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Aliases for ACCSL Gene

Aliases for ACCSL Gene

  • 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like 2 3 5
  • ACC Synthase-Like Protein 2 3 4
  • 1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Arabidopsis)(Non-Functional)-Like 2
  • Probable Inactive 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 2 3
  • 1-Aminocyclopropane-1-Carboxylate Synthase Homolog(Non-Functional)-Like 3
  • 1-Aminocyclopropane-1-Carboxylate Synthase (Inactive)-Like 3
  • 1-Aminocyclopropane-1-Carboxylate Synthase-Like Protein 2 3

External Ids for ACCSL Gene

Previous GeneCards Identifiers for ACCSL Gene

  • GC11P044027
  • GC11P043778

Summaries for ACCSL Gene

GeneCards Summary for ACCSL Gene

ACCSL (1-Aminocyclopropane-1-Carboxylate Synthase Homolog (Inactive) Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding. An important paralog of this gene is ACCS.

Additional gene information for ACCSL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ACCSL Gene

Genomics for ACCSL Gene

GeneHancer (GH) Regulatory Elements for ACCSL Gene

Promoters and enhancers for ACCSL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J044043 Promoter 0.5 EPDnew 650.1 +122.3 122313 0.1 ACCSL ALKBH3 LOC105376644 EXT2 ACCS GC11P043987
GH11J043917 Enhancer 1.4 Ensembl ENCODE dbSUPER 0.7 +2.5 2476 12.1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 FOS KLF13 ALKBH3 ALKBH3-AS1 ACCSL ENSG00000254409 C11orf96
GH11J043941 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 0.3 +22.5 22503 4.9 ATF1 SIN3A ZNF48 YY1 GLIS2 ZNF143 FOS RUNX3 RXRA REST C11orf96 SEC14L1P1 ALKBH3 EXT2 ENSG00000254907 TTC17 ACCS ALKBH3-AS1 ENSG00000254409 LOC105376644
GH11J043932 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +12.7 12735 2.1 ZNF768 MXI1 KLF1 ZSCAN4 ZNF133 KLF17 ZMYM3 ZIC2 HIC1 GLIS2 C11orf96 ACCSL ENSG00000254409
GH11J043936 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +16.6 16608 2 KLF1 ESRRA BACH1 FOSL1 ZFHX2 ZNF316 EGR1 SCRT2 FOS PRDM10 C11orf96 ACCSL ENSG00000254409
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ACCSL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ACCSL gene promoter:
  • STAT6
  • HOXA5
  • Ik-2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A

Genomic Locations for ACCSL Gene

Genomic Locations for ACCSL Gene
chr11:43,921,084-44,060,307
(GRCh38/hg38)
Size:
139,224 bases
Orientation:
Plus strand
chr11:44,069,531-44,081,527
(GRCh37/hg19)
Size:
11,997 bases
Orientation:
Plus strand

Genomic View for ACCSL Gene

Genes around ACCSL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ACCSL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ACCSL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ACCSL Gene

Proteins for ACCSL Gene

  • Protein details for ACCSL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4AC99-1A1L2_HUMAN
    Recommended name:
    Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2
    Protein Accession:
    Q4AC99

    Protein attributes for ACCSL Gene

    Size:
    568 amino acids
    Molecular mass:
    65249 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ACCSL Gene

Post-translational modifications for ACCSL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ACCSL Gene

No data available for DME Specific Peptides for ACCSL Gene

Domains & Families for ACCSL Gene

Gene Families for ACCSL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ACCSL Gene

Graphical View of Domain Structure for InterPro Entry

Q4AC99

UniProtKB/Swiss-Prot:

1A1L2_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with ACCSL: view

Function for ACCSL Gene

Gene Ontology (GO) - Molecular Function for ACCSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with ACCSL: view

Phenotypes for ACCSL Gene

genes like me logo Genes that share phenotypes with ACCSL: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ACCSL Gene

Localization for ACCSL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ACCSL gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ACCSL Gene

Pathways & Interactions for ACCSL Gene

SuperPathways for ACCSL Gene

No Data Available

Interacting Proteins for ACCSL Gene

Gene Ontology (GO) - Biological Process for ACCSL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with ACCSL: view

No data available for Pathways by source and SIGNOR curated interactions for ACCSL Gene

Drugs & Compounds for ACCSL Gene

No Compound Related Data Available

Transcripts for ACCSL Gene

mRNA/cDNA for ACCSL Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ACCSL Gene

1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ACCSL Gene

No ASD Table

Relevant External Links for ACCSL Gene

GeneLoc Exon Structure for
ACCSL
ECgene alternative splicing isoforms for
ACCSL

Expression for ACCSL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ACCSL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ACCSL Gene

This gene is overexpressed in Testis (x13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ACCSL Gene



NURSA nuclear receptor signaling pathways regulating expression of ACCSL Gene:

ACCSL

SOURCE GeneReport for Unigene cluster for ACCSL Gene:

Hs.558851
genes like me logo Genes that share expression patterns with ACCSL: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ACCSL Gene

Orthologs for ACCSL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ACCSL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ACCSL 34 33
  • 99.18 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ACCSL 34 33
  • 79.2 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Accsl 16 34 33
  • 70.86 (n)
rat
(Rattus norvegicus)
Mammalia Accsl 33
  • 70.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ACCSL 34
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ACCSL 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii accs 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T04F3.1 34
  • 4 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ACS2 33
  • 45.59 (n)
rice
(Oryza sativa)
Liliopsida Os04g0578000 33
  • 46.25 (n)
Species where no ortholog for ACCSL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ACCSL Gene

ENSEMBL:
Gene Tree for ACCSL (if available)
TreeFam:
Gene Tree for ACCSL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ACCSL: view image

Paralogs for ACCSL Gene

Paralogs for ACCSL Gene

(1) SIMAP similar genes for ACCSL Gene using alignment to 2 proteins:

  • 1A1L2_HUMAN
  • E9PI59_HUMAN

Pseudogenes.org Pseudogenes for ACCSL Gene

genes like me logo Genes that share paralogs with ACCSL: view

Variants for ACCSL Gene

Sequence variations from dbSNP and Humsavar for ACCSL Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000021892 -- 44,020,252(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000031004 -- 44,007,919(+) AAAA/AAA genic_upstream_transcript_variant, intron_variant
rs1000034707 -- 43,927,272(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000042761 -- 43,982,532(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000043997 -- 44,048,836(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ACCSL Gene

Variant ID Type Subtype PubMed ID
nsv510251 OTHER sequence alteration 20534489

Variation tolerance for ACCSL Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ACCSL Gene

Human Gene Mutation Database (HGMD)
ACCSL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ACCSL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ACCSL Gene

Disorders for ACCSL Gene

Additional Disease Information for ACCSL

No disorders were found for ACCSL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ACCSL Gene

Publications for ACCSL Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for ACCSL Gene

Sources for ACCSL Gene

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