Gene
GPS-Prot Interaction Network for ACCSL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009058 | biosynthetic process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ACCSL Gene
Transcripts for ACCSL Gene
mRNA/cDNA for ACCSL Gene
- 2 REFSEQ mRNAs :
- 5 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000378832 1820 nts (view in UCSC)
- ENST00000527145 1806 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ACCSL - Select products 50% OFF >
- * ACCSL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for ACCSL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACCSL
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACCSL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACCSL
Clone Products
- Applied Biological Materials (abm): Clones for ACCSL - Select products 50% OFF >
- * ACCSL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
Relevant External Links for ACCSL Gene
- GeneLoc Exon Structure for
- ACCSL
Expression for ACCSL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ACCSL Gene
This gene is overexpressed in Testis (x13.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACCSL Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ACCSL
SOURCE GeneReport for Unigene cluster for ACCSL Gene:
Hs.558851Primer Products
-
OriGene qPCR primer pairs for ACCSL
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACCSL Gene
Orthologs for ACCSL Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ACCSL 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | ACCSL 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Accsl 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Accsl 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | ACCSL 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | ACCSL 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | accs 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | T04F3.1 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | ACS2 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os04g0578000 30 |
|
- Species where no ortholog for ACCSL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for ACCSL Gene
- ENSEMBL:
- Gene Tree for ACCSL (if available)
- TreeFam:
- Gene Tree for ACCSL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ACCSL: view image
Paralogs for ACCSL Gene
Variants for ACCSL Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ACCSL Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2074051 | - | p.Cys529Arg |
Residual Variation Intolerance Score:
57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ACCSL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACCSL Gene
Disorders for ACCSL Gene
Additional Disease Information for ACCSL
No disorders were found for ACCSL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACCSL Gene
Publications for ACCSL Gene
- Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
ExternalLinks
Products for ACCSL Gene
- Custom Antibody ServicesOriGene Antibodies for ACCSL
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ACCSL
- Search Origene for MassSpec and Protein Over-expression Lysates for ACCSL
- Origene Custom Protein Services for ACCSL
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- OriGene qPCR primer pairs for ACCSL
- OriGene CRISPR knockouts for ACCSL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ACCSL
- Sino Biological Human cDNA Clone for ACCSL
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ACCSL
- Novus Biologicals lysates for ACCSL
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for ACCSL (AFLGC-ACCSL)
- VectorBuilder Custom and pre-made DNA vectors for ACCSL (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for ACCSL (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for ACCSL (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for ACCSL CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for ACCSL
- antibodies-online: Show 23 available ACCSL Antibodies ranked by validation data
- antibodies-online: Search results for available ACCSL related products ranked by validation data
- antibodies-online: Search results for available ACCSL related products ranked by validation data
- Horizon Cell Lines for ACCSL
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ACCSL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACCSL
Sources for ACCSL Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB