Aliases for ACCSL Gene
Aliases for ACCSL Gene
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like 2 3 5
- Probable Inactive 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 2 3 4
- ACC Synthase-Like Protein 2 3 4
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)-Like 2
- 1-Aminocyclopropane-1-Carboxylate Synthase Homolog(Non-Functional)-Like 3
- 1-Aminocyclopropane-1-Carboxylate Synthase (Inactive)-Like 3
- 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 2 3
External Ids for ACCSL Gene
- HGNC: 34391
- Entrez Gene: 390110
- Ensembl: ENSG00000205126
- UniProtKB: Q4AC99
Previous GeneCards Identifiers for ACCSL Gene
- GC11P044027
- GC11P043778
Summaries for ACCSL Gene
GeneCards Summary for ACCSL Gene
ACCSL (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding. An important paralog of this gene is ACCS.
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ACCSL Gene
Genomics for ACCSL Gene
GeneHancer (GH) Regulatory Elements for ACCSL Gene
Promoters and enhancers for ACCSL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around ACCSL on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ACCSL gene promoter:
-
- HOXA5
- Ik-2
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- STAT4
- STAT5A
- STAT6
Genomic Locations for ACCSL Gene
Genomic Locations for ACCSL Gene
- chr11:43,921,084-44,060,307
- (GRCh38/hg38)
- Size:
- 139,224 bases
- Orientation:
- Plus strand
- chr11:44,069,531-44,081,527
- (GRCh37/hg19)
- Size:
- 11,997 bases
- Orientation:
- Plus strand
Genomic View for ACCSL Gene
Genes around ACCSL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11p11.2 by HGNC
- 11p11.2 by Entrez Gene
- 11p11.2 by Ensembl
ACCSL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ACCSL Gene
Proteins for ACCSL Gene
-
Protein details for ACCSL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4AC99-1A1L2_HUMAN
- Recommended name:
- Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
- Protein Accession:
- Q4AC99
Protein attributes for ACCSL Gene
- Size:
- 568 amino acids
- Molecular mass:
- 65249 Da
- Quaternary structure:
- No Data Available
Protein Expression for ACCSL Gene
Post-translational modifications for ACCSL Gene
Other Protein References for ACCSL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ACCSL
- Novus Biologicals Antibodies for ACCSL
- Invitrogen Antibodies for ACCSL (AFLGC-ACCSL)
- antibodies-online: Show 23 available ACCSL Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for ACCSL
- Search Origene for MassSpec and Protein Over-expression Lysates for ACCSL
- Origene Custom Protein Services for ACCSL
- Novus Biologicals lysates for ACCSL
No data available for DME Specific Peptides for ACCSL Gene
Domains & Families for ACCSL Gene
Gene Families for ACCSL Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for ACCSL Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ACCSL Gene
- GenScript: Design optimal peptide antigens:
-
- 1-aminocyclopropane-1-carboxylate synthase-like protein 2 (1A1L2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q4AC99UniProtKB/Swiss-Prot:
1A1L2_HUMAN :- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
- Family:
-
- Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Function for ACCSL Gene
Phenotypes From GWAS Catalog for ACCSL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0030170 | pyridoxal phosphate binding | IEA | -- |
Phenotypes for ACCSL Gene
- GenomeRNAi human phenotypes for ACCSL:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ACCSL - Select products 50% OFF >
- * ACCSL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ACCSL CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ACCSL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACCSL
- genomics-online: gRNA clones - Search for available ACCSL gRNA products
- Overview of 76 available ACCSL gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACCSL
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACCSL
- genomics-online: shRNA clones - Search for available ACCSL shRNA products
- Overview of 76 available ACCSL gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ACCSL - Select products 50% OFF >
- * ACCSL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ACCSL tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
- genomics-online: cdna clones - Search for available ACCSL CDNA products
- Overview of 76 available ACCSL gene related products
- orf clones - Search for available ACCSL ORF products
- Overview of 76 available ACCSL gene related products
Cell Line Products
-
Horizon Cell Lines for ACCSL
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACCSL Gene
Localization for ACCSL Gene
| Compartment | Confidence |
|---|---|
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| plasma membrane | 0 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ACCSL Gene
Pathways & Interactions for ACCSL Gene
Interacting Proteins for ACCSL Gene
GPS-Prot Interaction Network for ACCSL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009058 | biosynthetic process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ACCSL Gene
Transcripts for ACCSL Gene
mRNA/cDNA for ACCSL Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000378832 1820 bps (ENST00000378832.1)
- ENST00000527145 1806 bps (ENST00000527145.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for ACCSL - Select products 50% OFF >
- * ACCSL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * ACCSL CRISPR applications: KO, Activation, Repression, and more - Browse All
-
OriGene CRISPR knockouts for ACCSL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACCSL
- genomics-online: gRNA clones - Search for available ACCSL gRNA products
- Overview of 76 available ACCSL gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for ACCSL
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACCSL
- genomics-online: shRNA clones - Search for available ACCSL shRNA products
- Overview of 76 available ACCSL gene related products
Clone Products
- Applied Biological Materials (abm): Clones for ACCSL - Select products 50% OFF >
- * ACCSL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * ACCSL tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
- Sino Biological Human cDNA Clone for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
- genomics-online: cdna clones - Search for available ACCSL CDNA products
- Overview of 76 available ACCSL gene related products
- orf clones - Search for available ACCSL ORF products
- Overview of 76 available ACCSL gene related products
Expression for ACCSL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Eye (Sensory Organs)
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- nGnG Amacrine Cells Inner Nuclear Layer
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for ACCSL Gene
This gene is overexpressed in Testis (x13.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACCSL Gene
NURSA nuclear receptor signaling pathways regulating expression of ACCSL Gene:
ACCSLSOURCE GeneReport for Unigene cluster for ACCSL Gene:
Hs.558851Primer Products
-
OriGene qPCR primer pairs for ACCSL
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACCSL Gene
Orthologs for ACCSL Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ACCSL 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ACCSL 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Accsl 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Accsl 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ACCSL 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ACCSL 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 33 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | accs 33 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | T04F3.1 33 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | ACS2 32 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os04g0578000 32 |
|
- Species where no ortholog for ACCSL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Evolution for ACCSL Gene
- ENSEMBL:
- Gene Tree for ACCSL (if available)
- TreeFam:
- Gene Tree for ACCSL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ACCSL: view image
Paralogs for ACCSL Gene
Variants for ACCSL Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000043997 | -- | 44,048,836(+) | G/A | intron_variant | |
| rs1000142690 | -- | 44,055,347(+) | G/C | intron_variant | |
| rs1000527354 | -- | 44,058,656(+) | G/T | coding_sequence_variant, missense_variant | |
| rs1000538797 | -- | 44,057,283(+) | G/A | intron_variant | |
| rs1001089200 | -- | 44,056,941(+) | G/C | intron_variant |
Residual Variation Intolerance Score:
57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ACCSL Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACCSL Gene
Disorders for ACCSL Gene
Additional Disease Information for ACCSL
No disorders were found for ACCSL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACCSL Gene
Publications for ACCSL Gene
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 56
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 56
ExternalLinks
Products for ACCSL Gene
- Custom Antibody ServicesOriGene Antibodies for ACCSL
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for ACCSL
- Search Origene for MassSpec and Protein Over-expression Lysates for ACCSL
- Origene Custom Protein Services for ACCSL
- Origene sirna, shrna, and RNAi products in human, mouse, rat for ACCSL
- Browse OriGene Inhibitory RNA Products For ACCSL
- OriGene qPCR primer pairs for ACCSL
- OriGene CRISPR knockouts for ACCSL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ACCSL
- Sino Biological Human cDNA Clone for ACCSL
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for ACCSL
- Novus Biologicals lysates for ACCSL
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for ACCSL (AFLGC-ACCSL)
- antibodies-online: Show 23 available ACCSL Antibodies ranked by validation data
- antibodies-online: Search results for available ACCSL related products ranked by validation data
- antibodies-online: Search results for available ACCSL related products ranked by validation data
- Horizon Cell Lines for ACCSL
- genomics-online: cdna clones - Search for available ACCSL CDNA products
- Overview of 76 available ACCSL gene related products
- orf clones - Search for available ACCSL ORF products
- Overview of 76 available ACCSL gene related products
- genomics-online: gRNA clones - Search for available ACCSL gRNA products
- Overview of 76 available ACCSL gene related products
- genomics-online: primer clones - Search for available ACCSL Primer products
- Overview of 76 available ACCSL gene related products
- genomics-online: shRNA clones - Search for available ACCSL shRNA products
- Overview of 76 available ACCSL gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ACCSL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ACCSL
- Search GeneCopoeia for miRNA 3'UTR Target clone products for ACCSL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ACCSL
Sources for ACCSL Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource