Aliases for ACCSL Gene
Aliases for ACCSL Gene
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like 2 3 5
- ACC Synthase-Like Protein 2 3 4
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)-Like 2
- Probable Inactive 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 2 3
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog(Non-Functional)-Like 3
- 1-Aminocyclopropane-1-Carboxylate Synthase (Inactive)-Like 3
- 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 2 3
External Ids for ACCSL Gene
- HGNC: 34391
- Entrez Gene: 390110
- Ensembl: ENSG00000205126
- UniProtKB: Q4AC99
Previous GeneCards Identifiers for ACCSL Gene
- GC11P044027
- GC11P043778
Summaries for ACCSL Gene
GeneCards Summary for ACCSL Gene
ACCSL (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding. An important paralog of this gene is ACCS.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACCSL Gene
Genomics for ACCSL Gene
GeneHancer (GH) Regulatory Elements for ACCSL Gene
Promoters and enhancers for ACCSL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ACCSL on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ACCSL gene promoter:
-
- STAT6
- HOXA5
- Ik-2
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- STAT4
- STAT5A
Regulatory Element Products
Genomic Locations for ACCSL Gene
Genomic Locations for ACCSL Gene
- chr11:43,921,084-44,060,307
- (GRCh38/hg38)
- Size:
- 139,224 bases
- Orientation:
- Plus strand
- chr11:44,069,531-44,081,527
- (GRCh37/hg19)
- Size:
- 11,997 bases
- Orientation:
- Plus strand
Genomic View for ACCSL Gene
Genes around ACCSL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by Entrez Gene
- 11p11.2 by HGNC
- 11p11.2 by Ensembl
ACCSL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACCSL Gene
Proteins for ACCSL Gene
-
Protein details for ACCSL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4AC99-1A1L2_HUMAN
- Recommended name:
- Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
- Protein Accession:
- Q4AC99
Protein attributes for ACCSL Gene
- Size:
- 568 amino acids
- Molecular mass:
- 65249 Da
- Quaternary structure:
- No Data Available
Protein Expression for ACCSL Gene
Post-translational modifications for ACCSL Gene
Other Protein References for ACCSL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACCSL
- Novus Biologicals Antibodies for ACCSL
- Invitrogen Antibodies for ACCSL (AFLGC-ACCSL)
- GeneTex ACCSL Antibody for ACCSL
-
Boster Bio Antibodies for ACCSL
Protein Products
-
OriGene Purified Proteins for ACCSL
- Search Origene for MassSpec and Protein Over-expression Lysates for ACCSL
- Origene Custom Protein Services for ACCSL
- Novus Biologicals lysates for ACCSL
- Search GeneTex for Proteins for ACCSL
Assay Products
No data available for DME Specific Peptides for ACCSL Gene
Domains & Families for ACCSL Gene
Gene Families for ACCSL Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ACCSL Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACCSL Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q4AC99UniProtKB/Swiss-Prot:
1A1L2_HUMAN :- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
- Family:
-
- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Function for ACCSL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0030170 | pyridoxal phosphate binding | IEA | -- |
Phenotypes for ACCSL Gene
- GenomeRNAi human phenotypes for ACCSL:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ACCSL
-
CRISPR Products
-
OriGene CRISPR knockouts for ACCSL
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- genomics-online: gRNA clones - Search results for 61 available ACCSL gene related products
- Overview of 61 available ACCSL gene related products
- Applied Biological Materials CRISPR for ACCSL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACCSL
- GenScript: Design CRISPR guide RNA sequences for ACCSL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACCSL
- genomics-online: shRNA clones - Search results for 61 available ACCSL gene related products
- Overview of 61 available ACCSL gene related products
Clone Products
- Sino Biological Human cDNA Clone for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
- Applied Biological Materials Clones for ACCSL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ACCSL
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACCSL Gene
Localization for ACCSL Gene
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ACCSL Gene
Pathways & Interactions for ACCSL Gene
No Data Available
Interacting Proteins for ACCSL Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| AADAT | ||
| ABHD14A-ACY1 | ||
| ACACB | ||
| ACCSL | ||
| ACLY |
GPS-Prot Interaction Network for ACCSL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009058 | biosynthetic process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ACCSL Gene
Transcripts for ACCSL Gene
mRNA/cDNA for ACCSL Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000378832 1820 bps (uc001mxw.1)
- ENST00000527145 1806 bps (uc058apu.1)
Unigene Clusters for ACCSL Gene
- 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ACCSL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACCSL
- genomics-online: gRNA clones - Search results for 61 available ACCSL gene related products
- Overview of 61 available ACCSL gene related products
- Applied Biological Materials CRISPR for ACCSL
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACCSL
- GenScript: Design CRISPR guide RNA sequences for ACCSL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACCSL
- genomics-online: shRNA clones - Search results for 61 available ACCSL gene related products
- Overview of 61 available ACCSL gene related products
Clone Products
- Sino Biological Human cDNA Clone for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
- Applied Biological Materials Clones for ACCSL
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ACCSL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ACCSL Gene
This gene is overexpressed in Testis (x13.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACCSL Gene
NURSA nuclear receptor signaling pathways regulating expression of ACCSL Gene:
ACCSLSOURCE GeneReport for Unigene cluster for ACCSL Gene:
Hs.558851Primer Products
-
OriGene qPCR primer pairs for ACCSL
- genomics-online: primer clones - Search results for 61 available ACCSL gene related products
- Overview of 61 available ACCSL gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACCSL Gene
Orthologs for ACCSL Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACCSL 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ACCSL 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Accsl 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Accsl 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACCSL 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ACCSL 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | accs 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | T04F3.1 34 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ACS2 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0578000 33 |
|
- Species where no ortholog for ACCSL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ACCSL Gene
- ENSEMBL:
- Gene Tree for ACCSL (if available)
- TreeFam:
- Gene Tree for ACCSL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ACCSL: view image
Paralogs for ACCSL Gene
(1) SIMAP similar genes for ACCSL Gene using alignment to 2 proteins:
- 1A1L2_HUMAN
- E9PI59_HUMAN
Pseudogenes.org Pseudogenes for ACCSL Gene
Variants for ACCSL Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000021892 | -- | 44,020,252(+) | A/G | genic_upstream_transcript_variant, intron_variant | |
| rs1000031004 | -- | 44,007,919(+) | AAAA/AAA | genic_upstream_transcript_variant, intron_variant | |
| rs1000034707 | -- | 43,927,272(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000042761 | -- | 43,982,532(+) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000043997 | -- | 44,048,836(+) | G/A | intron_variant |
Residual Variation Intolerance Score:
57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ACCSL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACCSL Gene
Disorders for ACCSL Gene
Additional Disease Information for ACCSL
No disorders were found for ACCSL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACCSL Gene
Publications for ACCSL Gene
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for ACCSL Gene
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- Browse Human Proteins and Enzymes
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ACCSL
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ACCSL
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- OriGene qPCR primer pairs for ACCSL
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- High-throughput Antibody Production Service
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- Novus Biologicals
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- Browse Antibodies
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- Invitrogen Antibodies for ACCSL (AFLGC-ACCSL)
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- antibodies-online: Search results for available ACCSL related products ranked by validation data
- antibodies-online: Search results for available ACCSL related products ranked by validation data
- antibodies-online: Search results for available ACCSL related products ranked by validation data
- GeneTex ACCSL Antibody for ACCSL
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- Horizon Cell Lines for ACCSL
- genomics-online: cdna clones - Search results for 61 available ACCSL gene related products
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- Overview of 61 available ACCSL gene related products
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- Overview of 61 available ACCSL gene related products
- genomics-online: primer clones - Search results for 61 available ACCSL gene related products
- Overview of 61 available ACCSL gene related products
- genomics-online: shRNA clones - Search results for 61 available ACCSL gene related products
- Overview of 61 available ACCSL gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
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- Boster Bio Antibodies for ACCSL
- Browse Boster Bio ELISA Kits
Sources for ACCSL Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt